| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sziraki, M N Lipovac, A Hashim, H Sershen, D Allen, T Cooper, P Czobor, A Lajth. Differences in nicotine-induced dopamine release and nicotine pharmacokinetics between Lewis and Fischer 344 rats. Neurochemical research. vol 26. issue 6. 2002-01-29. PMID:11519721. |
dopamine release expressed in relative terms (as percent of baseline), however, was significantly greater in lewis rats than in fischer rats at 30 min after the first nicotine injection. |
2002-01-29 |
2023-08-12 |
rat |
| Sziraki, M N Lipovac, A Hashim, H Sershen, D Allen, T Cooper, P Czobor, A Lajth. Differences in nicotine-induced dopamine release and nicotine pharmacokinetics between Lewis and Fischer 344 rats. Neurochemical research. vol 26. issue 6. 2002-01-29. PMID:11519721. |
a significant effect of nicotine was lowering the electrically induced release of dopamine in frontal cortex slices from fischer brain and increasing this dopamine release in the ventral tegmentum of lewis brain slices indicating that the ventral tegmentum, an area controlling dopamine release in the accumbens, is more responsive to nicotine in the lewis rat. |
2002-01-29 |
2023-08-12 |
rat |
| Sziraki, M N Lipovac, A Hashim, H Sershen, D Allen, T Cooper, P Czobor, A Lajth. Differences in nicotine-induced dopamine release and nicotine pharmacokinetics between Lewis and Fischer 344 rats. Neurochemical research. vol 26. issue 6. 2002-01-29. PMID:11519721. |
several factors contribute to nicotine preference, including the endogenous dopamine level, and the sensitivity of ventral tegmentum neurons to nicotine-induced dopamine release. |
2002-01-29 |
2023-08-12 |
rat |
| T T Iyaniwura, A E Wright, D J Balfou. Evidence that mesoaccumbens dopamine and locomotor responses to nicotine in the rat are influenced by pretreatment dose and strain. Psychopharmacology. vol 158. issue 1. 2002-01-15. PMID:11685386. |
evidence that mesoaccumbens dopamine and locomotor responses to nicotine in the rat are influenced by pretreatment dose and strain. |
2002-01-15 |
2023-08-12 |
rat |
| T T Iyaniwura, A E Wright, D J Balfou. Evidence that mesoaccumbens dopamine and locomotor responses to nicotine in the rat are influenced by pretreatment dose and strain. Psychopharmacology. vol 158. issue 1. 2002-01-15. PMID:11685386. |
sensitisation of the mesoaccumbens dopamine response to nicotine has been implicated in the development of nicotine dependence. |
2002-01-15 |
2023-08-12 |
rat |
| T A Green, P A Crooks, M T Bardo, L P Dwoski. Contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3H]dopamine overflow from rat nucleus accumbens slices. Biochemical pharmacology. vol 62. issue 12. 2002-01-15. PMID:11755112. |
contributory role for nornicotine in nicotine neuropharmacology: nornicotine-evoked [3h]dopamine overflow from rat nucleus accumbens slices. |
2002-01-15 |
2023-08-12 |
rat |
| J W Pettegrew, K Panchalingam, R J McClure, J Levin. Brain metabolic effects of acute nicotine. Neurochemical research. vol 26. issue 2. 2002-01-14. PMID:11478746. |
the behavioral rewards from (-)nicotine and perhaps addiction appear to be related to dopamine release. |
2002-01-14 |
2023-08-12 |
rat |
| F M Zhou, Y Liang, J A Dan. Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nature neuroscience. vol 4. issue 12. 2002-01-11. PMID:11713470. |
nicotine at the concentration experienced by smokers also regulated dopamine release. |
2002-01-11 |
2023-08-12 |
mouse |
| E B Gauda, R Cooper, P K Akins, G W. Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion. Journal of applied physiology (Bethesda, Md. : 1985). vol 91. issue 5. 2002-01-03. PMID:11641357. |
we used in situ hybridization histochemistry to determine the effect of prenatal and early postnatal nicotine exposure on tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbetah), preproenkephalin (ppe), and d2-dopamine receptor mrna levels in the rat carotid body and petrosal ganglion during postnatal development. |
2002-01-03 |
2023-08-12 |
rat |
| E B Gauda, R Cooper, P K Akins, G W. Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion. Journal of applied physiology (Bethesda, Md. : 1985). vol 91. issue 5. 2002-01-03. PMID:11641357. |
dopamine d2-receptor mrna levels in the carotid body increased with postnatal age but were unaffected by nicotine exposure. |
2002-01-03 |
2023-08-12 |
rat |
| E B Gauda, R Cooper, P K Akins, G W. Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion. Journal of applied physiology (Bethesda, Md. : 1985). vol 91. issue 5. 2002-01-03. PMID:11641357. |
prenatal nicotine exposure upregulates mrnas involved in the synthesis of two inhibitory neuromodulators, dopamine and norepinephrine, in peripheral arterial chemoreceptors, which may contribute to abnormalities in cardiorespiratory control observed in nicotine exposed animals. |
2002-01-03 |
2023-08-12 |
rat |
| L Kent, F Middle, Z Hawi, M Fitzgerald, M Gill, C Feehan, N Craddoc. Nicotinic acetylcholine receptor alpha4 subunit gene polymorphism and attention deficit hyperactivity disorder. Psychiatric genetics. vol 11. issue 1. 2001-12-04. PMID:11409698. |
there are several lines of evidence suggesting that the nicotinic system may be functionally significant in adhd: (a) nicotine promotes the release of dopamine and has been shown to improve attention in adults with adhd, smokers and non-smokers; (b) adhd is a significant risk factor for early initiation of cigarette smoking in children; (c) maternal cigarette smoking appears to be a risk factor for adhd; (d) animal studies in rats and monkeys also suggest that nicotine may be involved in attentional systems and locomotor activity; and (e) a central nicotinic agonist, abt-418, improves attention in both monkeys and adhd adults. |
2001-12-04 |
2023-08-12 |
rat |
| S Nakamura, T Takahashi, H Yamashita, H Kawakam. Nicotinic acetylcholine receptors and neurodegenerative disease. Alcohol (Fayetteville, N.Y.). vol 24. issue 2. 2001-12-04. PMID:11522426. |
we observed an increase in extracellular dopamine concentrations after administration of nicotine through a microdialysis tube. |
2001-12-04 |
2023-08-12 |
Not clear |
| S Nakamura, T Takahashi, H Yamashita, H Kawakam. Nicotinic acetylcholine receptors and neurodegenerative disease. Alcohol (Fayetteville, N.Y.). vol 24. issue 2. 2001-12-04. PMID:11522426. |
nicotine might inhibit the uptake of dopamine through the nachr, which could serve as a preventive factor against neurodegenerative diseases. |
2001-12-04 |
2023-08-12 |
Not clear |
| P Rada, K Jensen, B G Hoebe. Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens. Psychopharmacology. vol 157. issue 1. 2001-10-25. PMID:11512050. |
effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens. |
2001-10-25 |
2023-08-12 |
rat |
| M J Neal, J R Cunningham, K L Matthew. Activation of nicotinic receptors on GABAergic amacrine cells in the rabbit retina indirectly stimulates dopamine release. Visual neuroscience. vol 18. issue 1. 2001-09-13. PMID:11347816. |
exposure of the retina to nicotine, epibatidine, and other nicotinic agonists increased the release of both gaba and dopamine. |
2001-09-13 |
2023-08-12 |
rabbit |
| M J Neal, J R Cunningham, K L Matthew. Activation of nicotinic receptors on GABAergic amacrine cells in the rabbit retina indirectly stimulates dopamine release. Visual neuroscience. vol 18. issue 1. 2001-09-13. PMID:11347816. |
these results suggested that nicotine might increase dopamine release indirectly by stimulating the release of gaba, which in turn inhibited the release of an inhibitory transmitter acting tonically on the dopaminergic amacrines. |
2001-09-13 |
2023-08-12 |
rabbit |
| M J Neal, J R Cunningham, K L Matthew. Activation of nicotinic receptors on GABAergic amacrine cells in the rabbit retina indirectly stimulates dopamine release. Visual neuroscience. vol 18. issue 1. 2001-09-13. PMID:11347816. |
however, metergoline, a 5ht1/5ht2 receptor antagonist, and ketanserin, a 5ht2a receptor antagonist, but not the 5ht1a antagonist way100635, increased the resting release of dopamine and blocked the effects of nicotine. |
2001-09-13 |
2023-08-12 |
rabbit |
| M J Neal, J R Cunningham, K L Matthew. Activation of nicotinic receptors on GABAergic amacrine cells in the rabbit retina indirectly stimulates dopamine release. Visual neuroscience. vol 18. issue 1. 2001-09-13. PMID:11347816. |
the 5ht1a/5ht7 agonist 8-hydroxy dpat inhibited both the nicotine and gaba-evoked release of dopamine. |
2001-09-13 |
2023-08-12 |
rabbit |
| J K Staley, S Krishnan-Sarin, S Zoghbi, G Tamagnan, M Fujita, J P Seibyl, P K Maciejewski, S O'Malley, R B Inni. Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse (New York, N.Y.). vol 41. issue 4. 2001-09-13. PMID:11494398. |
nicotine and other constituents of tobacco smoke elevate dopamine (da) and serotonin (5-ht) levels in brain and may cause homeostatic adaptations in da and 5-ht transporters. |
2001-09-13 |
2023-08-12 |
human |