| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wafaa Laabbar, Abdeljalil Elgot, Omar Elhiba, Halima Gamran. Curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat. Journal of chemical neuroanatomy. vol 100. 2020-09-11. PMID:31170442. |
curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat. |
2020-09-11 |
2023-08-13 |
rat |
| Oum Kaltoum Hassani, Vladimir V Rymar, Khanh Q Nguyen, Lia Huo, Jean-François Cloutier, Freda D Miller, Abbas F Sadiko. The noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: implications for development and Parkinson's disease. Neurobiology of aging. vol 85. 2020-09-11. PMID:31734438. |
the noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: implications for development and parkinson's disease. |
2020-09-11 |
2023-08-13 |
mouse |
| Oum Kaltoum Hassani, Vladimir V Rymar, Khanh Q Nguyen, Lia Huo, Jean-François Cloutier, Freda D Miller, Abbas F Sadiko. The noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: implications for development and Parkinson's disease. Neurobiology of aging. vol 85. 2020-09-11. PMID:31734438. |
the cause of midbrain dopaminergic (mda) neuron loss in sporadic parkinson's disease (pd) is multifactorial, involving cell autonomous factors, cell-cell interactions, and the effects of environmental toxins. |
2020-09-11 |
2023-08-13 |
mouse |
| Norman E Taylor, Hu Long, JunZhu Pei, Phanidhar Kukutla, Anthony Phero, Farnaz Hadaegh, Ahmed Abdelnabi, Ken Solt, Gary J Brenne. The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia. Pain. vol 160. issue 11. 2020-09-10. PMID:31246732. |
this region is composed of gabaergic cells that send afferent projections to the ventral midbrain and synapse onto dopaminergic cells in the vta and substantia nigra. |
2020-09-10 |
2023-08-13 |
Not clear |
| Jun Takahash. Preclinical evaluation of patient-derived cells shows promise for Parkinson's disease. The Journal of clinical investigation. vol 130. issue 2. 2020-09-04. PMID:31929191. |
parkinson's disease (pd) is a neurodegenerative disease caused by the progressive loss of dopaminergic (da) neurons in the midbrain projecting to the striatum, which leads to motor dysfunctions, such as bradykinesia (slowed movement), rigidity, and tremors. |
2020-09-04 |
2023-08-13 |
Not clear |
| Oscar Maldonado, Alexandra Jenkins, Helen M Belalcazar, Helena Hernandez-Cuervo, Katelynn M Hyman, Giannina Ladaga, Lucia Padilla, Gabriel A de Erausqui. Age-dependent neuroprotective effect of an SK3 channel agonist on excitotoxity to dopaminergic neurons in organotypic culture. PloS one. vol 15. issue 7. 2020-09-04. PMID:32701951. |
small conductance, calcium-activated (sk3) potassium channels control the intrinsic excitability of dopaminergic neurons (dn) in the midbrain and modulate their susceptibility to toxic insults during development. |
2020-09-04 |
2023-08-13 |
Not clear |
| Meng-Yang Zhu, Muhammad U Raza, Yanqiang Zhan, Yan Fa. Norepinephrine upregulates the expression of tyrosine hydroxylase and protects dopaminegic neurons against 6-hydrodopamine toxicity. Neurochemistry international. vol 131. 2020-09-03. PMID:31539561. |
using primary cultures from rat ventral mesencephalon (vm) and dopaminergic cell line mn9d, the present study examined the neuroprotective effects of ne and its effects on the expression of tyrosine hydroxylase (th). |
2020-09-03 |
2023-08-13 |
rat |
| Chung-Yang Kao, Mafei Xu, Leiming Wang, Shih-Chieh Lin, Hui-Ju Lee, Lita Duraine, Hugo J Bellen, David S Goldstein, Sophia Y Tsai, Ming-Jer Tsa. Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction. PLoS genetics. vol 16. issue 6. 2020-08-31. PMID:32579581. |
parkinson's disease (pd) is a neurodegenerative disorder featuring progressive loss of midbrain dopaminergic (da) neurons that leads to motor symptoms. |
2020-08-31 |
2023-08-13 |
mouse |
| Lars-Lennart Oettl, Max Scheller, Carla Filosa, Sebastian Wieland, Franziska Haag, Cathrin Loeb, Daniel Durstewitz, Roman Shusterman, Eleonora Russo, Wolfgang Kelsc. Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction. Nature communications. vol 11. issue 1. 2020-08-31. PMID:32651365. |
ventral striatum and dopaminergic midbrain neurons form a larger network for generating reward prediction signals from sensory cues. |
2020-08-31 |
2023-08-13 |
Not clear |
| Clement Soleilhavoup, Marco Travaglio, Kieran Patrick, Pedro Garção, Elangovan Boobalan, Youri Adolfs, Ruth V Spriggs, Emma Moles-Garcia, Dalbir Dhiraj, Tony Oosterveen, Sarah L Ferri, Ted Abel, Edward S Brodkin, R Jeroen Pasterkamp, Brian P Brooks, Lia Panma. Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nature communications. vol 11. issue 1. 2020-08-28. PMID:32561725. |
midbrain dopaminergic (da) axons make long longitudinal projections towards the striatum. |
2020-08-28 |
2023-08-13 |
Not clear |
| Karin Sandager-Nielsen, Philip K Ahring, Jessica Klein, Marloes van Hout, Siganya Thaneshwaran, Altair B Dos Santos, Thomas A Jacobsen, Dipak V Amrutkar, Dan Peters, Anders A Jensen, Kristi A Kohlmeier, Palle Christophersen, Tino Dyhrin. Characterization of AN317, a novel selective agonist of α6β2-containing nicotinic acetylcholine receptors. Biochemical pharmacology. vol 174. 2020-08-24. PMID:31887288. |
α6β2-containing (α6β2*) nachrs are highly expressed in and regulate the activity of midbrain dopaminergic neurons, which makes them attractive drug targets in several psychiatric and neurological diseases, including nicotine addiction and parkinson's disease. |
2020-08-24 |
2023-08-13 |
Not clear |
| Marloes van Hout, Jessica Klein, Philip K Ahring, David T Brown, Siganya Thaneshwaran, Altair B Dos Santos, Anders A Jensen, Kristi A Kohlmeier, Palle Christophersen, Tino Dyhrin. Characterization of AN6001, a positive allosteric modulator of α6β2-containing nicotinic acetylcholine receptors. Biochemical pharmacology. vol 174. 2020-08-24. PMID:31887290. |
α6β2-containing nicotinic acetylcholine receptors (α6β2* nachrs) are predominantly expressed in midbrain dopaminergic neurons, including substantia nigra pars compacta (snc) neurons and their projections to striatal regions, where they regulate dopamine release and nigrostriatal activity. |
2020-08-24 |
2023-08-13 |
human |
| Riya Muckom, Xiaoping Bao, Eric Tran, Evelyn Chen, Abirami Murugappan, Jonathan S Dordick, Douglas S Clark, David V Schaffe. High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates. Science advances. vol 6. issue 32. 2020-08-24. PMID:32821815. |
here, we demonstrate a high-throughput 3d culture platform used to systematically screen 1200 culture conditions with varying doses, durations, dynamics, and combinations of signaling cues to derive oligodendrocyte progenitor cells and midbrain dopaminergic neurons from human pluripotent stem cells (hpscs). |
2020-08-24 |
2023-08-13 |
human |
| Sheng-Xia Wan, Xin Pan, Jin-Jun Qian, Yu Shu, Ping Xu, Jing Zhao, Qi-Xia Gong, Jiang-Tao Yi. Downregulation of ATP13A2 in midbrain dopaminergic neurons is related to defective autophagy in a mouse model of Parkinson's disease. International journal of clinical and experimental pathology. vol 13. issue 7. 2020-08-14. PMID:32782714. |
downregulation of atp13a2 in midbrain dopaminergic neurons is related to defective autophagy in a mouse model of parkinson's disease. |
2020-08-14 |
2023-08-13 |
mouse |
| Sheng-Xia Wan, Xin Pan, Jin-Jun Qian, Yu Shu, Ping Xu, Jing Zhao, Qi-Xia Gong, Jiang-Tao Yi. Downregulation of ATP13A2 in midbrain dopaminergic neurons is related to defective autophagy in a mouse model of Parkinson's disease. International journal of clinical and experimental pathology. vol 13. issue 7. 2020-08-14. PMID:32782714. |
parkinson's disease (pd) is one of the most common diseases of the nervous system characterized by movement disorders arising from loss of midbrain dopaminergic neurons. |
2020-08-14 |
2023-08-13 |
mouse |
| Sheng-Xia Wan, Xin Pan, Jin-Jun Qian, Yu Shu, Ping Xu, Jing Zhao, Qi-Xia Gong, Jiang-Tao Yi. Downregulation of ATP13A2 in midbrain dopaminergic neurons is related to defective autophagy in a mouse model of Parkinson's disease. International journal of clinical and experimental pathology. vol 13. issue 7. 2020-08-14. PMID:32782714. |
in conclusion, our findings suggest that decreased expression of atp13a2 may lead to defective autophagy and damage to midbrain dopaminergic neurons. |
2020-08-14 |
2023-08-13 |
mouse |
| Benedetto Romoli, Adrian F Lozada, Ivette M Sandoval, Fredric P Manfredsson, Thomas S Hnasko, Darwin K Berg, Davide Dulci. Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption. Biological psychiatry. vol 86. issue 5. 2020-08-13. PMID:31202491. |
neonatal nicotine exposure primes midbrain neurons to a dopaminergic phenotype and increases adult drug consumption. |
2020-08-13 |
2023-08-13 |
Not clear |
| Carole Morel, Sarah Montgomery, Ming-Hu Ha. Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement. The European journal of neuroscience. vol 50. issue 3. 2020-08-07. PMID:30251377. |
nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement. |
2020-08-07 |
2023-08-13 |
Not clear |
| Maaike M H van Swieten, Rafal Bogac. Modeling the effects of motivation on choice and learning in the basal ganglia. PLoS computational biology. vol 16. issue 5. 2020-08-07. PMID:32453725. |
a key role in this process is played by the basal ganglia, where neural activity and plasticity are modulated by dopaminergic input from the midbrain. |
2020-08-07 |
2023-08-13 |
Not clear |
| Clara Grudina, Georgia Kouroupi, Takashi Nonaka, Masato Hasegawa, Rebecca Matsas, Chiara Zurzol. Human NPCs can degrade α-syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures. Neurobiology of disease. vol 132. 2020-08-06. PMID:31494284. |
parkinson's disease (pd) is the second most common neurodegenerative disorder whereby loss of midbrain dopaminergic neurons results in motor dysfunction. |
2020-08-06 |
2023-08-13 |
human |