| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Mijnster, A Schotte, G J Docter, P Voor. Effects of risperidone and haloperidol on tachykinin and opioid precursor peptide mRNA levels in the caudate-putamen and nucleus accumbens of the rat. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517839. |
furthermore, we studied the contribution of the dopamine d2 and serotonin 5-ht2a antagonist components of risperidone in establishing its effects on neuropeptide mrna levels in the striatum. |
1998-04-30 |
2023-08-12 |
rat |
| M O'Connor, H Silve. Adding risperidone to selective serotonin reuptake inhibitor improves chronic depression. Journal of clinical psychopharmacology. vol 18. issue 1. 1998-04-02. PMID:9472852. |
adding risperidone to selective serotonin reuptake inhibitor improves chronic depression. |
1998-04-02 |
2023-08-12 |
Not clear |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
the effects of risperidone on brain 5-hydroxytryptamine (5-ht) neuronal functions were investigated and compared with other antipsychotic drugs and selective receptor antagonists by use of single cell recording and microdialysis in the dorsal raphe nucleus (drn). |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
), a drug previously shown to antagonize effectively the inhibition of 5-ht cells induced by risperidone, failed to prevent the prazosin-induced decrease in 5-ht cell firing. |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
the inhibitory effect of risperidone on 5-ht cell firing in the drn was significantly attenuated in rats pretreated with the 5-ht depletor pcpa (p-chlorophenylalanine; 300 mg kg-1, i.p., day-1 for 3 consecutive days) in comparison with drug naive animals. |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
administration of risperidone (2.0 mg kg-1, s.c.) significantly enhanced 5-ht output in the drn. |
1998-01-28 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
consequently, the reduction in 5-ht cell firing by risperidone appears to be related to increased availability of 5-ht in the somatodendritic region of the neurones leading to an enhanced 5-ht1a autoreceptor activation and, in turn, to inhibition of firing, and is probably only to a minor extent caused by its alpha 1-adrenoceptor antagonistic action. |
1998-01-28 |
2023-08-12 |
rat |
| G Mas. Atypical neuroleptics in the treatment of early onset schizophrenia. Panminerva medica. vol 39. issue 3. 1998-01-13. PMID:9360425. |
the more recently synthesized neuroleptics, with combined action on dopamine and serotonin receptors, have been called atypical neuroleptics; the atypical neuroleptics currently used in clinical practice are clozapine and risperidone. |
1998-01-13 |
2023-08-12 |
Not clear |
| M B Knable, A Heinz, T Raedler, D R Weinberge. Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels. Psychiatry research. vol 75. issue 2. 1997-12-16. PMID:9351491. |
risperidone is an antipsychotic drug with high affinity at dopamine d2 and serotonin 5-ht2 receptors. |
1997-12-16 |
2023-08-12 |
human |
| W Liu, M Alrej. Atypical antipsychotics block the excitatory effects of serotonin in septohippocampal neurons in the rat. Neuroscience. vol 79. issue 2. 1997-09-05. PMID:9200722. |
additionally, the atypical antipsychotics risperidone and clozapine but not the typical antipsychotic haloperidol, blocked the excitatory effects of serotonin at clinically relevant concentrations. |
1997-09-05 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
we have previously shown that risperidone, an antipsychotic drug with high affinity for 5-hydroxytryptamine (5-ht)2a and dopamine (da)2 receptors, as well as for alpha 2- and alpha 2-adrenoceptors, enhances 5-ht metabolism selectively in the rat frontal cortex (fc). |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
to further study the influence of risperidone on central 5-ht systems, we compared its effects on dialysate 5-ht in the fc, as assessed by microdialysis, with those obtained with other antipsychotic drugs, i.e., clozapine, haloperidol, and amperozide, as well as with the selective alpha 2- or 5-ht2a receptor antagonists idazoxan or mdl 100,907, respectively. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
the underlying mechanism for risperidone's effect on 5-ht output in the fc was also investigated using single-cell recording in the dorsal raphe nucleus (drn). |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
administration of risperidone (0.2, 0.6, and 2.0 mg/kg, sc) dose-dependently increased 5-ht levels in the fc. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
local administration of risperidone or idazoxan (1.0-1000 mumol/l) in the fc dose-dependently increased dialysate levels of 5-ht in this region. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
on the other hand, risperidone 25-800 micrograms/kg, iv) dose-dependently decreased the firing rate of 5-ht cells in the drn, an effect that was largely antagonized by pretreatment with the selective 5-ht1a receptor antagonist way 100,635 (5.0 micrograms/kg, iv). |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
the inhibition of 5-ht cell firing by risperidone is probably secondary to increased 5-ht availability, e.g., in the drn, since it could be antagonized by a 5-ht1a receptor antagonist. |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
the enhanced 5-ht output in the fc by risperidone may be of particular relevance for the treatment of schizophrenia when associated with depression and in schizoaffective disorder. |
1997-08-13 |
2023-08-12 |
rat |