| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M C Longuemare, E C Keung, S Chun, F R Sharp, P H Chan, R A Swanso. MK-801 reduces uptake and stimulates efflux of excitatory amino acids via membrane depolarization. The American journal of physiology. vol 270. issue 5 Pt 1. 1996-12-06. PMID:8967440. |
in the present study, high concentrations of mk-801 (100-1,000 microm) caused uncompetitive inhibition of glutamate uptake in astrocyte and neuronal cultures and stimulated d-aspartate efflux from astrocytes. |
1996-12-06 |
2023-08-12 |
Not clear |
| S Miller, N Sehati, C Romano, C W Cotma. Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5. Journal of neurochemistry. vol 67. issue 4. 1996-12-02. PMID:8858925. |
in astrocyte cultures that have been morphologically differentiated by exposure to transforming growth factor-alpha, addition of thrombin induced a retraction of astrocytic processes and suppressed the stimulation of phosphoinositide hydrolysis by the selective metabotropic glutamate receptor (mglur) agonist 1-aminocyclopentane-1s,3r-dicarboxylic acid. |
1996-12-02 |
2023-08-12 |
Not clear |
| E B Dreyer, S A Lipto. The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. The European journal of neuroscience. vol 7. issue 12. 1996-10-22. PMID:8845955. |
here we show that gp120 impairs astrocyte uptake of excitatory amino acids and the excess glutamate thus engendered may contribute to the increased neuronal damage. |
1996-10-22 |
2023-08-12 |
human |
| M E Harris, Y Wang, N W Pedigo, K Hensley, D A Butterfield, J M Carne. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8667003. |
amyloid beta peptide (25-35) inhibits na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. |
1996-08-06 |
2023-08-12 |
rat |
| M E Harris, Y Wang, N W Pedigo, K Hensley, D A Butterfield, J M Carne. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8667003. |
one mechanism that may explain this finding is inhibition of the astrocyte glutamate transporter by abeta. |
1996-08-06 |
2023-08-12 |
rat |
| M E Harris, Y Wang, N W Pedigo, K Hensley, D A Butterfield, J M Carne. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8667003. |
the aim of the current study was to determine if abetas inhibit astrocyte glutamate uptake and if this inhibition involves free radical damage to the transporter/astrocytes. |
1996-08-06 |
2023-08-12 |
rat |
| M E Harris, Y Wang, N W Pedigo, K Hensley, D A Butterfield, J M Carne. Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8667003. |
we have previously reported that abeta can generate free radicals, and this radical production was correlated with the oxidation of neurons in culture and inhibition of astrocyte glutamate uptake. |
1996-08-06 |
2023-08-12 |
rat |
| J C David, K A Yamada, M R Bagwe, M P Goldber. AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 1. 1996-06-03. PMID:8613786. |
neither agonist increased cytosolic calcium, and astrocyte toxicity occurred only after 24 hr exposure to high (500-1000 microm) concentrations of kainate but not to ampa or glutamate. |
1996-06-03 |
2023-08-12 |
mouse |
| J C David, K A Yamada, M R Bagwe, M P Goldber. AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 1. 1996-06-03. PMID:8613786. |
coapplication of 10-100 microm cyclothiazide with glutamate, ampa, or kainate produced widespread astrocyte cell death within 2 hr or application. |
1996-06-03 |
2023-08-12 |
mouse |
| S D Jeftinija, K V Jeftinija, G Stefanovic, F Li. Neuroligand-evoked calcium-dependent release of excitatory amino acids from cultured astrocytes. Journal of neurochemistry. vol 66. issue 2. 1996-04-03. PMID:8592139. |
the neuroligand bradykinin caused a dose-dependent receptor-mediated increase in release of the eaas glutamate and aspartate from type 1 astrocyte cell cultures obtained from rat cerebral cortex. |
1996-04-03 |
2023-08-12 |
rat |
| G Eriksson, A Peterson, K Iverfeldt, E Walu. Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat. Glia. vol 15. issue 2. 1996-03-07. PMID:8567066. |
sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat. |
1996-03-07 |
2023-08-12 |
rat |
| M E Harris, J M Carney, P S Cole, K Hensley, B J Howard, L Martin, P Bummer, Y Wang, N W Pedigo, D A Butterfiel. beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease. Neuroreport. vol 6. issue 14. 1996-02-22. PMID:8547588. |
an implication of inhibited astrocyte glutamate uptake in brain is increased extracellular levels of glutamate, which is excitotoxic to neurons. |
1996-02-22 |
2023-08-12 |
Not clear |
| J W Dani, S J Smit. The triggering of astrocytic calcium waves by NMDA-induced neuronal activation. Ciba Foundation symposium. vol 188. 1995-12-08. PMID:7587618. |
these findings strongly suggest that glutamate released during synaptic transmission triggers such phenomena within the perisynaptic astrocyte in situ. |
1995-12-08 |
2023-08-12 |
Not clear |
| D Hantaz-Ambroise, D Cambier, A Aït-Ikhlef, P Parvy, M Murawsky, F Riege. Excess extracellular and low intracellular glutamate in poorly differentiating wobbler astrocytes and astrocyte recovery in glutamine-depleted culture medium. Journal of neurochemistry. vol 65. issue 3. 1995-09-18. PMID:7643098. |
excess extracellular and low intracellular glutamate in poorly differentiating wobbler astrocytes and astrocyte recovery in glutamine-depleted culture medium. |
1995-09-18 |
2023-08-12 |
mouse |
| D Hantaz-Ambroise, D Cambier, A Aït-Ikhlef, P Parvy, M Murawsky, F Riege. Excess extracellular and low intracellular glutamate in poorly differentiating wobbler astrocytes and astrocyte recovery in glutamine-depleted culture medium. Journal of neurochemistry. vol 65. issue 3. 1995-09-18. PMID:7643098. |
furthermore, decreasing initial glutamine concentrations in the culture medium (glutamine-depleted medium) led to the recovery of normal extra- and intracellular concentrations of glutamate and recovery of quasi-normal morphological differentiation and increased cell-cell contacts, leading to an essentially normal looking astrocyte network after 3 days of culture. |
1995-09-18 |
2023-08-12 |
mouse |
| L Venance, D Piomelli, J Glowinski, C Giaum. Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature. vol 376. issue 6541. 1995-09-13. PMID:7637807. |
we find that anandamide blocks the propagation of astrocyte calcium waves generated by either mechanical stimulation or local glutamate application. |
1995-09-13 |
2023-08-12 |
Not clear |
| R A Swanson, K Farrell, R P Simo. Acidosis causes failure of astrocyte glutamate uptake during hypoxia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 15. issue 3. 1995-05-18. PMID:7713999. |
acidosis causes failure of astrocyte glutamate uptake during hypoxia. |
1995-05-18 |
2023-08-12 |
rat |
| R A Swanson, K Farrell, R P Simo. Acidosis causes failure of astrocyte glutamate uptake during hypoxia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 15. issue 3. 1995-05-18. PMID:7713999. |
we used primary rat astrocyte cultures to study the effects of acidosis, chemical hypoxia, and the combination of acidosis plus chemical hypoxia on glutamate uptake. |
1995-05-18 |
2023-08-12 |
rat |
| R A Swanson, K Farrell, R P Simo. Acidosis causes failure of astrocyte glutamate uptake during hypoxia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 15. issue 3. 1995-05-18. PMID:7713999. |
astrocyte atp levels, like glutamate uptake, were significantly reduced by chemical hypoxia and further reduced by the combination of hypoxia plus acidosis. |
1995-05-18 |
2023-08-12 |
rat |
| R A Swanson, K Farrell, R P Simo. Acidosis causes failure of astrocyte glutamate uptake during hypoxia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 15. issue 3. 1995-05-18. PMID:7713999. |
these results suggest two mechanisms by which acidosis may contribute to failure of astrocyte glutamate uptake during ischemia: acidosis may act in concert with hypoxia to cause atp depletion, and acidosis may also have direct effects on glutamate transporters unrelated to effects on cellular atp levels. |
1995-05-18 |
2023-08-12 |
rat |