| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefan Leuch. Amisulpride a selective dopamine antagonist and atypical antipsychotic: results of a meta-analysis of randomized controlled trials. The international journal of neuropsychopharmacology. vol 7 Suppl 1. 2004-09-14. PMID:14972080. |
the pharmacological profiles of the atypical antipsychotics, clozapine, olanzapine, quetiapine and risperidone, all show a combined serotonin (5-ht2) and dopamine type-2 (d2) receptor antagonism. |
2004-09-14 |
2023-08-12 |
Not clear |
| Mohammad Razaq, Muneeb Samm. A case of risperidone-induced hypothermia. American journal of therapeutics. vol 11. issue 3. 2004-08-17. PMID:15133539. |
risperidone has more affinity for serotonin type 2 (5-ht(2)) than for d(2) receptors. |
2004-08-17 |
2023-08-12 |
Not clear |
| Mohammad Razaq, Muneeb Samm. A case of risperidone-induced hypothermia. American journal of therapeutics. vol 11. issue 3. 2004-08-17. PMID:15133539. |
risperidone has higher potency for occupying 5-ht(2) than d(2) receptors. |
2004-08-17 |
2023-08-12 |
Not clear |
| K Nisijima, K Shioda, T Yoshino, K Takano, S Kat. Memantine, an NMDA antagonist, prevents the development of hyperthermia in an animal model for serotonin syndrome. Pharmacopsychiatry. vol 37. issue 2. 2004-08-02. PMID:15048612. |
in the present study, the efficacy of nmda antagonists, including memantine and mk-801, and potent 5-ht (2a) antagonists, including risperidone and ketanserin, was evaluated in a 5-ht syndrome animal model. |
2004-08-02 |
2023-08-12 |
Not clear |
| Eric Hollander, Nicolò Baldini Rossi, Erica Sood, Stefano Pallant. Risperidone augmentation in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. The international journal of neuropsychopharmacology. vol 6. issue 4. 2004-05-06. PMID:14604454. |
this double-blind, placebo-controlled trial was performed to determine the efficacy and tolerability of 8 wk of risperidone augmentation of serotonin reuptake inhibitor (sri) treatment in adult subjects with treatment-resistant obsessive-compulsive disorder (ocd) (failure of at least two sri trials). |
2004-05-06 |
2023-08-12 |
human |
| Geoffrey K Isbiste. Comment: combination risperidone and SSRI-induced serotonin syndrome. The Annals of pharmacotherapy. vol 37. issue 10. 2004-02-26. PMID:14519058. |
comment: combination risperidone and ssri-induced serotonin syndrome. |
2004-02-26 |
2023-08-12 |
Not clear |
| L M McDonald, P M Moran, G N Vythelingum, M H Joseph, J D Stephenson, J A Gra. Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning. Psychopharmacology. vol 169. issue 3-4. 2004-02-23. PMID:14530903. |
clozapine-like atypical antipsychotic drugs, such as olanzapine, risperidone and sertindole, bind most strongly to 5-ht(2a) receptors, which may contribute to their antipsychotic effects. |
2004-02-23 |
2023-08-12 |
rat |
| Patricia A Broderick, David N Rahni, Yueping Zho. Acute and subacute effects of risperidone and cocaine on accumbens dopamine and serotonin release using in vivo microvoltammetry on line with open-field behavior. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 6. 2004-01-05. PMID:14499322. |
acute and subacute effects of risperidone and cocaine on accumbens dopamine and serotonin release using in vivo microvoltammetry on line with open-field behavior. |
2004-01-05 |
2023-08-12 |
human |
| Patricia A Broderick, David N Rahni, Yueping Zho. Acute and subacute effects of risperidone and cocaine on accumbens dopamine and serotonin release using in vivo microvoltammetry on line with open-field behavior. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 6. 2004-01-05. PMID:14499322. |
the purpose was to evaluate the neuropharmacology of the 5-ht(2)/da(2) antagonist risperidone in its current therapeutic role as an atypical antipsychotic medication as well as in its potential role as pharmacotherapy for cocaine psychosis and withdrawal symptoms. |
2004-01-05 |
2023-08-12 |
human |
| Patricia A Broderick, David N Rahni, Yueping Zho. Acute and subacute effects of risperidone and cocaine on accumbens dopamine and serotonin release using in vivo microvoltammetry on line with open-field behavior. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 6. 2004-01-05. PMID:14499322. |
results showed that (1) acute administration of risperidone (2 mg/kg sc) significantly increased da and 5-ht release in nacc above baseline (habituation) values (p<.001) while locomotion and stereotypy were virtually unaffected. |
2004-01-05 |
2023-08-12 |
human |
| Patricia A Broderick, David N Rahni, Yueping Zho. Acute and subacute effects of risperidone and cocaine on accumbens dopamine and serotonin release using in vivo microvoltammetry on line with open-field behavior. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 6. 2004-01-05. PMID:14499322. |
(b) taken together with other data, these acute studies suggest that risperidone may possibly act via inhibition of presynaptic autoreceptors to produce the observed increases in accumbens da and 5-ht release, whereas cocaine may be acting at least in part via serotoninergic modulation of da postsynaptically. |
2004-01-05 |
2023-08-12 |
human |
| Craig R Rush, William W Stoops, Lon R Hays, Paul E A Glaser, Lon S Hay. Risperidone attenuates the discriminative-stimulus effects of d-amphetamine in humans. The Journal of pharmacology and experimental therapeutics. vol 306. issue 1. 2003-07-24. PMID:12676890. |
after acquiring the discrimination (i.e., > or = 80% correct responding on four consecutive days), the effects of a range of doses of d-amphetamine (0, 2.5, 5, 10, and 15 mg), alone and after pretreatment with risperidone (0 and 1 mg), a d2 dopamine and 5-hydroxytryptamine (5-ht)2 serotonin antagonist, were assessed. |
2003-07-24 |
2023-08-12 |
Not clear |
| A Dekeyne, L Iob, M J Milla. Generalization of clozapine as compared to other antipsychotic agents to a discriminative stimulus elicited by the serotonin (5-HT)2A antagonist, MDL100,907. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668046. |
s16924 (0.05 mg/kg, s.c.), s18327 (0.09 mg/kg, s.c.), quetiapine (1.8 mg/kg, s.c.), risperidone (0.02 mg/kg, s.c.) and ziprasidone (0.01 mg/kg, s.c.), antipsychotics which possess-like clozapine-marked affinity for 5-ht(2a) versus d(2) receptors, also generalized to mdl100,907. |
2003-06-23 |
2023-08-12 |
rat |
| Lefteris Lykouras, Basil Alevizos, Panayiota Michalopoulou, Andreas Rabavila. Obsessive-compulsive symptoms induced by atypical antipsychotics. A review of the reported cases. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 3. 2003-06-23. PMID:12691768. |
atypical aps, mainly risperidone and olanzapine, have been used as adjunctive treatment in (selective) serotonin reuptake inhibitor [(s)sri]-refractory cases with obsessive symptoms. |
2003-06-23 |
2023-08-12 |
Not clear |
| Shyam D Karki, Gule-Rana Masoo. Combination risperidone and SSRI-induced serotonin syndrome. The Annals of pharmacotherapy. vol 37. issue 3. 2003-06-20. PMID:12639169. |
combination risperidone and ssri-induced serotonin syndrome. |
2003-06-20 |
2023-08-12 |
Not clear |
| Shyam D Karki, Gule-Rana Masoo. Combination risperidone and SSRI-induced serotonin syndrome. The Annals of pharmacotherapy. vol 37. issue 3. 2003-06-20. PMID:12639169. |
to report 2 cases of serotonin syndrome associated with combined therapy of risperidone and selective serotonin-reuptake inhibitors (ssris) in elderly patients. |
2003-06-20 |
2023-08-12 |
Not clear |
| Robert R Conley, Deanna L Kell. Current status of antipsychotic treatment. Current drug targets. CNS and neurological disorders. vol 1. issue 2. 2003-06-18. PMID:12769630. |
the second generation antipsychotics (sgas), clozapine, risperidone, olanzapine, quetiapine and ziprasidone all have relatively high serotonin to dopamine binding ratios. |
2003-06-18 |
2023-08-12 |
Not clear |
| Yoshito Kamijo, Kazui Soma, Tomonori Nagai, Katsuyoshi Kurihara, Takashi Ohwad. Acute massive pulmonary thromboembolism associated with risperidone and conventional phenothiazines. Circulation journal : official journal of the Japanese Circulation Society. vol 67. issue 1. 2003-06-13. PMID:12520151. |
in 5 cases, chlorpromazine and other phenothiazines had been prescribed, whereas in 2 cases, risperidone, a mixed serotonin 5ht(2a) and dopamine d(2) receptor antagonist, had been taken for 40 days and 6 days, respectively. |
2003-06-13 |
2023-08-12 |
Not clear |
| Lene Ørskov Reuther, Steffen Thirstrup Pedersen, Anita Mandrup Røn. [Drug-induced seizures]. Ugeskrift for laeger. vol 165. issue 14. 2003-06-02. PMID:12715674. |
the risk of seizure is greatest in patients predisposed to seizure by use of conventional antipsychotics, olanzapine, risperidone, bupropion, tricyclic antidepressants/selective serotonin reuptake inhibitors, cyclosporin, interferon, corticosteroids, propofol, imipenem, chloroquine, and mefloquine. |
2003-06-02 |
2023-08-12 |
Not clear |
| Jonathan E Cohen, Chiadi U Onyike, Virginia L McElroy, Allison H Lin, Thomas W Abram. Pharmacological characterization of an adenylyl cyclase-coupled 5-HT receptor in aplysia: comparison with mammalian 5-HT receptors. Journal of neurophysiology. vol 89. issue 3. 2003-05-09. PMID:12611939. |
eight of the 14 antagonists tested were effective against 5-ht(apac) in cns membranes with the following rank order of potency: methiothepin > metergoline approximately fluphenazine > clozapine > cyproheptadine approximately risperidone approximately ritanserin > nan-190. |
2003-05-09 |
2023-08-12 |
aplysia |