| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
the homeo-domain gene, pit x 3, is essential for proper development of midbrain dopaminergic neurons in the substantia nigra pars compacta and might be involved in midbrain dopaminergic survival pathways. |
2006-02-14 |
2023-08-12 |
mouse |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
the mglur1-signaling downstream-effector phospholipase c beta 4 was identified in a suppression subtractive hybridization screen comparing wild-type and pit x 3-deficient aphakia midbrain dopaminergic neurons. |
2006-02-14 |
2023-08-12 |
mouse |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
expression pattern analysis revealed that phospholipase c beta 4 was expressed in midbrain dopaminergic neurons of the substantia nigra pars compacta and part of the ventral tegmental area, whereas expression of mglur1alpha was predominantly observed in the more vulnerable midbrain dopaminergic neurons in the lateral substantia nigra pars compacta. |
2006-02-14 |
2023-08-12 |
mouse |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
however, clear expression of phospholipase c beta 4 in spared midbrain dopaminergic neurons of aphakia mice located in the ventral tegmental area, indicated that induction and maintenance of phospholipase c beta 4 expression is pit x 3-independent in these neurons. |
2006-02-14 |
2023-08-12 |
mouse |
| S M Smits, S van der Nobelen, K J M Hornman, L von Oerthel, J P H Burbach, M P Smid. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16198487. |
furthermore, we report here a normal distribution of midbrain dopaminergic cell bodies and axonal projection to the striatum in phospholipase c beta 4-/- mice, indicating that signaling of phospholipase c beta 4 is not essential for the survival of midbrain dopaminergic neurons. |
2006-02-14 |
2023-08-12 |
mouse |
| Pepijn van den Munckhof, François Gilbert, Michel Chamberland, Daniel Lévesque, Jacques Droui. Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16269007. |
preferential neurodegeneration of dopaminergic neurons in the ventral substantia nigra of the midbrain is a hallmark of parkinson's disease. |
2006-02-14 |
2023-08-12 |
mouse |
| Pepijn van den Munckhof, François Gilbert, Michel Chamberland, Daniel Lévesque, Jacques Droui. Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease. Journal of neurochemistry. vol 96. issue 1. 2006-02-14. PMID:16269007. |
taken collectively, these data support the idea that the aphakia mice represent a selective model of dopaminergic deficiency that closely resembles the midbrain and striatal neuropathology associated with parkinson's disease, and this suggests that these mice are a good model to assess therapies for parkinson's disease as well as to understand the susceptibility of these neurons to neurodegeneration. |
2006-02-14 |
2023-08-12 |
mouse |
| Sharon K Michelhaugh, Henrikas Vaitkevicius, Jun Wang, Mohamad Bouhamdan, Alexys R Krieg, Jennifer L Walker, Varsha Mendiratta, Michael J Banno. Dopamine neurons express multiple isoforms of the nuclear receptor nurr1 with diminished transcriptional activity. Journal of neurochemistry. vol 95. issue 5. 2006-02-07. PMID:16313515. |
nurr1 (nr4a2) is an orphan nuclear receptor required for the development and maintenance of the dopaminergic phenotype in neurons of the ventral midbrain. |
2006-02-07 |
2023-08-12 |
human |
| Laurent Roybon, Patrik Brundin, Jia-Yi L. Stromal cell-derived inducing activity does not promote dopaminergic differentiation, but enhances differentiation and proliferation of neural stem cell-derived astrocytes. Experimental neurology. vol 196. issue 2. 2006-01-25. PMID:16199035. |
to examine whether pa6 stromal cells can enhance the yield of dopaminergic differentiation from neural progenitors, we generated neurospheres from embryonic day 11.5 (e11.5) (midbrain and forebrain) and e14.5 (ventral mesencephalon and cortex) rat embryos and allowed them to differentiate in co-culture with pa6 cells or poly-l-lysine/laminin-coated dishes. |
2006-01-25 |
2023-08-12 |
mouse |
| Birgit Liss, Olga Haeckel, Johannes Wildmann, Takashi Miki, Susumu Seino, Jochen Roepe. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nature neuroscience. vol 8. issue 12. 2006-01-24. PMID:16299504. |
k-atp channels promote the differential degeneration of dopaminergic midbrain neurons. |
2006-01-24 |
2023-08-12 |
mouse |
| Birgit Liss, Olga Haeckel, Johannes Wildmann, Takashi Miki, Susumu Seino, Jochen Roepe. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nature neuroscience. vol 8. issue 12. 2006-01-24. PMID:16299504. |
the selective degeneration of dopaminergic (da) midbrain neurons in the substantia nigra (sn) is a hallmark of parkinson disease. |
2006-01-24 |
2023-08-12 |
mouse |
| Björn Steiniger-Brach, Beate D Kretschme. Different function of pedunculopontine GABA and glutamate receptors in nucleus accumbens dopamine, pedunculopontine glutamate and operant discriminative behavior. The European journal of neuroscience. vol 22. issue 7. 2006-01-23. PMID:16197512. |
however, the pedunculopontine tegmental nucleus (pptg) in the brainstem is connected with limbic structures as well as dopaminergic midbrain areas, which also project to the nucleus accumbens. |
2006-01-23 |
2023-08-12 |
rat |
| J Jankovic, S Chen, W D L. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Progress in neurobiology. vol 77. issue 1-2. 2006-01-20. PMID:16243425. |
experimental studies in nurr1 knock-out mice indicate that nurr1 deficiency results in impaired dopaminergic function and increased vulnerability of those midbrain dopaminergic neurons that degenerate in pd. |
2006-01-20 |
2023-08-12 |
mouse |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
differential expression of the homeobox gene pitx3 in midbrain dopaminergic neurons. |
2006-01-10 |
2023-08-12 |
rat |
| Tatiana M Korotkova, Alexei A Ponomarenko, Helmut L Haas, Olga A Sergeev. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. The European journal of neuroscience. vol 22. issue 6. 2006-01-10. PMID:16190884. |
the transcription factor pitx3 is expressed selectively in the midbrain and regulates the differentiation and survival of dopaminergic neurons. |
2006-01-10 |
2023-08-12 |
rat |
| Simone M Smits, Daniel S Mathon, J Peter H Burbach, Geert M J Ramakers, Marten P Smid. Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system. Molecular and cellular neurosciences. vol 30. issue 3. 2006-01-05. PMID:16140547. |
molecular and cellular alterations in the pitx3-deficient midbrain dopaminergic system. |
2006-01-05 |
2023-08-12 |
mouse |
| Simone M Smits, Daniel S Mathon, J Peter H Burbach, Geert M J Ramakers, Marten P Smid. Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system. Molecular and cellular neurosciences. vol 30. issue 3. 2006-01-05. PMID:16140547. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by loss of midbrain dopaminergic (mda) neurons in the substantia nigra compacta (snc). |
2006-01-05 |
2023-08-12 |
mouse |
| Hannah Taylor, Stephen L Minge. Regenerative medicine in Parkinson's disease: generation of mesencephalic dopaminergic cells from embryonic stem cells. Current opinion in biotechnology. vol 16. issue 5. 2005-12-16. PMID:16143504. |
parkinson's disease is a progressive neurodegenerative disorder caused by the loss of midbrain dopaminergic neurons. |
2005-12-16 |
2023-08-12 |
human |
| Vincent Seuti. Dopaminergic neurones: much more than dopamine? British journal of pharmacology. vol 146. issue 2. 2005-12-09. PMID:16025140. |
midbrain dopaminergic (da) neurones sustain important physiological functions such as control of motricity, signalling of the error in prediction of rewards and modulation of emotions and cognition. |
2005-12-09 |
2023-08-12 |
Not clear |
| Suzanne Numan, Christine M Gall, Kim B Seroog. Developmental expression of neurotrophins and their receptors in postnatal rat ventral midbrain. Journal of molecular neuroscience : MN. vol 27. issue 2. 2005-12-06. PMID:16186635. |
two members of the neurotrophin family, brain-derived neurotrophic factor (bdnf) and neurotrophin-3 (nt-3), have been shown to increase the survival of dopaminergic neurons from the ventral midbrain in vitro. |
2005-12-06 |
2023-08-12 |
rat |