| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edward J Robinson, Sebastian P Aguiar, Willemieke M Kouwenhoven, Dorinde S Starmans, Lars von Oerthel, Marten P Smidt, Lars P van der Heid. Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell death discovery. vol 4. 2020-09-30. PMID:30479840. |
the dependence of mouse dopaminergic midbrain neurons on mcl1 was confirmed using ex vivo slice cultures from pitx3gfp/+ and wildtype mice. |
2020-09-30 |
2023-08-13 |
mouse |
| Edward J Robinson, Sebastian P Aguiar, Willemieke M Kouwenhoven, Dorinde S Starmans, Lars von Oerthel, Marten P Smidt, Lars P van der Heid. Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell death discovery. vol 4. 2020-09-30. PMID:30479840. |
in mouse dopaminergic midbrain neurons positive for the midbrain dopaminergic marker pitx3, or tyrosine hydroxylase, umi-77 treatment caused a dramatic increase in cleaved caspase 3, indicating that mcl1 activity is required for basal neuronal survival. |
2020-09-30 |
2023-08-13 |
mouse |
| Edward J Robinson, Sebastian P Aguiar, Willemieke M Kouwenhoven, Dorinde S Starmans, Lars von Oerthel, Marten P Smidt, Lars P van der Heid. Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell death discovery. vol 4. 2020-09-30. PMID:30479840. |
boosting the pro-survival function of mcl1 should be pursued as a therapeutic approach to augment the resilience of midbrain dopaminergic neurons to apoptotic stress in parkinson's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Claude Brodski, Sandra Blaess, Juha Partanen, Nilima Prakas. Crosstalk of Intercellular Signaling Pathways in the Generation of Midbrain Dopaminergic Neurons In Vivo and from Stem Cells. Journal of developmental biology. vol 7. issue 1. 2020-09-30. PMID:30650592. |
crosstalk of intercellular signaling pathways in the generation of midbrain dopaminergic neurons in vivo and from stem cells. |
2020-09-30 |
2023-08-13 |
human |
| Claude Brodski, Sandra Blaess, Juha Partanen, Nilima Prakas. Crosstalk of Intercellular Signaling Pathways in the Generation of Midbrain Dopaminergic Neurons In Vivo and from Stem Cells. Journal of developmental biology. vol 7. issue 1. 2020-09-30. PMID:30650592. |
the induction of midbrain dopaminergic (mda) neurons depends on two important signaling centers of the mammalian embryo: the ventral midline or floor plate (fp) of the neural tube, and the isthmic organizer (iso) at the mid-/hindbrain boundary (mhb). |
2020-09-30 |
2023-08-13 |
human |
| Lisa M Smits, Lydia Reinhardt, Peter Reinhardt, Michael Glatza, Anna S Monzel, Nancy Stanslowsky, Marcelo D Rosato-Siri, Alessandra Zanon, Paul M Antony, Jessica Bellmann, Sarah M Nicklas, Kathrin Hemmer, Xiaobing Qing, Emanuel Berger, Norman Kalmbach, Marc Ehrlich, Silvia Bolognin, Andrew A Hicks, Florian Wegner, Jared L Sterneckert, Jens C Schwambor. Modeling Parkinson's disease in midbrain-like organoids. NPJ Parkinson's disease. vol 5. 2020-09-30. PMID:30963107. |
these organoids are composed of midbrain dopaminergic neurons (mdans), which produce and secrete dopamine. |
2020-09-30 |
2023-08-13 |
human |
| Aimée I Vester, Merry Chen, Carmen J Marsit, W Michael Caudl. A Neurodevelopmental Model of Combined Pyrethroid and Chronic Stress Exposure. Toxics. vol 7. issue 2. 2020-09-30. PMID:31052489. |
midbrain rna expression as well as striatal and cortical protein expression of key dopaminergic components were investigated, in addition to adhd-like behavioral tasks and electrochemical dopamine dynamics via fast-scan cyclic voltammetry. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jun Yang, Yujie Xiao, Liang Li, Quansheng He, Min Li, Yousheng Sh. Biophysical Properties of Somatic and Axonal Voltage-Gated Sodium Channels in Midbrain Dopaminergic Neurons. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31354436. |
biophysical properties of somatic and axonal voltage-gated sodium channels in midbrain dopaminergic neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jun Yang, Yujie Xiao, Liang Li, Quansheng He, Min Li, Yousheng Sh. Biophysical Properties of Somatic and Axonal Voltage-Gated Sodium Channels in Midbrain Dopaminergic Neurons. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31354436. |
spiking activities of midbrain dopaminergic neurons are critical for key brain functions including motor control and affective behaviors. |
2020-09-30 |
2023-08-13 |
Not clear |
| Biswarup Ghosh, Chen Zhang, Kristine S Ziemba, Anita M Fletcher, David M Yurek, George M Smit. Partial Reconstruction of the Nigrostriatal Circuit along a Preformed Molecular Guidance Pathway. Molecular therapy. Methods & clinical development. vol 14. 2020-09-30. PMID:31417940. |
the overall goal of our research is to establish a preformed molecular guidance pathway to direct the growth of dopaminergic axons from embryonic ventral mesencephalon (vm), tissue placed within the substantia nigra (sn), into the striatum to reconstruct the nigrostriatal pathway in a hemi-parkinson's disease rat model. |
2020-09-30 |
2023-08-13 |
rat |
| Hyun Jin Park, Ting Ting Zhao, Seung Hwan Kim, Chong Kil Lee, Bang Yeon Hwang, Kyung Eun Lee, Myung Koo Le. Ethanol extract from Neural regeneration research. vol 15. issue 2. 2020-09-30. PMID:31552910. |
in the present study, we investigated the ameliorative effects of gp-ex, including gypenosides, on the cell death of dopaminergic neurons in the midbrain of a53t α-synuclein transgenic mouse models of pd (a53t). |
2020-09-30 |
2023-08-13 |
mouse |
| Hyun Jin Park, Ting Ting Zhao, Seung Hwan Kim, Chong Kil Lee, Bang Yeon Hwang, Kyung Eun Lee, Myung Koo Le. Ethanol extract from Neural regeneration research. vol 15. issue 2. 2020-09-30. PMID:31552910. |
taken together, gp-ex, including gypenosides, has ameliorative effects on dopaminergic neuronal cell death due to the overexpression of α-synuclein by modulating erk1/2, bad at ser112, and jnk1/2 signaling in the midbrain of a53t mouse model of pd. |
2020-09-30 |
2023-08-13 |
mouse |
| Doug J Peterson, Darcy N Marckini, Jordan L Straight, Elizabeth M King, William Johnson, Sarala S Sarah, Puneet K Chowdhary, Merritt K DeLano-Taylo. The Basic Helix-Loop-Helix Gene Nato3 Drives Expression of Dopaminergic Neuron Transcription Factors in Neural Progenitors. Neuroscience. vol 421. 2020-09-30. PMID:31672641. |
the floor plate of the developing midbrain gives rise to dopaminergic (da) neurons, an important class of cells involved in parkinson's disease (pd). |
2020-09-30 |
2023-08-13 |
chicken |
| Yuchen Du, Qiang Guo, Minghui Shan, Yongmei Wu, Sizhou Huang, Haixia Zhao, Huarong Hong, Ming Yang, Xi Yang, Liyi Ren, Jiali Peng, Jing Sun, Hongli Zhou, Shurong Li, Bingyin S. Spatial and Temporal Distribution of Dopaminergic Neurons during Development in Zebrafish. Frontiers in neuroanatomy. vol 10. 2020-09-29. PMID:27965546. |
however, there is no midbrain dopaminergic system in zebrafish when compared with mammals, and the location and projection of the dopaminergic neurons are seldom reported. |
2020-09-29 |
2023-08-13 |
human |
| Mahdi Eskandarian Boroujeni, Mossa Gardane. Umbilical cord: an unlimited source of cells differentiable towards dopaminergic neurons. Neural regeneration research. vol 12. issue 7. 2020-09-29. PMID:28852404. |
parkinson's disease (pd) is a common, chronic neurodegenerative disorder hallmarked by localized degeneration of a specific set of dopaminergic neurons within a midbrain sub-region. |
2020-09-29 |
2023-08-13 |
human |
| Simone Mesman, Marten P Smid. Frontiers in molecular neuroscience. vol 10. 2020-09-29. PMID:29163030. |
the basic helix-loop-helix (bhlh) protein family has previously been shown to be involved in the development of mesodiencephalic dopaminergic (mdda) neurons in the murine midbrain. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shane V Hegarty, Aideen M Sullivan, Gerard W O'Keeff. Protocol for evaluation of neurotrophic strategies in Parkinson's disease-related dopaminergic and sympathetic neurons Journal of biological methods. vol 3. issue 3. 2020-09-29. PMID:31453215. |
protocol for evaluation of neurotrophic strategies in parkinson's disease-related dopaminergic and sympathetic neurons parkinson's disease (pd) is a neurodegenerative disease that is characterized by motor and non-motor symptoms which result from the progressive degeneration of nigrostriatal ventral midbrain (vm) dopaminergic (da) neurons, as well as peripheral sympathetic neurons. |
2020-09-29 |
2023-08-13 |
Not clear |
| Angelo Iannielli, Giovanni Stefano Ugolini, Chiara Cordiglieri, Simone Bido, Alicia Rubio, Gaia Colasante, Marco Valtorta, Tommaso Cabassi, Marco Rasponi, Vania Broccol. Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses. Cell reports. vol 29. issue 13. 2020-09-28. PMID:31875567. |
co-culture of human midbrain dopaminergic and striatal medium spiny neurons on the microchip establishes an orchestrated nigro-striatal circuitry with functional dopaminergic synapses. |
2020-09-28 |
2023-08-13 |
human |
| Hicham Chatoui, Geneviève Chazal, Omar El Hiba, Faissal Aziz, Halima Gamran. Long term osmotic stress exposure outcomes on rat dopaminergic innervations and the associated motor behavior. Saudi journal of biological sciences. vol 27. issue 1. 2020-09-28. PMID:31889838. |
the lack of data regarding the impact on the dopaminergic system and locomotion led us to investigate the effect of prolonged water deprivation in rat on the midbrain dopaminergic system and locomotor performance by dehydrating rats for one and two weeks. |
2020-09-28 |
2023-08-13 |
rat |
| Hicham Chatoui, Geneviève Chazal, Omar El Hiba, Faissal Aziz, Halima Gamran. Long term osmotic stress exposure outcomes on rat dopaminergic innervations and the associated motor behavior. Saudi journal of biological sciences. vol 27. issue 1. 2020-09-28. PMID:31889838. |
our data suggest a substantial implication of midbrain dopaminergic system in the central response to the osmotic stimuli accompanied with locomotor deficiencies. |
2020-09-28 |
2023-08-13 |
rat |