| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sven Bocklandt, Eric Vilai. Sex differences in brain and behavior: hormones versus genes. Advances in genetics. vol 59. 2007-10-15. PMID:17888801. |
we will argue that genetic factors play a role in sexually dimorphic traits such as the number of dopaminergic cells in the mesencephalon, aggression, and sexual orientation, independently from gonadal hormones. |
2007-10-15 |
2023-08-12 |
Not clear |
| Nilima Prakash, Wolfgang Wurs. A Wnt signal regulates stem cell fate and differentiation in vivo. Neuro-degenerative diseases. vol 4. issue 4. 2007-10-12. PMID:17627138. |
our knowledge about the normal generation of midbrain dopaminergic neurons in vivois still rudimentary, despite many attempts to recapitulate the underlying events in vitro. |
2007-10-12 |
2023-08-12 |
human |
| Nilima Prakash, Wolfgang Wurs. A Wnt signal regulates stem cell fate and differentiation in vivo. Neuro-degenerative diseases. vol 4. issue 4. 2007-10-12. PMID:17627138. |
recently, substantial advances have been made by demonstrating that the secreted molecule wnt1 regulates a genetic network, including the transcription factors otx2 and nkx2-2, for the initial establishment of the dopaminergic progenitor domain in the mammalian ventral midbrain. |
2007-10-12 |
2023-08-12 |
human |
| Nilima Prakash, Wolfgang Wurs. A Wnt signal regulates stem cell fate and differentiation in vivo. Neuro-degenerative diseases. vol 4. issue 4. 2007-10-12. PMID:17627138. |
a genetic cascade controlled by the secreted molecule sonic hedgehog, including the transcription factors lmx1a, msx1 and nkx6-1, acts in parallel with the wnt1-regulated network to establish the midbrain dopaminergic progenitor domain. |
2007-10-12 |
2023-08-12 |
human |
| Nilima Prakash, Wolfgang Wurs. A Wnt signal regulates stem cell fate and differentiation in vivo. Neuro-degenerative diseases. vol 4. issue 4. 2007-10-12. PMID:17627138. |
the sonic-hedgehog-controlled cascade may diverge from the wnt1-regulated network at later stages of neural development through induction of proneural transcription factors required for the acquisition of generic neuronal properties by the midbrain dopaminergic progeny. |
2007-10-12 |
2023-08-12 |
human |
| Edgar R Kramer, Liviu Aron, Geert M J Ramakers, Sabine Seitz, Xiaoxi Zhuang, Klaus Beyer, Marten P Smidt, Rüdiger Klei. Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS biology. vol 5. issue 3. 2007-10-11. PMID:17298183. |
gdnf has been tested in clinical trials for the treatment of parkinson disease (pd), a common neurodegenerative disorder characterized by the loss of midbrain dopaminergic (da) neurons. |
2007-10-11 |
2023-08-12 |
mouse |
| Joaquín Martí, M C Santa-Cruz, Shirley A Bayer, Bernardino Ghetti, José P Hervá. Generation and survival of midbrain dopaminergic neurons in weaver mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 25. issue 5. 2007-10-03. PMID:17582722. |
generation and survival of midbrain dopaminergic neurons in weaver mice. |
2007-10-03 |
2023-08-12 |
mouse |
| Joaquín Martí, M C Santa-Cruz, Shirley A Bayer, Bernardino Ghetti, José P Hervá. Generation and survival of midbrain dopaminergic neurons in weaver mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 25. issue 5. 2007-10-03. PMID:17582722. |
generation and survival of midbrain dopaminergic (da) neurons were investigated using tyrosine hydroxylase (th) immunocytochemistry combined with tritiated thymidine autoradiography at appropriate anatomical levels throughout the anteroposterior (a/p) axes of the substantia nigra pars compacta (snc) and the ventral tegmental area (vta). |
2007-10-03 |
2023-08-12 |
mouse |
| Anna L M Ferri, Wei Lin, Yannis E Mavromatakis, Julie C Wang, Hiroshi Sasaki, Jeffrey A Whitsett, Siew-Lan An. Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development (Cambridge, England). vol 134. issue 15. 2007-09-28. PMID:17596284. |
the role of transcription factors in regulating the development of midbrain dopaminergic (mda) neurons is intensively studied owing to the involvement of these neurons in diverse neurological disorders. |
2007-09-28 |
2023-08-12 |
mouse |
| Anna L M Ferri, Wei Lin, Yannis E Mavromatakis, Julie C Wang, Hiroshi Sasaki, Jeffrey A Whitsett, Siew-Lan An. Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development (Cambridge, England). vol 134. issue 15. 2007-09-28. PMID:17596284. |
subsequently, foxa1 and foxa2 regulate the expression of nurr1 (nr4a2) and engrailed 1 in immature neurons and the expression of aromatic l-amino acid decarboxylase and tyrosine hydroxylase in mature neurons during early and late differentiation of midbrain dopaminergic neurons. |
2007-09-28 |
2023-08-12 |
mouse |
| Clare L Parish, Anna Beljajeva, Ernest Arenas, András Simo. Midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model. Development (Cambridge, England). vol 134. issue 15. 2007-09-28. PMID:17611231. |
midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model. |
2007-09-28 |
2023-08-12 |
Not clear |
| Clare L Parish, Anna Beljajeva, Ernest Arenas, András Simo. Midbrain dopaminergic neurogenesis and behavioural recovery in a salamander lesion-induced regeneration model. Development (Cambridge, England). vol 134. issue 15. 2007-09-28. PMID:17611231. |
death and lack of functional regeneration of midbrain dopaminergic (da) neurons, decreased da input in the target striatum and movement anomalies characterise parkinson's disease (pd). |
2007-09-28 |
2023-08-12 |
Not clear |
| E Dowd, S B Dunnet. Movement without dopamine: striatal dopamine is required to maintain but not to perform learned actions. Biochemical Society transactions. vol 35. issue Pt 2. 2007-09-27. PMID:17371292. |
the different populations of dopaminergic neurons located in the ventral mesencephalon have long been associated with distinct functional roles. |
2007-09-27 |
2023-08-12 |
rat |
| P Rojas, E Joodmardi, Y Hong, T Perlmann, S O Ogre. Adult mice with reduced Nurr1 expression: an animal model for schizophrenia. Molecular psychiatry. vol 12. issue 8. 2007-09-25. PMID:17457314. |
the transcription factor nurr1 (nr4a2) has been found to play a critical role in the development of midbrain dopaminergic neurons. |
2007-09-25 |
2023-08-12 |
mouse |
| Stephen Bennett, Benjamin Gronie. Effects of antipsychotic treatments and D-serine supplementation on the electrophysiological activation of midbrain dopamine neurons induced by the noncompetitive NMDA antagonist MK 801. Synapse (New York, N.Y.). vol 61. issue 8. 2007-09-12. PMID:17523181. |
these results suggest that a chronic antipsychotic regime alters the function of the nmda receptors that tonically control the firing activity of midbrain dopaminergic neurons. |
2007-09-12 |
2023-08-12 |
human |
| Jongpil Kim, Keiichi Inoue, Jennifer Ishii, William B Vanti, Sergey V Voronov, Elizabeth Murchison, Gregory Hannon, Asa Abeliovic. A MicroRNA feedback circuit in midbrain dopamine neurons. Science (New York, N.Y.). vol 317. issue 5842. 2007-09-11. PMID:17761882. |
we investigated the role of mirnas in mammalian midbrain dopaminergic neurons (dns). |
2007-09-11 |
2023-08-12 |
Not clear |
| Christopher D Herzog, Biplob Dass, James E Holden, James Stansell, Mehdi Gasmi, Mark H Tuszynski, Raymond T Bartus, Jeffrey H Kordowe. Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys. Movement disorders : official journal of the Movement Disorder Society. vol 22. issue 8. 2007-09-07. PMID:17443702. |
neurturin (ntn) is a potent survival factor for midbrain dopaminergic neurons. |
2007-09-07 |
2023-08-12 |
human |
| Floriana Volpicelli, Massimiliano Caiazzo, Dario Greco, Claudia Consales, Luigi Leone, Carla Perrone-Capano, Luca Colucci D'Amato, Umberto di Porzi. Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17506860. |
the transcription factor nurr1 is essential for the generation of midbrain dopaminergic neurons (mda). |
2007-09-07 |
2023-08-12 |
rat |
| Floriana Volpicelli, Massimiliano Caiazzo, Dario Greco, Claudia Consales, Luigi Leone, Carla Perrone-Capano, Luca Colucci D'Amato, Umberto di Porzi. Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17506860. |
to identify novel nurr1 target genes we have used genome-wide expression profiling in rat midbrain primary cultures, enriched in dopaminergic neurons, following up-regulation of nurr1 expression by depolarization. |
2007-09-07 |
2023-08-12 |
rat |
| Floriana Volpicelli, Massimiliano Caiazzo, Dario Greco, Claudia Consales, Luigi Leone, Carla Perrone-Capano, Luca Colucci D'Amato, Umberto di Porzi. Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17506860. |
taken together, our findings suggest that nurr1 might also influence the development and the function of midbrain dopaminergic neurons via direct regulation of bdnf expression. |
2007-09-07 |
2023-08-12 |
rat |