| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F J Nasif, G R Cuadra, O A Ramire. Effects of chronic risperidone on central noradrenergic transmission. European journal of pharmacology. vol 394. issue 1. 2000-05-31. PMID:10771036. |
similarly, the id(50) for (+/-)-2,5-dimetoxy-4-iodoamphetamine (doi), an agonist of 5-ht(2) receptors which inhibits the activity of locus coeruleus neurons by acting on these receptors, did not show any differences between the firing rate of these neurons in risperidone treated rats and controls. |
2000-05-31 |
2023-08-12 |
rat |
| E C Lauterbach, A Abdelhamid, J B Annandal. Posthallucinogen-like visual illusions (palinopsia) with risperidone in a patient without previous hallucinogen exposure: possible relation to serotonin 5HT2a receptor blockade. Pharmacopsychiatry. vol 33. issue 1. 2000-05-10. PMID:10721882. |
posthallucinogen-like visual illusions (palinopsia) with risperidone in a patient without previous hallucinogen exposure: possible relation to serotonin 5ht2a receptor blockade. |
2000-05-10 |
2023-08-12 |
Not clear |
| J Ichikawa, H Y Meltze. The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens. Brain research. vol 858. issue 2. 2000-04-24. PMID:10708676. |
in both str and nac, r(+)-8-oh-dpat (0.2 mg/kg) decreased basal da release; r(+)-8-oh-dpat (0.05 mg/kg) inhibited da release produced by the 5-ht(2a)/d(2) receptor antagonists clozapine (20 mg/kg), low dose risperidone (0.01 and 0. |
2000-04-24 |
2023-08-12 |
rat |
| S Hamilton, K Malon. Serotonin syndrome during treatment with paroxetine and risperidone. Journal of clinical psychopharmacology. vol 20. issue 1. 2000-03-15. PMID:10653219. |
serotonin syndrome during treatment with paroxetine and risperidone. |
2000-03-15 |
2023-08-12 |
Not clear |
| S M Dursun, J K Patel, J G Burke, M A Revele. Effects of typical antipsychotic drugs and risperidone on the quality of sleep in patients with schizophrenia: a pilot study. Journal of psychiatry & neuroscience : JPN. vol 24. issue 4. 2000-02-29. PMID:10516800. |
to investigate the effects of a newer antipsychotic drug, risperidone (a potent serotonin 5-ht2a/2c and dopamine d2-receptor blocker), on the quantity and quality of sleep in patients with schizophrenia. |
2000-02-29 |
2023-08-12 |
Not clear |
| C J McDougle, L Scahill, J T McCracken, M G Aman, E Tierney, L E Arnold, B J Freeman, A Martin, J J McGough, P Cronin, D J Posey, M A Riddle, L Ritz, N B Swiezy, B Vitiello, F R Volkmar, N A Votolato, P Walso. Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. Background and rationale for an initial controlled study of risperidone. Child and adolescent psychiatric clinics of North America. vol 9. issue 1. 2000-02-29. PMID:10674197. |
risperidone has potent effects on 5-ht and da neuronal systems, both of which have been implicated in the pathophysiology of autism. |
2000-02-29 |
2023-08-12 |
Not clear |
| P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462130. |
the antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. |
1999-10-12 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462130. |
we have previously shown that the antipsychotic drug risperidone enhances serotonin (5-ht) output in the rat frontal cortex (fc), but the precise underlying mechanism has not been revealed. |
1999-10-12 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462130. |
consequently, the present study using in vivo microdialysis was undertaken to (i) characterize the effects of alpha2d, 5-ht1b and 5-ht1d receptor stimulation or blockade on 5-ht efflux in the fc given the purported regulatory role of these sites on 5-ht release, and (ii) to investigate the ability of risperidone to interfere with these receptors in order to examine their putative role in the facilitatory action or risperidone on cortical 5-ht output. |
1999-10-12 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462130. |
cortical perfusion with risperidone or the alpha2a/d, 5-ht1b and 5-ht1b/1d receptor antagonists idazoxan, isamoltane or gr 127,935, respectively, dose-dependently increased 5-ht efflux in the fc. |
1999-10-12 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462130. |
risperidone attenuated the decrease in cortical 5-ht efflux elicited by clonidine or cp 135,807 but failed to affect the decrease elicited by cp 93,129. |
1999-10-12 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, T H Svensso. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462130. |
moreover, the results indicate that risperidone acts as an antagonist at alpha2d and possibly 5-ht1d receptors in vivo, two properties which most likely contribute to its stimulatory effect on cortical 5-ht efflux. |
1999-10-12 |
2023-08-12 |
rat |
| K D Fitzgerald, C M Stewart, V Tawile, D R Rosenber. Risperidone augmentation of serotonin reuptake inhibitor treatment of pediatric obsessive compulsive disorder. Journal of child and adolescent psychopharmacology. vol 9. issue 2. 1999-09-30. PMID:10461822. |
risperidone augmentation of serotonin reuptake inhibitor treatment of pediatric obsessive compulsive disorder. |
1999-09-30 |
2023-08-12 |
Not clear |
| K D Fitzgerald, C M Stewart, V Tawile, D R Rosenber. Risperidone augmentation of serotonin reuptake inhibitor treatment of pediatric obsessive compulsive disorder. Journal of child and adolescent psychopharmacology. vol 9. issue 2. 1999-09-30. PMID:10461822. |
in this case series, risperidone augmentation of treatment with a serotonin reuptake inhibitor (sri) is described in four pediatric patients diagnosed with obsessive compulsive disorder (ocd). |
1999-09-30 |
2023-08-12 |
Not clear |
| H Y Meltze. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432496. |
recent interest in the role of serotonin (5-ht) in antipsychotic drug action is based mainly upon the fact that antipsychotic drugs such as clozapine, olanzapine, quetiapine, risperidone, sertindole, and ziprasidone are potent 5-ht2a receptor antagonists and relatively weaker dopamine d2 antagonists. |
1999-09-17 |
2023-08-12 |
Not clear |
| J A Terrón, A Falcón-Ner. Pharmacological evidence for the 5-HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries. British journal of pharmacology. vol 127. issue 3. 1999-09-01. PMID:10401550. |
in dog basilar artery, pre-incubated with gr127935 (1 microm) and ketanserin (0.1 microm) and precontracted with prostaglandin f2 alpha (2 microm), the 5-ht7 ligands, clozapine (1 microm), mesulergine (0.3 microm), methiothepin (3 nm), risperidone (3 nm), spiperone (1 microm) and ly215840 (10-100 nm), produced significant rightward shifts of the concentration-response curves for 5-ht and 5-ct. only methiothepin and risperidone reduced significantly the maximum relaxant response (emax), whilst the other drugs behaved as competitive antagonists with affinity values (pkb) that significantly correlated with their binding affinity (pki) at recombinant 5-ht7 receptors. |
1999-09-01 |
2023-08-12 |
dog |
| C N Epperson, D Fasula, S Wasylink, L H Price, C J McDougl. Risperidone addition in serotonin reuptake inhibitor-resistant trichotillomania: three cases. Journal of child and adolescent psychopharmacology. vol 9. issue 1. 1999-08-02. PMID:10357517. |
risperidone addition in serotonin reuptake inhibitor-resistant trichotillomania: three cases. |
1999-08-02 |
2023-08-12 |
Not clear |
| P B Bergqvist, J Dong, P Blie. Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. Psychopharmacology. vol 143. issue 1. 1999-07-02. PMID:10227084. |
low doses of the atypical antipsychotic drug risperidone are effective in patients with obsessive compulsive disorder (ocd) not responding to serotonin (5-ht) reuptake inhibitors, although higher doses have been reported to induce ocd symptoms in psychotic patients. |
1999-07-02 |
2023-08-12 |
rat |
| P B Bergqvist, J Dong, P Blie. Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. Psychopharmacology. vol 143. issue 1. 1999-07-02. PMID:10227084. |
these results suggest that the 5-ht2 response in the ofc is more akin to the 5-ht2c subtype and that the deleterious effect sometimes observed with high doses of risperidone and clozapine may be due to a decrease in 5-ht neurotransmission. |
1999-07-02 |
2023-08-12 |
rat |
| S Nyberg, B Eriksson, G Oxenstierna, C Halldin, L Fard. Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients. The American journal of psychiatry. vol 156. issue 6. 1999-06-16. PMID:10360125. |
the aim of this positron emission tomography (pet) study was to suggest a minimal effective dose of risperidone based on measurements of dopamine d2 and serotonin 5-ht2a receptor occupancy. |
1999-06-16 |
2023-08-12 |
Not clear |