| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christa Überbacher, Julia Obergasteiger, Mattia Volta, Serena Venezia, Stefan Müller, Isabella Pesce, Sara Pizzi, Giulia Lamonaca, Anne Picard, Giada Cattelan, Giorgio Malpeli, Michele Zoli, Dayne Beccano-Kelly, Rowan Flynn, Richard Wade-Martins, Peter P Pramstaller, Andrew A Hicks, Sally A Cowley, Corrado Cort. Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons. Stem cell research. vol 41. 2020-06-02. PMID:31733438. |
derivation of midbrain dopaminergic (daergic) neurons from hipscs of pd patients represents the only option to model physiological processes in a cell type that is not otherwise accessible from human patients. |
2020-06-02 |
2023-08-13 |
human |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Swati Chaturvedi, M Wahajuddin, Shubha Shukl. Dopamine receptor activation mitigates mitochondrial dysfunction and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA lesioned rats: A role of Wnt signalling. Neurochemistry international. vol 129. 2020-06-01. PMID:31078578. |
nigral dopaminergic (daergic) cell degeneration and depletion of dopamine neurotransmitter in the midbrain are cardinal features of parkinson's disease (pd). |
2020-06-01 |
2023-08-13 |
rat |
| Nicolas Mallet, Lorena Delgado, Marine Chazalon, Cristina Miguelez, Jérôme Baufreto. Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum. Cells. vol 8. issue 9. 2020-05-26. PMID:31470672. |
this network is also the region primarily affected by the degeneration of midbrain dopaminergic neurons localized in the substantia nigra pars compacta (snc). |
2020-05-26 |
2023-08-13 |
Not clear |
| Brónagh McCoy, Sara Jahfari, Gwenda Engels, Tomas Knapen, Jan Theeuwe. Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson's disease. Brain : a journal of neurology. vol 142. issue 11. 2020-05-26. PMID:31603493. |
reduced levels of dopamine in parkinson's disease contribute to changes in learning, resulting from the loss of midbrain neurons that transmit a dopaminergic teaching signal to the striatum. |
2020-05-26 |
2023-08-13 |
human |
| Jeffrey S Schweitzer, Bin Song, Todd M Herrington, Tae-Yoon Park, Nayeon Lee, Sanghyeok Ko, Jeha Jeon, Young Cha, Kyungsang Kim, Quanzheng Li, Claire Henchcliffe, Michael Kaplitt, Carolyn Neff, Otto Rapalino, Hyemyung Seo, In-Hee Lee, Jisun Kim, Taewoo Kim, Gregory A Petsko, Jerome Ritz, Bruce M Cohen, Sek-Won Kong, Pierre Leblanc, Bob S Carter, Kwang-Soo Ki. Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease. The New England journal of medicine. vol 382. issue 20. 2020-05-22. PMID:32402162. |
we report the implantation of patient-derived midbrain dopaminergic progenitor cells, differentiated in vitro from autologous induced pluripotent stem cells (ipscs), in a patient with idiopathic parkinson's disease. |
2020-05-22 |
2023-08-13 |
mouse |
| Liping Zhang, LingYu Zhang, Lin Li, Christian Hölsche. Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue 1. 2020-05-20. PMID:30741689. |
a key feature is the loss of midbrain dopaminergic neurons and the accumulation of aggregated alpha-synuclein (α-syn). |
2020-05-20 |
2023-08-13 |
mouse |
| Longping Yao, Zhiyuan Zhu, Jiayu Wu, Yizhou Zhang, Hongbo Zhang, Xiang Sun, Chen Qian, Baoyan Wang, Linghai Xie, Shizhong Zhang, Guohui L. MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 7. 2020-05-20. PMID:30995872. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by motor and nonmotor symptoms due to the selective loss of midbrain dopaminergic neurons. |
2020-05-20 |
2023-08-13 |
mouse |
| Segev Barak, Somayeh Ahmadiantehrani, Marian L Logrip, Dorit Ro. GDNF and alcohol use disorder. Addiction biology. vol 24. issue 3. 2020-05-18. PMID:29726054. |
glial cell line-derived neurotrophic factor (gdnf) has been extensively studied for its role in the development and maintenance of the midbrain dopaminergic system, although evidence suggests that gdnf also plays a role in drug and alcohol addiction. |
2020-05-18 |
2023-08-13 |
Not clear |
| Yu-Chia Kao, Wei-Yen Wei, Kuen-Jer Tsai, Liang-Chao Wan. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892244. |
for five months, starting from weaning, we gave c57bl/6 mice a high-fat diet (hfd) to generate an obese mouse model and investigate whether the diet reprogrammed the midbrain dopaminergic system. |
2020-05-14 |
2023-08-13 |
mouse |
| Yu-Chia Kao, Wei-Yen Wei, Kuen-Jer Tsai, Liang-Chao Wan. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892244. |
this study showed that a prolonged hfd induced neuroinflammation, suppressed ppar levels, caused degeneration of midbrain dopaminergic neurons, and resulted in symptoms reminiscent of human pd. |
2020-05-14 |
2023-08-13 |
mouse |
| Sonu Singh, Akanksha Mishra, Virendra Tiwari, Shubha Shukl. Enhanced neuroinflammation and oxidative stress are associated with altered hippocampal neurogenesis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treated mice. Behavioural pharmacology. vol 30. issue 8. 2020-05-11. PMID:31703031. |
loss of midbrain dopaminergic neurons in parkinson's disease not only induces motor impairments but also leads to the development of non-motor symptoms such as memory impairment, anxiety and depression. |
2020-05-11 |
2023-08-13 |
mouse |
| Sonu Singh, Akanksha Mishra, Virendra Tiwari, Shubha Shukl. Enhanced neuroinflammation and oxidative stress are associated with altered hippocampal neurogenesis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treated mice. Behavioural pharmacology. vol 30. issue 8. 2020-05-11. PMID:31703031. |
taken together, our results suggest that degeneration of midbrain dopaminergic neurons directly affects the local hippocampal microenvironment by enhancing inflammatory influences. |
2020-05-11 |
2023-08-13 |
mouse |
| Aurelie de Rus Jacque. Preparation and Co-Culture of iPSC-Derived Dopaminergic Neurons and Astrocytes. Current protocols in cell biology. vol 85. issue 1. 2020-05-11. PMID:31763766. |
we developed a streamlined procedure to produce high-quality/high-purity cultures of dopaminergic neurons and astrocytes that originate from the same population of midbrain floor-plate progenitors. |
2020-05-11 |
2023-08-13 |
Not clear |
| Hailan Hu, Yihui Cui, Yan Yan. Circuits and functions of the lateral habenula in health and in disease. Nature reviews. Neuroscience. vol 21. issue 5. 2020-05-11. PMID:32269316. |
the lhb, sometimes referred to as the brain's 'antireward centre', receives inputs from diverse limbic forebrain and basal ganglia structures, and targets essentially all midbrain neuromodulatory systems, including the noradrenergic, serotonergic and dopaminergic systems. |
2020-05-11 |
2023-08-13 |
Not clear |
| I Madrazo, O Kopyov, M A Ávila-Rodríguez, F Ostrosky, H Carrasco, A Kopyov, A Avendaño-Estrada, F Jiménez, E Magallón, C Zamorano, G González, T Valenzuela, R Carrillo, F Palma, R Rivera, R E Franco-Bourland, G Guízar-Sahagú. Transplantation of Human Neural Progenitor Cells (NPC) into Putamina of Parkinsonian Patients: A Case Series Study, Safety and Efficacy Four Years after Surgery. Cell transplantation. vol 28. issue 3. 2020-04-30. PMID:30574805. |
pet imaging showed a trend toward enhanced midbrain dopaminergic activity. |
2020-04-30 |
2023-08-13 |
human |
| Sanghyun Park, Jeong-Eun Yoo, Dongjin R Lee, Jiho Jang, Myung Soo Cho, Dae-Sung Kim, Dong-Wook Ki. Establishment of PITX3-mCherry knock-in reporter human embryonic stem cell line (WAe009-A-23). Stem cell research. vol 39. 2020-04-27. PMID:31352199. |
pituitary homeobox 3 (pitx3) is a key transcription factor that plays an important role in the development and maintenance of midbrain dopaminergic (mda) neurons. |
2020-04-27 |
2023-08-13 |
human |
| Simon Rw Stott, Suzanne J Randle, Sara Al Rawi, Paulina A Rowicka, Rebecca Harris, Bethany Mason, Jing Xia, Jeffrey W Dalley, Roger A Barker, Heike Lama. Loss of FBXO7 results in a Parkinson's-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway. The Journal of pathology. vol 249. issue 2. 2020-04-13. PMID:31144295. |
these data suggest that the neuroprotective role of fbxo7 involves its suppression of the rpl23-mdm2-p53 axis that promotes cell death in dopaminergic midbrain neurons. |
2020-04-13 |
2023-08-13 |
Not clear |
| Collin Challis, Acacia Hori, Timothy R Sampson, Bryan B Yoo, Rosemary C Challis, Adam M Hamilton, Sarkis K Mazmanian, Laura A Volpicelli-Daley, Viviana Gradinar. Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Nature neuroscience. vol 23. issue 3. 2020-04-13. PMID:32066981. |
parkinson's disease is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (α-syn) aggregates. |
2020-04-13 |
2023-08-13 |
mouse |
| Ankita Ravi Vaswani, Beatrice Weykopf, Cathleen Hagemann, Hans-Ulrich Fried, Oliver Brüstle, Sandra Blaes. Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons. eLife. vol 8. 2020-04-10. PMID:30689541. |
midbrain dopaminergic (mda) neurons migrate to form the laterally-located substantia nigra pars compacta (sn) and medially-located ventral tegmental area (vta), but little is known about the underlying cellular and molecular processes. |
2020-04-10 |
2023-08-13 |
Not clear |
| Yingchao Xue, Xiping Zhan, Shisheng Sun, Senthilkumar S Karuppagounder, Shuli Xia, Valina L Dawson, Ted M Dawson, John Laterra, Jianmin Zhang, Mingyao Yin. Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons. Stem cells translational medicine. vol 8. issue 2. 2020-04-08. PMID:30387318. |
here, we used synthetic mrnas coding two proneural tfs (atoh1 and ngn2) to differentiate induced pluripotent stem cells (ipscs) into midbrain dopaminergic (mda) neurons. |
2020-04-08 |
2023-08-13 |
Not clear |