| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anton N M Schoffelmeer, Taco J De Vries, George Wardeh, Henrica W M van de Ven, Louk J M J Vanderschure. Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943828. |
coadministration of mecamylamine during pretreatment with nicotine, amphetamine, or cocaine prevented the development of this long-term hyperreactivity of nucleus accumbens dopamine neurons. |
2002-04-22 |
2023-08-12 |
rat |
| Erik Dybing, Tore Sanne. [Nicotine dependence--medico-biological aspects]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 122. issue 3. 2002-04-18. PMID:11894603. |
nicotine acts as an addictive substance by binding to acetylcholine receptors and causing the release of dopamine in the brain, though other signalling substances are also important for the action of nicotine in the central nervous system. |
2002-04-18 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, J Russel Keath, Daniel S McGehe. Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron. vol 33. issue 6. 2002-04-08. PMID:11906697. |
a single nicotine exposure increases dopamine levels in the mesolimbic reward system for hours, but nicotine concentrations experienced by smokers desensitize nachrs on dopamine neurons in seconds to minutes. |
2002-04-08 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, J Russel Keath, Daniel S McGehe. Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron. vol 33. issue 6. 2002-04-08. PMID:11906697. |
here, we show that persistent modulation of both gabaergic and glutamatergic synaptic transmission by nicotine can contribute to the sustained increase in dopamine neuron excitability. |
2002-04-08 |
2023-08-12 |
Not clear |
| John G Partridge, Subbu Apparsundaram, Greg A Gerhardt, Jennifer Ronesi, David M Lovinge. Nicotinic acetylcholine receptors interact with dopamine in induction of striatal long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 7. 2002-04-08. PMID:11923419. |
dopamine release is modulated by activation of nicotinic receptors in the dorsal striatum, and activation of nicotinic receptors during high-frequency synaptic activation appears to be capable of interacting with dopaminergic actions that lead to striatal ltd. our results suggest that stimulation of mechanisms involved in striatal synaptic plasticity is an important role for striatal nicotinic acetylcholine receptors and that these mechanisms may contribute to the enhancement of learning and habit formation produced by nicotine intake. |
2002-04-08 |
2023-08-12 |
Not clear |
| L P Dwoskin, L H Teng, P A Crook. Nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum. European journal of pharmacology. vol 428. issue 1. 2002-04-02. PMID:11779039. |
nornicotine, a nicotine metabolite and tobacco alkaloid: desensitization of nicotinic receptor-stimulated dopamine release from rat striatum. |
2002-04-02 |
2023-08-12 |
rat |
| Linda P Dwoskin, Peter A Crook. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochemical pharmacology. vol 63. issue 2. 2002-03-27. PMID:11841781. |
lobeline inhibits nicotine-evoked dopamine release and [3h]nicotine binding, thus acting as a potent antagonist at both alpha3beta2(*) and alpha4beta2(*) neuronal nicotinic receptor subtypes. |
2002-03-27 |
2023-08-12 |
rat |
| David J K Balfou. The neurobiology of tobacco dependence: a commentary. Respiration; international review of thoracic diseases. vol 69. issue 1. 2002-03-27. PMID:11844955. |
within the brain, acute nicotine stimulates the release of dopamine (da) in the shell of the nucleus accumbens whereas repeated nicotine results in selective sensitization of its effects on da overflow in the accumbal core. |
2002-03-27 |
2023-08-12 |
Not clear |
| L H Brauer, M J Cramblett, D A Paxton, J E Ros. Haloperidol reduces smoking of both nicotine-containing and denicotinized cigarettes. Psychopharmacology. vol 159. issue 1. 2002-03-13. PMID:11797066. |
studies with laboratory animals and humans suggest that dopamine may play a role in maintaining cigarette smoking behavior via its interactions with nicotine. |
2002-03-13 |
2023-08-12 |
Not clear |
| H Gäddnäs, K Pietilä, T P Piepponen, L Ahte. Enhanced motor activity and brain dopamine turnover in mice during long-term nicotine administration in the drinking water. Pharmacology, biochemistry, and behavior. vol 70. issue 4. 2002-03-12. PMID:11796149. |
enhanced motor activity and brain dopamine turnover in mice during long-term nicotine administration in the drinking water. |
2002-03-12 |
2023-08-12 |
mouse |
| P J Kenny, A Marko. Neurobiology of the nicotine withdrawal syndrome. Pharmacology, biochemistry, and behavior. vol 70. issue 4. 2002-03-12. PMID:11796152. |
nicotine interacts with several neurotransmitter systems, including acetylcholine, dopamine, opioid peptides, serotonin, and glutamate systems. |
2002-03-12 |
2023-08-12 |
human |
| J E Rose, F M Behm, C Ramsey, J C Ritchi. Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 3. issue 4. 2002-03-06. PMID:11694206. |
this enzyme is important in the breakdown of the amine neurotransmitters, including dopamine, which is thought to mediate the reinforcing effects of nicotine and contribute to tobacco dependence. |
2002-03-06 |
2023-08-12 |
human |
| L Kent, E Green, J Holmes, A Thapar, M Gill, Z Hawi, M Fitzgerald, P Asherson, S Curran, J Mills, A Payton, N Craddoc. No association between CHRNA7 microsatellite markers and attention-deficit hyperactivity disorder. American journal of medical genetics. vol 105. issue 8. 2002-03-05. PMID:11803515. |
first, nicotine promotes the release of dopamine and has been shown to improve attention in adults with adhd, smokers, and nonsmokers. |
2002-03-05 |
2023-08-12 |
rat |
| Layla Azam, Ursula H Winzer-Serhan, Yiling Chen, Frances M Lesli. Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. The Journal of comparative neurology. vol 444. issue 3. 2002-03-05. PMID:11840479. |
nicotine regulates dopamine release not only by stimulation of nicotinic acetylcholine receptors (nachrs) on dopamine cell bodies within the substantia nigra and ventral tegmental area (sn/vta), but also on presynaptic nachrs located on striatal terminals. |
2002-03-05 |
2023-08-12 |
Not clear |
| H Matsubayashi, T Amano, H Amano, M Sas. Excitation of rat striatal large neurons by dopamine and/or glutamate released from nerve terminals via presynaptic nicotinic receptor (A4beta2 type) stimulation. Japanese journal of pharmacology. vol 86. issue 4. 2002-02-22. PMID:11569617. |
previous in vivo experiments using rats anesthetized with chloral hydrate have revealed that nicotine applied iontophoretically increased firing of striatal neurons receiving excitatory dopaminergic input from the substantia nigra, and nicotine-induced firing was inhibited by domperidone, a dopamine d2 antagonist. |
2002-02-22 |
2023-08-12 |
rat |
| H Matsubayashi, T Amano, H Amano, M Sas. Excitation of rat striatal large neurons by dopamine and/or glutamate released from nerve terminals via presynaptic nicotinic receptor (A4beta2 type) stimulation. Japanese journal of pharmacology. vol 86. issue 4. 2002-02-22. PMID:11569617. |
the results suggest that nicotine increases release of dopamine from the terminals of dopaminergic neurons. |
2002-02-22 |
2023-08-12 |
rat |
| H Matsubayashi, T Amano, H Amano, M Sas. Excitation of rat striatal large neurons by dopamine and/or glutamate released from nerve terminals via presynaptic nicotinic receptor (A4beta2 type) stimulation. Japanese journal of pharmacology. vol 86. issue 4. 2002-02-22. PMID:11569617. |
the present findings suggest that nicotine mainly acts on the presynaptic nicotinic receptors in the nerve terminals to release neurotransmitters such as dopamine and/or glutamate, thereby activating the striatal large neurons. |
2002-02-22 |
2023-08-12 |
rat |
| G W Ross, H Petrovitc. Current evidence for neuroprotective effects of nicotine and caffeine against Parkinson's disease. Drugs & aging. vol 18. issue 11. 2002-02-19. PMID:11772120. |
nicotine has been shown in animals to stimulate the release of dopamine in the striatum, and to preserve nigral neurons and striatal dopamine levels in laboratory animals with lesioned nigrostriatal pathways. |
2002-02-19 |
2023-08-12 |
mouse |
| Sziraki, M N Lipovac, A Hashim, H Sershen, D Allen, T Cooper, P Czobor, A Lajth. Differences in nicotine-induced dopamine release and nicotine pharmacokinetics between Lewis and Fischer 344 rats. Neurochemical research. vol 26. issue 6. 2002-01-29. PMID:11519721. |
differences in nicotine-induced dopamine release and nicotine pharmacokinetics between lewis and fischer 344 rats. |
2002-01-29 |
2023-08-12 |
rat |
| Sziraki, M N Lipovac, A Hashim, H Sershen, D Allen, T Cooper, P Czobor, A Lajth. Differences in nicotine-induced dopamine release and nicotine pharmacokinetics between Lewis and Fischer 344 rats. Neurochemical research. vol 26. issue 6. 2002-01-29. PMID:11519721. |
nicotine (50-100 microg/kg)-induced release of dopamine, expressed in absolute terms, was similar in the two strains. |
2002-01-29 |
2023-08-12 |
rat |