| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Siew-Lan An. Transcriptional control of midbrain dopaminergic neuron development. Development (Cambridge, England). vol 133. issue 18. 2007-01-04. PMID:16899537. |
although loss of midbrain dopaminergic neurons is associated with one of the most common human neurological disorders, parkinson's disease, little is known about the specification of this neuronal subtype. |
2007-01-04 |
2023-08-12 |
human |
| Siew-Lan An. Transcriptional control of midbrain dopaminergic neuron development. Development (Cambridge, England). vol 133. issue 18. 2007-01-04. PMID:16899537. |
these new findings will help to elucidate the genetic program that promotes the generation of midbrain dopaminergic neurons. |
2007-01-04 |
2023-08-12 |
human |
| Siew-Lan An. Transcriptional control of midbrain dopaminergic neuron development. Development (Cambridge, England). vol 133. issue 18. 2007-01-04. PMID:16899537. |
importantly, these discoveries will also significantly advance efforts to differentiate stem cells into midbrain dopaminergic neurons that can be used for therapeutic use in treating parkinson's disease. |
2007-01-04 |
2023-08-12 |
human |
| Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal, Steven A Goldma. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature medicine. vol 12. issue 11. 2006-12-19. PMID:17057709. |
functional engraftment of human es cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. |
2006-12-19 |
2023-08-12 |
human |
| Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal, Steven A Goldma. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature medicine. vol 12. issue 11. 2006-12-19. PMID:17057709. |
to direct human embryonic stem (hes) cells to a dopaminergic neuronal fate, we cocultured hes cells that were exposed to both sonic hedgehog and fibroblast growth factor 8 with telomerase-immortalized human fetal midbrain astrocytes. |
2006-12-19 |
2023-08-12 |
human |
| Neeta S Roy, Carine Cleren, Shashi K Singh, Lichuan Yang, M Flint Beal, Steven A Goldma. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nature medicine. vol 12. issue 11. 2006-12-19. PMID:17057709. |
these results show the utility of recreating the cellular environment of the developing human midbrain while driving dopaminergic neurogenesis from hes cells, and they demonstrate the potential of the resultant cells to mediate substantial functional recovery in a model of parkinson disease. |
2006-12-19 |
2023-08-12 |
human |
| Samuel D Gale, David J Perke. Physiological properties of zebra finch ventral tegmental area and substantia nigra pars compacta neurons. Journal of neurophysiology. vol 96. issue 5. 2006-12-06. PMID:16870835. |
the strong dopaminergic projection to striatal regions and more moderate dopaminergic projections to other regions of the telencephalon predominantly arise from midbrain dopaminergic neurons in the substantia nigra pars compacta (snc) and ventral tegmental area (vta). |
2006-12-06 |
2023-08-12 |
Not clear |
| D S Mathon, L J M J Vanderschuren, G M J Ramaker. Reduced psychostimulant effects on dopamine dynamics in the nucleus accumbens of mu-opioid receptor knockout mice. Neuroscience. vol 141. issue 4. 2006-12-04. PMID:16777349. |
in addition, we found decreased impulse activity of midbrain dopaminergic neurons and an increased gabaergic input to these neurons in mu-opioid receptor knockout mice. |
2006-12-04 |
2023-08-12 |
mouse |
| Jun Peng, Lin Xie, Fang Feng Stevenson, Simon Melov, Donato A Di Monte, Julie K Anderse. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 45. 2006-11-28. PMID:17093086. |
here, we present data demonstrating that degeneration of midbrain dopaminergic neurons in weaver is mediated via neuroinflammation. |
2006-11-28 |
2023-08-12 |
mouse |
| Lixia Lu, Frauke Neff, Daniel Alvarez Fischer, Carmen Henze, Etienne C Hirsch, Wolfgang H Oertel, Jürgen Schlegel, Andreas Hartman. Regional vulnerability of mesencephalic dopaminergic neurons prone to degenerate in Parkinson's disease: a post-mortem study in human control subjects. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16753304. |
parkinson's disease (pd) is characterized by loss of dopaminergic (da) neurons in the human midbrain, which varies greatly among mesencephalic subregions. |
2006-11-27 |
2023-08-12 |
human |
| C E Rick, A Ebert, T Virag, M C Bohn, D J Surmeie. Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons. Developmental neuroscience. vol 28. issue 6. 2006-11-24. PMID:17028430. |
differentiated dopaminergic mn9d cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons. |
2006-11-24 |
2023-08-12 |
mouse |
| Sanjay Jain, Judith P Golden, David Wozniak, Elizabeth Pehek, Eugene M Johnson, Jeffrey Milbrand. RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 43. 2006-11-24. PMID:17065462. |
ret is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. |
2006-11-24 |
2023-08-12 |
mouse |
| Sanjay Jain, Judith P Golden, David Wozniak, Elizabeth Pehek, Eugene M Johnson, Jeffrey Milbrand. RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 43. 2006-11-24. PMID:17065462. |
a detailed morphometric and biochemical analysis including dopaminergic neuron number and size in snc and vta, and fiber density in the striatum and nucleus accumbens, and dopamine levels indicate that ret is not required for providing global trophic support to midbrain dopaminergic neurons in adult mice. |
2006-11-24 |
2023-08-12 |
mouse |
| Geeta Ravindran, Harinarayana S Ra. Enriched NCAM-positive cells form functional dopaminergic neurons in the rat model of Parkinson's disease. Stem cells and development. vol 15. issue 4. 2006-11-13. PMID:16978060. |
we describe a method of generating an enriched population of ncam-positive cells from a human teratocarcinoma cell line (ntera2/d1) and their differentiation into midbrain dopaminergic neurons in the absence of the caudalizing factor retinoic acid (ra). |
2006-11-13 |
2023-08-12 |
human |
| Claire E Heise, John Mitrofani. Reduction in parvalbumin expression in the zona incerta after 6OHDA lesion in rats. Journal of neurocytology. vol 34. issue 6. 2006-11-03. PMID:16902763. |
in summary, our results indicate that a loss of the midbrain dopaminergic cells induces a major change in parvalbumin expression within the zona incerta. |
2006-11-03 |
2023-08-12 |
rat |
| Kertu Rünkorg, Siim Värv, Toshimitsu Matsui, Sulev Kõks, Eero Vasa. Differences in behavioural effects of amphetamine and dopamine-related gene expression in wild-type and homozygous CCK2 receptor deficient mice. Neuroscience letters. vol 406. issue 1-2. 2006-11-03. PMID:16916582. |
the increased tone of dopaminergic projections from the mesencephalon to mesolimbic structures is probably related to increased amphetamine-induced motor sensitization in homozygous mice. |
2006-11-03 |
2023-08-12 |
mouse |
| K Strecker, J P Schneider, H Barthel, W Hermann, F Wegner, A Wagner, J Schwarz, O Sabri, C Zimme. Profound midbrain atrophy in patients with Wilson's disease and neurological symptoms? Journal of neurology. vol 253. issue 8. 2006-10-26. PMID:16607473. |
in summary, we were able to show, that midbrain diameter is an easy to perform quantification of neurodegeneration induced by brain copper accumulation and that other structures than substantia nigra dopaminergic neurons seem to contribute to midbrain atrophy in wd. |
2006-10-26 |
2023-08-12 |
Not clear |
| Nilima Prakash, Wolfgang Wurs. Genetic networks controlling the development of midbrain dopaminergic neurons. The Journal of physiology. vol 575. issue Pt 2. 2006-10-26. PMID:16825303. |
genetic networks controlling the development of midbrain dopaminergic neurons. |
2006-10-26 |
2023-08-12 |
human |
| Nilima Prakash, Wolfgang Wurs. Genetic networks controlling the development of midbrain dopaminergic neurons. The Journal of physiology. vol 575. issue Pt 2. 2006-10-26. PMID:16825303. |
firstly, a wnt1-regulated genetic network, including otx2 and nkx2-2, and a shh-controlled genetic cascade, including lmx1a, msx1 and nkx6-1, have been unravelled, acting in parallel or sequentially to establish a territory competent for midbrain dopaminergic precursor production at relatively early stages of neural development. |
2006-10-26 |
2023-08-12 |
human |
| Nilima Prakash, Wolfgang Wurs. Genetic networks controlling the development of midbrain dopaminergic neurons. The Journal of physiology. vol 575. issue Pt 2. 2006-10-26. PMID:16825303. |
secondly, the same factors (wnt1 and lmx1a/msx1) appear to regulate midbrain dopaminergic and/or neuronal fate specification in the postmitotic progeny of these precursors by controlling the expression of midbrain dopaminergic-specific and/or general proneural factors at later stages of neural development. |
2006-10-26 |
2023-08-12 |
human |