| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerard J Marek, Linda L Carpenter, Christopher J McDougle, Lawrence H Pric. Synergistic action of 5-HT2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589395. |
recently, the addition of drugs with prominent 5-ht(2) receptor antagonist properties (risperidone, olanzapine, mirtazapine, and mianserin) to selective serotonin reuptake inhibitors (ssris) has been shown to enhance therapeutic responses in patients with major depression and treatment-refractory obsessive-compulsive disorder (ocd). |
2003-04-21 |
2023-08-12 |
Not clear |
| Sathapana Kongsamut, Jiesheng Kang, Xiao-Liang Chen, Joachim Roehr, David Ramp. A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. European journal of pharmacology. vol 450. issue 1. 2003-04-01. PMID:12176106. |
of the other drugs tested (ziprasidone, quetiapine, risperidone and olanzapine), olanzapine displayed the greatest selectivity for dopamine d(2) and 5-ht(2a) receptor binding (100-1000-fold) compared to its herg channel ic(50). |
2003-04-01 |
2023-08-12 |
human |
| Miyuki Ota, Keiji Mori, Akira Nakashima, Yoko S Kaneko, Kentaro Fujiwara, Mitsuyasu Itoh, Akio Nagasaka, Akira Ot. Peripheral injection of risperidone, an atypical antipsychotic, alters the bodyweight gain of rats. Clinical and experimental pharmacology & physiology. vol 29. issue 11. 2003-03-05. PMID:12366389. |
risperidone is an atypical antipsychotic drug that possesses 5-hydroxytryptamine 5-ht2 receptor antagonism combined with milder dopamine d2 receptor antagonism. |
2003-03-05 |
2023-08-12 |
rat |
| Nicole Aymard, Annie Viala, Marie-Noelle Clement, Marc Jacquot, Marie-Noelle Vacheron, Jacques Gauillard, Francois Carol. Long-term pharmacoclinical follow-up in schizophrenic patients treated with risperidone. Plasma and red blood cell concentrations of risperidone and its 9-hydroxymetabolite and their relationship to whole blood serotonin and tryptophan, plasma homovanillic acid, 5-hydroxyindoleacetic acid, dihydroxyphenylethyleneglycol and clinical evaluations. Progress in neuro-psychopharmacology & biological psychiatry. vol 26. issue 5. 2003-02-11. PMID:12369274. |
plasma and red blood cell concentrations of risperidone and its 9-hydroxymetabolite and their relationship to whole blood serotonin and tryptophan, plasma homovanillic acid, 5-hydroxyindoleacetic acid, dihydroxyphenylethyleneglycol and clinical evaluations. |
2003-02-11 |
2023-08-12 |
Not clear |
| Frank I Tarazi, Kehong Zhang, Ross J Baldessarin. Long-term effects of olanzapine, risperidone, and quetiapine on serotonin 1A, 2A and 2C receptors in rat forebrain regions. Psychopharmacology. vol 161. issue 3. 2003-01-13. PMID:12021829. |
long-term effects of olanzapine, risperidone, and quetiapine on serotonin 1a, 2a and 2c receptors in rat forebrain regions. |
2003-01-13 |
2023-08-12 |
rat |
| D Van Oekelen, A Megens, T Meert, W H M L Luyten, J E Leyse. Role of 5-HT(2) receptors in the tryptamine-induced 5-HT syndrome in rats. Behavioural pharmacology. vol 13. issue 4. 2002-12-24. PMID:12218512. |
we distinguished the functions of the different 5-hydroxytryptamine-2 (5-ht(2)) receptor (5-ht(2)r) subtypes in the tryptamine-induced 5-ht syndrome in rats using (1) the 5-ht(2a)r antagonist r93274 (n-[(3-p-fluorophenyl-1-propyl)-4-methyl-4-piperidinyl]-4-amino-5-iodo-2-methoxybenzamide), the 5-ht(2a/c)r antagonist r99647 (2-(dimethylaminomethyl)2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine), the 5-ht(2b/c)r antagonist sb-242084 (6-chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-indoline), and several 5-ht(2)r antagonists (ketanserin, risperidone, pipamperone and mianserin); and (2) chronic 5-ht(2)r activation by 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (dom). |
2002-12-24 |
2023-08-12 |
rat |
| D Van Oekelen, A Megens, T Meert, W H M L Luyten, J E Leyse. Role of 5-HT(2) receptors in the tryptamine-induced 5-HT syndrome in rats. Behavioural pharmacology. vol 13. issue 4. 2002-12-24. PMID:12218512. |
in contrast to sb-242084, the selective 5-ht(2a)r antagonist r93274 as well as the non-selective 5-ht(2a)r antagonists (r99647, ketanserin, risperidone, pipamperone and mianserin) significantly inhibited tryptamine-induced forepaw treading and tremors, and reversed peripherally mediated cyanosis into hyperaemia; only the 5-ht(2a/c)r antagonists r99647 and mianserin inhibited the tryptamine-induced hunched back. |
2002-12-24 |
2023-08-12 |
rat |
| Trino Baptista, Anny Lacruz, Ximena Pàez, Luis Hernàndez, Serge Beaulie. The antipsychotic drug sulpiride does not affect bodyweight in male rats. Is insulin resistance involved? European journal of pharmacology. vol 447. issue 1. 2002-12-13. PMID:12106808. |
since the same sex-dependent effect on body weight and food intake in rats has been observed during administration of risperidone, which has a different pharmacological profile than sulpiride, future studies must evaluate other neurotransmitters involved in food intake regulation such as serotonin, noradrenaline and histamine. |
2002-12-13 |
2023-08-12 |
rat |
| Basil Alevizos, Lefteris Lykouras, Iannis M Zervas, George N Christodoulo. Risperidone-induced obsessive-compulsive symptoms: a series of six cases. Journal of clinical psychopharmacology. vol 22. issue 5. 2002-11-19. PMID:12352268. |
risperidone is a novel and atypical agent with a dual antagonistic effect on 5-ht and d receptors. |
2002-11-19 |
2023-08-12 |
Not clear |
| Basil Alevizos, Lefteris Lykouras, Iannis M Zervas, George N Christodoulo. Risperidone-induced obsessive-compulsive symptoms: a series of six cases. Journal of clinical psychopharmacology. vol 22. issue 5. 2002-11-19. PMID:12352268. |
open-label reports and one controlled study suggest that risperidone addition is effective in patients with obsessive-compulsive disorder refractory to treatment with serotonin reuptake inhibitors. |
2002-11-19 |
2023-08-12 |
Not clear |
| Stephen R Wachtel, Amanda Ortengren, Harriet de Wi. The effects of acute haloperidol or risperidone on subjective responses to methamphetamine in healthy volunteers. Drug and alcohol dependence. vol 68. issue 1. 2002-11-05. PMID:12167550. |
the goal of this study was to examine the effects of haloperidol, a drug that primarily blocks dopamine receptors, and risperidone, a drug that blocks both dopamine and serotonin receptors, on the physiological and subjective effects of methamphetamine in healthy volunteers. |
2002-11-05 |
2023-08-12 |
human |
| Yasuhiko Yamada, Yoshiyuki Ohno, Yoshifumi Nakashima, Masato Fukuda, Risa Takayanagi, Hitoshi Sato, Fumito Tsuchiya, Yasufumi Sawada, Tatsuji Ig. Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy. Synapse (New York, N.Y.). vol 46. issue 1. 2002-10-16. PMID:12211096. |
the occupancies of d(2) and 5-ht(2) receptors at various doses of risperidone were calculated by means of a receptor occupancy theory. |
2002-10-16 |
2023-08-12 |
Not clear |
| Yasuhiko Yamada, Yoshiyuki Ohno, Yoshifumi Nakashima, Masato Fukuda, Risa Takayanagi, Hitoshi Sato, Fumito Tsuchiya, Yasufumi Sawada, Tatsuji Ig. Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy. Synapse (New York, N.Y.). vol 46. issue 1. 2002-10-16. PMID:12211096. |
the pharmacokinetic/pharmacodynamic analysis utilized the data concerning the pharmacokinetics of risperidone and 9-hydroxyrisperidone (active metabolite), their binding affinities with d(2) and 5-ht(2) receptors, and the clinical evidence of extrapyramidal symptoms (extrapyramidal symptom rating scale: esrs), gathered from the literature. |
2002-10-16 |
2023-08-12 |
Not clear |
| Yasuhiko Yamada, Yoshiyuki Ohno, Yoshifumi Nakashima, Masato Fukuda, Risa Takayanagi, Hitoshi Sato, Fumito Tsuchiya, Yasufumi Sawada, Tatsuji Ig. Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy. Synapse (New York, N.Y.). vol 46. issue 1. 2002-10-16. PMID:12211096. |
the mean occupancy of 5-ht(2) receptors after the administration of regular doses of risperidone was suggested to be more than 90%, whereas the mean occupancy of d(2) receptors varied between 50-80%, depending on the dose. |
2002-10-16 |
2023-08-12 |
Not clear |
| Shigehiro Hirose, Charles R Ashb. An open pilot study combining risperidone and a selective serotonin reuptake inhibitor as initial antidepressant therapy. The Journal of clinical psychiatry. vol 63. issue 8. 2002-09-20. PMID:12197455. |
an open pilot study combining risperidone and a selective serotonin reuptake inhibitor as initial antidepressant therapy. |
2002-09-20 |
2023-08-12 |
Not clear |
| Shigehiro Hirose, Charles R Ashb. An open pilot study combining risperidone and a selective serotonin reuptake inhibitor as initial antidepressant therapy. The Journal of clinical psychiatry. vol 63. issue 8. 2002-09-20. PMID:12197455. |
atypical antipsychotics such as risperidone or olanzapine have been reported to be effective when added to a selective serotonin reuptake inhibitor (ssri) in cases of depression in which treatment with an ssri alone is not effective. |
2002-09-20 |
2023-08-12 |
Not clear |
| Hsien-Yuan Lane, Yue-Cune Chang, Chih-Chiang Chiu, Mao-Liang Chen, Min-Hua Hsieh, Wen-Ho Chan. Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene. The American journal of psychiatry. vol 159. issue 9. 2002-09-20. PMID:12202283. |
association of risperidone treatment response with a polymorphism in the 5-ht(2a) receptor gene. |
2002-09-20 |
2023-08-12 |
Not clear |
| Hsien-Yuan Lane, Yue-Cune Chang, Chih-Chiang Chiu, Mao-Liang Chen, Min-Hua Hsieh, Wen-Ho Chan. Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene. The American journal of psychiatry. vol 159. issue 9. 2002-09-20. PMID:12202283. |
this study investigated the effect of the 102-t/c polymorphism in the 5-ht(2a) receptor gene on risperidone efficacy. |
2002-09-20 |
2023-08-12 |
Not clear |
| Vincenzo Di Matteo, Marisa Cacchio, Camillo Di Giulio, Giuseppe Di Giovanni, Ennio Esposit. Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888552. |
biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-ht(2c) receptors in vivo. |
2002-09-11 |
2023-08-12 |
human |
| Vincenzo Di Matteo, Marisa Cacchio, Camillo Di Giulio, Giuseppe Di Giovanni, Ennio Esposit. Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888552. |
clozapine and risperidone are two atypical antipsychotic drugs which bind, among other receptors, to 5-ht(2c) receptor subtypes. |
2002-09-11 |
2023-08-12 |
human |