| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P J Magistretti, L Pelleri. Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 354. issue 1387. 1999-10-04. PMID:10466143. |
the stoichiometry of this process is such that for one glutamate molecule taken up with three na+ ions, one glucose molecule enters an astrocyte, two atp molecules are produced through aerobic glycolysis and two lactate molecules are released. |
1999-10-04 |
2023-08-12 |
Not clear |
| P J Magistretti, L Pelleri. Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 354. issue 1387. 1999-10-04. PMID:10466143. |
within the astrocyte, one atp molecule fuels one 'turn of the pump' while the other provides the energy needed to convert glutamate to glutamine by glutamine synthase. |
1999-10-04 |
2023-08-12 |
Not clear |
| D B Stanimirovic, R Ball, D L Small, A Murugananda. Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 17. issue 3. 1999-09-30. PMID:10452361. |
developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro. |
1999-09-30 |
2023-08-12 |
rat |
| D B Stanimirovic, R Ball, D L Small, A Murugananda. Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiated in vitro. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 17. issue 3. 1999-09-30. PMID:10452361. |
the differences in expression/inducibility of glutamate transporters and glutamine synthetase observed in astrocyte cultures derived from various stages of fetal and postnatal development suggest that astrocytes in vivo might also respond differently to environmental or injurious stimuli during development and maturation. |
1999-09-30 |
2023-08-12 |
rat |
| C P Holden, N J Haughey, A Nath, J D Geige. Role of Na+/H+ exchangers, excitatory amino acid receptors and voltage-operated Ca2+ channels in human immunodeficiency virus type 1 gp120-mediated increases in intracellular Ca2+ in human neurons and astrocytes. Neuroscience. vol 91. issue 4. 1999-08-24. PMID:10391443. |
gp120 appears to activate astrocyte na+/h+ exchangers to release glutamate and potassium and, subsequent to this, increases in [ca2+]i in neurons and astrocytes result from activation of excitatory amino acid receptors on astrocytes and neurons, and voltage-operated calcium channels on neurons. |
1999-08-24 |
2023-08-12 |
human |
| F J Northington, R J Traystman, R C Koehler, L J Marti. GLT1, glial glutamate transporter, is transiently expressed in neurons and develops astrocyte specificity only after midgestation in the ovine fetal brain. Journal of neurobiology. vol 39. issue 4. 1999-07-28. PMID:10380073. |
glt1, glial glutamate transporter, is transiently expressed in neurons and develops astrocyte specificity only after midgestation in the ovine fetal brain. |
1999-07-28 |
2023-08-12 |
Not clear |
| G A Silva, E Theriault, L R Mills, P S Pennefather, C J Feene. Group I and II metabotropic glutamate receptor expression in cultured rat spinal cord astrocytes. Neuroscience letters. vol 263. issue 2-3. 1999-06-10. PMID:10213149. |
we have examined the development of expression of group i and ii metabotropic glutamate receptors (mglurs) in pure rat spinal cord astrocyte cultures, using immunocytological and calcium imaging techniques. |
1999-06-10 |
2023-08-12 |
rat |
| M K Shelton, K D McCarth. Mature hippocampal astrocytes exhibit functional metabotropic and ionotropic glutamate receptors in situ. Glia. vol 26. issue 1. 1999-05-13. PMID:10088667. |
in previous studies, neither metabotropic nor ionotropic glutamate receptor-mediated responses were detected by imaging ca2+ in astrocytes from mature (p21-p42) animals, suggesting astrocyte glutamate receptors only contribute to hippocampus physiology during development. |
1999-05-13 |
2023-08-12 |
Not clear |
| L Wu, Z Cao, X Zh. [Effects of glutamate and ATP on interleukin 6 production by cultured neonatal rat astrocyte]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 22. issue 2. 1999-02-09. PMID:9868050. |
[effects of glutamate and atp on interleukin 6 production by cultured neonatal rat astrocyte]. |
1999-02-09 |
2023-08-12 |
rat |
| L Wu, Z Cao, X Zh. [Effects of glutamate and ATP on interleukin 6 production by cultured neonatal rat astrocyte]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 22. issue 2. 1999-02-09. PMID:9868050. |
the effects of glutamate (glu) and atp on interleukin-6 (il-6) production from cultured neonatal rat astrocyte were studied. |
1999-02-09 |
2023-08-12 |
rat |
| P Schubert, K Rudolph. Interfering with the pathologic activation of microglial cells and astrocytes in dementia. Alzheimer disease and associated disorders. vol 12 Suppl 2. 1999-02-02. PMID:9769026. |
as a consequence, physiologically required astrocyte functions may be impaired, such as uptake of glutamate and k+ from the extracellular space and release of neurotrophic factors. |
1999-02-02 |
2023-08-12 |
Not clear |
| R A Swanson, L L Sei. Barbiturates impair astrocyte glutamate uptake. Glia. vol 24. issue 4. 1999-01-28. PMID:9814816. |
barbiturates impair astrocyte glutamate uptake. |
1999-01-28 |
2023-08-12 |
rat |
| R A Swanson, L L Sei. Barbiturates impair astrocyte glutamate uptake. Glia. vol 24. issue 4. 1999-01-28. PMID:9814816. |
to examine this possibility, glutamate uptake was measured in primary rat astrocyte cultures in the presence of several barbiturates. |
1999-01-28 |
2023-08-12 |
rat |
| L Peng, E Arystarkhova, K J Sweadne. Plasticity of Na,K-ATPase isoform expression in cultures of flat astrocytes: species differences in gene expression. Glia. vol 24. issue 3. 1999-01-12. PMID:9775978. |
conditions that have been shown to increase na,k-atpase activity in astrocyte cultures, such as dibutyryl camp, high extracellular k+, and glutamate, did not specifically induce missing subunits, suggesting that cellular interactions are required to alter the ion transporter phenotype. |
1999-01-12 |
2023-08-12 |
mouse |
| D E Bergles, C E Jah. Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 19. 1998-10-09. PMID:9742141. |
astrocyte glutamate transporters are highly temperature sensitive, because l-glutamate-activated, anion-potentiated transporter currents in outside-out patches from these cells exhibited larger amplitudes and faster kinetics at 36 degreesc than at 24 degreesc. |
1998-10-09 |
2023-08-12 |
Not clear |
| D E Bergles, C E Jah. Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 19. 1998-10-09. PMID:9742141. |
these results are consistent with the hypothesis that astrocyte transporters are responsible for taking up the majority of glutamate released at schaffer collateral-commissural synapses in the hippocampus. |
1998-10-09 |
2023-08-12 |
Not clear |
| J S Diamond, D E Bergles, C E Jah. Glutamate release monitored with astrocyte transporter currents during LTP. Neuron. vol 21. issue 2. 1998-09-17. PMID:9728923. |
glutamate release monitored with astrocyte transporter currents during ltp. |
1998-09-17 |
2023-08-12 |
Not clear |
| X Yuan, A M Eisen, C J McBain, V Gall. A role for glutamate and its receptors in the regulation of oligodendrocyte development in cerebellar tissue slices. Development (Cambridge, England). vol 125. issue 15. 1998-08-31. PMID:9655812. |
these findings indicate that in rat cerebellar tissue slices: (i) glutamate specifically modulates oligodendrocyte but not astrocyte development through selective activation of alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, and (ii) cell depolarization and blockage of voltage-dependent k+ channels is likely to be the triggering mechanism. |
1998-08-31 |
2023-08-12 |
rat |
| S M Hutson, D Berkich, P Drown, B Xu, M Aschner, K F LaNou. Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism. Journal of neurochemistry. vol 71. issue 2. 1998-08-19. PMID:9681479. |
oxidation of glutamate appeared to be largely dependent on the presence of an alpha-keto acid acceptor for transamination in astrocyte cultures and independent of astrocytic glutamate dehydrogenase activity. |
1998-08-19 |
2023-08-12 |
rat |
| T Kommers, L Vinadé, C Pereira, C A Gonçalves, S Wofchuk, R Rodnigh. Regulation of the phosphorylation of glial fibrillary acidic protein (GFAP) by glutamate and calcium ions in slices of immature rat spinal cord: comparison with immature hippocampus. Neuroscience letters. vol 248. issue 2. 1998-08-17. PMID:9654363. |
the effect of glutamate and lack of external ca2+ on the phosphorylation of the astrocyte cell marker glial fibrillary acidic protein (gfap) was studied in slices of hippocampus and thoracic spinal cord from immature (p12-16) rats. |
1998-08-17 |
2023-08-12 |
rat |