| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Jankovic, S Chen, W D L. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Progress in neurobiology. vol 77. issue 1-2. 2006-01-20. PMID:16243425. |
experimental studies in nurr1 knock-out mice indicate that nurr1 deficiency results in impaired dopaminergic function and increased vulnerability of those midbrain dopaminergic neurons that degenerate in pd. |
2006-01-20 |
2023-08-12 |
mouse |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
differential expression of the homeobox gene pitx3 in midbrain dopaminergic neurons. |
2006-01-10 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
the transcription factor pitx3 is expressed selectively in the midbrain and regulates the differentiation and survival of dopaminergic neurons. |
2006-01-10 |
2023-08-12 |
rat |
| Simone M Smits, Daniel S Mathon, J Peter H Burbach, Geert M J Ramakers, Marten P Smid. Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system. Molecular and cellular neurosciences. vol 30. issue 3. 2006-01-05. PMID:16140547. |
molecular and cellular alterations in the pitx3-deficient midbrain dopaminergic system. |
2006-01-05 |
2023-08-12 |
mouse |
| Simone M Smits, Daniel S Mathon, J Peter H Burbach, Geert M J Ramakers, Marten P Smid. Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system. Molecular and cellular neurosciences. vol 30. issue 3. 2006-01-05. PMID:16140547. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by loss of midbrain dopaminergic (mda) neurons in the substantia nigra compacta (snc). |
2006-01-05 |
2023-08-12 |
mouse |
| Hannah Taylor, Stephen L Minge. Regenerative medicine in Parkinson's disease: generation of mesencephalic dopaminergic cells from embryonic stem cells. Current opinion in biotechnology. vol 16. issue 5. 2005-12-16. PMID:16143504. |
parkinson's disease is a progressive neurodegenerative disorder caused by the loss of midbrain dopaminergic neurons. |
2005-12-16 |
2023-08-12 |
human |
| Vincent Seuti. Dopaminergic neurones: much more than dopamine? British journal of pharmacology. vol 146. issue 2. 2005-12-09. PMID:16025140. |
midbrain dopaminergic (da) neurones sustain important physiological functions such as control of motricity, signalling of the error in prediction of rewards and modulation of emotions and cognition. |
2005-12-09 |
2023-08-12 |
Not clear |
| Suzanne Numan, Christine M Gall, Kim B Seroog. Developmental expression of neurotrophins and their receptors in postnatal rat ventral midbrain. Journal of molecular neuroscience : MN. vol 27. issue 2. 2005-12-06. PMID:16186635. |
two members of the neurotrophin family, brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3), have been shown to increase the survival of dopaminergic neurons from the ventral midbrain in vitro. |
2005-12-06 |
2023-08-12 |
rat |
| Tsugunobu Andoh, P Boon Chock, Dennis L Murphy, Chuang C Chiue. Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16099847. |
we therefore investigated whether the redox protein trx plays any role in the neuroprotective mechanism of selegiline against mpp+-induced cytotoxicity in human sh-sy5y neuroblastoma cells and also in primary neuronal cultures of mouse midbrain dopaminergic neurons. |
2005-11-28 |
2023-08-12 |
mouse |
| Tsugunobu Andoh, P Boon Chock, Dennis L Murphy, Chuang C Chiue. Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl. Molecular pharmacology. vol 68. issue 5. 2005-11-28. PMID:16099847. |
selegiline-induced trx and associated neuroprotection were concomitantly blocked by the antisense against trx mrna, but not the sense or antisense mutant phosphothionate oligonucleotides, not only in human sh-sy5y cells but also in mouse primary neuronal culture of midbrain dopaminergic neurons. |
2005-11-28 |
2023-08-12 |
mouse |
| Emily Fitzpatrick, Keyoumars Ashkan, Bradley A Wallace, Alim-Louis Benabid, John Mitrofani. Differential survival patterns among midbrain dopaminergic cells of MPTP-treated monkeys and 6OHDA-lesioned rats. Anatomy and embryology. vol 210. issue 2. 2005-11-22. PMID:16151853. |
differential survival patterns among midbrain dopaminergic cells of mptp-treated monkeys and 6ohda-lesioned rats. |
2005-11-22 |
2023-08-12 |
rat |
| Emily Fitzpatrick, Keyoumars Ashkan, Bradley A Wallace, Alim-Louis Benabid, John Mitrofani. Differential survival patterns among midbrain dopaminergic cells of MPTP-treated monkeys and 6OHDA-lesioned rats. Anatomy and embryology. vol 210. issue 2. 2005-11-22. PMID:16151853. |
we explore the patterns of survival among dopaminergic cells of the midbrain in mptp-treated macaque monkeys and 6ohda-lesioned sprague-dawley rats. |
2005-11-22 |
2023-08-12 |
rat |
| Emily Fitzpatrick, Keyoumars Ashkan, Bradley A Wallace, Alim-Louis Benabid, John Mitrofani. Differential survival patterns among midbrain dopaminergic cells of MPTP-treated monkeys and 6OHDA-lesioned rats. Anatomy and embryology. vol 210. issue 2. 2005-11-22. PMID:16151853. |
brains were processed for tyrosine hydroxylase (th) and calbindin immunocytochemistry to label populations in the ventral and dorsal tiers of midbrain dopaminergic cells. |
2005-11-22 |
2023-08-12 |
rat |
| Rebekah J Jakel, Jonathan T Kern, Delinda A Johnson, Jeffrey A Johnso. Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. Toxicological sciences : an official journal of the Society of Toxicology. vol 87. issue 1. 2005-10-31. PMID:15976186. |
parkinson's disease, a progressive neurodegenerative disorder, is characterized by loss of midbrain dopaminergic neurons. |
2005-10-31 |
2023-08-12 |
mouse |
| Kathleen Deschamps, Réjean Coutur. The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation. British journal of pharmacology. vol 145. issue 6. 2005-10-28. PMID:15895109. |
the present study provides the first pharmacological evidence that the three tachykinin receptors in the rat vta can affect the autonomic control of blood pressure and hr by increasing midbrain dopaminergic transmission. |
2005-10-28 |
2023-08-12 |
rat |
| Charleen T Chu, Jian-hui Zhu, Guodong Cao, Armando Signore, Suping Wang, Jun Che. Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16156740. |
parkinson's disease is a debilitating neurodegenerative disease characterized by loss of midbrain dopaminergic neurons. |
2005-10-27 |
2023-08-12 |
mouse |
| Charleen T Chu, Jian-hui Zhu, Guodong Cao, Armando Signore, Suping Wang, Jun Che. Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16156740. |
studies of primary mouse midbrain cultures further supported a role for aif in caspase-independent cell death in mpp+-treated dopaminergic neurons. |
2005-10-27 |
2023-08-12 |
mouse |
| Dong-Youn Hwang, Sheila M Fleming, Paul Ardayfio, Taylor Moran-Gates, Hansoo Kim, Frank I Tarazi, Marie-Francoise Chesselet, Kwang-Soo Ki. 3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 8. 2005-10-26. PMID:15728853. |
although current genetic models of pd produce behavioral impairment and nigrostriatal dysfunction, they do not reproduce the loss of midbrain dopaminergic neurons and 3,4-dihydroxyphenylalanine (l-dopa) reversible behavioral deficits. |
2005-10-26 |
2023-08-12 |
mouse |
| Jan Lewerenz, Bartosz Zurowski, Lars Jenicke, Tobias Bäumer, Andrew J Lees, Alexander Müncha. Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 8. 2005-10-19. PMID:15838851. |
we suggest that dorsorostral midbrain pathology rather than dopamine deficiency due to degeneration of nigrostriatal dopaminergic neurons or basal ganglia nuclei might be responsible for axial rigidity in extension. |
2005-10-19 |
2023-08-12 |
Not clear |
| Chee Yeun Chung, Hyemyung Seo, Kai Christian Sonntag, Andrew Brooks, Ling Lin, Ole Isacso. Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Human molecular genetics. vol 14. issue 13. 2005-10-11. PMID:15888489. |
cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. |
2005-10-11 |
2023-08-12 |
mouse |