| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Syed Z Imam, Joseph Jankovic, Syed F Ali, John T Skinner, Wenjie Xie, Orla M Conneely, Wei-Dong L. Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 11. 2006-03-06. PMID:16126911. |
knocking out of nurr1 gene, a member of nuclear receptor superfamily, causes selective agenesis of dopaminergic neurons in midbrain. |
2006-03-06 |
2023-08-12 |
mouse |
| Mahmood Amiry-Moghaddam, Heidi Lindland, Sergey Zelenin, Bjørg A Roberg, Brigitta B Gundersen, Petur Petersen, Eric Rinvik, Ingeborg A Torgner, Ole P Otterse. Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 11. 2006-03-06. PMID:16126913. |
our findings suggest that mitochondrial aqp9 is a hallmark of astrocytes and midbrain dopaminergic neurons. |
2006-03-06 |
2023-08-12 |
Not clear |
| Olivier Waroux, Laurent Massotte, Livia Alleva, Amaury Graulich, Elizabeth Thomas, Jean-François Liégeois, Jacqueline Scuvée-Moreau, Vincent Seuti. SK channels control the firing pattern of midbrain dopaminergic neurons in vivo. The European journal of neuroscience. vol 22. issue 12. 2006-03-02. PMID:16367777. |
sk channels control the firing pattern of midbrain dopaminergic neurons in vivo. |
2006-03-02 |
2023-08-12 |
rat |
| Olivier Waroux, Laurent Massotte, Livia Alleva, Amaury Graulich, Elizabeth Thomas, Jean-François Liégeois, Jacqueline Scuvée-Moreau, Vincent Seuti. SK channels control the firing pattern of midbrain dopaminergic neurons in vivo. The European journal of neuroscience. vol 22. issue 12. 2006-03-02. PMID:16367777. |
a vast body of experimental in vitro work and modelling studies suggests that the firing pattern and/or rate of a majority of midbrain dopaminergic neurons may be controlled in part by ca2+-activated k+ channels of the sk type. |
2006-03-02 |
2023-08-12 |
rat |
| Lachlan Thompson, Perrine Barraud, Elin Andersson, Deniz Kirik, Anders Björklun. Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 27. 2006-02-28. PMID:16000637. |
identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. |
2006-02-28 |
2023-08-12 |
mouse |
| Takashi Okamoto, Mark T Harnett, Hitoshi Morikaw. Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice. Journal of neurophysiology. vol 95. issue 2. 2006-02-28. PMID:16148268. |
ethanol stimulates the firing activity of midbrain dopamine (da) neurons, leading to enhanced dopaminergic transmission in the mesolimbic system. |
2006-02-28 |
2023-08-12 |
mouse |
| Alexey S Kuznetsov, Nancy J Kopell, Charles J Wilso. Transient high-frequency firing in a coupled-oscillator model of the mesencephalic dopaminergic neuron. Journal of neurophysiology. vol 95. issue 2. 2006-02-28. PMID:16207783. |
dopaminergic neurons of the midbrain fire spontaneously at rates <10/s and ordinarily will not exceed this range even when driven with somatic current injection. |
2006-02-28 |
2023-08-12 |
Not clear |
| Dong-Kug Choi, Subramaniam Pennathur, Celine Perier, Kim Tieu, Peter Teismann, Du-Chu Wu, Vernice Jackson-Lewis, Miquel Vila, Jean-Paul Vonsattel, Jay W Heinecke, Serge Przedborsk. Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 28. 2006-02-21. PMID:16014720. |
parkinson's disease (pd) is characterized by a loss of ventral midbrain dopaminergic neurons, which can be modeled by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2006-02-21 |
2023-08-12 |
mouse |
| Dong-Kug Choi, Subramaniam Pennathur, Celine Perier, Kim Tieu, Peter Teismann, Du-Chu Wu, Vernice Jackson-Lewis, Miquel Vila, Jean-Paul Vonsattel, Jay W Heinecke, Serge Przedborsk. Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 28. 2006-02-21. PMID:16014720. |
we also show that ventral midbrain dopaminergic neurons of mutant mice deficient in mpo are more resistant to mptp-induced cytotoxicity than their wild-type littermates. |
2006-02-21 |
2023-08-12 |
mouse |
| Armando P Signore, Zhongfang Weng, Teresa Hastings, Amber D Van Laar, Qinghua Liang, Yong J Lee, Jun Che. Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death. Journal of neurochemistry. vol 96. issue 2. 2006-02-17. PMID:16336625. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the death of midbrain dopaminergic neurons. |
2006-02-17 |
2023-08-12 |
mouse |
| Wiplove Lamba, Wendy Prichett, David Munoz, David S Park, John M Woulf. MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons. Brain research. vol 1066. issue 1-2. 2006-02-15. PMID:16325158. |
mptp induces intranuclear rodlet formation in midbrain dopaminergic neurons. |
2006-02-15 |
2023-08-12 |
mouse |
| Miguel Angel Sánchez-González, Miguel Angel García-Cabezas, Beatriz Rico, Carmen Cavad. The primate thalamus is a key target for brain dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 26. 2006-02-14. PMID:15987937. |
the origin of thalamic dopamine is multiple, and thus more complex, than in any other dopaminergic system defined to date: dopaminergic neurons of the hypothalamus, periaqueductal gray matter, ventral mesencephalon, and the lateral parabrachial nucleus project bilaterally to the monkey thalamus. |
2006-02-14 |
2023-08-12 |
human |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
the homeo-domain gene, pit x 3, is essential for proper development of midbrain dopaminergic neurons in the substantia nigra pars compacta and might be involved in midbrain dopaminergic survival pathways. |
2006-02-14 |
2023-08-12 |
mouse |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
the mglur1-signaling downstream-effector phospholipase c beta 4 was identified in a suppression subtractive hybridization screen comparing wild-type and pit x 3-deficient aphakia midbrain dopaminergic neurons. |
2006-02-14 |
2023-08-12 |
mouse |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
expression pattern analysis revealed that phospholipase c beta 4 was expressed in midbrain dopaminergic neurons of the substantia nigra pars compacta and part of the ventral tegmental area, whereas expression of mglur1alpha was predominantly observed in the more vulnerable midbrain dopaminergic neurons in the lateral substantia nigra pars compacta. |
2006-02-14 |
2023-08-12 |
mouse |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
however, clear expression of phospholipase c beta 4 in spared midbrain dopaminergic neurons of aphakia mice located in the ventral tegmental area, indicated that induction and maintenance of phospholipase c beta 4 expression is pit x 3-independent in these neurons. |
2006-02-14 |
2023-08-12 |
mouse |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
furthermore, we report here a normal distribution of midbrain dopaminergic cell bodies and axonal projection to the striatum in phospholipase c beta 4-/- mice, indicating that signaling of phospholipase c beta 4 is not essential for the survival of midbrain dopaminergic neurons. |
2006-02-14 |
2023-08-12 |
mouse |
| Pepijn van den Munckhof, François Gilbert, Michel Chamberland, Daniel Lévesque, Jacques Droui. Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16269007. |
preferential neurodegeneration of dopaminergic neurons in the ventral substantia nigra of the midbrain is a hallmark of parkinson's disease. |
2006-02-14 |
2023-08-12 |
mouse |
| Pepijn van den Munckhof, François Gilbert, Michel Chamberland, Daniel Lévesque, Jacques Droui. Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16269007. |
taken collectively, these data support the idea that the aphakia mice represent a selective model of dopaminergic deficiency that closely resembles the midbrain and striatal neuropathology associated with parkinson's disease, and this suggests that these mice are a good model to assess therapies for parkinson's disease as well as to understand the susceptibility of these neurons to neurodegeneration. |
2006-02-14 |
2023-08-12 |
mouse |
| Sharon K Michelhaugh, Henrikas Vaitkevicius, Jun Wang, Mohamad Bouhamdan, Alexys R Krieg, Jennifer L Walker, Varsha Mendiratta, Michael J Banno. Dopamine neurons express multiple isoforms of the nuclear receptor nurr1 with diminished transcriptional activity. Journal of neurochemistry. vol 95. issue 5. 2006-02-07. PMID:16313515. |
nurr1 (nr4a2) is an orphan nuclear receptor required for the development and maintenance of the dopaminergic phenotype in neurons of the ventral midbrain. |
2006-02-07 |
2023-08-12 |
human |