| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas R Kosten, Tony P George, Therese A Koste. The potential of dopamine agonists in drug addiction. Expert opinion on investigational drugs. vol 11. issue 4. 2002-08-15. PMID:11922858. |
the use of dopamine agonists in alcohol, stimulant and nicotine dependence has been examined. |
2002-08-15 |
2023-08-12 |
Not clear |
| A Ravi Kumar, P A Kuru. Endogenous sodium-potassium ATPase inhibition related biochemical cascade in trisomy 21 and Huntington's disease: neural regulation of genomic function. Neurology India. vol 50. issue 2. 2002-08-14. PMID:12134182. |
there were increased levels of tryptophan catabolites (nicotine, strychnine, quinolinic acid and serotonin) and decreased levels of tyrosine catabolites (dopamine, noradrenaline and morphine) in both trisomy 21 and huntington's disease. |
2002-08-14 |
2023-08-12 |
Not clear |
| Yousef Tizabi, Robert L Copeland, Vely A Louis, Robert E Taylo. Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. Alcoholism, clinical and experimental research. vol 26. issue 3. 2002-07-25. PMID:11923594. |
effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. |
2002-07-25 |
2023-08-12 |
Not clear |
| Yousef Tizabi, Robert L Copeland, Vely A Louis, Robert E Taylo. Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. Alcoholism, clinical and experimental research. vol 26. issue 3. 2002-07-25. PMID:11923594. |
this study was undertaken to determine whether simultaneous administration of systemic ethanol and microinjection of nicotine into the ventral tegmental area (vta) would result in exaggerated release of dopamine (da) in the shell region of nucleus accumbens. |
2002-07-25 |
2023-08-12 |
Not clear |
| Adrian J Mogg, Paul Whiteaker, J Michael McIntosh, Michael Marks, Allan C Collins, Susan Wonnacot. Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum. The Journal of pharmacology and experimental therapeutics. vol 302. issue 1. 2002-07-12. PMID:12065717. |
however, 50 nm mla partially inhibited (by 16%) [(3)h]dopamine release from rat striatal synaptosomes stimulated with 10 microm nicotine. |
2002-07-12 |
2023-08-12 |
rat |
| Adrian J Mogg, Paul Whiteaker, J Michael McIntosh, Michael Marks, Allan C Collins, Susan Wonnacot. Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum. The Journal of pharmacology and experimental therapeutics. vol 302. issue 1. 2002-07-12. PMID:12065717. |
mla was not additive with a maximally effective concentration of alpha-ctx-mii (100 nm) in inhibiting [(3)h]dopamine release elicited by 10 microm nicotine or 0.2 microm ub-165, suggesting that both toxins act at the same site. |
2002-07-12 |
2023-08-12 |
rat |
| Amanda A Harrison, Fabrizio Gasparini, Athina Marko. Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats. Psychopharmacology. vol 160. issue 1. 2002-06-24. PMID:11862374. |
systemic nicotine administration increases dopamine and glutamate levels in reward-related brain areas. |
2002-06-24 |
2023-08-12 |
rat |
| Nicholas Zwar, Robyn Richmon. Bupropion sustained release. A therapeutic review of Zyban. Australian family physician. vol 31. issue 5. 2002-06-21. PMID:12043548. |
originally developed as an antidepressant, bupropion hydrochloride is a selective re-uptake inhibitor of dopamine and noradrenalin which was found to reduce nicotine withdrawal symptoms and the urge to smoke. |
2002-06-21 |
2023-08-12 |
Not clear |
| D H Overstreet, V Djuri. A genetic rat model of cholinergic hypersensitivity: implications for chemical intolerance, chronic fatigue, and asthma. Annals of the New York Academy of Sciences. vol 933. 2002-05-24. PMID:12000038. |
in some cases, the increased sensitivity has been detected in the absence of any changes in the receptors with which the drugs interact (dopamine receptors), while receptor changes have been seen in other cases (nicotine receptors). |
2002-05-24 |
2023-08-12 |
human |
| T A Slotkin, C A Tate, M M Cousins, F J Seidle. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Brain research. Developmental brain research. vol 133. issue 2. 2002-05-23. PMID:11882346. |
in the normal brain, nicotine increases the utilization of norepinephrine and dopamine. |
2002-05-23 |
2023-08-12 |
rat |
| Charles K Meshul, Darlene Kamel, Cindy Moore, Tom S Kay, Lisa Krent. Nicotine alters striatal glutamate function and decreases the apomorphine-induced contralateral rotations in 6-OHDA-lesioned rats. Experimental neurology. vol 175. issue 1. 2002-05-23. PMID:12009777. |
the data suggests that in this 6-ohda lesion model of parkinson's disease, treatment with nicotine may be useful in counteracting the increased behavioral effect (i.e., contralateral rotations) observed after treatment with a dopamine agonist, such as apomorphine. |
2002-05-23 |
2023-08-12 |
rat |
| M R Picciotto, M Zoli, J P Changeu. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 1 Suppl 2. 2002-05-22. PMID:11768168. |
experiments using mice lacking the beta2 subunit of the nachr have shown that binding of nicotine to receptors containing this subunit is the first step in a pathway leading to increased dopamine levels in the mesolimbic dopamine system, and ultimately to the behavioral effects of nicotine in a test of nicotine reinforcement. |
2002-05-22 |
2023-08-12 |
mouse |
| William A Corrigall, Kathleen M Coen, Jianhua Zhang, LaurelK Adamso. Pharmacological manipulations of the pedunculopontine tegmental nucleus in the rat reduce self-administration of both nicotine and cocaine. Psychopharmacology. vol 160. issue 2. 2002-05-10. PMID:11875638. |
the pedunculopontine tegmental nucleus (pptg) has been implicated in the self-administration of drugs, particularly nicotine, which acts directly through the pptg in addition to targeting midbrain dopamine neurons. |
2002-05-10 |
2023-08-12 |
rat |
| Sophie Erhardt, Lilly Schwieler, Göran Engber. Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Synapse (New York, N.Y.). vol 43. issue 4. 2002-04-23. PMID:11835517. |
excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. |
2002-04-23 |
2023-08-12 |
rat |
| Sophie Erhardt, Lilly Schwieler, Göran Engber. Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Synapse (New York, N.Y.). vol 43. issue 4. 2002-04-23. PMID:11835517. |
in the present electrophysiological study the mechanisms by which nicotine activates dopamine neurons in the ventral tegmental area in anesthetized sprague-dawley rats were analyzed. |
2002-04-23 |
2023-08-12 |
rat |
| Sophie Erhardt, Lilly Schwieler, Göran Engber. Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Synapse (New York, N.Y.). vol 43. issue 4. 2002-04-23. PMID:11835517. |
intravenous administration of nicotine caused a dose-dependent increase in firing rate and percentage of spikes fired in bursts of ventral tegmental area dopamine neurons. |
2002-04-23 |
2023-08-12 |
rat |
| Sophie Erhardt, Lilly Schwieler, Göran Engber. Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Synapse (New York, N.Y.). vol 43. issue 4. 2002-04-23. PMID:11835517. |
the excitation of dopamine neurons by nicotine (1.5-400 microg/kg i.v.) |
2002-04-23 |
2023-08-12 |
rat |
| Sophie Erhardt, Lilly Schwieler, Göran Engber. Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Synapse (New York, N.Y.). vol 43. issue 4. 2002-04-23. PMID:11835517. |
administration of the gaba(b)-receptor antagonist cgp 35348 (200 mg/kg, i.v., 3 min) facilitated the nicotine-induced increase in burst firing activity of dopamine neurons and antagonized the short-lasting decrease in firing rate by nicotine. |
2002-04-23 |
2023-08-12 |
rat |
| Sophie Erhardt, Lilly Schwieler, Göran Engber. Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Synapse (New York, N.Y.). vol 43. issue 4. 2002-04-23. PMID:11835517. |
the results of the present study show that nicotine produces both inhibition and excitation of ventral tegmental area dopamine neurons, actions that appear to be related to the release of gaba and glutamate, respectively. |
2002-04-23 |
2023-08-12 |
rat |
| Anton N M Schoffelmeer, Taco J De Vries, George Wardeh, Henrica W M van de Ven, Louk J M J Vanderschure. Psychostimulant-induced behavioral sensitization depends on nicotinic receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943828. |
behavioral sensitization induced by nicotine, amphetamine, or cocaine was associated with an increase in the electrically evoked release of [(3)h]dopamine from nucleus accumbens slices. |
2002-04-22 |
2023-08-12 |
rat |