| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Ciprian-Ollivier, M G Cetkovich-Bakma. Altered consciousness states and endogenous psychoses: a common molecular pathway? Schizophrenia research. vol 28. issue 2-3. 1998-05-14. PMID:9468359. |
interest in the role of indolamines in the pathogenesis of psychoses has been renewed in recent years by the development of atypical antipsychotic drugs such as clozapine, olanzapine, and risperidone, which act on serotonin receptors. |
1998-05-14 |
2023-08-12 |
Not clear |
| M J Mijnster, A Schotte, G J Docter, P Voor. Effects of risperidone and haloperidol on tachykinin and opioid precursor peptide mRNA levels in the caudate-putamen and nucleus accumbens of the rat. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517839. |
furthermore, we studied the contribution of the dopamine d2 and serotonin 5-ht2a antagonist components of risperidone in establishing its effects on neuropeptide mrna levels in the striatum. |
1998-04-30 |
2023-08-12 |
rat |
| M O'Connor, H Silve. Adding risperidone to selective serotonin reuptake inhibitor improves chronic depression. Journal of clinical psychopharmacology. vol 18. issue 1. 1998-04-02. PMID:9472852. |
adding risperidone to selective serotonin reuptake inhibitor improves chronic depression. |
1998-04-02 |
2023-08-12 |
Not clear |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
the effects of risperidone on brain 5-hydroxytryptamine (5-ht) neuronal functions were investigated and compared with other antipsychotic drugs and selective receptor antagonists by use of single cell recording and microdialysis in the dorsal raphe nucleus (drn). |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
), a drug previously shown to antagonize effectively the inhibition of 5-ht cells induced by risperidone, failed to prevent the prazosin-induced decrease in 5-ht cell firing. |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
the inhibitory effect of risperidone on 5-ht cell firing in the drn was significantly attenuated in rats pretreated with the 5-ht depletor pcpa (p-chlorophenylalanine; 300 mg kg-1, i.p., day-1 for 3 consecutive days) in comparison with drug naive animals. |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
administration of risperidone (2.0 mg kg-1, s.c.) significantly enhanced 5-ht output in the drn. |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
consequently, the reduction in 5-ht cell firing by risperidone appears to be related to increased availability of 5-ht in the somatodendritic region of the neurones leading to an enhanced 5-ht1a autoreceptor activation and, in turn, to inhibition of firing, and is probably only to a minor extent caused by its alpha 1-adrenoceptor antagonistic action. |
1998-01-28 |
2023-08-12 |
rat |
| G Mas. Atypical neuroleptics in the treatment of early onset schizophrenia. Panminerva medica. vol 39. issue 3. 1998-01-13. PMID:9360425. |
the more recently synthesized neuroleptics, with combined action on dopamine and serotonin receptors, have been called atypical neuroleptics; the atypical neuroleptics currently used in clinical practice are clozapine and risperidone. |
1998-01-13 |
2023-08-12 |
Not clear |
| M B Knable, A Heinz, T Raedler, D R Weinberge. Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels. Psychiatry research. vol 75. issue 2. 1997-12-16. PMID:9351491. |
risperidone is an antipsychotic drug with high affinity at dopamine d2 and serotonin 5-ht2 receptors. |
1997-12-16 |
2023-08-12 |
human |
| W Liu, M Alrej. Atypical antipsychotics block the excitatory effects of serotonin in septohippocampal neurons in the rat. Neuroscience. vol 79. issue 2. 1997-09-05. PMID:9200722. |
additionally, the atypical antipsychotics risperidone and clozapine but not the typical antipsychotic haloperidol, blocked the excitatory effects of serotonin at clinically relevant concentrations. |
1997-09-05 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
we have previously shown that risperidone, an antipsychotic drug with high affinity for 5-hydroxytryptamine (5-ht)2a and dopamine (da)2 receptors, as well as for alpha 2- and alpha 2-adrenoceptors, enhances 5-ht metabolism selectively in the rat frontal cortex (fc). |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
to further study the influence of risperidone on central 5-ht systems, we compared its effects on dialysate 5-ht in the fc, as assessed by microdialysis, with those obtained with other antipsychotic drugs, i.e., clozapine, haloperidol, and amperozide, as well as with the selective alpha 2- or 5-ht2a receptor antagonists idazoxan or mdl 100,907, respectively. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
the underlying mechanism for risperidone's effect on 5-ht output in the fc was also investigated using single-cell recording in the dorsal raphe nucleus (drn). |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
administration of risperidone (0.2, 0.6, and 2.0 mg/kg, sc) dose-dependently increased 5-ht levels in the fc. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
local administration of risperidone or idazoxan (1.0-1000 mumol/l) in the fc dose-dependently increased dialysate levels of 5-ht in this region. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
on the other hand, risperidone 25-800 micrograms/kg, iv) dose-dependently decreased the firing rate of 5-ht cells in the drn, an effect that was largely antagonized by pretreatment with the selective 5-ht1a receptor antagonist way 100,635 (5.0 micrograms/kg, iv). |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
the inhibition of 5-ht cell firing by risperidone is probably secondary to increased 5-ht availability, e.g., in the drn, since it could be antagonized by a 5-ht1a receptor antagonist. |
1997-08-13 |
2023-08-12 |
rat |