| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vincenzo Di Matteo, Marisa Cacchio, Camillo Di Giulio, Giuseppe Di Giovanni, Ennio Esposit. Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888552. |
however, clozapine and risperidone completely prevented the inhibitory action of ro 60-0175 (1 mg/kg ip), a 5-ht(2c) receptor agonist, on da release. |
2002-09-11 |
2023-08-12 |
human |
| Vincenzo Di Matteo, Marisa Cacchio, Camillo Di Giulio, Giuseppe Di Giovanni, Ennio Esposit. Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888552. |
taken together, these data indicate that clozapine and risperidone, unlike haloperidol, are capable of blocking 5-ht(2c) receptors in the nucleus accumbens. |
2002-09-11 |
2023-08-12 |
human |
| B Pouzet, M Didriksen, J Arn. Effects of the 5-HT(7) receptor antagonist SB-258741 in animal models for schizophrenia. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888557. |
the 5-ht(7) receptor is targeted by several new antipsychotics such as clozapine and risperidone. |
2002-09-11 |
2023-08-12 |
rat |
| R Bullock, S Librett. Risperidone in the treatment of psychoses in the elderly: a case report series. European psychiatry : the journal of the Association of European Psychiatrists. vol 17. issue 2. 2002-06-27. PMID:11973118. |
risperidone is one of the newer atypical antipsychotic agents, which combines potent serotonin and dopamine receptor antagonism. |
2002-06-27 |
2023-08-12 |
Not clear |
| F Hässler, J Buchmann, S Bohn. [Possibilities and limits of treatment of aggressive behavior in patients with mental retardation with risperidone]. Der Nervenarzt. vol 73. issue 3. 2002-06-25. PMID:11963264. |
in open and controlled studies, the administration of the atypical neuroleptic risperidone (a serotonin 2a-dopamine d2 antagonist) was associated with a long-term effect in reducing self-injuries. |
2002-06-25 |
2023-08-12 |
Not clear |
| Hidehisa Yamashita, Shigeru Morinobu, Shigeto Yamawaki, Jun Horiguchi, Masatsugu Naga. Effect of risperidone on sleep in schizophrenia: a comparison with haloperidol. Psychiatry research. vol 109. issue 2. 2002-06-19. PMID:11927138. |
this difference in the effect on sleep between risperidone and haloperidol may be due to their differential actions on serotonin (5-ht2) receptors. |
2002-06-19 |
2023-08-12 |
Not clear |
| Rajamannar Ramasubb. Antiobsessional effect of risperidone add-on treatment in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder may be dose-dependent. Archives of general psychiatry. vol 59. issue 5. 2002-06-06. PMID:11982460. |
antiobsessional effect of risperidone add-on treatment in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder may be dose-dependent. |
2002-06-06 |
2023-08-12 |
Not clear |
| P J Kruzich, R E Se. An evaluation of the role of 5-HT(2) receptor antagonism during subchronic antipsychotic drug administration in rats. Brain research. vol 875. issue 1-2. 2002-05-07. PMID:10967296. |
these drugs included: risperidone (high 5-ht(2a/2c)/high d(2)), clozapine (high 5-ht(2a/2c)/low d(2)), haloperidol (low 5-ht(2a/2c)/high d(2)), haloperidol+ritanserin (selective 5-ht(2a/2c)), or vehicle. |
2002-05-07 |
2023-08-12 |
rat |
| Stefan Leucht, Gabi Pitschel-Walz, Rolf R Engel, Werner Kisslin. Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials. The American journal of psychiatry. vol 159. issue 2. 2002-03-06. PMID:11823257. |
the "atypical" profile of the new antipsychotics clozapine, olanzapine, quetiapine, and risperidone has been linked to combined antagonism of serotonin 2 (5-ht(2)) and dopamine 2 (d(2)) receptors. |
2002-03-06 |
2023-08-12 |
Not clear |
| F P Bymaster, J F Falcone, D Bauzon, J S Kennedy, K Schenck, N W DeLapp, M L Cohe. Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine. European journal of pharmacology. vol 430. issue 2-3. 2002-01-14. PMID:11711053. |
among other antipsychotics investigated, clozapine antagonized 5-ht(6) receptors with a pk(b)=7.42+/-0.15, ziprasidone was three-fold less potent, and risperidone, quetiapine and haloperidol were weak antagonists. |
2002-01-14 |
2023-08-12 |
human |
| T F Sun, P Y Lin, C K W. Risperidone augmentation of specific serotonin reuptake inhibitors in the treatment of refractory obsessive-compulsive disorder: report of two cases. Chang Gung medical journal. vol 24. issue 9. 2001-12-13. PMID:11725630. |
risperidone augmentation of specific serotonin reuptake inhibitors in the treatment of refractory obsessive-compulsive disorder: report of two cases. |
2001-12-13 |
2023-08-12 |
Not clear |
| P K Gillma. Comments on "Serotonin syndrome during treatment with paroxetine and risperidone". Journal of clinical psychopharmacology. vol 21. issue 3. 2001-11-01. PMID:11386501. |
comments on "serotonin syndrome during treatment with paroxetine and risperidone". |
2001-11-01 |
2023-08-12 |
Not clear |
| M Markianos, J Hatzimanolis, L Lykoura. Neuroendocrine serotonergic and dopaminergic responsivity in male schizophrenic patients during treatment with neuroleptics and after switch to risperidone. Psychopharmacology. vol 157. issue 1. 2001-10-25. PMID:11512043. |
the pharmacological profile of risperidone is that of an atypical neuroleptic regarding its serotonin 5-ht2a and dopamine d2 receptor blocking properties. |
2001-10-25 |
2023-08-12 |
Not clear |
| E H Kossoff, H S Singe. Tourette syndrome: clinical characteristics and current management strategies. Paediatric drugs. vol 3. issue 5. 2001-10-04. PMID:11393328. |
obsessive compulsive disorder, when associated with ts, may be treated with either a selective serotonin reuptake inhibitor in association with a dopamine receptor antagonist or risperidone alone. |
2001-10-04 |
2023-08-12 |
Not clear |
| N Maneeton, S Intaprasert, M Srisurapanon. Risperidone for controlling aggressive behavior in a mentally retarded child: a case report. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 84. issue 6. 2001-10-04. PMID:11556472. |
risperidone is an atypical antipsychotic agent with dopamine and serotonin antagonistic effects. |
2001-10-04 |
2023-08-12 |
Not clear |
| J Feng, X Cai, J Zhao, Z Ya. Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517239. |
although multiple 5-ht receptors were coexpressed in pfc pyramidal neurons, the serotonergic modulation of gaba-evoked currents was mimicked by the 5-ht(2)-class agonist (-)-2,5-dimethoxy-4-iodoamphetamine and blocked by 5-ht(2) antagonists risperidone and ketanserin, indicating the mediation by 5-ht(2) receptors. |
2001-09-20 |
2023-08-12 |
Not clear |
| M Van Bellinghen, C De Troc. Risperidone in the treatment of behavioral disturbances in children and adolescents with borderline intellectual functioning: a double-blind, placebo-controlled pilot trial. Journal of child and adolescent psychopharmacology. vol 11. issue 1. 2001-08-30. PMID:11322745. |
risperidone, an antipsychotic agent with combined serotonin (5-ht2a) and dopamine (d2) receptor-blocking properties, is associated with fewer extrapyramidal side effects in adults than conventional neuroleptics. |
2001-08-30 |
2023-08-12 |
Not clear |
| J Cartmell, K W Perry, C R Salhoff, J A Monn, D D Schoep. Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378155. |
here, we compared the acute effects of ly379268 with those of clozapine and risperidone (atypical antipsychotics) on extracellular levels of both dopamine and 5-ht in the mpfc of freely-moving rats. |
2001-08-09 |
2023-08-12 |
rat |
| J Cartmell, K W Perry, C R Salhoff, J A Monn, D D Schoep. Acute increases in monoamine release in the rat prefrontal cortex by the mGlu2/3 agonist LY379268 are similar in profile to risperidone, not locally mediated, and can be elicited in the presence of uptake blockade. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378155. |
ly379268, at 3 and 10 mg/kg s.c., and risperidone (1 mg/kg s.c.) also increased dialysate 5-ht to 169, 179 and 140% of basal levels and 5-hiaa to 144, 154 and 121% of basal levels, respectively. |
2001-08-09 |
2023-08-12 |
rat |
| R Bruggeman, M Heeringa, B H Westerink, W Timmerma. Combined 5-HT2/D2 receptor blockade inhibits the firing rate of SNR neurons in the rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 24. issue 4. 2001-05-24. PMID:10958152. |
the aim of the present study was to evaluate the contribution of serotonin (5-ht) and dopamine (da) receptor antagonism to the distinct inhibitory effects of the atypical antipsychotics clozapine and risperidone on snr neurons, we have shown previously. |
2001-05-24 |
2023-08-12 |
rat |