| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fenfen Ji, Zhou Zhu, Mengtao Zhang, Huan Zhang, Lin Zhu, Xiaodong Cai, Wenlan Liu, Juxian Song, Min Li, Zongwei Ca. 6-OH-BDE-47 exposure-induced Parkinson's disease pathology in Sprague Dawley rat. The Science of the total environment. vol 711. 2020-04-07. PMID:32000351. |
the chemical with levels of 0.1, 1 and 10 µg was stereotaxically injected into the right midbrain regions of rat where contain abundant dopaminergic neurons. |
2020-04-07 |
2023-08-13 |
rat |
| Stefanie Köhler, Gerd Wagner, Karl-Jürgen Bä. Activation of brainstem and midbrain nuclei during cognitive control in medicated patients with schizophrenia. Human brain mapping. vol 40. issue 1. 2020-04-06. PMID:30184301. |
we sought to investigate the putatively abnormal activation pattern of the dopaminergic midbrain nuclei, that is, ventral tegmental area (vta) and substantia nigra as well as that of the noradrenergic locus coeruleus (lc) in patients with schizophrenia during cognitive control. |
2020-04-06 |
2023-08-13 |
Not clear |
| Zhinian Lei, Guangliang Cao, Gang We. A30P mutant α-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons. Cell death & disease. vol 10. issue 2. 2020-04-06. PMID:30755581. |
a30p mutant α-synuclein impairs autophagic flux by inactivating jnk signaling to enhance zkscan3 activity in midbrain dopaminergic neurons. |
2020-04-06 |
2023-08-13 |
Not clear |
| Benjamin Chew, Tobias U Hauser, Marina Papoutsi, Joerg Magerkurth, Raymond J Dolan, Robb B Rutledg. Endogenous fluctuations in the dopaminergic midbrain drive behavioral choice variability. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 37. 2020-04-06. PMID:31451671. |
endogenous fluctuations in the dopaminergic midbrain drive behavioral choice variability. |
2020-04-06 |
2023-08-13 |
human |
| Benjamin Chew, Tobias U Hauser, Marina Papoutsi, Joerg Magerkurth, Raymond J Dolan, Robb B Rutledg. Endogenous fluctuations in the dopaminergic midbrain drive behavioral choice variability. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 37. 2020-04-06. PMID:31451671. |
here, using real-time functional magnetic resonance imaging, we tested whether risky decision making is influenced by endogenous fluctuations in blood oxygenation level-dependent (bold) activity in the dopaminergic midbrain, encompassing ventral tegmental area and substantia nigra. |
2020-04-06 |
2023-08-13 |
human |
| Luke T Coddington, Joshua T Dudma. Learning from Action: Reconsidering Movement Signaling in Midbrain Dopamine Neuron Activity. Neuron. vol 104. issue 1. 2020-03-31. PMID:31600516. |
in vertebrates, this is thought to depend upon the release of dopamine from midbrain dopaminergic neurons. |
2020-03-31 |
2023-08-13 |
Not clear |
| Minho Moon, Eun Sun Jung, Seong Gak Jeon, Moon-Yong Cha, Yongwoo Jang, Woori Kim, Claudia Lopes, Inhee Mook-Jung, Kwang-Soo Ki. Nurr1 (NR4A2) regulates Alzheimer's disease-related pathogenesis and cognitive function in the 5XFAD mouse model. Aging cell. vol 18. issue 1. 2020-03-30. PMID:30515963. |
the orphan nuclear receptor nurr1 (also known as nr4a2) is critical for the development and maintenance of midbrain dopaminergic neurons, and is associated with parkinson's disease. |
2020-03-30 |
2023-08-13 |
mouse |
| Douglas R Miller, Joseph J Lebowitz, Dylan T Guenther, Alexander J Refowich, Carissa Hansen, Andrew P Maurer, Habibeh Khoshboue. Methamphetamine regulation of activity and topology of ventral midbrain networks. PloS one. vol 14. issue 9. 2020-03-23. PMID:31536584. |
both gabaergic and dopaminergic neurons were heavily featured within the primary ventral midbrain network model system. |
2020-03-23 |
2023-08-13 |
Not clear |
| John M Bruning, Yan Wang, Francesca Oltrabella, Boxue Tian, Svetlana A Kholodar, Harrison Liu, Paulomi Bhattacharya, Su Guo, James M Holton, Robert J Fletterick, Matthew P Jacobson, Pamela M Englan. Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell chemical biology. vol 26. issue 5. 2020-03-12. PMID:30853418. |
nurr1, a nuclear receptor essential for the development, maintenance, and survival of midbrain dopaminergic neurons, is a potential therapeutic target for parkinson's disease, a neurological disorder characterized by the degeneration of these same neurons. |
2020-03-12 |
2023-08-13 |
zebrafish |
| Carl G Gottschalk, Avik Roy, Malabendu Jana, Madhuchhanda Kundu, Kalipada Paha. Activation of Peroxisome Proliferator-Activated Receptor-α Increases the Expression of Nuclear Receptor Related 1 Protein (Nurr1) in Dopaminergic Neurons. Molecular neurobiology. vol 56. issue 11. 2020-03-12. PMID:31127527. |
nuclear receptor related 1 protein (nurr1) is an important transcription factor required for differentiation and maintenance of midbrain dopaminergic (da) neurons. |
2020-03-12 |
2023-08-13 |
Not clear |
| Francesca Montarolo, Serena Martire, Simona Perga, Michela Spadaro, Irene Brescia, Sarah Allegra, Silvia De Francia, Antonio Bertolott. NURR1 deficiency is associated to ADHD-like phenotypes in mice. Translational psychiatry. vol 9. issue 1. 2020-03-09. PMID:31455763. |
the transcription factor nurr1 regulates the dopamine (da) signaling pathway and exerts a critical role in the development of midbrain dopaminergic neurons (mda). |
2020-03-09 |
2023-08-13 |
mouse |
| Angelique di Domenico, Giulia Carola, Carles Calatayud, Meritxell Pons-Espinal, Juan Pablo Muñoz, Yvonne Richaud-Patin, Irene Fernandez-Carasa, Marta Gut, Armida Faella, Janani Parameswaran, Jordi Soriano, Isidro Ferrer, Eduardo Tolosa, Antonio Zorzano, Ana Maria Cuervo, Angel Raya, Antonella Consigli. Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease. Stem cell reports. vol 12. issue 2. 2020-03-04. PMID:30639209. |
parkinson's disease (pd) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmdans) and the accumulation of toxic α-synuclein. |
2020-03-04 |
2023-08-13 |
Not clear |
| Jianbin Zheng, Sohee Jeon, Weilan Jiang, Lena F Burbulla, Daniel Ysselstein, Kristine Oevel, Dimitri Krainc, Richard B Silverma. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of medicinal chemistry. vol 62. issue 3. 2020-03-03. PMID:30645117. |
pd patient-derived fibroblasts and dopaminergic midbrain neurons were treated with a selected compound (9q) that partially stabilized gcase and improved its activity. |
2020-03-03 |
2023-08-13 |
Not clear |
| Rachel J Sharkey, Josiane Bourque, Kevin Larcher, Bratislav Mišić, Yu Zhang, Ayça Altınkaya, Abbas Sadikot, Patricia Conrod, Alan C Evans, Hugh Garavan, Marco Leyton, Jean R Séguin, Robert Pihl, Alain Daghe. Mesolimbic connectivity signatures of impulsivity and BMI in early adolescence. Appetite. vol 132. 2020-03-02. PMID:30273626. |
to determine how the relationship between sensation-seeking, impulsivity and body mass index (bmi) is related to shared neural correlates we measured their relationships with the connectivity of nuclei in the striatum and dopaminergic midbrain in young adolescents. |
2020-03-02 |
2023-08-13 |
Not clear |
| Javier A Suarez, James D Howard, Geoffrey Schoenbaum, Thorsten Kahn. Sensory prediction errors in the human midbrain signal identity violations independent of perceptual distance. eLife. vol 8. 2020-02-28. PMID:30950792. |
the firing of dopaminergic midbrain neurons is thought to reflect prediction errors (pe) that depend on the difference between the value of expected and received rewards. |
2020-02-28 |
2023-08-13 |
human |
| Qiuyu Lin, Sen Hou, Yuyin Dai, Nan Jiang, Yingjie Li. LncRNA HOTAIR targets miR-126-5p to promote the progression of Parkinson's disease through RAB3IP. Biological chemistry. vol 400. issue 9. 2020-02-17. PMID:30738012. |
parkinson's disease (pd) is a common neurological disorder characterized by dopaminergic (da) neuron degeneration and death in the midbrain, and the long noncoding rna hotair has been shown to affect disease progression in pd. |
2020-02-17 |
2023-08-13 |
mouse |
| Francesca Montarolo, Serena Martire, Simona Perga, Antonio Bertolott. NURR1 Impairment in Multiple Sclerosis. International journal of molecular sciences. vol 20. issue 19. 2020-02-10. PMID:31574937. |
in parallel, nurr1 has been also linked to dopamine-associated brain disorders, such as parkinson's disease (pd) and schizophrenia, since it is involved in the development and in the maintenance of midbrain dopaminergic neurons (mda). |
2020-02-10 |
2023-08-13 |
human |
| Courtney A Marshall, Kirsten M King, Sandhya Kortager. Limitations of the rat medial forebrain lesion model to study prefrontal cortex mediated cognitive tasks in Parkinson's disease. Brain research. vol 1702. 2020-02-07. PMID:29608880. |
parkinson's disease (pd) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. |
2020-02-07 |
2023-08-13 |
rat |
| Kirsten E Zeuner, Eva Schäffer, Franziska Hopfner, Norbert Brüggemann, Daniela Ber. Progress of Pharmacological Approaches in Parkinson's Disease. Clinical pharmacology and therapeutics. vol 105. issue 5. 2020-02-07. PMID:30661251. |
the progressive neurodegenerative process in parkinson's disease (pd) is not restricted to dopaminergic midbrain neurons but involves the entire nervous system. |
2020-02-07 |
2023-08-13 |
Not clear |
| Andrew Lutas, Hakan Kucukdereli, Osama Alturkistani, Crista Carty, Arthur U Sugden, Kayla Fernando, Veronica Diaz, Vanessa Flores-Maldonado, Mark L Anderman. State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala. Nature neuroscience. vol 22. issue 11. 2020-01-31. PMID:31611706. |
state-specific gating of salient cues by midbrain dopaminergic input to basal amygdala. |
2020-01-31 |
2023-08-13 |
Not clear |