| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Swanson, J Liu, J W Miller, J D Rothstein, K Farrell, B A Stein, M C Longuemar. Neuronal regulation of glutamate transporter subtype expression in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 3. 1997-03-17. PMID:8994048. |
these studies show that astrocyte expression of glutamate transporter subtypes is influenced by neurons, and that dbcamp can partially mimic this influence. |
1997-03-17 |
2023-08-12 |
rat |
| B Chisamore, M Solc, K Do. Excitatory amino acid regulation of astrocyte proteoglycans. Brain research. Developmental brain research. vol 97. issue 1. 1997-02-27. PMID:8946051. |
glutamate exposure did not regulate the release of a specific family of pg, but glutamate inhibited the synthesis of heparan sulfate (hs) pgs that appeared within the extracellular environment of the astrocyte. |
1997-02-27 |
2023-08-12 |
Not clear |
| G Chen, P Q Trombley, A N van den Po. GABA receptors precede glutamate receptors in hypothalamic development; differential regulation by astrocytes. Journal of neurophysiology. vol 74. issue 4. 1997-02-04. PMID:8989386. |
both the amplitude of the responses to glutamate and the percentage of cells responding to glutamate were increased by growing neurons either on an astrocyte substrate or in high-density cultures. |
1997-02-04 |
2023-08-12 |
rat |
| G Chen, P Q Trombley, A N van den Po. GABA receptors precede glutamate receptors in hypothalamic development; differential regulation by astrocytes. Journal of neurophysiology. vol 74. issue 4. 1997-02-04. PMID:8989386. |
after 3 days in vitro, gaba (30 microm) elicited a mean current of 1,648 pa, whereas glutamate (500 microm) only elicited a 266-pa current, and glycine (500 microm) elicited a 278-pa current from neurons growing on an astrocyte layer. |
1997-02-04 |
2023-08-12 |
rat |
| G Chen, P Q Trombley, A N van den Po. GABA receptors precede glutamate receptors in hypothalamic development; differential regulation by astrocytes. Journal of neurophysiology. vol 74. issue 4. 1997-02-04. PMID:8989386. |
however, glutamate and glycine receptors appear more sensitive to regulation by the local environment than gaba receptors because culture density and the astrocyte substrate have greater inductive effects on glutamate and glycine receptors than on gaba receptors. |
1997-02-04 |
2023-08-12 |
rat |
| J J Jensen, U H Winzer-Serhan, F M Lesli. Glial regulation of alpha 7-type nicotinic acetylcholine receptor expression in cultured rat cortical neurons. Journal of neurochemistry. vol 68. issue 1. 1997-01-27. PMID:8978716. |
an additional mechanism of glial regulation may involve removal of glutamate from the surrounding medium, as added glutamate (200 microm) increased 125i-alpha-bungarotoxin binding in astrocyte-poor cultures but not in those that were astrocyte enriched. |
1997-01-27 |
2023-08-12 |
rat |
| H Akaoka, H Hardin-Pouzet, A Bernard, B Verrier, M F Belin, P Giraudo. Imbalanced expression of glutamate-glutamine cycle enzymes induced by human T-cell lymphotropic virus type 1 Tax protein in cultivated astrocytes. Journal of virology. vol 70. issue 12. 1997-01-23. PMID:8971000. |
in both human astrocyte precursors and rat glial cells, the levels of expression of glutamine synthetase (gs) and glutamate dehydrogenase (gdh) were increased and decreased, respectively, after coculture with htlv-1 t cells. |
1997-01-23 |
2023-08-12 |
human |
| M C Longuemare, E C Keung, S Chun, F R Sharp, P H Chan, R A Swanso. MK-801 reduces uptake and stimulates efflux of excitatory amino acids via membrane depolarization. The American journal of physiology. vol 270. issue 5 Pt 1. 1996-12-06. PMID:8967440. |
in the present study, high concentrations of mk-801 (100-1,000 microm) caused uncompetitive inhibition of glutamate uptake in astrocyte and neuronal cultures and stimulated d-aspartate efflux from astrocytes. |
1996-12-06 |
2023-08-12 |
Not clear |
| S Miller, N Sehati, C Romano, C W Cotma. Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5. Journal of neurochemistry. vol 67. issue 4. 1996-12-02. PMID:8858925. |
in astrocyte cultures that have been morphologically differentiated by exposure to transforming growth factor-alpha, addition of thrombin induced a retraction of astrocytic processes and suppressed the stimulation of phosphoinositide hydrolysis by the selective metabotropic glutamate receptor (mglur) agonist 1-aminocyclopentane-1s,3r-dicarboxylic acid. |
1996-12-02 |
2023-08-12 |
Not clear |
| E B Dreyer, S A Lipto. The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. The European journal of neuroscience. vol 7. issue 12. 1996-10-22. PMID:8845955. |
here we show that gp120 impairs astrocyte uptake of excitatory amino acids and the excess glutamate thus engendered may contribute to the increased neuronal damage. |
1996-10-22 |
2023-08-12 |
human |
| M E Harris, Y Wang, N W Pedigo, K Hensley, D A Butterfield, J M Carne. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8667003. |
amyloid beta peptide (25-35) inhibits na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. |
1996-08-06 |
2023-08-12 |
rat |
| M E Harris, Y Wang, N W Pedigo, K Hensley, D A Butterfield, J M Carne. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8667003. |
one mechanism that may explain this finding is inhibition of the astrocyte glutamate transporter by abeta. |
1996-08-06 |
2023-08-12 |
rat |
| M E Harris, Y Wang, N W Pedigo, K Hensley, D A Butterfield, J M Carne. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8667003. |
the aim of the current study was to determine if abetas inhibit astrocyte glutamate uptake and if this inhibition involves free radical damage to the transporter/astrocytes. |
1996-08-06 |
2023-08-12 |
rat |
| M E Harris, Y Wang, N W Pedigo, K Hensley, D A Butterfield, J M Carne. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8667003. |
we have previously reported that abeta can generate free radicals, and this radical production was correlated with the oxidation of neurons in culture and inhibition of astrocyte glutamate uptake. |
1996-08-06 |
2023-08-12 |
rat |
| J C David, K A Yamada, M R Bagwe, M P Goldber. AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 1. 1996-06-03. PMID:8613786. |
neither agonist increased cytosolic calcium, and astrocyte toxicity occurred only after 24 hr exposure to high (500-1000 microm) concentrations of kainate but not to ampa or glutamate. |
1996-06-03 |
2023-08-12 |
mouse |
| J C David, K A Yamada, M R Bagwe, M P Goldber. AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 1. 1996-06-03. PMID:8613786. |
coapplication of 10-100 microm cyclothiazide with glutamate, ampa, or kainate produced widespread astrocyte cell death within 2 hr or application. |
1996-06-03 |
2023-08-12 |
mouse |
| S D Jeftinija, K V Jeftinija, G Stefanovic, F Li. Neuroligand-evoked calcium-dependent release of excitatory amino acids from cultured astrocytes. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592139. |
the neuroligand bradykinin caused a dose-dependent receptor-mediated increase in release of the eaas glutamate and aspartate from type 1 astrocyte cell cultures obtained from rat cerebral cortex. |
1996-04-03 |
2023-08-12 |
rat |
| G Eriksson, A Peterson, K Iverfeldt, E Walu. Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat. Glia. vol 15. issue 2. 1996-03-07. PMID:8567066. |
sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat. |
1996-03-07 |
2023-08-12 |
rat |
| M E Harris, J M Carney, P S Cole, K Hensley, B J Howard, L Martin, P Bummer, Y Wang, N W Pedigo, D A Butterfiel. beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease. Neuroreport. vol 6. issue 14. 1996-02-22. PMID:8547588. |
an implication of inhibited astrocyte glutamate uptake in brain is increased extracellular levels of glutamate, which is excitotoxic to neurons. |
1996-02-22 |
2023-08-12 |
Not clear |
| J W Dani, S J Smit. The triggering of astrocytic calcium waves by NMDA-induced neuronal activation. Ciba Foundation symposium. vol 188. 1995-12-08. PMID:7587618. |
these findings strongly suggest that glutamate released during synaptic transmission triggers such phenomena within the perisynaptic astrocyte in situ. |
1995-12-08 |
2023-08-12 |
Not clear |