| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vincent Coulon, Aurore L'Honoré, Jean-François Ouimette, Emilie Dumontier, Pepijn van den Munckhof, Jacques Droui. A muscle-specific promoter directs Pitx3 gene expression in skeletal muscle cells. The Journal of biological chemistry. vol 282. issue 45. 2007-12-12. PMID:17848564. |
the pitx homeobox transcription factor genes have been implicated in different developmental processes, including determination of hind limb identity for pitx1, left-right asymmetry for pitx2, and eye development and survival of midbrain dopaminergic neurons for pitx3. |
2007-12-12 |
2023-08-12 |
mouse |
| Gilberto Fisone, Kerstin Håkansson, Anders Borgkvist, Emanuela Santin. Signaling in the basal ganglia: postsynaptic and presynaptic mechanisms. Physiology & behavior. vol 92. issue 1-2. 2007-12-06. PMID:17585965. |
these cells are innervated by excitatory glutamatergic fibers from cortex and thalamus, and modulatory dopaminergic fibers from the midbrain. |
2007-12-06 |
2023-08-12 |
Not clear |
| Hirochika Kitagawa, William J Ray, Helmut Glantschnig, Pascale V Nantermet, Yuanjiang Yu, Chih-Tai Leu, Shun-ichi Harada, Shigeaki Kato, Leonard P Freedma. A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling. Molecular and cellular biology. vol 27. issue 21. 2007-11-28. PMID:17709391. |
the orphan nuclear receptor nurr1 is essential for the development and maintenance of midbrain dopaminergic neurons, the cells that degenerate during parkinson's disease, by promoting the transcription of genes involved in dopaminergic neurotransmission. |
2007-11-28 |
2023-08-12 |
Not clear |
| Amaury Graulich, Sébastien Dilly, Amaury Farce, Jacqueline Scuvée-Moreau, Olivier Waroux, Cédric Lamy, Philippe Chavatte, Vincent Seutin, Jean-François Liégeoi. Synthesis and radioligand binding studies of bis-isoquinolinium derivatives as small conductance Ca(2+)-activated K(+) channel blockers. Journal of medicinal chemistry. vol 50. issue 21. 2007-11-27. PMID:17867663. |
finally, the most effective compounds have been tested in electrophysiological experiments on midbrain dopaminergic neurons and demonstrate the blocking potential of the apamin-sensitive after-hyperpolarization. |
2007-11-27 |
2023-08-12 |
Not clear |
| Bianca C Wittmann, Nico Bunzeck, Raymond J Dolan, Emrah Düze. Anticipation of novelty recruits reward system and hippocampus while promoting recollection. NeuroImage. vol 38. issue 1. 2007-11-26. PMID:17764976. |
the dopaminergic midbrain, which comprises the substantia nigra and ventral tegmental area (sn/vta), plays a central role in reward processing. |
2007-11-26 |
2023-08-12 |
human |
| Silvia A Mandel, Yotam Sagi, Tamar Ami. Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway. Neurochemical research. vol 32. issue 10. 2007-11-20. PMID:17701352. |
more recently, employing conventional neurochemical techniques, as well as transcriptomic and proteomic screening tools, combined with a biology-based clustering method, it was shown that rasagiline also possesses neurorescue/neurogenesis activity in mice midbrain dopaminergic neurons when given chronically, post-mptp (n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). |
2007-11-20 |
2023-08-12 |
mouse |
| Thomas E Hazy, Michael J Frank, Randall C O'reill. Towards an executive without a homunculus: computational models of the prefrontal cortex/basal ganglia system. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 362. issue 1485. 2007-11-13. PMID:17428778. |
this learning is based on reinforcement learning mechanisms associated with the midbrain dopaminergic system and its activation via the bg and amygdala. |
2007-11-13 |
2023-08-12 |
Not clear |
| Florian Kempf, Christof Brücke, Andrea A Kühn, Gerd-Helge Schneider, Andreas Kupsch, Chiung Chu Chen, Alexandros G Androulidakis, Shouyan Wang, Wim Vandenberghe, Bart Nuttin, Tipu Aziz, Peter Brow. Modulation by dopamine of human basal ganglia involvement in feedback control of movement. Current biology : CB. vol 17. issue 15. 2007-11-09. PMID:17686426. |
the results suggest that the midbrain dopaminergic system may be important, not only in signaling explicit positive outcomes or rewards in tasks requiring choices between options [2,3], but also in trial-to-trial learning and in reinforcing the selection of optimal parameters in more automatic motor control. |
2007-11-09 |
2023-08-12 |
human |
| Yong Ren, Jian Fen. Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism. Journal of neurochemistry. vol 103. issue 1. 2007-11-07. PMID:17587308. |
our recent study has shown that midbrain dopaminergic neurons are particularly vulnerable to microtubule-depolymerizing agents including rotenone, an environmental toxin linked to pd. |
2007-11-07 |
2023-08-12 |
Not clear |
| Yuichi Ono, Tomoya Nakatani, Yoshimasa Sakamoto, Eri Mizuhara, Yasuko Minaki, Minoru Kumai, Akiko Hamaguchi, Miyuki Nishimura, Yoko Inoue, Hideki Hayashi, Jun Takahashi, Toshio Ima. Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development (Cambridge, England). vol 134. issue 17. 2007-11-07. PMID:17670789. |
differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. |
2007-11-07 |
2023-08-12 |
mouse |
| Thong C Ma, Michael J Mihm, John Anthony Bauer, Kari R Hoy. Bioenergetic and oxidative effects of free 3-nitrotyrosine in culture: selective vulnerability of dopaminergic neurons and increased sensitivity of non-dopaminergic neurons to dopamine oxidation. Journal of neurochemistry. vol 103. issue 1. 2007-11-07. PMID:17877636. |
in primary ventral midbrain cultures, free 3nt damaged dopaminergic neurons, while adjacent non-dopaminergic neurons were unaffected. |
2007-11-07 |
2023-08-12 |
mouse |
| Christina H L Teh, Chin Chieh Loh, Kevin K Y Lam, Jia Min Loo, Tie Yan, Tit Meng Li. Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17457889. |
dopamine is the main neurotransmitter present in dopaminergic neurons of the ventral midbrain, where dysfunction of these neurons can lead to parkinson's disease and schizophrenia. |
2007-11-05 |
2023-08-12 |
mouse |
| Christina H L Teh, Chin Chieh Loh, Kevin K Y Lam, Jia Min Loo, Tie Yan, Tit Meng Li. Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17457889. |
these results suggest that npas1 plays a novel and important role in regulating th level of dopaminergic neurons in the ventral midbrain during development. |
2007-11-05 |
2023-08-12 |
mouse |
| Björn H Schott, Ludwig Niehaus, Bianca C Wittmann, Hartmut Schütze, Constanze I Seidenbecher, Hans-Jochen Heinze, Emrah Düze. Ageing and early-stage Parkinson's disease affect separable neural mechanisms of mesolimbic reward processing. Brain : a journal of neurology. vol 130. issue Pt 9. 2007-11-01. PMID:17626038. |
the ability to learn stimulus-reward associations on the basis of reward prediction errors critically depends on the mesolimbic dopaminergic system including the dopaminergic midbrain and the ventral striatum. |
2007-11-01 |
2023-08-12 |
human |
| Dirk Eulitz, Harald Prüss, Christian Derst, Rüdiger W Ve. Heterogeneous distribution of kir3 potassium channel proteins within dopaminergic neurons in the mesencephalon of the rat brain. Cellular and molecular neurobiology. vol 27. issue 3. 2007-10-30. PMID:17235695. |
heterogeneous distribution of kir3 potassium channel proteins within dopaminergic neurons in the mesencephalon of the rat brain. |
2007-10-30 |
2023-08-12 |
rat |
| Dirk Eulitz, Harald Prüss, Christian Derst, Rüdiger W Ve. Heterogeneous distribution of kir3 potassium channel proteins within dopaminergic neurons in the mesencephalon of the rat brain. Cellular and molecular neurobiology. vol 27. issue 3. 2007-10-30. PMID:17235695. |
dopaminergic neurons in the substantia nigra pars compacta (snc) and the ventral tegmental area (vta) of the ventral mesencephalon play an important role in the regulation of the parallel basal ganglia loops.2. |
2007-10-30 |
2023-08-12 |
rat |
| Dirk Eulitz, Harald Prüss, Christian Derst, Rüdiger W Ve. Heterogeneous distribution of kir3 potassium channel proteins within dopaminergic neurons in the mesencephalon of the rat brain. Cellular and molecular neurobiology. vol 27. issue 3. 2007-10-30. PMID:17235695. |
we have raised affinity-purified polyclonal rabbit antibodies specific for all four members of the kir3 family of inwardly rectifying potassium channels (kir3.1-kir3.4) to investigate the distribution of the channel proteins in the dopaminergic neurons of the rat mesencephalon at light and electron microscopic level. |
2007-10-30 |
2023-08-12 |
rat |
| Hideko Yamamoto, Etsuko Kamegaya, Yoko Hagino, Kazuhide Imai, Akihiro Fujikawa, Kohei Tamura, Tomoyuki Enokiya, Toshifumi Yamamoto, Takao Takeshima, Hisashi Koga, George R Uhl, Kazutaka Ikeda, Ichiro Sor. Genetic deletion of vesicular monoamine transporter-2 (VMAT2) reduces dopamine transporter activity in mesencephalic neurons in primary culture. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17664021. |
we examined mesencephalon dopaminergic cultures prepared from vmat2 wild-type, heterozygous or homozygous knockout (ko) 14-day-old mouse fetuses to determine the number of tyrosine hydroxylase (th)-positive cells and dopamine transporter activity. |
2007-10-25 |
2023-08-12 |
mouse |
| Haruhisa Inoue, Ling Lin, Xinhua Lee, Zhaohui Shao, Shannon Mendes, Pamela Snodgrass-Belt, Harry Sweigard, Tom Engber, Blake Pepinsky, Lichuan Yang, M Flint Beal, Sha Mi, Ole Isacso. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 36. 2007-10-24. PMID:17726113. |
lingo-1 expression is present in midbrain dopaminergic (da) neurons in the human and rodent brain. |
2007-10-24 |
2023-08-12 |
mouse |
| O von Bohlen Und Halbach, L Minichiell. Neurotrophin receptor heterozygosity causes deficits in catecholaminergic innervation of amygdala and hippocampus in aged mice. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 12. 2007-10-17. PMID:16736233. |
consistent with this observation and the expression of trkb and trkc by midbrain dopaminergic neurons, we show now that heterozygous deletion of the trkb or/and trkc receptor genes significantly reduces catecholaminergic, tyrosine hydroxylase (th-) positive fiber densities in the hippocampus and amygdala mainly in aged (21-23 month old) mice. |
2007-10-17 |
2023-08-12 |
mouse |