| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toni S Pearson, Nalin Gupta, Waldy San Sebastian, Jill Imamura-Ching, Amy Viehoever, Ana Grijalvo-Perez, Alex J Fay, Neha Seth, Shannon M Lundy, Youngho Seo, Miguel Pampaloni, Keith Hyland, Erin Smith, Gardenia de Oliveira Barbosa, Jill C Heathcock, Amy Minnema, Russell Lonser, J Bradley Elder, Jeffrey Leonard, Paul Larson, Krystof S Bankiewic. Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons. Nature communications. vol 12. issue 1. 2021-07-21. PMID:34253733. |
gene therapy for aromatic l-amino acid decarboxylase deficiency by mr-guided direct delivery of aav2-aadc to midbrain dopaminergic neurons. |
2021-07-21 |
2023-08-13 |
Not clear |
| Hyo In Kim, Seungbeom Lee, Juhee Lim, Sungkyun Chung, Tae-Sung Koo, Yu-Geun Ji, Young-Ger Suh, Woo Sung Son, Seok-Ho Kim, Hyun Jin Cho. ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype. Pharmacological research. vol 165. 2021-07-16. PMID:33434621. |
brain derived neurotrophic factor (bdnf) promotes maturation of dopaminergic (daergic) neurons in the midbrain and positively regulates their maintenance and outgrowth. |
2021-07-16 |
2023-08-13 |
Not clear |
| Lily Sarrafha, Gustavo M Parfitt, Ricardo Reyes, Camille Goldman, Elena Coccia, Tatyana Kareva, Tim Ahfeld. High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells. STAR protocols. vol 2. issue 2. 2021-07-13. PMID:33997803. |
here, we describe a high-throughput 3d differentiation protocol for deriving midbrain dopaminergic neurons from human pluripotent stem cells. |
2021-07-13 |
2023-08-13 |
human |
| Lily Sarrafha, Gustavo M Parfitt, Ricardo Reyes, Camille Goldman, Elena Coccia, Tatyana Kareva, Tim Ahfeld. High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells. STAR protocols. vol 2. issue 2. 2021-07-13. PMID:33997803. |
our approach is advantageous for large-scale production of uniform midbrain organoids that can be maintained in diverse formats, and our reporters allow for sorting of dopaminergic neurons. |
2021-07-13 |
2023-08-13 |
human |
| Rolando Lara-Rodarte, Daniel Cortés, Karla Soriano, Francia Carmona, Luisa Rocha, Enrique Estudillo, Adolfo López-Ornelas, Iván Velasc. Mouse Embryonic Stem Cells Expressing GDNF Show Enhanced Dopaminergic Differentiation and Promote Behavioral Recovery After Grafting in Parkinsonian Rats. Frontiers in cell and developmental biology. vol 9. 2021-07-10. PMID:34239871. |
parkinson's disease (pd) is characterized by the progressive loss of midbrain dopaminergic neurons (dans) of the |
2021-07-10 |
2023-08-13 |
mouse |
| Laetitia Etchepare, Hélène Gréa, Pauline Durand, Delphine Bouchet, Laurent Gro. NMDA receptor membrane dynamics tunes the firing pattern of midbrain dopaminergic neurons. The Journal of physiology. vol 599. issue 11. 2021-07-07. PMID:33651437. |
nmda receptor membrane dynamics tunes the firing pattern of midbrain dopaminergic neurons. |
2021-07-07 |
2023-08-13 |
Not clear |
| Susan R Goulding, Martin Lévesque, Aideen M Sullivan, Louise M Collins, Gerard W O'Keeff. Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33713017. |
quinacrine and niclosamide promote neurite growth in midbrain dopaminergic neurons through the canonical bmp-smad pathway and protect against neurotoxin and α-synuclein-induced neurodegeneration. |
2021-07-06 |
2023-08-13 |
human |
| Susan R Goulding, Martin Lévesque, Aideen M Sullivan, Louise M Collins, Gerard W O'Keeff. Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33713017. |
we report that quinacrine and niclosamide, like bmp2, significantly increased neurite length, as a readout of neurotrophic action, in sh-sy5y cells and dopaminergic neurons in primary cultures of rat ventral mesencephalon. |
2021-07-06 |
2023-08-13 |
human |
| Kiyohito Iigaya, Tobias U Hauser, Zeb Kurth-Nelson, John P O'Doherty, Peter Dayan, Raymond J Dola. The value of what's to come: Neural mechanisms coupling prediction error and the utility of anticipation. Science advances. vol 6. issue 25. 2021-07-05. PMID:32596456. |
specifically, ventromedial prefrontal cortex tracks the value of anticipatory utility, dopaminergic midbrain correlates with information that enhances anticipation, while sustained hippocampal activity mediates a functional coupling between these regions. |
2021-07-05 |
2023-08-13 |
human |
| Rodrigo Sosa, Jesús Mata-Luévanos, Mario Buenrostro-Jáuregu. The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission. eNeuro. vol 8. issue 3. 2021-07-02. PMID:33962969. |
the most widely described physiological effect of lhb activation is acutely suppressing midbrain dopaminergic signaling. |
2021-07-02 |
2023-08-13 |
Not clear |
| Li An, Qing Tao, Yue Wu, Nana Wang, Yan Liu, Feifei Wang, Lixing Zhang, Aihua Shi, Xiumin Zhou, Shuang Yu, Jingzhong Zhan. Synthesis of SPIO Nanoparticles and the Subsequent Applications in Stem Cell Labeling for Parkinson's Disease. Nanoscale research letters. vol 16. issue 1. 2021-07-02. PMID:34128153. |
parkinson's disease (pd) is characterized by the progressive loss of dopaminergic neurons in the midbrain, and the stem cell transplantation method provides a promising strategy for the treatment. |
2021-07-02 |
2023-08-13 |
Not clear |
| Sara Nolbrant, Jessica Giacomoni, Deirdre B Hoban, Andreas Bruzelius, Marcella Birtele, Devin Chandler-Militello, Maria Pereira, Daniella Rylander Ottosson, Steven A Goldman, Malin Parma. Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons. Stem cell reports. vol 15. issue 4. 2021-06-30. PMID:32976765. |
direct reprogramming of human fetal- and stem cell-derived glial progenitor cells into midbrain dopaminergic neurons. |
2021-06-30 |
2023-08-13 |
mouse |
| Atsushi Noritake, Taihei Ninomiya, Masaki Isod. Subcortical encoding of agent-relevant associative signals for adaptive social behavior in the macaque. Neuroscience and biobehavioral reviews. vol 125. 2021-06-28. PMID:33609569. |
here, we review the literature supporting the hypothesis that behavioral variables important for decision-making, i.e., stimulus, action, and outcome, are associated with agent information (self and other) in subcortical regions, such as the amygdala, striatum, lateral hypothalamus, and dopaminergic midbrain nuclei. |
2021-06-28 |
2023-08-13 |
monkey |
| Diego Sucunza, Alberto J Rico, Elvira Roda, María Collantes, Gloria González-Aseguinolaza, Ana I Rodríguez-Pérez, Iván Peñuelas, Alfonso Vázquez, José L Labandeira-García, Vania Broccoli, José L Lancieg. Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques. International journal of molecular sciences. vol 22. issue 9. 2021-06-28. PMID:34062940. |
glucocerebrosidase gene therapy induces alpha-synuclein clearance and neuroprotection of midbrain dopaminergic neurons in mice and macaques. |
2021-06-28 |
2023-08-13 |
mouse |
| Nabeel Ali, Amna Syeda, Tenzin Topgyal, Naseem Gaur, Asimul Isla. Parkinson's disease: A current perspectives on Parkinson's disease and key bioactive natural compounds as future potential drug candidates. Current drug targets. 2021-06-24. PMID:34165406. |
the hallmark of pd includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. |
2021-06-24 |
2023-08-13 |
Not clear |
| Alberto F Cintrón-Colón, Gabriel Almeida-Alves, Alicia M Boynton, John M Spitsberge. GDNF synthesis, signaling, and retrograde transport in motor neurons. Cell and tissue research. vol 382. issue 1. 2021-06-23. PMID:32897420. |
gdnf was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons. |
2021-06-23 |
2023-08-13 |
rat |
| Rupinder Kaur Sodhi, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Ranjana Bhandari, Baldeep Kumar, Anurag Kuha. IDO-1 inhibition protects against neuroinflammation, oxidative stress and mitochondrial dysfunction in 6-OHDA induced murine model of Parkinson's disease. Neurotoxicology. vol 84. 2021-06-22. PMID:33774066. |
parkinson's disease (pd), a common neurodegenerative motor disorder characterized by striatal dopaminergic neuronal loss and localized neuroinflammation in the midbrain region. |
2021-06-22 |
2023-08-13 |
Not clear |
| Hidefumi Suzuki, Naohiro Egawa, Takayuki Kondo, Keiko Imamura, Takako Enami, Kayoko Tsukita, Mika Suga, Ran Shibukawa, Yasue Okanishi, Tsuyoshi Uchiyama, Haruhisa Inoue, Ryosuke Takahash. Generation of a human induced pluripotent stem cell line derived from a Parkinson's disease patient carrying SNCA duplication. Stem cell research. vol 45. 2021-06-21. PMID:32413791. |
the ipsc line displayed a capacity to differentiate into midbrain dopaminergic neurons affected in pd. |
2021-06-21 |
2023-08-13 |
human |
| Silvia Cerri, Fabio Blandin. In vivo modeling of prodromal stage of Parkinson's disease. Journal of neuroscience methods. vol 342. 2021-06-21. PMID:32512030. |
prodromal animal models of pd represent an important tool for testing new therapeutic strategies and shedding light on the early pathogenic steps that set the ground for the extensive dopaminergic cell death observed in the midbrain. |
2021-06-21 |
2023-08-13 |
Not clear |
| Qiankun Lv, Zhen Zhong, Binbin Hu, Si Yan, Yufang Yan, Junjun Zhang, Ting Shi, Lijuan Jiang, Wen Li, Wei Huan. MicroRNA-3473b regulates the expression of TREM2/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson disease. Journal of neurochemistry. vol 157. issue 3. 2021-06-21. PMID:33448372. |
parkinson disease (pd) is a neurodegenerative disease characterized by selective loss of dopaminergic (da) neurons in the midbrain. |
2021-06-21 |
2023-08-13 |
mouse |