| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giulia Tomagra, Federico Picollo, Alfio Battiato, Barbara Picconi, Silvia De Marchis, Alberto Pasquarelli, Paolo Olivero, Andrea Marcantoni, Paolo Calabresi, Emilio Carbone, Valentina Carabell. Quantal Release of Dopamine and Action Potential Firing Detected in Midbrain Neurons by Multifunctional Diamond-Based Microarrays. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31024230. |
in the amperometric configuration, the 4 × 4 μg-scd-meas resolved quantal exocytosis from midbrain dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ashish Kumar Gupta, Gaurav Khunger Kumar, Komal Rani, Ruchika Pokhriyal, Mohd Imran Khan, Domada Ratna Kumar, Vinay Goyal, Manjari Tripathi, Rishab Gupta, Rakesh Kumar Chadda, Perumal Vanamail, Ashok Kumar Mohanty, Gururao Hariprasa. 2D-DIGE as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine-dictated states of Parkinson's disease and schizophrenia. Neuropsychiatric disease and treatment. vol 15. 2020-10-01. PMID:31114209. |
parkinson's disease and schizophrenia are clinical scenarios that occur due to dopaminergic deficit and hyperactivity in the midbrain, respectively. |
2020-10-01 |
2023-08-13 |
Not clear |
| Philip W Gold, Bashkim Kadri. A Major Role for the Lateral Habenula in Depressive Illness: Physiologic and Molecular Mechanisms. Frontiers in psychiatry. vol 10. 2020-10-01. PMID:31231247. |
lack of perceived reward experienced during the adverse outcomes also precipitates lateral habenula firing, while outcomes that meet or exceed expectations decrease lateral habenula firing and, in turn, increase midbrain dopaminergic and serotonergic neurotransmission. |
2020-10-01 |
2023-08-13 |
Not clear |
| Batoul Darwish, Farah Chamaa, Elie D Al-Chaer, Nayef E Saadé, Wassim Abou-Khei. Intranigral Injection of Endotoxin Suppresses Proliferation of Hippocampal Progenitor Cells. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31333405. |
this study provides an experimental simulation of the remote effects of moderate and reversible neuroinflammation resulting in impaired communication between midbrain dopaminergic neurons and the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Nicoletta L Lilli, Delphine Révy, Sandra Robelet, Béatrice Lejeun. Effect of the micro-immunotherapy medicine 2LPARK Degenerative neurological and neuromuscular disease. vol 9. 2020-10-01. PMID:31372089. |
effect of the micro-immunotherapy medicine 2lpark parkinson's disease (pd) is a neurodegenerative disease characterized by motor impairments and resulting from progressive degenerative loss of midbrain dopaminergic (daergic) neurons in the substantia nigra. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. |
2020-10-01 |
2023-08-13 |
Not clear |
| Cheng Xiao, Chun-Yi Zhou, Jin-Hong Jiang, Cui Yi. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta pharmacologica Sinica. vol 41. issue 1. 2020-10-01. PMID:31554960. |
midbrain dopaminergic (da) neurons are governed by an endogenous cholinergic system, originated in the mesopontine nuclei. |
2020-10-01 |
2023-08-13 |
Not clear |
| Tineke K Steiger, Nico Bunzec. Reward Dependent Invigoration Relates to Theta Oscillations and Is Predicted by Dopaminergic Midbrain Integrity in Healthy Elderly. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28174533. |
reward dependent invigoration relates to theta oscillations and is predicted by dopaminergic midbrain integrity in healthy elderly. |
2020-09-30 |
2023-08-13 |
human |
| Andrew C Peterson, Sheng Zhang, Sien Hu, Herta H Chao, Chiang-Shan R L. The Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain. Frontiers in human neuroscience. vol 11. 2020-09-30. PMID:28223929. |
the effects of age, from young to middle adulthood, and gender on resting state functional connectivity of the dopaminergic midbrain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Guo-Qing Wang, Dai-Di Li, Chun Huang, Di-Sheng Lu, Chao Zhang, Shao-Yu Zhou, Jie Liu, Feng Zhan. Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29375304. |
icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation parkinson's disease (pd) is one of the most common neurodegenerative diseases characterized with a gradual loss of midbrain substantia nigra (sn) dopamine (da) neurons. |
2020-09-30 |
2023-08-13 |
rat |
| Francesca L'Episcopo, Cataldo Tirolo, Maria F Serapide, Salvatore Caniglia, Nunzio Testa, Loredana Leggio, Silvia Vivarelli, Nunzio Iraci, Stefano Pluchino, Bianca Marchett. Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:29483868. |
while the causes responsible for the progressive loss of midbrain dopaminergic (mda) neuronal cell bodies in the subtantia nigra pars compacta are poorly understood, aging, genetics, environmental toxicity, and particularly inflammation, represent prominent etiological factors in pd development. |
2020-09-30 |
2023-08-13 |
mouse |
| Elisabeth G Vichaya, Robert Dantze. Inflammation-induced motivational changes: Perspective gained by evaluating positive and negative valence systems. Current opinion in behavioral sciences. vol 22. 2020-09-30. PMID:29888301. |
while changes in both approach and avoidance motivation appear to be mediated by midbrain dopaminergic neurotransmission to the ventral striatum, it is unclear if the enhanced contrast is mediated by the same system. |
2020-09-30 |
2023-08-13 |
Not clear |
| Eoin O'Neill, Andrew Harki. Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease. Neural regeneration research. vol 13. issue 8. 2020-09-30. PMID:30106035. |
noradrenaline inhibits microglial activation and suppresses pro-inflammatory mediator production (e.g., tumor necrosis factor-α, interleukin-1β & inducible nitric oxide synthase activity), thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflammatory stimulus. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bridget Martinez, Philip V Peplo. Neuroprotection by immunomodulatory agents in animal models of Parkinson's disease. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127102. |
all of the agents were effective in reducing the motor deficit and alleviating dopaminergic neurotoxicity and, when measured, preventing the decrease of dopamine upon being administered therapeutically after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 6-hydroxydopamine, rotenone-lesioning or delivery of adeno-associated virus-α-synuclein to the ventral midbrain of animals. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuko Nakamura, Naohiro Okada, Akira Kunimatsu, Kiyoto Kasai, Shinsuke Koik. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:30210369. |
increasing evidence shows that the midbrain dopaminergic system is involved in various functions. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuko Nakamura, Naohiro Okada, Akira Kunimatsu, Kiyoto Kasai, Shinsuke Koik. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:30210369. |
however, details of the role of the midbrain dopaminergic system in these functions are still to be determined in humans. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuko Nakamura, Naohiro Okada, Akira Kunimatsu, Kiyoto Kasai, Shinsuke Koik. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:30210369. |
considering that the ventral tegmental area (vta) and substantia nigra (sn) in the midbrain are the primary dopamine producers, creating reliable anatomical templates of the vta and sn through neuroimaging studies would be useful for achieving a detailed understanding of this dopaminergic system. |
2020-09-30 |
2023-08-13 |
Not clear |
| Na Feng, Scott Simanski, Kazi Islam, Linda S Hynan, Thomas Kodadek, Dwight C Germa. Antibody biomarker for de novo Parkinson disease: attempted validation. NPJ Parkinson's disease. vol 4. 2020-09-30. PMID:30211310. |
parkinson disease (pd) is a progressive neurodegenerative disease with motor symptoms that result from degeneration of midbrain dopaminergic neurons. |
2020-09-30 |
2023-08-13 |
human |
| Edward J Robinson, Sebastian P Aguiar, Willemieke M Kouwenhoven, Dorinde S Starmans, Lars von Oerthel, Marten P Smidt, Lars P van der Heid. Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell death discovery. vol 4. 2020-09-30. PMID:30479840. |
mitochondria-dependent apoptosis plays an important role in the embryonic development of the midbrain dopaminergic system as well as in parkinson's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Edward J Robinson, Sebastian P Aguiar, Willemieke M Kouwenhoven, Dorinde S Starmans, Lars von Oerthel, Marten P Smidt, Lars P van der Heid. Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1. Cell death discovery. vol 4. 2020-09-30. PMID:30479840. |
here, we identify mcl1 as a critical bcl2 pro-survival factor in midbrain dopaminergic neurons. |
2020-09-30 |
2023-08-13 |
mouse |