| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G B Varty, V P Bakshi, M A Geye. M100907, a serotonin 5-HT2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 4. 1999-06-03. PMID:10088132. |
in a recent study using wistar rats, the serotonergic 5-ht2 receptor antagonists ketanserin and risperidone reduced the disruptive effects of the noncompetitive n-methyl-d-aspartate (nmda) antagonist dizocilpine on prepulse inhibition (ppi), suggesting that there is an interaction between serotonin and glutamate in the modulation of ppi. |
1999-06-03 |
2023-08-12 |
rat |
| J W Grimm, R E Se. Unique activation of extracellular striato-pallidal neurotransmitters in rats following acute risperidone. Brain research. vol 801. issue 1-2. 1999-05-12. PMID:9729373. |
in the striatum, risperidone increased extracellular levels of dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac) at all doses and the serotonin (5-ht) metabolite, 5-hydroxyindoleacetic acid (5-hiaa), at the highest dose. |
1999-05-12 |
2023-08-12 |
rat |
| R B Ostroff, J C Nelso. Risperidone augmentation of selective serotonin reuptake inhibitors in major depression. The Journal of clinical psychiatry. vol 60. issue 4. 1999-05-06. PMID:10221288. |
risperidone augmentation of selective serotonin reuptake inhibitors in major depression. |
1999-05-06 |
2023-08-12 |
Not clear |
| R B Ostroff, J C Nelso. Risperidone augmentation of selective serotonin reuptake inhibitors in major depression. The Journal of clinical psychiatry. vol 60. issue 4. 1999-05-06. PMID:10221288. |
this report examines the clinical use of risperidone to augment selective serotonin reuptake inhibitor (ssri) anti-depressants in patients who have not responded to ssri therapy. |
1999-05-06 |
2023-08-12 |
Not clear |
| M Hemedah, I M Coupar, F J Mitchelso. [3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum. British journal of pharmacology. vol 126. issue 1. 1999-05-03. PMID:10051134. |
[3h]-mesulergine binding in the rat brain and guinea-pig ileum was displaced with the agonists 5-carboxamidotryptamine (5-ct) > 5-hydroxytryptamine (5-ht) > or = 5-methoxytryptamine (5-meot) > sumatriptan and the antagonists risperidone > or = lsd > or = metergoline > ritanserin > > pindolol. |
1999-05-03 |
2023-08-12 |
rat |
| S Morisset, U G Sahm, E Traiffort, J Tardivel-Lacombe, J M Arrang, J C Schwart. Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade. The Journal of pharmacology and experimental therapeutics. vol 288. issue 2. 1999-02-22. PMID:9918563. |
other antipsychotics displaying, such as clozapine and olanzapine, high 5-hydroxytryptamine (5-ht)2a receptor antagonist potency, i.e., risperidone, thioridazine, seroquel, and iloperidone, also enhanced markedly tele-methylhistamine levels. |
1999-02-22 |
2023-08-12 |
mouse |
| H Jones, V A Curtis, P A Wright, J V Luce. Risperidone is associated with blunting of D-fenfluramine evoked serotonergic responses in schizophrenia. International clinical psychopharmacology. vol 13. issue 5. 1999-01-29. PMID:9817624. |
significantly reduced 5-ht mediated serum prolactin responses were seen in risperidone treated patients. |
1999-01-29 |
2023-08-12 |
Not clear |
| H Jones, V A Curtis, P A Wright, J V Luce. Risperidone is associated with blunting of D-fenfluramine evoked serotonergic responses in schizophrenia. International clinical psychopharmacology. vol 13. issue 5. 1999-01-29. PMID:9817624. |
risperidone treatment was associated with a significant functional in-vivo 5-ht antagonism similar to clozapine. |
1999-01-29 |
2023-08-12 |
Not clear |
| H Jones, V A Curtis, P A Wright, J V Luce. Risperidone is associated with blunting of D-fenfluramine evoked serotonergic responses in schizophrenia. International clinical psychopharmacology. vol 13. issue 5. 1999-01-29. PMID:9817624. |
5-ht antagonism may contribute to the efficacy of risperidone against positive schizophrenic symptoms. |
1999-01-29 |
2023-08-12 |
Not clear |
| W J Naja, J P Reneric, M P Bouvar. [Atypical neuroleptics in the child and adolescent]. L'Encephale. vol 24. issue 4. 1999-01-05. PMID:9809243. |
the pharmacological action of clozapine and risperidone is mainly on d2 and 5ht. |
1999-01-05 |
2023-08-12 |
human |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Modulation of central serotonergic neurotransmission by risperidone: underlying mechanism(s) and significance of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723122. |
the effects of risperidone on brain 5-hydroxytryptamine (5-ht) neuronal activity were investigated using microdialysis in the frontal cortex (fc) or the dorsal raphe nucleus (drn) as well as single cell recording in the drn. |
1998-11-18 |
2023-08-12 |
rat |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Modulation of central serotonergic neurotransmission by risperidone: underlying mechanism(s) and significance of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723122. |
systemic administration of risperidone (0.6 and 2.0 mg/kg, s.c.) dose-dependently increased 5-ht output in both the fc and the drn. |
1998-11-18 |
2023-08-12 |
rat |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Modulation of central serotonergic neurotransmission by risperidone: underlying mechanism(s) and significance of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723122. |
local cortical administration of both risperidone or idazoxan enhanced the 5-ht efflux in the fc, whereas local raphe administration of risperidone but not idazoxan increased the output of 5-ht in the drn. |
1998-11-18 |
2023-08-12 |
rat |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Modulation of central serotonergic neurotransmission by risperidone: underlying mechanism(s) and significance of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723122. |
effectively antagonized the inhibition of 5-ht cells induced by risperidone, but failed to prevent the prazosin-induced decrease in 5-ht cell firing in the drn. |
1998-11-18 |
2023-08-12 |
rat |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Modulation of central serotonergic neurotransmission by risperidone: underlying mechanism(s) and significance of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723122. |
the inhibitory effect of risperidone on 5-ht cell firing in the drn was significantly attenuated in rats pretreated with the 5-ht depletor pcpa (p-chlorophenylalanine; 300 mg/kg/day i.p. |
1998-11-18 |
2023-08-12 |
rat |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Modulation of central serotonergic neurotransmission by risperidone: underlying mechanism(s) and significance of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723122. |
consequently, the risperidone-induced increase in 5-ht output in the fc may be related to its alpha 2 adrenoceptor antagonistic action, an effect probably executed at the nerve terminal level, whereas the reduction in 5-ht cell firing by risperidone appears to be associated with increased availability of 5-ht in the somatodendritic region of the neurones leading to an enhanced 5-ht1a autoreceptor activation and, in turn, to inhibition of cell firing. |
1998-11-18 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, J Dai, H Y Meltze. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. European journal of pharmacology. vol 351. issue 2. 1998-10-26. PMID:9686999. |
amperozide, clozapine, olanzapine and risperidone are more potent serotonin (5-hydroxytryptamine, 5-ht)2a receptor antagonists than dopamine d2-like receptor antagonists. |
1998-10-26 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, J Dai, H Y Meltze. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. European journal of pharmacology. vol 351. issue 2. 1998-10-26. PMID:9686999. |
risperidone (1 mg/kg) and clozapine (20 mg/kg) significantly increased extracellular 5-ht levels in the medial prefrontal cortex and the nucleus accumbens, respectively. |
1998-10-26 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, J Dai, H Y Meltze. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. European journal of pharmacology. vol 351. issue 2. 1998-10-26. PMID:9686999. |
the increase in extracellular 5-ht levels in the medial prefrontal cortex or nucleus accumbens following amperozide, clozapine, or risperidone administration may not be related to the effect on psychotic symptoms but could be related to effects on other types of psychopathology such as depression, negative symptoms, or cognition. |
1998-10-26 |
2023-08-12 |
rat |
| J Ciprian-Ollivier, M G Cetkovich-Bakma. Altered consciousness states and endogenous psychoses: a common molecular pathway? Schizophrenia research. vol 28. issue 2-3. 1998-05-14. PMID:9468359. |
interest in the role of indolamines in the pathogenesis of psychoses has been renewed in recent years by the development of atypical antipsychotic drugs such as clozapine, olanzapine, and risperidone, which act on serotonin receptors. |
1998-05-14 |
2023-08-12 |
Not clear |