| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Receptor-mediated regulation of serotonin output in the rat dorsal raphe nucleus: effects of risperidone. Psychopharmacology. vol 153. issue 3. 2001-05-17. PMID:11271402. |
receptor-mediated regulation of serotonin output in the rat dorsal raphe nucleus: effects of risperidone. |
2001-05-17 |
2023-08-12 |
rat |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Receptor-mediated regulation of serotonin output in the rat dorsal raphe nucleus: effects of risperidone. Psychopharmacology. vol 153. issue 3. 2001-05-17. PMID:11271402. |
the present study was undertaken to characterize the regulation of serotonin (5-ht) efflux and neuronal activity in the dorsal raphe nucleus (drn) as well as to examine the potential ability of the antipsychotic drug risperidone to interfere with these mechanisms. |
2001-05-17 |
2023-08-12 |
rat |
| J Ichikawa, H Ishii, S Bonaccorso, W L Fowler, I A O'Laughlin, H Y Meltze. 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238736. |
the present study tested the hypothesis that clozapine, olanzapine, risperidone, and perhaps other atypical apds, increase dopamine release in rat medial prefrontal cortex (mpfc) via 5-ht(1a) receptor activation, as a result of the blockade of 5-ht(2a) and d(2) receptors. |
2001-04-05 |
2023-08-12 |
rat |
| J Ichikawa, H Ishii, S Bonaccorso, W L Fowler, I A O'Laughlin, H Y Meltze. 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release. Journal of neurochemistry. vol 76. issue 5. 2001-04-05. PMID:11238736. |
clozapine is a direct acting 5-ht(1a) partial agonist, whereas olanzapine and risperidone are not. |
2001-04-05 |
2023-08-12 |
rat |
| M Phillips, C Wang, K M Johnso. Pharmacological characterization of locomotor sensitization induced by chronic phencyclidine administration. The Journal of pharmacology and experimental therapeutics. vol 296. issue 3. 2001-03-15. PMID:11181923. |
risperidone, a d(2)/serotonin (5-ht(2)) antagonist, also resulted in a marginal attenuation of 15%. |
2001-03-15 |
2023-08-12 |
rat |
| J Cartmell, C R Salhoff, K W Perry, J A Monn, D D Schoep. Dopamine and 5-HT turnover are increased by the mGlu2/3 receptor agonist LY379268 in rat medial prefrontal cortex, nucleus accumbens and striatum. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134627. |
here, we have compared the effects of ly379268 with clozapine as well as risperidone on ex vivo tissue levels of dopamine, dopac, hva, 5-ht and 5-hiaa in multiple brain regions. |
2001-02-15 |
2023-08-12 |
rat |
| C Pfanner, D Marazziti, L Dell'Osso, S Presta, A Gemignani, A Milanfranchi, G B Cassan. Risperidone augmentation in refractory obsessive-compulsive disorder: an open-label study. International clinical psychopharmacology. vol 15. issue 5. 2001-01-18. PMID:10993132. |
we report the results of an open-label trial on the use of the combination of serotonin reuptake inhibitors (sris) with risperidone in 20 refractory ocd outpatients. |
2001-01-18 |
2023-08-12 |
Not clear |
| E Richelson, T Soude. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life sciences. vol 68. issue 1. 2001-01-11. PMID:11132243. |
using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (k(d)s) for nine new antipsychotic drugs (iloperidone, melperone, olanzapine, org 5222, quetiapine, risperidone, sertindole, ziprasidone, and zotepine), one metabolite of a new drug (9-oh-risperidone), and three older antipsychotics (clozapine, haloperidol, and pimozide) at nine different receptors (alpha1-adrenergic, alpha2-adrenergic, dopamine d2, histamine h1, muscarinic, and serotonin 5-ht1a, 5-ht1d, 5-ht2a, and 5-ht2c receptors). |
2001-01-11 |
2023-08-12 |
human |
| A Jobe, D Lewis, M Wainwright, G R DeLon. Three children with a syndrome of obesity and overgrowth, atypical psychosis, and seizures: a problem in neuropsychopharmacology. Journal of child neurology. vol 15. issue 8. 2000-12-20. PMID:10961790. |
empirical treatment with anticonvulsants (carbamazepine and acetazolamide) together with psychotropic agents (selective serotonin reuptake inhibitors and risperidone) controlled seizures, improved behavior, and stopped weight gain in each patient. |
2000-12-20 |
2023-08-12 |
Not clear |
| N Bhana, C M Spence. Risperidone: a review of its use in the management of the behavioural and psychological symptoms of dementia. Drugs & aging. vol 16. issue 6. 2000-11-30. PMID:10939309. |
risperidone has antagonistic activity primarily at serotonin 5-ht2a and dopamine d2 receptors. |
2000-11-30 |
2023-08-12 |
Not clear |
| K Herrick-Davis, E Grinde, M Teitle. Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991983. |
atypical antipsychotic drugs (sertindole, clozapine, olanzapine, ziprasidone, risperidone, zotepine, tiospirone, fluperlapine, tenilapine) displayed potent inverse agonist activity at rat and human 5-ht(2c) receptors. |
2000-11-03 |
2023-08-12 |
human |
| Y Noda, H Kamei, T Mamiya, H Furukawa, T Nabeshim. Repeated phencyclidine treatment induces negative symptom-like behavior in forced swimming test in mice: imbalance of prefrontal serotonergic and dopaminergic functions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 4. 2000-11-01. PMID:10989264. |
the enhancing effect of pcp on the immobility in a forced swimming test was attenuated by clozapine, risperidone and olanzapine, which have serotonin (5-ht) and dopamine receptor antagonistic properties. |
2000-11-01 |
2023-08-12 |
mouse |
| K Antoniou, S Bekris, M Saranti, P Stathis, M Rimikis, Z Papadopoulou-Daifot. The effects of antipsychotic drugs on serotonergic activity in the rat hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 5. 2000-10-30. PMID:10974601. |
acute administration of risperidone, the serotonin(2) (5-ht(2)) receptor antagonist ketanserin, and the dopamine (da)-d(2) receptor antagonist raclopride increased the 5-hydroxyindoleacetic acid/serotonin (5-hiaa/5-ht) ratio. |
2000-10-30 |
2023-08-12 |
rat |
| K Nisijima, T Yoshino, T Ishigur. Risperidone counteracts lethality in an animal model of the serotonin syndrome. Psychopharmacology. vol 150. issue 1. 2000-10-11. PMID:10867971. |
risperidone counteracts lethality in an animal model of the serotonin syndrome. |
2000-10-11 |
2023-08-12 |
Not clear |
| F Angelucci, A A Mathé, L Alo. Brain-derived neurotrophic factor and tyrosine kinase receptor TrkB in rat brain are significantly altered after haloperidol and risperidone administration. Journal of neuroscience research. vol 60. issue 6. 2000-09-06. PMID:10861791. |
the former drug mainly acts on the dopamine (da) d(2) receptor whereas risperidone binds to both da and serotonin (5ht) receptors, particularly in the neurons of striatal and limbic structures. |
2000-09-06 |
2023-08-12 |
rat |
| J Grabowski, H Rhoades, P Silverman, J M Schmitz, A Stotts, D Creson, R Baile. Risperidone for the treatment of cocaine dependence: randomized, double-blind trial. Journal of clinical psychopharmacology. vol 20. issue 3. 2000-09-01. PMID:10831016. |
risperidone, a 5-hydroxytryptamine and dopamine d2 antagonist, is an atypical antipsychotic and was a candidate medication for the treatment of cocaine dependence. |
2000-09-01 |
2023-08-12 |
human |
| C J McDougle, C N Epperson, G H Pelton, S Wasylink, L H Pric. A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Archives of general psychiatry. vol 57. issue 8. 2000-08-22. PMID:10920469. |
a double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. |
2000-08-22 |
2023-08-12 |
Not clear |
| L M Koran, A L Ringold, M A Elliot. Olanzapine augmentation for treatment-resistant obsessive-compulsive disorder. The Journal of clinical psychiatry. vol 61. issue 7. 2000-08-21. PMID:10937610. |
adding the atypical neuroleptic risperidone to a serotonin reuptake inhibitor (sri) has benefited patients with treatment-refractory obsessive-compulsive disorder (ocd). |
2000-08-21 |
2023-08-12 |
Not clear |
| F I Tarazi, K Zhang, R J Baldessarin. Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain. Neuroscience letters. vol 287. issue 2. 2000-08-17. PMID:10854717. |
we compared labeling of dopamine (dat) and serotonin (sert) transporter proteins in subregions of rat corpus striatum by quantitative autoradiography with [(3)h]2-beta-carbomethoxy-3-beta-[4'-iodophenyl]tropane ([(3)h]beta-cit) and [(3)h]paroxetine after 28 days of continuous subcutaneous infusion of olanzapine, quetiapine, risperidone, or vehicle controls. |
2000-08-17 |
2023-08-12 |
rat |
| I Kusumi, Y Takahashi, K Suzuki, K Kameda, T Koyam. Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 3. 2000-08-02. PMID:10821438. |
the effects of 3-week treatment with a typical antipsychotic drug chlorpromazine and three atypical antipsychotic drugs (risperidone, olanzapine and perospirone) on the binding to dopamine d2 and serotonin 5-ht2a receptors were examined in the rat stratum and frontal cortex, respectively. |
2000-08-02 |
2023-08-12 |
rat |