| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julian L Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W L Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K Luthra, William D Shingleton, Steve K W Oh, Li Zeng, Edward G Robin. Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease. Stem cell research & therapy. vol 11. issue 1. 2021-05-24. PMID:32771055. |
the current study examines the utility of neuroimaging to characterise the in vivo maturation, innervation and functional dopamine release of transplanted human embryonic stem cell-derived midbrain dopaminergic neurons (hesc-mdas) in a preclinical model of pd. |
2021-05-24 |
2023-08-13 |
human |
| Natalia Jimenez-Moreno, Jon D Lan. Autophagy and Redox Homeostasis in Parkinson's: A Crucial Balancing Act. Oxidative medicine and cellular longevity. vol 2020. 2021-05-20. PMID:33224433. |
parkinson's is caused by the loss of midbrain dopaminergic neurons (mdans), resulting in progressive disruption of the nigrostriatal pathway, leading to motor, behavioural, and cognitive impairments. |
2021-05-20 |
2023-08-13 |
Not clear |
| Tertia D Purves-Tyson, Ulrike Weber-Stadlbauer, Juliet Richetto, Debora A Rothmond, Marie A Labouesse, Marcello Polesel, Kate Robinson, Cynthia Shannon Weickert, Urs Meye. Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation. Molecular psychiatry. vol 26. issue 3. 2021-05-14. PMID:31168068. |
thus, we quantified inflammatory markers in dopaminergic areas of the midbrain of people with schizophrenia and matched controls. |
2021-05-14 |
2023-08-13 |
mouse |
| Tertia D Purves-Tyson, Ulrike Weber-Stadlbauer, Juliet Richetto, Debora A Rothmond, Marie A Labouesse, Marcello Polesel, Kate Robinson, Cynthia Shannon Weickert, Urs Meye. Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation. Molecular psychiatry. vol 26. issue 3. 2021-05-14. PMID:31168068. |
these data demonstrate that immune-related changes in schizophrenia extend to dopaminergic areas of the midbrain and exist in the absence of changes in microglial cell number, but with putative evidence of microglial and astrocytic activation in the high immune subgroup. |
2021-05-14 |
2023-08-13 |
mouse |
| Gregor Leicht, Christina Andreou, Till Nafe, Felix Nägele, Jonas Rauh, Stjepan Curic, Paul Schauer, Daniel Schöttle, Saskia Steinmann, Christoph Muler. Alterations of oscillatory neuronal activity during reward processing in schizophrenia. Journal of psychiatric research. vol 129. 2021-05-14. PMID:32619750. |
remarkably, midbrain dopaminergic signalling also includes theta and high-beta frequency modes, which have been assumed to reflect tonic and phasic dopamine responses, respectively. |
2021-05-14 |
2023-08-13 |
Not clear |
| Smitha Bhaskar, Jeevan Gowda, Jyothi Prasanna, Anujith Kuma. Does altering proteasomal activity and trafficking reduce the arborization mediated specific vulnerability of SNpc dopaminergic neurons of Parkinson's disease? Medical hypotheses. vol 143. 2021-05-14. PMID:32652429. |
the disease originates majorly due to compromised function of the dopaminergic (da) neurons in the substantia nigra pars compacta (snpc), but not the ventral tegmental area (vta) region of the midbrain. |
2021-05-14 |
2023-08-13 |
Not clear |
| Bo-Ryoung Choi, Dong-Hee Kim, Michela Gallagher, Jung-Soo Ha. Engagement of the Lateral Habenula in the Association of a Conditioned Stimulus with the Absence of an Unconditioned Stimulus. Neuroscience. vol 444. 2021-05-14. PMID:32717296. |
neurons in the lateral habenula (lhb) are activated by reward omission and inhibited by reward delivery-reward processing functions opposite those of midbrain dopaminergic neurons. |
2021-05-14 |
2023-08-13 |
rat |
| Bo-Ryoung Choi, Dong-Hee Kim, Michela Gallagher, Jung-Soo Ha. Engagement of the Lateral Habenula in the Association of a Conditioned Stimulus with the Absence of an Unconditioned Stimulus. Neuroscience. vol 444. 2021-05-14. PMID:32717296. |
the number of c-fos-positive signals in lhb neurons projecting to dopaminergic midbrain neurons was higher in the unpaired group than in the paired group. |
2021-05-14 |
2023-08-13 |
rat |
| Afia Asif, Silvia García-López, Arto Heiskanen, Alberto Martínez-Serrano, Stephan S Keller, Marta P Pereira, Jenny Emnéu. Pyrolytic Carbon Nanograss Enhances Neurogenesis and Dopaminergic Differentiation of Human Midbrain Neural Stem Cells. Advanced healthcare materials. vol 9. issue 20. 2021-05-14. PMID:32902188. |
pyrolytic carbon nanograss enhances neurogenesis and dopaminergic differentiation of human midbrain neural stem cells. |
2021-05-14 |
2023-08-13 |
human |
| Gianpaolo Antonio Basile, Alessia Bramanti, Salvatore Bertino, Giuseppina Cutroneo, Antonio Bruno, Adriana Tisano, Giuseppe Paladina, Demetrio Milardi, Giuseppe Anastas. Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients. Medicina (Kaunas, Lithuania). vol 56. issue 12. 2021-05-14. PMID:33322072. |
structural connectivity-based parcellation of the dopaminergic midbrain in healthy subjects and schizophrenic patients. |
2021-05-14 |
2023-08-13 |
human |
| Li-Ping Liang, Ruth Fulton, Erica L Bradshaw-Pierce, Jennifer Pearson-Smith, Brian J Day, Manisha Pate. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. The Journal of pharmacology and experimental therapeutics. vol 377. issue 1. 2021-05-14. PMID:33500265. |
in addition, both compounds significantly attenuated 6-hydroxydopamine (6-ohda)-induced neurotoxic damage, including dopamine depletion, cytokine production, and microglial activation in the striata; dopaminergic neuronal loss in the substantia nigra; oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain; and rotation behavioral abnormality in rats. |
2021-05-14 |
2023-08-13 |
mouse |
| Luca Magistrelli, Marco Ferrari, Alessia Furgiuele, Anna Vera Milner, Elena Contaldi, Cristoforo Comi, Marco Cosentino, Franca Marin. Polymorphisms of Dopamine Receptor Genes and Parkinson's Disease: Clinical Relevance and Future Perspectives. International journal of molecular sciences. vol 22. issue 7. 2021-05-12. PMID:33917417. |
parkinson's disease (pd) is a neurodegenerative disease caused by loss of dopaminergic neurons in the midbrain. |
2021-05-12 |
2023-08-13 |
Not clear |
| Tae Hwan Kwak, Ji Hyun Kang, Sai Hali, Jonghun Kim, Kee-Pyo Kim, Chanhyeok Park, Ju-Hyun Lee, Ha Kyun Ryu, Ji Eun Na, Junghyun Jo, Hyunsoo Shawn Je, Huck-Hui Ng, Jeongwoo Kwon, Nam-Hyung Kim, Kwon Ho Hong, Woong Sun, Chi Hye Chung, Im Joo Rhyu, Dong Wook Ha. Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling. Stem cells (Dayton, Ohio). vol 38. issue 6. 2021-05-07. PMID:32083763. |
here we describe the robust generation of mos with homogeneous distribution of midbrain dopaminergic (mda) neurons. |
2021-05-07 |
2023-08-13 |
human |
| Shermaine Huiping Tay, Winanto, Zi Jian Khong, Yong Hui Koh, Shi Yan N. Generation of Cortical, Dopaminergic, Motor, and Sensory Neurons from Human Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.). 2021-05-07. PMID:33959917. |
in this chapter, we provide details of the differentiation protocols to reliably derive four currently relevant neuronal subtypes, i.e., cortical neurons, midbrain dopaminergic neurons, spinal motor neurons, and sensory neurons. |
2021-05-07 |
2023-08-13 |
human |
| Aaron Lerne. The intestinal luminal sources of α-synuclein: a gastroenterologist perspective. Nutrition reviews. 2021-05-04. PMID:33942062. |
parkinson's disease is characterized by nonmotor/motor dysfunction, midbrain dopaminergic neuronal death, and α-synuclein (asn) deposits. |
2021-05-04 |
2023-08-13 |
Not clear |
| Xin Liu, Zhong-Rui Du, Xiong Wang, Kar-Him Luk, Cheuk-Hin Chan, Xu Cao, Qing Zhao, Fang Zhao, Wing-Tak Wong, Ka-Hing Wong, Xiao-Li Don. Colonic Dopaminergic Neurons Changed Reversely With Those in the Midbrain via Gut Microbiota-Mediated Autophagy in a Chronic Parkinson's Disease Mice Model. Frontiers in aging neuroscience. vol 13. 2021-04-30. PMID:33912026. |
colonic dopaminergic neurons changed reversely with those in the midbrain via gut microbiota-mediated autophagy in a chronic parkinson's disease mice model. |
2021-04-30 |
2023-08-13 |
mouse |
| Xin Liu, Zhong-Rui Du, Xiong Wang, Kar-Him Luk, Cheuk-Hin Chan, Xu Cao, Qing Zhao, Fang Zhao, Wing-Tak Wong, Ka-Hing Wong, Xiao-Li Don. Colonic Dopaminergic Neurons Changed Reversely With Those in the Midbrain via Gut Microbiota-Mediated Autophagy in a Chronic Parkinson's Disease Mice Model. Frontiers in aging neuroscience. vol 13. 2021-04-30. PMID:33912026. |
our study employed a classical pd mice model achieved by chronic mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) injection to study concurrent changes of dopaminergic neurons in the midbrain and the colon of mice. |
2021-04-30 |
2023-08-13 |
mouse |
| Nora N Esmaiel, Engy A Ashaat, Rehab Mosaad, Alaaeldin Fayez, Mona Ibrahim, Zeinab Y Abdallah, Mahmoud Y Issa, Sohair Salem, Abeer Ramadan, Maged A El Wakeel, Neveen A Ashaat, Maha S Zaki, Samira Ismai. The potential impact of COMT gene variants on dopamine regulation and phenotypic traits of ASD patients. Behavioural brain research. vol 378. 2021-04-29. PMID:31586564. |
the pathogenesis of autism may be related to dysfunction in the midbrain dopaminergic system. |
2021-04-29 |
2023-08-13 |
human |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Shameema Bano, Shubha Shukl. Dopamine D1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of Parkinson's disease. Behavioural brain research. vol 378. 2021-04-29. PMID:31626851. |
the depletion of da in midbrain due to degeneration of nigral dopaminergic (daergic) neurons leads to parkinson's disease (pd). |
2021-04-29 |
2023-08-13 |
rat |
| Lingling Zhang, Hao Yan. Promotive effects of tetrahydroxystilbene glucoside on the differentiation of neural stem cells from the mesencephalon into dopaminergic neurons. Neuroscience letters. vol 742. 2021-04-29. PMID:33246026. |
promotive effects of tetrahydroxystilbene glucoside on the differentiation of neural stem cells from the mesencephalon into dopaminergic neurons. |
2021-04-29 |
2023-08-13 |
mouse |