| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roy V Sillitoe, Michael W Voge. Desire, disease, and the origins of the dopaminergic system. Schizophrenia bulletin. vol 34. issue 2. 2008-06-27. PMID:18283047. |
the dopaminergic neurons in the midbrain region of the central nervous system project an extensive network of connections throughout the forebrain, including the neocortex. |
2008-06-27 |
2023-08-12 |
Not clear |
| Roy V Sillitoe, Michael W Voge. Desire, disease, and the origins of the dopaminergic system. Schizophrenia bulletin. vol 34. issue 2. 2008-06-27. PMID:18283047. |
based on the importance of the midbrain dopaminergic neurons to normal and pathological brain function, there is considerable interest in the molecular mechanisms that regulate their development. |
2008-06-27 |
2023-08-12 |
Not clear |
| Roy V Sillitoe, Michael W Voge. Desire, disease, and the origins of the dopaminergic system. Schizophrenia bulletin. vol 34. issue 2. 2008-06-27. PMID:18283047. |
midbrain dopaminergic neurons are descended from progenitor cells located near the ventral midline of the neural tube floor plate around the cephalic flexure. |
2008-06-27 |
2023-08-12 |
Not clear |
| Trine R Larsen, Ann-Sofi Söderling, Kenneth Caidahl, Peter Roepstorff, Jan Bert Gramsberge. Nitration of soluble proteins in organotypic culture models of Parkinson's disease. Neurochemistry international. vol 52. issue 3. 2008-06-20. PMID:17900761. |
here we quantified protein-bound 3-nitrotyrosine (3-nt) by a novel gas chromatography/negative chemical ionization tandem mass spectrometry technique and da and 3,4-dihydroxyphenylalanine (dopa) by hplc in tissues or medium of organotypic, mouse mesencephalon cultures after acute or chronic treatments with the peroxynitrite donor 3-morpholino-sydnonimine (sin-1), the dopaminergic toxin 1-methyl-4-phenylpyridinium (mpp(+)) or the lipophilic complex i inhibitor rotenone. |
2008-06-20 |
2023-08-12 |
mouse |
| Xiqun Chen, Lu Xu, Pheona Radcliffe, Baoyong Sun, A William Tan. Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. Molecular pharmacology. vol 73. issue 6. 2008-06-10. PMID:18349104. |
activation of tyrosine hydroxylase mrna translation by camp in midbrain dopaminergic neurons. |
2008-06-10 |
2023-08-12 |
Not clear |
| Jun Takahash. [Neuromodulation for Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 48. issue 4. 2008-06-10. PMID:18453154. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by a progressive loss of midbrain dopaminergic (da) neurons and a subsequent reduction in striatal dopamine. |
2008-06-10 |
2023-08-12 |
human |
| Heather Walsh, Anitha P Govind, Ryan Mastro, J C Hoda, Daniel Bertrand, Yolanda Vallejo, William N Gree. Up-regulation of nicotinic receptors by nicotine varies with receptor subtype. The Journal of biological chemistry. vol 283. issue 10. 2008-05-30. PMID:18174175. |
recent evidence suggests that in addition to alpha4beta2 and alpha3-containing nicotinic receptors, alpha6-containing receptors are present in midbrain dopaminergic neurons and involved in the nicotine reward pathway. |
2008-05-30 |
2023-08-12 |
Not clear |
| Taku Nagai, Kazuhiro Takuma, Toshitaka Nabeshima, Kiyofumi Yamad. [Regulation by tissue plasminogen activator of rewarding effects of drugs of abuse]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 28. issue 1. 2008-05-30. PMID:18411702. |
drugs of abuse acutely modulate the activity of mesolimbic dopaminergic neurons, projecting from the ventral tegmental area of the midbrain to the nucleus accumbens (nac). |
2008-05-30 |
2023-08-12 |
mouse |
| Florian Nagel, Björn H Falkenburger, Lars Tönges, Sebastian Kowsky, Charlotte Pöppelmeyer, Jörg B Schulz, Mathias Bähr, Gunnar P H Diet. Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease. Journal of neurochemistry. vol 105. issue 3. 2008-05-22. PMID:18182047. |
tat-hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of parkinson's disease. |
2008-05-22 |
2023-08-12 |
Not clear |
| Jan Gründemann, Falk Schlaudraff, Olga Haeckel, Birgit Lis. Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic acids research. vol 36. issue 7. 2008-05-19. PMID:18332041. |
in sporadic, idiopathic pd, abnormal accumulation and deposition of alpha-synuclein might also cause degeneration of dopaminergic midbrain neurons, the clinically most relevant neuronal population in pd. |
2008-05-19 |
2023-08-12 |
human |
| Laurent Roybon, Tord Hjalt, Nicolaj S Christophersen, Jia-Yi Li, Patrik Brundi. Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 14. 2008-05-19. PMID:18385323. |
to achieve controlled differentiation of neural stem cells, we expressed transcription factors involved in the development of midbrain dopaminergic neurons in rat and human neural progenitors. |
2008-05-19 |
2023-08-12 |
human |
| Guido K W Frank, Tyson A Oberndorfer, Alan N Simmons, Martin P Paulus, Julie L Fudge, Tony T Yang, Walter H Kay. Sucrose activates human taste pathways differently from artificial sweetener. NeuroImage. vol 39. issue 4. 2008-05-12. PMID:18096409. |
the results indicate that (1) both sucrose and sucralose activate functionally connected primary taste pathways; (2) taste pleasantness predicts left insula response; (3) sucrose elicits a stronger brain response in the anterior insula, frontal operculum, striatum and anterior cingulate, compared to sucralose; (4) only sucrose, but not sucralose, stimulation engages dopaminergic midbrain areas in relation to the behavioral pleasantness response. |
2008-05-12 |
2023-08-12 |
human |
| Erik B Bloss, Richard G Hunter, Elizabeth M Waters, Carmen Munoz, Katie Bernard, Bruce S McEwe. Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging. Experimental neurology. vol 210. issue 1. 2008-05-02. PMID:18035355. |
in addition, chronic s18986 treatment retards the decline of forebrain cholinergic neurons by roughly 37% and midbrain dopaminergic neurons by as much as 43% during aging and attenuates the age-related increase in the expression of a microglial marker in the hippocampus. |
2008-05-02 |
2023-08-12 |
rat |
| Tatsuhide Tanaka, Kentaro Oh-Hashi, Hironobu Shitara, Yoko Hirata, Kazutoshi Kiuch. NF-kappaB independent signaling pathway is responsible for LPS-induced GDNF gene expression in primary rat glial cultures. Neuroscience letters. vol 431. issue 3. 2008-05-02. PMID:18164817. |
glial cell line-derived neurotrophic factor (gdnf), a distant member of the transforming growth factor-beta superfamily, was originally purified and cloned as a potent survival factor for midbrain dopaminergic neurons. |
2008-05-02 |
2023-08-12 |
rat |
| Fiona E O'Keeffe, Sarah A Scott, Pam Tyers, Gerard W O'Keeffe, Jeffrey W Dalley, Romain Zufferey, Maeve A Caldwel. Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease. Brain : a journal of neurology. vol 131. issue Pt 3. 2008-05-01. PMID:18202103. |
in order to direct dopaminergic neuronal fate, we overexpressed pitx3 in nscs that were then exposed to e11 developing ventral mesencephalon (vm) in explant culture. |
2008-05-01 |
2023-08-12 |
rat |
| Joaquim Vives, Piriya Sasajala, Kuo Hsuan Chang, Suling Zhao, Meng L. A mouse model for tracking nigrostriatal dopamine neuron axon growth. Genesis (New York, N.Y. : 2000). vol 46. issue 3. 2008-05-01. PMID:18327786. |
the midbrain dopaminergic system, which consists of neurons of the substantia nigra and the ventral tegmental area, is a subject of intense interest, since the loss of neurons from the substantia nigra results in motor disorders characteristic of parkinson's disease. |
2008-05-01 |
2023-08-12 |
mouse |
| Joaquim Vives, Piriya Sasajala, Kuo Hsuan Chang, Suling Zhao, Meng L. A mouse model for tracking nigrostriatal dopamine neuron axon growth. Genesis (New York, N.Y. : 2000). vol 46. issue 3. 2008-05-01. PMID:18327786. |
this approach permitted the visualisation of midbrain specific dopaminergic axonal tracts from both the substantia nigra and the ventral tegmental area in phenotypically normal heterozygous pitx3-taulacz brain tissues, either in situ or following culture in vitro, by a simple and sensitive beta-galactosidase enzyme reaction. |
2008-05-01 |
2023-08-12 |
mouse |
| Joaquim Vives, Piriya Sasajala, Kuo Hsuan Chang, Suling Zhao, Meng L. A mouse model for tracking nigrostriatal dopamine neuron axon growth. Genesis (New York, N.Y. : 2000). vol 46. issue 3. 2008-05-01. PMID:18327786. |
thus the pitx3-taulacz mice could serve as a valuable tool for the identification of molecules regulating midbrain dopaminergic neuritogenesis, either in vivo in combination with genetic manipulation in mice, or in vitro using organ cultures. |
2008-05-01 |
2023-08-12 |
mouse |
| Alida Filippi, Katrin Dürr, Soojin Ryu, Marc Willaredt, Jochen Holzschuh, Wolfgang Drieve. Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development. BMC developmental biology. vol 7. 2008-04-25. PMID:18053265. |
dopaminergic neurons form in diverse areas of the vertebrate di- and mesencephalon to constitute several major neuromodulatory systems. |
2008-04-25 |
2023-08-12 |
zebrafish |
| Kaia Kala, Tomi Jukkola, Illar Pata, Juha Partane. Analysis of the midbrain-hindbrain boundary cell fate using a boundary cell-specific Cre-mouse strain. Genesis (New York, N.Y. : 2000). vol 46. issue 1. 2008-04-23. PMID:18196597. |
interestingly, dorsocaudally oriented fibers of the midbrain dopaminergic neurons follow the path marked by the boundary cells. |
2008-04-23 |
2023-08-12 |
mouse |