| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aparna Khanna, Anna Maria Swistowska, Mahendra S Rao, Xianmin Zen. Generation and transplantation of dopaminergic neurons derived from embryonic stem cells. Current stem cell research & therapy. vol 2. issue 2. 2008-02-14. PMID:18220899. |
because of the important roles of dopaminergic (da) neurons in modulating motor control, and in particular that the selective degeneration of da neurons in midbrain cause the neurodegenerative disorder parkinson's disease (pd), there has been significant interest in using hesc-derived da neurons as a source of cells for drug screening, discovery and transplant purposes. |
2008-02-14 |
2023-08-12 |
mouse |
| Fernanda Ledda, Oliver Bieraugel, Shahrzad Shirazi Fard, Marçal Vilar, Gustavo Paratch. Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 1. 2008-02-07. PMID:18171921. |
glial cell line-derived neurotrophic factor (gdnf)/ret signaling has potent trophic effects on ventral midbrain dopaminergic, motor, sensory, and sympathetic neurons. |
2008-02-07 |
2023-08-12 |
Not clear |
| Sarven Sabunciyan, Robert Yolken, Christina M Ragan, James B Potash, Vishwajit L Nimgaonkar, Faith Dickerson, Ida C Llenos, Serge Wei. Polymorphisms in the homeobox gene OTX2 may be a risk factor for bipolar disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 8. 2008-02-05. PMID:17541950. |
the disruption of this gene results in cortical malformations and causes serotonergic and dopaminergic cells in the midbrain to be expressed in aberrant locations. |
2008-02-05 |
2023-08-12 |
Not clear |
| Nadia Stefanova, Markus Reindl, Manuela Neumann, Philipp J Kahle, Werner Poewe, Gregor K Wennin. Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 15. 2008-01-31. PMID:17853477. |
the role of microglial activation in multiple system atrophy (msa) was investigated in a transgenic mouse model featuring oligodendroglial alpha-synuclein inclusions and loss of midbrain dopaminergic neurons by means of histopathology and morphometric analysis. |
2008-01-31 |
2023-08-12 |
mouse |
| Francesco Angelucci, Valerio Ricci, Massimiliano Pomponi, Gianluigi Conte, Aleksander A Mathé, Pietro Attilio Tonali, Pietro Bri. Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. Journal of psychopharmacology (Oxford, England). vol 21. issue 8. 2008-01-29. PMID:17715210. |
in particular, nerve growth factor (ngf) plays an important role in the survival and function of cholinergic neurons while brain-derived neurotrophic factor (bdnf) is involved in synaptic plasticity and in the maintenance of midbrain dopaminergic and cholinergic neurons. |
2008-01-29 |
2023-08-12 |
human |
| Justin D Boyd, Haeman Jang, Kennie R Shepherd, Ciaran Faherty, Sally Slack, Yun Jiao, Richard J Smeyn. Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta. Brain research. vol 1175. 2008-01-25. PMID:17884023. |
parkinson's disease (pd) is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. |
2008-01-25 |
2023-08-12 |
mouse |
| Nico Bunzeck, Hartmut Schütze, Sabine Stallforth, Jörn Kaufmann, Sandra Düzel, Hans-Jochen Heinze, Emrah Düze. Mesolimbic novelty processing in older adults. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 12. 2008-01-23. PMID:17383999. |
normal aging is associated with neuronal loss in the dopaminergic midbrain (substantia nigra/ventral tegmental area, sn/vta), a region that has recently been implicated in processing novel stimuli as part of a mesolimbic network including the hippocampus. |
2008-01-23 |
2023-08-12 |
Not clear |
| Zhongfang Weng, Armando P Signore, Yanqin Gao, Suping Wang, Feng Zhang, Teresa Hastings, Xiao-Ming Yin, Jun Che. Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. The Journal of biological chemistry. vol 282. issue 47. 2008-01-23. PMID:17895242. |
the death of midbrain dopaminergic neurons in sporadic parkinson disease is of unknown etiology but may involve altered growth factor signaling. |
2008-01-23 |
2023-08-12 |
mouse |
| Ling T Guo, Theodore Friedmann, Charles C Kin. Partial characterization of the proteome of the mouse striatum. Proteomics. vol 7. issue 21. 2008-01-22. PMID:17922512. |
many diseases of the mammalian cns, including parkinson's (pd) and lesch nyhan disease (lnd), are associated with programmatic neurodegeneration or dysfunction of dopaminergic neurons in the mesencephalon, the nigrostriatal pathway, and its projections in the striatum [1-4]. |
2008-01-22 |
2023-08-12 |
mouse |
| M D Neely, D E Schmidt, A Y Deutc. Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons. Neuroscience. vol 149. issue 2. 2008-01-16. PMID:17888581. |
the striatal dopamine innervation was lesioned by treatment of the cultures with the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium (mpp+) or by removing the mesencephalon. |
2008-01-16 |
2023-08-12 |
rat |
| Ryan M Drenan, Raad Nashmi, Princess Imoukhuede, Herwig Just, Sheri McKinney, Henry A Leste. Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits. Molecular pharmacology. vol 73. issue 1. 2008-01-16. PMID:17932221. |
nicotinic receptors containing alpha4, alpha6, beta2, and beta3 subunits are expressed in midbrain dopaminergic neurons, and they are implicated in the response to smoked nicotine. |
2008-01-16 |
2023-08-12 |
Not clear |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. |
2008-01-14 |
2023-08-12 |
mouse |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
parkinson's disease is a neurodegenerative disorder characterized by the preferential loss of midbrain dopaminergic neurons in the substantia nigra (sn). |
2008-01-14 |
2023-08-12 |
mouse |
| Shankar J Chinta, M J Kumar, Michael Hsu, Subramanian Rajagopalan, Deepinder Kaur, Anand Rane, David G Nicholls, Jinah Choi, Julie K Anderse. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 51. 2008-01-14. PMID:18094238. |
one of the earliest detectable biochemical alterations that occurs in the parkinsonian brain is a marked reduction in sn levels of total glutathione (glutathione plus glutathione disulfide), occurring before losses in mitochondrial complex i (ci) activity, striatal dopamine levels, or midbrain dopaminergic neurodegeneration associated with the disease. |
2008-01-14 |
2023-08-12 |
mouse |
| Sebastian Kowsky, Charlotte Pöppelmeyer, Edgar R Kramer, Björn H Falkenburger, Anja Kruse, Rüdiger Klein, Jörg B Schul. RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 50. 2008-01-11. PMID:18056810. |
activation of the ret (rearranged during transfection) receptor by glial cell-line-derived neurotrophic factor (gdnf) has been identified as an important differentiation and survival factor for dopaminergic neurons of the midbrain in preclinical experiments. |
2008-01-11 |
2023-08-12 |
mouse |
| Mauro Federici, Luca Sebastianelli, Silvia Natoli, Giorgio Bernardi, Nicola B Mercur. Electrophysiologic changes in ventral midbrain dopaminergic neurons resulting from (+/-) -3,4-methylenedioxymethamphetamine (MDMA-"Ecstasy"). Biological psychiatry. vol 62. issue 6. 2008-01-02. PMID:17511969. |
electrophysiologic changes in ventral midbrain dopaminergic neurons resulting from (+/-) -3,4-methylenedioxymethamphetamine (mdma-"ecstasy"). |
2008-01-02 |
2023-08-12 |
Not clear |
| Mauro Federici, Luca Sebastianelli, Silvia Natoli, Giorgio Bernardi, Nicola B Mercur. Electrophysiologic changes in ventral midbrain dopaminergic neurons resulting from (+/-) -3,4-methylenedioxymethamphetamine (MDMA-"Ecstasy"). Biological psychiatry. vol 62. issue 6. 2008-01-02. PMID:17511969. |
although dopamine (da) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (mdma), there is no detailed information on its modalities of action on single ventral midbrain dopaminergic neurons. |
2008-01-02 |
2023-08-12 |
Not clear |
| Jianyong Wang, Zengjun Xu, Hong Fang, Helen M Duhart, Tucker A Patterson, Syed F Al. Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study. Neurotoxicology. vol 28. issue 5. 2007-12-26. PMID:17475336. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. |
2007-12-26 |
2023-08-12 |
mouse |
| Birgit Völlm, Paul Richardson, Shane McKie, Rebecca Elliott, Mairead Dolan, Bill Deaki. Neuronal correlates of reward and loss in Cluster B personality disorders: a functional magnetic resonance imaging study. Psychiatry research. vol 156. issue 2. 2007-12-21. PMID:17920821. |
areas implicated in reward include ventral striatum, dopaminergic midbrain, amygdala and orbitofrontal cortex. |
2007-12-21 |
2023-08-12 |
human |
| Tom Schönberg, Nathaniel D Daw, Daphna Joel, John P O'Dohert. Reinforcement learning signals in the human striatum distinguish learners from nonlearners during reward-based decision making. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 47. 2007-12-18. PMID:18032658. |
these findings support a crucial role of prediction error signals, likely originating from dopaminergic midbrain neurons, in enabling learning of action selection preferences on the basis of obtained rewards. |
2007-12-18 |
2023-08-12 |
human |