| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sreekanth Rajan, Yongwoo Jang, Chun-Hyung Kim, Woori Kim, Hui Ting Toh, Jeha Jeon, Bin Song, Aida Serra, Julien Lescar, Jun Yeob Yoo, Serap Beldar, Hong Ye, Congbao Kang, Xue-Wei Liu, Melissa Feitosa, Yeahan Kim, Dabin Hwang, Geraldine Goh, Kah-Leong Lim, Hye Min Park, Choong Hwan Lee, Sungwhan F Oh, Gregory A Petsko, Ho Sup Yoon, Kwang-Soo Ki. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nature chemical biology. vol 16. issue 8. 2020-11-23. PMID:32451509. |
the orphan nuclear receptor nurr1 is critical for the development, maintenance and protection of midbrain dopaminergic (mda) neurons. |
2020-11-23 |
2023-08-13 |
mouse |
| Ashutosh Dhingra, Joachim Täger, Elisangela Bressan, Salvador Rodriguez-Nieto, Manmeet-Sakshi Bedi, Stefanie Bröer, Eldem Sadikoglou, Noémia Fernandes, Melissa Castillo-Lizardo, Patrizia Rizzu, Peter Heutin. Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring. Journal of visualized experiments : JoVE. issue 162. 2020-11-20. PMID:32831313. |
we describe the automation of a short-term differentiation protocol using neurogenin-2 (ngn2) over-expression to produce hipsc-derived cortical neurons within 6‒8 days, and the implementation of a long-term differentiation protocol to generate hipsc-derived midbrain dopaminergic (mda) neurons within 65 days. |
2020-11-20 |
2023-08-13 |
human |
| b' Slobodan Kapor, Milan Aksi\\xc4\\x87, Laslo Pu\\xc5\\xa1ka\\xc5\\xa1, Marin Juki\\xc4\\x87, Joko Poleksi\\xc4\\x87, Filip Milosavljevi\\xc4\\x87, Suncica Bjelica, Branislav Filipovi\\xc4\\x8. Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats. Frontiers in neuroanatomy. vol 14. 2020-11-17. PMID:33192342.' |
maternally deprived and control wistar rats were sacrificed on postnatal day 35 or 60, and the dopaminergic neurons were stained in coronal histological sections of ventral midbrain with the tyrosine hydroxylase antibody. |
2020-11-17 |
2023-08-13 |
rat |
| Yujuan Gui, Mélanie H Thomas, Pierre Garcia, Mona Karout, Rashi Halder, Alessandro Michelucci, Heike Kollmus, Cuiqi Zhou, Shlomo Melmed, Klaus Schughart, Rudi Balling, Michel Mittelbronn, Joseph H Nadeau, Robert W Williams, Thomas Sauter, Manuel Buttini, Lasse Sinkkone. Frontiers in genetics. vol 11. 2020-11-13. PMID:33173537. |
dopaminergic neurons in the midbrain are of particular interest due to their role in diseases such as parkinson's disease and schizophrenia. |
2020-11-13 |
2023-08-13 |
mouse |
| Yujuan Gui, Mélanie H Thomas, Pierre Garcia, Mona Karout, Rashi Halder, Alessandro Michelucci, Heike Kollmus, Cuiqi Zhou, Shlomo Melmed, Klaus Schughart, Rudi Balling, Michel Mittelbronn, Joseph H Nadeau, Robert W Williams, Thomas Sauter, Manuel Buttini, Lasse Sinkkone. Frontiers in genetics. vol 11. 2020-11-13. PMID:33173537. |
genetic variation between individuals can affect the integrity and function of dopaminergic neurons but the dna variants and molecular cascades modulating dopaminergic neurons and other cells types of ventral midbrain remain poorly defined. |
2020-11-13 |
2023-08-13 |
mouse |
| Zhu Zhu, Wu Yichen, Zhang Ziheng, Ge Dinghao, Lu Ming, Liu Wei, Shan Enfang, Hu Gang, Hiroaki Honda, Yang Jia. The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling. Aging. vol 11. issue 24. 2020-11-10. PMID:31884423. |
here we study the effects of differentiated embryonic chondrocyte gene 1(dec1) deficiency on midbrain dopaminergic(da) neurons in the substantia nigra pars compacta(snpc) through behavioral, histological and molecular analysis. |
2020-11-10 |
2023-08-13 |
mouse |
| Jose A Morales-Garcia, Sandra Alonso-Gil, Ángel Santos, Ana Perez-Castill. Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease. Molecular neurobiology. vol 57. issue 2. 2020-11-05. PMID:31473904. |
parkinson's disease is characterized by a loss of dopaminergic neurons in the ventral midbrain. |
2020-11-05 |
2023-08-13 |
mouse |
| Francesco Napolitano, Arianna De Rosa, Rosita Russo, Anna Di Maio, Martina Garofalo, Mauro Federici, Sara Migliarini, Ada Ledonne, Francesca Romana Rizzo, Luigi Avallone, Tommaso Nuzzo, Tommaso Biagini, Massimo Pasqualetti, Nicola Biagio Mercuri, Tommaso Mazza, Angela Chambery, Alessandro Usiell. The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31653935. |
despite dramatic striatal alterations associated to cocaine exposure, our data did not reveal any significant changes in midbrain dopaminergic neurons as a lack of rhes did not affect: (i) dat activity; (ii) d2r-dependent regulation of girk; and (iii) d2r-dependent regulation of dopamine release. |
2020-11-05 |
2023-08-13 |
mouse |
| Tae-Yoon Park, Yongwoo Jang, Woori Kim, Joon Shin, Hui Ting Toh, Chun-Hyung Kim, Ho Sup Yoon, Pierre Leblanc, Kwang-Soo Ki. Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases. Scientific reports. vol 9. issue 1. 2020-11-02. PMID:31664129. |
the orphan nuclear receptor nurr1 (also known as nr4a2) is an essential transcription factor affecting the development and maintenance of midbrain dopaminergic neurons. |
2020-11-02 |
2023-08-13 |
Not clear |
| Matthijs C Dorst, Anna Tokarska, Ming Zhou, Kwang Lee, Stefanos Stagkourakis, Christian Broberger, Sotiris Masmanidis, Gilad Silberber. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature communications. vol 11. issue 1. 2020-11-02. PMID:33037215. |
synchronized pauses in the activity of striatal cholinergic interneurons (chins) are correlated with elevated activity of midbrain dopaminergic neurons, whereas synchronous firing of chins induces local release of dopamine. |
2020-11-02 |
2023-08-13 |
Not clear |
| Matthijs C Dorst, Anna Tokarska, Ming Zhou, Kwang Lee, Stefanos Stagkourakis, Christian Broberger, Sotiris Masmanidis, Gilad Silberber. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature communications. vol 11. issue 1. 2020-11-02. PMID:33037215. |
inhibition between chins is attenuated by dopaminergic midbrain afferents acting presynaptically on d2 receptors. |
2020-11-02 |
2023-08-13 |
Not clear |
| Matías Cavelli, Giselle Prunell, Gustavo Costa, Noelia Velásquez, Joaquín Gonzalez, Santiago Castro-Zaballa, Marcelo M S Lima, Pablo Torterol. Electrocortical high frequency activity and respiratory entrainment in 6-hydroxydopamine model of Parkinson's disease. Brain research. vol 1724. 2020-10-29. PMID:31499018. |
), which are associated with the degeneration of the dopaminergic neurons of the midbrain. |
2020-10-29 |
2023-08-13 |
rat |
| Matías Cavelli, Giselle Prunell, Gustavo Costa, Noelia Velásquez, Joaquín Gonzalez, Santiago Castro-Zaballa, Marcelo M S Lima, Pablo Torterol. Electrocortical high frequency activity and respiratory entrainment in 6-hydroxydopamine model of Parkinson's disease. Brain research. vol 1724. 2020-10-29. PMID:31499018. |
in the present study, we evaluate the role of midbrain dopaminergic neurons, in the modulation of the electrocorticogram activity and its respiratory entrainment during wakefulness and sleep. |
2020-10-29 |
2023-08-13 |
rat |
| Carlos W Gantner, Agustín Cota-Coronado, Lachlan H Thompson, Clare L Paris. An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions. STAR protocols. vol 1. issue 2. 2020-10-29. PMID:33111103. |
here, we describe a xeno-free, feeder-free, and chemically defined protocol for the generation of ventral midbrain dopaminergic (vmda) progenitors from human pluripotent stem cells (hpscs). |
2020-10-29 |
2023-08-13 |
human |
| Mary-Frances E Hall, Frank C Churc. Exercise for Older Adults Improves the Quality of Life in Parkinson's Disease and Potentially Enhances the Immune Response to COVID-19. Brain sciences. vol 10. issue 9. 2020-10-28. PMID:32899958. |
parkinson's disease (pd) is a progressive neurodegenerative disorder brought about due to dopaminergic neuronal cell loss in the midbrain substantia nigra pars compacta region. |
2020-10-28 |
2023-08-13 |
Not clear |
| J A Hosp, K L Greiner, L Martinez Arellano, F Roth, F Löffler, J Reis, B Fritsc. Progressive secondary exo-focal dopaminergic neurodegeneration occurs in not directly connected midbrain nuclei after pure motor-cortical stroke. Experimental neurology. vol 327. 2020-10-27. PMID:31987834. |
progressive secondary exo-focal dopaminergic neurodegeneration occurs in not directly connected midbrain nuclei after pure motor-cortical stroke. |
2020-10-27 |
2023-08-13 |
rat |
| J A Hosp, K L Greiner, L Martinez Arellano, F Roth, F Löffler, J Reis, B Fritsc. Progressive secondary exo-focal dopaminergic neurodegeneration occurs in not directly connected midbrain nuclei after pure motor-cortical stroke. Experimental neurology. vol 327. 2020-10-27. PMID:31987834. |
in the case of middle cerebral artery occlusion (mcao), in which striato-nigral connections are affected, the hypothesis of inflammation-induced remote neurodegeneration is based on the temporal dynamics of an early appearance of inflammatory markers in midbrain followed by dopaminergic neuronal loss. |
2020-10-27 |
2023-08-13 |
rat |
| J A Hosp, K L Greiner, L Martinez Arellano, F Roth, F Löffler, J Reis, B Fritsc. Progressive secondary exo-focal dopaminergic neurodegeneration occurs in not directly connected midbrain nuclei after pure motor-cortical stroke. Experimental neurology. vol 327. 2020-10-27. PMID:31987834. |
to test the hypothesis of a direct transsynaptic mediation of secondary exo-focal post-ischemic neurodegeneration, we used a photochemical induction of a stroke (pts) in sprague-dawley rats restricted to motor cortex (mc), thereby sparing the striatal connections to dopaminergic midbrain nuclei. |
2020-10-27 |
2023-08-13 |
rat |
| Teresia M Osborn, Penelope J Hallett, James M Schumacher, Ole Isacso. Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients. Frontiers in cellular neuroscience. vol 14. 2020-10-27. PMID:32317934. |
restoration of dopaminergic synapses using neuronal cell replacement therapy has shown benefit in clinical studies using cells from fetal ventral midbrain. |
2020-10-27 |
2023-08-13 |
Not clear |
| Jeffrey Kim, Marcel M Daad. Non-cell autonomous mechanism of Parkinson's disease pathology caused by G2019S LRRK2 mutation in Ashkenazi Jewish patient: Single cell analysis. Brain research. vol 1722. 2020-10-21. PMID:31330122. |
parkinson's disease (pd) is the second most prevalent neurodegenerative disease, characterized by the loss of the midbrain dopaminergic neurons, which leads to impaired motor and cognitive functions. |
2020-10-21 |
2023-08-13 |
Not clear |