| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Johannes Schwarz, Sigrid C Schwarz, Oliver Dorigo, Alexandra Stützer, Florian Wegner, Cesar Labarca, Purnima Deshpande, Jose S Gil, Arnold J Berk, Henry A Leste. Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 7. 2006-06-01. PMID:16675851. |
enhanced expression of hypersensitive alpha4* nachr in adult mice increases the loss of midbrain dopaminergic neurons. |
2006-06-01 |
2023-08-12 |
mouse |
| Johannes Schwarz, Sigrid C Schwarz, Oliver Dorigo, Alexandra Stützer, Florian Wegner, Cesar Labarca, Purnima Deshpande, Jose S Gil, Arnold J Berk, Henry A Leste. Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 7. 2006-06-01. PMID:16675851. |
we describe an inducible genetic model for degeneration of midbrain dopaminergic neurons in adults. |
2006-06-01 |
2023-08-12 |
mouse |
| Johannes Schwarz, Sigrid C Schwarz, Oliver Dorigo, Alexandra Stützer, Florian Wegner, Cesar Labarca, Purnima Deshpande, Jose S Gil, Arnold J Berk, Henry A Leste. Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 7. 2006-06-01. PMID:16675851. |
in previous studies, knock-in mice expressing hypersensitive m2 domain leu9'ser (l9's) alpha4 nicotinic receptors (nachr) at near-normal levels displayed dominant neonatal lethality and dopaminergic deficits in embryonic midbrain, because the hypersensitive nachr is excitotoxic. |
2006-06-01 |
2023-08-12 |
mouse |
| Johannes Schwarz, Sigrid C Schwarz, Oliver Dorigo, Alexandra Stützer, Florian Wegner, Cesar Labarca, Purnima Deshpande, Jose S Gil, Arnold J Berk, Henry A Leste. Enhanced expression of hypersensitive alpha4* nAChR in adult mice increases the loss of midbrain dopaminergic neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 7. 2006-06-01. PMID:16675851. |
thus, hda-mediated gene transfer into adult midbrain induced sufficient functional expression of cre in dopaminergic neurons to allow for postnatal deletion of neo. |
2006-06-01 |
2023-08-12 |
mouse |
| Hitoshi Fukuda, Jun Takahash. Embryonic stem cells as a cell source for treating Parkinson's disease. Expert opinion on biological therapy. vol 5. issue 10. 2006-05-31. PMID:16197334. |
parkinson's disease (pd) is a neurodegenerative disease characterised by a loss of midbrain dopaminergic (da) neurons. |
2006-05-31 |
2023-08-12 |
Not clear |
| S Zechel, J Jarosik, I Kiprianova, A Schober, K Unsicker, O von Bohlen und Halbac. FGF-2 deficiency does not alter vulnerability of the dopaminergic nigrostriatal system towards MPTP intoxication in mice. The European journal of neuroscience. vol 23. issue 6. 2006-05-30. PMID:16553632. |
to address the putative physiological relevance of endogenous fgf-2 for midbrain dopaminergic neurons, we have analysed densities of tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) and th-positive fibers in the striatum and amygdala of adult fgf-2-deficient mice. |
2006-05-30 |
2023-08-12 |
mouse |
| Masahiko Funada, Mio Sato, Naoya Aoo, Kiyoshi Wad. [Role of the monoamine system in the brain on the development of psychological dependence on toluene]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. vol 41. issue 1. 2006-05-30. PMID:16619847. |
the mesolimbic dopamine pathway, which includes dopaminergic neurons in the ventral tegmental area (vta) of the midbrain and their targets in the limbic forebrain, especially the nucleus accumbens (nac), is one of the most important substrates for the development of psychological dependence on drugs such as stimulants, cocaine, and heroin. |
2006-05-30 |
2023-08-12 |
Not clear |
| Nilima Prakash, Claude Brodski, Thorsten Naserke, Eduardo Puelles, Robindra Gogoi, Anita Hall, Markus Panhuysen, Diego Echevarria, Lori Sussel, Daniela M Vogt Weisenhorn, Salvador Martinez, Ernest Arenas, Antonio Simeone, Wolfgang Wurs. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (Cambridge, England). vol 133. issue 1. 2006-05-25. PMID:16339193. |
the secreted glycoprotein wnt1 is expressed in close vicinity to developing midbrain dopaminergic neurons. |
2006-05-25 |
2023-08-12 |
Not clear |
| Nilima Prakash, Claude Brodski, Thorsten Naserke, Eduardo Puelles, Robindra Gogoi, Anita Hall, Markus Panhuysen, Diego Echevarria, Lori Sussel, Daniela M Vogt Weisenhorn, Salvador Martinez, Ernest Arenas, Antonio Simeone, Wolfgang Wurs. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (Cambridge, England). vol 133. issue 1. 2006-05-25. PMID:16339193. |
here, we show that wnt1 regulates the genetic network, including otx2 and nkx2-2, that is required for the establishment of the midbrain dopaminergic progenitor domain during embryonic development. |
2006-05-25 |
2023-08-12 |
Not clear |
| Nilima Prakash, Claude Brodski, Thorsten Naserke, Eduardo Puelles, Robindra Gogoi, Anita Hall, Markus Panhuysen, Diego Echevarria, Lori Sussel, Daniela M Vogt Weisenhorn, Salvador Martinez, Ernest Arenas, Antonio Simeone, Wolfgang Wurs. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (Cambridge, England). vol 133. issue 1. 2006-05-25. PMID:16339193. |
in addition, wnt1 is required for the terminal differentiation of midbrain dopaminergic neurons at later stages of embryogenesis. |
2006-05-25 |
2023-08-12 |
Not clear |
| Nilima Prakash, Claude Brodski, Thorsten Naserke, Eduardo Puelles, Robindra Gogoi, Anita Hall, Markus Panhuysen, Diego Echevarria, Lori Sussel, Daniela M Vogt Weisenhorn, Salvador Martinez, Ernest Arenas, Antonio Simeone, Wolfgang Wurs. A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (Cambridge, England). vol 133. issue 1. 2006-05-25. PMID:16339193. |
these results identify wnt1 as a key molecule in the development of midbrain dopaminergic neurons in vivo. |
2006-05-25 |
2023-08-12 |
Not clear |
| Joaquín Martí, M Carmen Santa-Cruz, Shirley A Bayer, José P Hervá. The weaver gene expression affects neuronal generation patterns depending on age and encephalic region. Neuroscience letters. vol 396. issue 3. 2006-05-25. PMID:16387438. |
there is already a substantial reduction in the number of purkinje and fastigial cells at p8, but loss of dopaminergic neurons was only detected in 90-day-old weavers and, therefore, vulnerability is built into this midbrain neural system during its late postnatal development. |
2006-05-25 |
2023-08-12 |
mouse |
| Lilly Schwieler, Sophie Erhardt, Linda Nilsson, Klas Linderholm, Göran Engber. Effects of COX-1 and COX-2 inhibitors on the firing of rat midbrain dopaminergic neurons--possible involvement of endogenous kynurenic acid. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16416446. |
effects of cox-1 and cox-2 inhibitors on the firing of rat midbrain dopaminergic neurons--possible involvement of endogenous kynurenic acid. |
2006-05-25 |
2023-08-12 |
rat |
| Donald L Bliwise, Liqiong He, Farzaneh Pour Ansari, David B Ry. Quantification of electromyographic activity during sleep: a phasic electromyographic metric. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 23. issue 1. 2006-05-25. PMID:16514352. |
it may have particular relevance for the identification of neurodegenerative conditions in which disinhibition of midbrain dopaminergic pathways results in excessive motor discharge during sleep. |
2006-05-25 |
2023-08-12 |
human |
| J G McHaffie, H Jiang, P J May, V Coizet, P G Overton, B E Stein, P Redgrav. A direct projection from superior colliculus to substantia nigra pars compacta in the cat. Neuroscience. vol 138. issue 1. 2006-05-24. PMID:16361067. |
the midbrain superior colliculus also is sensitive to such stimuli, exhibits sensory responses with latencies reliably less than those of dopaminergic neurons, and, in rat, has been shown to send direct projections to regions of the substantia nigra and ventral tegmental area containing dopaminergic neurons (e.g. |
2006-05-24 |
2023-08-12 |
rat |
| J G McHaffie, H Jiang, P J May, V Coizet, P G Overton, B E Stein, P Redgrav. A direct projection from superior colliculus to substantia nigra pars compacta in the cat. Neuroscience. vol 138. issue 1. 2006-05-24. PMID:16361067. |
recent electrophysiological and electrochemical evidence also suggests that tectonigral connections may be critical for relaying short-latency (<100 ms) visual information to midbrain dopaminergic neurons. |
2006-05-24 |
2023-08-12 |
rat |
| C S Lam, S Rastegar, U Strähl. Distribution of cannabinoid receptor 1 in the CNS of zebrafish. Neuroscience. vol 138. issue 1. 2006-05-24. PMID:16368195. |
in relation to dopaminergic neurons in the diencephalic posterior tuberculum (considered to be the teleostean homologue of the mammalian midbrain dopaminergic system), both cb1 and tyrosine hydroxylase-expressing cells occupy non-overlapping domains. |
2006-05-24 |
2023-08-12 |
zebrafish |
| Shih-Ling Hsuan, Heather M Klintworth, Zhengui Xi. Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 17. 2006-05-23. PMID:16641227. |
moreover, primary cultured dopaminergic neurons from mesencephalon were more sensitive to rotenone-induced cell death than nondopaminergic neurons in the same culture. |
2006-05-23 |
2023-08-12 |
human |
| Sung Yul Kim, Kyou Chan Choi, Min Seok Chang, Myoung Hwan Kim, Sa Yong Kim, Young-Soon Na, Jong Eun Lee, Byung Kwan Jin, Bong-Hee Lee, Ja-Hyun Bai. The dopamine D2 receptor regulates the development of dopaminergic neurons via extracellular signal-regulated kinase and Nurr1 activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 17. 2006-05-23. PMID:16641236. |
because the dopaminergic pathways in the midbrain have been closely associated with serious neuropsychiatric disorders, the elucidation of the mechanisms underlying dopaminergic neuronal development should provide some important clues for related disorders. |
2006-05-23 |
2023-08-12 |
mouse |
| Anthony E Lang, Steven Gill, Nik K Patel, Andres Lozano, John G Nutt, Richard Penn, David J Brooks, Gary Hotton, Elena Moro, Peter Heywood, Matthew A Brodsky, Kim Burchiel, Patrick Kelly, Arif Dalvi, Burton Scott, Mark Stacy, Dennis Turner, V G Frederich Wooten, William J Elias, Edward R Laws, Vijay Dhawan, A Jon Stoessl, James Matcham, Robert J Coffey, Michael Trau. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Annals of neurology. vol 59. issue 3. 2006-05-09. PMID:16429411. |
glial cell line-derived neurotrophic factor (gdnf) exerts potent trophic influence on midbrain dopaminergic neurons. |
2006-05-09 |
2023-08-12 |
human |