| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lingling Zhang, Hao Yan. Promotive effects of tetrahydroxystilbene glucoside on the differentiation of neural stem cells from the mesencephalon into dopaminergic neurons. Neuroscience letters. vol 742. 2021-04-29. PMID:33246026. |
parkinson's disease (pd) is a common neurodegenerative disorder characterized by the loss of midbrain dopaminergic (da) neurons. |
2021-04-29 |
2023-08-13 |
mouse |
| Tsukika Sato, Kent Imaizumi, Hirotaka Watanabe, Mitsuru Ishikawa, Hideyuki Okan. Generation of region-specific and high-purity neurons from human feeder-free iPSCs. Neuroscience letters. vol 746. 2021-04-29. PMID:33516803. |
this system is the best optimized approach for feeder-free ipsc culture and generates specific neuronal subtypes with high purity and functionality, including forebrain cortical neurons, forebrain interneurons, midbrain dopaminergic neurons, and spinal motor neurons. |
2021-04-29 |
2023-08-13 |
human |
| Lukas Meyerolbersleben, Christine Winter, Nadine Bernhard. Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats. Behavioural brain research. vol 378. 2021-04-28. PMID:31629834. |
the predominant theory of mesolimbic dopamine function in recent years has been the incentive salience hypothesis, which describes the role of midbrain dopaminergic circuits as encoding 'wanting', but not 'liking' of rewards, resulting in a dissociation of the two functions. |
2021-04-28 |
2023-08-13 |
rat |
| Guozhen Qiu, Chunyan Xu, Qiwen Guo, Fei-Qi Zh. SORL1 mutations are associated with parkinsonian and psychiatric features in Alzheimer disease: Case reports. Medicine. vol 100. issue 16. 2021-04-26. PMID:33879716. |
sorla also mediates a trophic pathway that acts through glial cell line-derived neurotrophic factor (gdnf), a critical survival factor for the midbrain dopaminergic (da) neurons. |
2021-04-26 |
2023-08-13 |
Not clear |
| Dvijen C Purohit, Atulya D Mandyam, Michael J Terranova, Chitra D Mandya. Voluntary wheel running during adolescence distinctly alters running output in adulthood in male and female rats. Behavioural brain research. vol 377. 2021-04-23. PMID:31521739. |
adult female rats show greater running output compared with age-matched male rats, and the midbrain dopaminergic system may account for behavioral differences in running output. |
2021-04-23 |
2023-08-13 |
rat |
| Akihiro Yamaguchi, Kei-Ichi Ishikawa, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Shinji Saiki, Taku Hatano, Akio Mori, Yutaka Oji, Ayami Okuzumi, Yuanzhe Li, Manabu Funayama, Yuzuru Imai, Nobutaka Hattori, Wado Akamats. Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease. Stem cell reports. vol 14. issue 6. 2021-04-19. PMID:32470327. |
parkinson disease (pd) is a neurodegenerative disorder caused by the progressive loss of midbrain dopaminergic neurons, and mitochondrial dysfunction is involved in its pathogenesis. |
2021-04-19 |
2023-08-13 |
drosophila_melanogaster |
| Serena Corti, Remi Bonjean, Thomas Legier, Diane Rattier, Christophe Melon, Pascal Salin, Erik A Toso, Michael Kyba, Lydia Kerkerian-Le Goff, Flavio Maina, Rosanna Don. Enhanced differentiation of human induced pluripotent stem cells toward the midbrain dopaminergic neuron lineage through GLYPICAN-4 downregulation. Stem cells translational medicine. vol 10. issue 5. 2021-04-18. PMID:33528918. |
here, we show that hipscs downregulated for the signaling modulator glypican-4 (gpc4) acquire a new biological state characterized by increased hipsc differentiation capabilities toward ventral midbrain dopaminergic (vmda) neuron progenitors. |
2021-04-18 |
2023-08-13 |
human |
| Rachel M Furlong, Gerard W O'Keeffe, Cora O'Neill, Aideen M Sulliva. Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons. Neuroscience letters. vol 720. 2021-04-16. PMID:31978495. |
accumulation of α-synuclein is a pathological hallmark of parkinson's disease (pd) and has been linked to reductions in neurite length and axonal degeneration of midbrain dopaminergic neurons. |
2021-04-16 |
2023-08-13 |
rat |
| Yumin Zheng, Li Dong, Na Liu, Xiaoguang Luo, Zhiyi H. Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson's Disease. BioMed research international. vol 2020. 2021-04-15. PMID:33204711. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons in the substantia nigra. |
2021-04-15 |
2023-08-13 |
Not clear |
| Wenhao Li, Han Gao, Wentao L. Effects of Combined Bushen Zhichan Recipe and Levodopa in a Rodent Model of Parkinson Disease: Potential Mechanisms. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-04-14. PMID:32555131. |
the number of midbrain dopaminergic neurons in rats in the levodopa and bushen zhichan recipe group was greater compared to controls. |
2021-04-14 |
2023-08-13 |
rat |
| Julie Jerber, Daniel D Seaton, Anna S E Cuomo, Natsuhiko Kumasaka, James Haldane, Juliette Steer, Minal Patel, Daniel Pearce, Malin Andersson, Marc Jan Bonder, Ed Mountjoy, Maya Ghoussaini, Madeline A Lancaster, John C Marioni, Florian T Merkle, Daniel J Gaffney, Oliver Stegl. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation. Nature genetics. vol 53. issue 3. 2021-04-08. PMID:33664506. |
to address this, we use an efficient multiplexing strategy to differentiate 215 human induced pluripotent stem cell (ipsc) lines toward a midbrain neural fate, including dopaminergic neurons, and use single-cell rna sequencing (scrna-seq) to profile over 1 million cells across three differentiation time points. |
2021-04-08 |
2023-08-13 |
human |
| Florian Krach, Marios-Evangelos Bogiongko, Beate Winne. Decoding Parkinson's disease - iPSC-derived models in the OMICs era. Molecular and cellular neurosciences. vol 106. 2021-04-07. PMID:32439399. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the midbrain. |
2021-04-07 |
2023-08-13 |
Not clear |
| Soojin Kim, Yvette C Wong, Fanding Gao, Dimitri Krain. Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson's disease. Nature communications. vol 12. issue 1. 2021-04-05. PMID:33753743. |
together, our work demonstrates a potential role of mitochondria-lysosome contacts as an upstream regulator of mitochondrial function and dynamics in midbrain dopaminergic neurons in gba1-linked parkinson's disease. |
2021-04-05 |
2023-08-13 |
human |
| Ryohei Norioka, Keizo Sugaya, Aki Murayama, Tomoya Kawazoe, Shinsuke Tobisawa, Akihiro Kawata, Kazushi Takahash. Midbrain atrophy related to parkinsonism in a non-coding repeat expansion disorder: five cases of spinocerebellar ataxia type 31 with nigrostriatal dopaminergic dysfunction. Cerebellum & ataxias. vol 8. issue 1. 2021-04-03. PMID:33785066. |
midbrain atrophy related to parkinsonism in a non-coding repeat expansion disorder: five cases of spinocerebellar ataxia type 31 with nigrostriatal dopaminergic dysfunction. |
2021-04-03 |
2023-08-13 |
Not clear |
| Alicia Costa, Jaime Monti, Pablo Torterol. Hypocretin (orexin) immunoreactivity in the feline midbrain: Relevance for the generation of wakefulness. Journal of chemical neuroanatomy. vol 105. 2021-04-02. PMID:32145304. |
in addition, we studied in detail the hcrtergic projection towards the dopaminergic nuclei of the midbrain. |
2021-04-02 |
2023-08-13 |
cat |
| Floriana Volpicelli, Carla Perrone-Capano, Gian Carlo Bellenchi, Luca Colucci-D'Amato, Umberto di Porzi. Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration. International journal of molecular sciences. vol 21. issue 11. 2021-03-31. PMID:32503161. |
the relatively few dopaminergic neurons in the mammalian brain are mostly located in the midbrain and regulate many important neural functions, including motor integration, cognition, emotive behaviors and reward. |
2021-03-31 |
2023-08-13 |
Not clear |
| Floriana Volpicelli, Carla Perrone-Capano, Gian Carlo Bellenchi, Luca Colucci-D'Amato, Umberto di Porzi. Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration. International journal of molecular sciences. vol 21. issue 11. 2021-03-31. PMID:32503161. |
unraveling the mechanisms of midbrain dopaminergic (mda) phenotype induction and maturation and elucidating the role of the gene network involved in the development and maintenance of these neurons is of pivotal importance to rescue or substitute these cells in order to restore dopaminergic functions. |
2021-03-31 |
2023-08-13 |
Not clear |
| Zhaohui Liu, Hoi-Hung Cheun. Stem Cell-Based Therapies for Parkinson Disease. International journal of molecular sciences. vol 21. issue 21. 2021-03-29. PMID:33137927. |
however, proposed cell replacement therapies are promising because midbrain dopaminergic neurons have been shown to restore dopaminergic neurotransmission and functionally rescue the dopamine-depleted striatum. |
2021-03-29 |
2023-08-13 |
Not clear |
| Akihiro Yamaguchi, Kei-Ichi Ishikawa, Wado Akamats. Methods to Induce Small-Scale Differentiation of iPS Cells into Dopaminergic Neurons and to Detect Disease Phenotypes. Methods in molecular biology (Clifton, N.J.). 2021-03-23. PMID:33755905. |
in this chapter, we describe a procedure to efficiently induce small-scale differentiation of patient ips cells into midbrain dopaminergic neurons to detect cell death and mitochondrial clearance by using immunostaining. |
2021-03-23 |
2023-08-13 |
Not clear |
| Jordan Follett, Matthew J Farre. LRRK2; a dynamic regulator of cellular trafficking. Brain research. vol 1761. 2021-03-21. PMID:33662339. |
nevertheless, the age-associated midbrain pathology observed post-mortem in lrrk2-parkinsonism may involve the abnormal accumulation of either α-synuclein or tau, or just the loss of dopaminergic neurons and gliosis. |
2021-03-21 |
2023-08-13 |
Not clear |