| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nina Rawal, Gonçalo Castelo-Branco, Kyle M Sousa, Julianna Kele, Kazuto Kobayashi, Hideyuki Okano, Ernest Arena. Dynamic temporal and cell type-specific expression of Wnt signaling components in the developing midbrain. Experimental cell research. vol 312. issue 9. 2006-07-21. PMID:16510140. |
wnt1 and -5a have been shown to modulate the proliferation and differentiation of midbrain dopaminergic (da) neurons. |
2006-07-21 |
2023-08-12 |
mouse |
| Hiroshi Katsuki, Mitsugi Okawara, Haruki Shibata, Toshiaki Kume, Akinori Akaik. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16638023. |
nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. |
2006-07-21 |
2023-08-12 |
rat |
| Hiroshi Katsuki, Mitsugi Okawara, Haruki Shibata, Toshiaki Kume, Akinori Akaik. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16638023. |
activated microglia are considered to play important roles in degenerative processes of midbrain dopaminergic neurons. |
2006-07-21 |
2023-08-12 |
rat |
| Hiroshi Katsuki, Mitsugi Okawara, Haruki Shibata, Toshiaki Kume, Akinori Akaik. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16638023. |
moreover, depletion of resident microglia from midbrain slices abrogated thrombin-induced no production and dopaminergic cell death, but did not inhibit tissue injury. |
2006-07-21 |
2023-08-12 |
rat |
| Hiroshi Katsuki, Mitsugi Okawara, Haruki Shibata, Toshiaki Kume, Akinori Akaik. Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16638023. |
hence, no production resulting from mapk-dependent microglial inos induction is a crucial event in thrombin-induced dopaminergic neurodegeneration, whereas damage of other midbrain cells is mapk-dependent but is no-independent. |
2006-07-21 |
2023-08-12 |
rat |
| Andrzej Dekundy, Malgorzata Pietraszek, Daniela Schaefer, M Angela Cenci, Wojciech Danys. Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease. Brain research bulletin. vol 69. issue 3. 2006-07-06. PMID:16564428. |
the present study was devoted to investigate the effects of the metabotropic glutamate receptor(mglur)5 antagonist [(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (mtep) and the mglur1 antagonist, (3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)-methanone methanesulfonate (emqmcm), in animal studies indicative of antiparkinsonian-like activity such as haloperidol-induced catalepsy, hypoactivity in open field following haloperidol, and rotation in rats with unilateral 6-hydroxydopamine(ohda)-induced lesions of the midbrain dopaminergic system (alone and in combination with l-dopa). |
2006-07-06 |
2023-08-12 |
rat |
| T E Hazy, M J Frank, R C O'Reill. Banishing the homunculus: making working memory work. Neuroscience. vol 139. issue 1. 2006-06-30. PMID:16343792. |
it is capable of developing human-like performance largely on its own by taking advantage of powerful reinforcement learning mechanisms, based on the midbrain dopaminergic system and its activation via the basal ganglia and amygdala. |
2006-06-30 |
2023-08-12 |
Not clear |
| D A Dorsey, D H Mascó, K Dikranian, K Hyrc, L Masciotra, B Faddis, M Soriano, A A Gru, M P Goldberg, G A de Erausqui. Ultrastructural characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced cell death in embryonic dopaminergic neurons. Apoptosis : an international journal on programmed cell death. vol 11. issue 4. 2006-06-30. PMID:16532276. |
in primary cultures of mesencephalon, death of dopaminergic neurons is triggered by activation of glutamate receptors sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), and differs ultrastructurally from both neuronal apoptosis or typical excitotoxicity. |
2006-06-30 |
2023-08-12 |
mouse |
| Hironori Yamazoe, Masato Kobori, Yoshinobu Murakami, Keiichi Yano, Mitsuo Satoh, Kenji Mizuseki, Yoshiki Sasai, Hiroo Iwat. One-step induction of neurons from mouse embryonic stem cells in serum-free media containing vitamin B12 and heparin. Cell transplantation. vol 15. issue 2. 2006-06-27. PMID:16719047. |
in addition, specific gene analyses by rt-pcr demonstrated expression of an early central nerve system, mature neuron, and midbrain dopaminergic neuron-specific molecules (i.e., nestin, middle molecular mass neurofilament protein, nurr1, and th, respectively). |
2006-06-27 |
2023-08-12 |
mouse |
| Seung U Kim, In H Park, Tae H Kim, Kwang S Kim, Hyun B Choi, Seok H Hong, Jung H Bang, Myung A Lee, In S Joo, Chong S Lee, Yong S Ki. Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 26. issue 2. 2006-06-23. PMID:16708545. |
parkinson disease is a neurodegenerative disease characterized by loss of midbrain dopaminergic neurons resulting in movement disorder. |
2006-06-23 |
2023-08-12 |
human |
| Nathaniel D Daw, Kenji Doy. The computational neurobiology of learning and reward. Current opinion in neurobiology. vol 16. issue 2. 2006-06-22. PMID:16563737. |
following the suggestion that midbrain dopaminergic neurons encode a signal, known as a 'reward prediction error', used by artificial intelligence algorithms for learning to choose advantageous actions, the study of the neural substrates for reward-based learning has been strongly influenced by computational theories. |
2006-06-22 |
2023-08-12 |
human |
| Gundula Griesel, Dieter Treichel, Patrick Collombat, Jens Krull, Andreas Zembrzycki, Willem M R van den Akker, Peter Gruss, Antonio Simeone, Ahmed Mansour. Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border. Development (Cambridge, England). vol 133. issue 9. 2006-06-21. PMID:16571633. |
in this context, midbrain dopaminergic neurons are found posterior to the iso. |
2006-06-21 |
2023-08-12 |
mouse |
| Gonçalo Castelo-Branco, Kyle M Sousa, Vitezslav Bryja, Luisa Pinto, Joseph Wagner, Ernest Arena. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Molecular and cellular neurosciences. vol 31. issue 2. 2006-06-13. PMID:16243537. |
ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through wnt-5a secretion. |
2006-06-13 |
2023-08-12 |
Not clear |
| Gonçalo Castelo-Branco, Kyle M Sousa, Vitezslav Bryja, Luisa Pinto, Joseph Wagner, Ernest Arena. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Molecular and cellular neurosciences. vol 31. issue 2. 2006-06-13. PMID:16243537. |
here, we report that ventral midbrain glia, including astrocytes and radial glia, are the source of signals required by neural precursors to acquire a dopaminergic phenotype. |
2006-06-13 |
2023-08-12 |
Not clear |
| Gonçalo Castelo-Branco, Kyle M Sousa, Vitezslav Bryja, Luisa Pinto, Joseph Wagner, Ernest Arena. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Molecular and cellular neurosciences. vol 31. issue 2. 2006-06-13. PMID:16243537. |
thus, our results identify wnt-5a as an important component of the dopaminergic inductive activity of the ventral midbrain glia. |
2006-06-13 |
2023-08-12 |
Not clear |
| Angélique Ducray, Sandra H Krebs, Benoît Schaller, Rolf W Seiler, Morten Meyer, Hans R Widme. GDNF family ligands display distinct action profiles on cultured GABAergic and serotonergic neurons of rat ventral mesencephalon. Brain research. vol 1069. issue 1. 2006-06-13. PMID:16380100. |
glial-cell-line-derived neurotrophic factor (gdnf), neurturin (nrtn), artemin (artn) and persephin (pspn), known as the gdnf family ligands (gfls), influence the development, survival and differentiation of cultured dopaminergic neurons from ventral mesencephalon (vm). |
2006-06-13 |
2023-08-12 |
rat |
| Jesper Roland Jørgensen, Bengt Juliusson, Karen Friis Henriksen, Claus Hansen, Steen Knudsen, Thomas Nordahl Petersen, Nikolaj Blom, Ake Seiger, Lars U Wahlber. Identification of novel genes regulated in the developing human ventral mesencephalon. Experimental neurology. vol 198. issue 2. 2006-06-09. PMID:16473350. |
in the human embryo, from approximately 6 weeks gestational age (ga), dopaminergic (da) neurons can be found in the ventral mesencephalon (vm). |
2006-06-09 |
2023-08-12 |
human |
| Brian C Kramer, Dale Woodbury, Ira B Blac. Adult rat bone marrow stromal cells express genes associated with dopamine neurons. Biochemical and biophysical research communications. vol 343. issue 4. 2006-06-09. PMID:16574067. |
mscs transcribe a variety of dopaminergic genes including patched and smoothened (components of the shh receptor), gli-1 (downstream mediator of shh), and otx-1, a gene associated with formation of the mesencephalon during development. |
2006-06-09 |
2023-08-12 |
rat |
| Hitoshi Fukuda, Jun Takahashi, Kiichi Watanabe, Hideki Hayashi, Asuka Morizane, Masaomi Koyanagi, Yoshiki Sasai, Nobuo Hashimot. Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem cells (Dayton, Ohio). vol 24. issue 3. 2006-06-08. PMID:16223855. |
the differentiation of dopaminergic (da) neurons from mouse embryonic stem cells (escs) can be efficiently induced, making these neurons a potential source for transplantation as a treatment for parkinson's disease, a condition characterized by the gradual loss of midbrain da neurons. |
2006-06-08 |
2023-08-12 |
mouse |
| Jessica N Da Silva, Kjell Fuxe, Paul R Mange. Nuclear parcellation of certain immunohistochemically identifiable neuronal systems in the midbrain and pons of the Highveld molerat (Cryptomys hottentotus). Journal of chemical neuroanatomy. vol 31. issue 1. 2006-06-02. PMID:16289497. |
the present paper details our findings following immunohistochemical examination of the midbrain and pons of the highveld molerat (cryptomys hottentotus) using antibodies for vesicular acetylcholine transporter (cholinergic neurons), tyrosine hydroxylase (dopaminergic and noradrenergic neurons), and serotonin (serotonergic neurons). |
2006-06-02 |
2023-08-12 |
rat |