| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Hu, W S Sheng, L C Ehrlich, P K Peterson, C C Cha. Cytokine effects on glutamate uptake by human astrocytes. Neuroimmunomodulation. vol 7. issue 3. 2000-06-21. PMID:10754403. |
using primary human fetal astrocyte cultures, we investigated the influence of selected cytokines on glutamate uptake activity. |
2000-06-21 |
2023-08-12 |
human |
| S Hu, W S Sheng, L C Ehrlich, P K Peterson, C C Cha. Cytokine effects on glutamate uptake by human astrocytes. Neuroimmunomodulation. vol 7. issue 3. 2000-06-21. PMID:10754403. |
interleukin (il)-1beta and tumor necrosis factor-alpha dose-dependently inhibited astrocyte glutamate uptake, whereas interferon (ifn)-gamma alone stimulated this activity. |
2000-06-21 |
2023-08-12 |
human |
| S Hu, W S Sheng, L C Ehrlich, P K Peterson, C C Cha. Cytokine effects on glutamate uptake by human astrocytes. Neuroimmunomodulation. vol 7. issue 3. 2000-06-21. PMID:10754403. |
taken together, these findings suggest that proinflammatory cytokines inhibit astrocyte glutamate uptake by a mechanism involving nitric oxide, and that ifn-beta may exert a therapeutically beneficial effect by blocking cytokine-induced nitric oxide production in inflammatory diseases of the brain. |
2000-06-21 |
2023-08-12 |
human |
| A Derouich. Topical correlation of increased hippocampal glutamine synthetase immunoreactivity and glutamatergic terminal fields after entorhinal cortex lesion. Glia. vol 29. issue 4. 2000-04-11. PMID:10652448. |
many astrocyte functions are related to glutamatergic transmission and to other synaptic functions, such as glutamate uptake and glutamate metabolism. |
2000-04-11 |
2023-08-12 |
rat |
| M K Shelton, K D McCarth. Hippocampal astrocytes exhibit Ca2+-elevating muscarinic cholinergic and histaminergic receptors in situ. Journal of neurochemistry. vol 74. issue 2. 2000-02-10. PMID:10646506. |
astrocyte responses to histamine and carbachol were compared with responses elicited by alpha1-adrenergic and metabotropic glutamate receptor agonists. |
2000-02-10 |
2023-08-12 |
Not clear |
| J N Billaud, D Selway, N Yu, T R Phillip. Replication rate of feline immunodeficiency virus in astrocytes is envelope dependent: implications for glutamate uptake. Virology. vol 266. issue 1. 2000-02-01. PMID:10612672. |
we also monitored the effects of these viruses on an important astrocyte function, glutamate uptake; all viruses significantly decreased this activity, but only the viruses containing the env of ppr significantly impaired glutamate uptake without altering the culture viability. |
2000-02-01 |
2023-08-12 |
Not clear |
| K Abe, H Sait. L-glutamate suppresses amyloid beta-protein-induced stellation of cultured rat cortical astrocytes. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617130. |
these results suggest that abeta-induced astrocyte stellation is suppressed by a mechanism related to glutamate transporters. |
2000-01-18 |
2023-08-12 |
rat |
| B G Zhou, M D Norenber. Ammonia downregulates GLAST mRNA glutamate transporter in rat astrocyte cultures. Neuroscience letters. vol 276. issue 3. 2000-01-05. PMID:10612626. |
ammonia downregulates glast mrna glutamate transporter in rat astrocyte cultures. |
2000-01-05 |
2023-08-12 |
rat |
| B G Zhou, M D Norenber. Ammonia downregulates GLAST mRNA glutamate transporter in rat astrocyte cultures. Neuroscience letters. vol 276. issue 3. 2000-01-05. PMID:10612626. |
to extend these observations, we performed a northern blot analysis of the astroglial glutamate transporter glast (eaat1) in nh4cl-treated primary rat astrocyte cultures. |
2000-01-05 |
2023-08-12 |
rat |
| R Silva, L R Mata, S Gulbenkian, M A Brito, C Tiribelli, D Brite. Inhibition of glutamate uptake by unconjugated bilirubin in cultured cortical rat astrocytes: role of concentration and pH. Biochemical and biophysical research communications. vol 265. issue 1. 1999-12-17. PMID:10548492. |
these findings indicate that ucb, and more precisely the monoanionic species, impairs a crucial function of astrocytes such as glutamate transport and support a potential role of astrocyte function in the pathogenesis of ucb-related brain damage (kernicterus). |
1999-12-17 |
2023-08-12 |
rat |
| S Duan, C M Anderson, B A Stein, R A Swanso. Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575016. |
glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of glast. |
1999-12-17 |
2023-08-12 |
Not clear |
| S Duan, C M Anderson, B A Stein, R A Swanso. Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575016. |
here, glutamate regulation of glutamate transport was studied using primary murine astrocyte cultures that express the glast (eaat1) and glt-1 (eaat2) transporter subtypes. |
1999-12-17 |
2023-08-12 |
Not clear |
| S Duan, C M Anderson, B A Stein, R A Swanso. Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575016. |
biotinylation labeling of membrane surface proteins showed that glutamate incubation produced an increase in glast expression at the astrocyte cell surface. |
1999-12-17 |
2023-08-12 |
Not clear |
| S Duan, C M Anderson, B A Stein, R A Swanso. Glutamate induces rapid upregulation of astrocyte glutamate transport and cell-surface expression of GLAST. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 23. 1999-12-17. PMID:10575016. |
this feedback loop provides a mechanism by which changes in extracellular glutamate concentrations could rapidly modulate astrocyte glutamate transport capacity. |
1999-12-17 |
2023-08-12 |
Not clear |
| R P Sanzgiri, A Araque, P G Haydo. Prostaglandin E(2) stimulates glutamate receptor-dependent astrocyte neuromodulation in cultured hippocampal cells. Journal of neurobiology. vol 41. issue 2. 1999-11-26. PMID:10512979. |
prostaglandin e(2) stimulates glutamate receptor-dependent astrocyte neuromodulation in cultured hippocampal cells. |
1999-11-26 |
2023-08-12 |
rat |
| R P Sanzgiri, A Araque, P G Haydo. Prostaglandin E(2) stimulates glutamate receptor-dependent astrocyte neuromodulation in cultured hippocampal cells. Journal of neurobiology. vol 41. issue 2. 1999-11-26. PMID:10512979. |
this neuronal response required the presence of an astrocyte ca(2+) wave and was mediated through both n-methyl-d-aspartate (nmda) and non-nmda glutamate receptors. |
1999-11-26 |
2023-08-12 |
rat |
| R P Sanzgiri, A Araque, P G Haydo. Prostaglandin E(2) stimulates glutamate receptor-dependent astrocyte neuromodulation in cultured hippocampal cells. Journal of neurobiology. vol 41. issue 2. 1999-11-26. PMID:10512979. |
taken together with previous studies, these data demonstrate that pge(2)-evoked ca(2+) elevations in astrocyte cause the release of glutamate which activates neuronal ionotropic receptors. |
1999-11-26 |
2023-08-12 |
rat |
| M Fukaya, K Yamada, M Nagashima, K Tanaka, M Watanab. Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella. Neuroscience research. vol 34. issue 3. 1999-11-10. PMID:10515259. |
glutamate transporter glast is highly expressed in the bergmann glia (bg), a unipolar cerebellar astrocyte associated structurally and functionally with purkinje cells (pcs). |
1999-11-10 |
2023-08-12 |
Not clear |
| M C Longuemare, C R Rose, K Farrell, B R Ransom, S G Waxman, R A Swanso. K(+)-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular Na+. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430492. |
k(+)-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular na+. |
1999-10-08 |
2023-08-12 |
Not clear |
| M C Longuemare, C R Rose, K Farrell, B R Ransom, S G Waxman, R A Swanso. K(+)-induced reversal of astrocyte glutamate uptake is limited by compensatory changes in intracellular Na+. Neuroscience. vol 93. issue 1. 1999-10-08. PMID:10430492. |
this possibility was examined using astrocyte cultures treated in two ways to reduce the driving force for glutamate uptake: incubation in high k+ (with reciprocal reduction in na+), and incubation with metabolic inhibitors to induce atp depletion. |
1999-10-08 |
2023-08-12 |
Not clear |