| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Boye, P B Clark. Enhancement of haloperidol-induced catalepsy by nicotine: an investigation of possible mechanisms. Canadian journal of physiology and pharmacology. vol 78. issue 11. 2001-05-31. PMID:11100936. |
this effect is paradoxical, since nicotine alone tends to increase nigrostriatal dopamine release. |
2001-05-31 |
2023-08-12 |
rat |
| J A Trauth, F J Seidler, S F Ali, T A Slotki. Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function. Brain research. vol 892. issue 2. 2001-05-17. PMID:11172774. |
we assessed norepinephrine and dopamine content, turnover (an index of neural activity), and the response to an acute challenge dose of nicotine. |
2001-05-17 |
2023-08-12 |
rat |
| K Miyasat. [Recent advances in research on nicotine dependence and reward mechanism]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 117. issue 1. 2001-05-10. PMID:11233293. |
there is growing evidence suggesting that nicotine depends on dopamine (da) for its reinforcing effects. |
2001-05-10 |
2023-08-12 |
Not clear |
| I Shim, J I Javaid, S E Ki. Effect of ginseng total saponin on extracellular dopamine release elicited by local infusion of nicotine into the striatum of freely moving rats. Planta medica. vol 66. issue 8. 2001-04-19. PMID:11199125. |
effect of ginseng total saponin on extracellular dopamine release elicited by local infusion of nicotine into the striatum of freely moving rats. |
2001-04-19 |
2023-08-12 |
rat |
| T Seppä, L Ahte. Comparison of the effects of epibatidine and nicotine on the output of dopamine in the dorsal and ventral striatum of freely-moving rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 4-5. 2001-03-29. PMID:11111841. |
comparison of the effects of epibatidine and nicotine on the output of dopamine in the dorsal and ventral striatum of freely-moving rats. |
2001-03-29 |
2023-08-12 |
rat |
| S Erhardt, H Oberg, G Engber. Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 1. 2001-03-29. PMID:11191832. |
previous studies have shown that systemically administered nicotine is associated with an activation of rat midbrain dopamine neurons. |
2001-03-29 |
2023-08-12 |
rat |
| S Erhardt, H Oberg, G Engber. Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 1. 2001-03-29. PMID:11191832. |
the aim of the present electrophysiological study was to investigate if manipulation of brain kynurenic acid, an endogenous excitatory amino acid receptor antagonist, can affect the response of nigral dopamine neurons to nicotine. |
2001-03-29 |
2023-08-12 |
rat |
| S Erhardt, H Oberg, G Engber. Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 1. 2001-03-29. PMID:11191832. |
this treatment, which caused a fourfold increase in brain kynurenic acid levels, abolished the increase in firing rate and burst activity of nigral dopamine neurons as induced by nicotine (25-400 microg/kg, i.v.). |
2001-03-29 |
2023-08-12 |
rat |
| S Erhardt, H Oberg, G Engber. Pharmacologically elevated levels of endogenous kynurenic acid prevent nicotine-induced activation of nigral dopamine neurons. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 1. 2001-03-29. PMID:11191832. |
it is proposed that the excitation of dopamine neurons in the substantia nigra following nicotine administration is an indirect effect, mediated by glutamate release. |
2001-03-29 |
2023-08-12 |
rat |
| M Roceri, R Molteni, F Fumagalli, G Racagni, M Gennarelli, G Corsini, R Maggio, M Riv. Stimulatory role of dopamine on fibroblast growth factor-2 expression in rat striatum. Journal of neurochemistry. vol 76. issue 4. 2001-03-22. PMID:11181818. |
because (-)nicotine can increase striatal release of dopamine and glutamate, in the present study we have investigated the contribution of these neurotransmitters in the modulation of fgf-2 expression. |
2001-03-22 |
2023-08-12 |
rat |
| G Costa, J A Abin-Carriquiry, F Daja. Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. Brain research. vol 888. issue 2. 2001-02-15. PMID:11150495. |
nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. |
2001-02-15 |
2023-08-12 |
rat |
| G Costa, J A Abin-Carriquiry, F Daja. Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. Brain research. vol 888. issue 2. 2001-02-15. PMID:11150495. |
in this context, we investigated the capability of various systemic administration schedules of nicotine to prevent the loss of striatal dopamine levels produced by partial or extensive 6-hydroxydopamine (6-ohda) lesion of rat substantia nigra (sn). |
2001-02-15 |
2023-08-12 |
rat |
| G Costa, J A Abin-Carriquiry, F Daja. Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. Brain research. vol 888. issue 2. 2001-02-15. PMID:11150495. |
subcutaneous nicotine (1 mg/kg) administered 4 h before and 20, 44 and 68 h after 6 microg 6-ohda, prevented significantly the striatal dopamine loss. |
2001-02-15 |
2023-08-12 |
rat |
| G Costa, J A Abin-Carriquiry, F Daja. Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. Brain research. vol 888. issue 2. 2001-02-15. PMID:11150495. |
administered only 18 or 4 h before or only 20, 44 and 68 h after, nicotine failed to counteract the loss of dopamine or the increase in dopamine turnover observed in the cs. |
2001-02-15 |
2023-08-12 |
rat |
| G Costa, J A Abin-Carriquiry, F Daja. Nicotine prevents striatal dopamine loss produced by 6-hydroxydopamine lesion in the substantia nigra. Brain research. vol 888. issue 2. 2001-02-15. PMID:11150495. |
nicotine also failed to prevent significantly the decrease of striatal dopamine levels produced by the 10-microg 6-ohda intranigral dose. |
2001-02-15 |
2023-08-12 |
rat |
| J Auta, D Lecca, M Nelson, A Guidotti, D H Overstreet, E Costa, J I Javai. Expression and function of striatal nAChRs differ in the flinders sensitive (FSL) and resistant (FRL) rat lines. Neuropharmacology. vol 39. issue 13. 2001-02-08. PMID:11044732. |
in the present study, we measured dopamine (da) content in striatal dialysates to investigate the sensitivity of fsl and frl rats to nicotine delivered locally through a microdialysis probe placed in the striatum. |
2001-02-08 |
2023-08-12 |
rat |
| Y Fu, S G Matta, W Gao, B M Shar. Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo. Neuroscience. vol 101. issue 2. 2001-02-01. PMID:11074160. |
nicotinic cholinergic receptors in the ventral tegmental area are required for the accumbal dopamine response to systemic nicotine. |
2001-02-01 |
2023-08-12 |
Not clear |
| Y Fu, S G Matta, W Gao, B M Shar. Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo. Neuroscience. vol 101. issue 2. 2001-02-01. PMID:11074160. |
in addition, the classical alpha7 subunit antagonist alpha-bungarotoxin infused into the nucleus accumbens adjacent to the microdialysis probe, significantly reduced dopamine release by 0.065 or 0.09mg/kg nicotine (i.v. |
2001-02-01 |
2023-08-12 |
Not clear |
| Y Fu, S G Matta, W Gao, B M Shar. Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo. Neuroscience. vol 101. issue 2. 2001-02-01. PMID:11074160. |
while activation of nicotinic cholinergic receptors in the ventral tegmentum is required for the accumbal dopamine response to systemic nicotine, accumbal nicotinic receptors themselves act as modulators of this response. |
2001-02-01 |
2023-08-12 |
Not clear |
| Y Fu, S G Matta, W Gao, B M Shar. Local alpha-bungarotoxin-sensitive nicotinic receptors in the nucleus accumbens modulate nicotine-stimulated dopamine secretion in vivo. Neuroscience. vol 101. issue 2. 2001-02-01. PMID:11074160. |
this fine tuning of the dopamine reward pathway through alpha7 nicotinic cholinergic receptors in the nucleus accumbens may amplify the secretion of dopamine, allowing a subthreshold brain concentration of nicotine to become an effective stimulus for dopamine secretion. |
2001-02-01 |
2023-08-12 |
Not clear |