| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K E Hutchison, R Niaura, R Swif. The effects of smoking high nicotine cigarettes on prepulse inhibition, startle latency, and subjective responses. Psychopharmacology. vol 150. issue 3. 2000-12-07. PMID:10923751. |
however, the administration of nicotine activates mesolimbic dopamine, and activation of mesolimbic dopamine is known to attenuate prepulse inhibition of the startle reflex (ppi), which might suggest that nicotine would decrease ppi. |
2000-12-07 |
2023-08-12 |
Not clear |
| S S Watkins, G F Koob, A Marko. Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 2. issue 1. 2000-11-30. PMID:11072438. |
the roles of various neurotransmitter systems, including acetylcholine, dopamine, serotonin, glutamate, gamma-aminobutyric acid, and opioid peptides in acute nicotine reinforcement and withdrawal from chronic administration are examined followed by a discussion of potential neuroadaptations within these neurochemical systems that may lead to the development of nicotine dependence. |
2000-11-30 |
2023-08-12 |
Not clear |
| R D Hurt, J E Ahlskog, G A Croghan, K P Offord, T D Wolter, I T Croghan, T P Moye. Carbidopa/levodopa for smoking cessation: a pilot study with negative results. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 2. issue 1. 2000-11-30. PMID:11072443. |
since dopamine may play a critical role in mediating the reinforcing effects of nicotine, we hypothesized that administering levodopa in its therapeutic form (carbidopa/levodopa) might be effective for smoking cessation by replacing the effects of dopamine that smokers may seek during smoking. |
2000-11-30 |
2023-08-12 |
human |
| V D Gueorguiev, R J Zeman, E M Meyer, E L Sabba. Involvement of alpha7 nicotinic acetylcholine receptors in activation of tyrosine hydroxylase and dopamine beta-hydroxylase gene expression in PC12 cells. Journal of neurochemistry. vol 75. issue 5. 2000-11-09. PMID:11032889. |
nicotine treatment increases intracellular free ca(2+) concentration [ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh). |
2000-11-09 |
2023-08-12 |
Not clear |
| T Seppä, M Ruotsalainen, I Laakso, R Tuominen, L Ahte. Effect of acute nicotine administration on striatal dopamine output and metabolism in rats kept at different ambient temperatures. British journal of pharmacology. vol 130. issue 5. 2000-10-17. PMID:10882401. |
effect of acute nicotine administration on striatal dopamine output and metabolism in rats kept at different ambient temperatures. |
2000-10-17 |
2023-08-12 |
rat |
| E Quattrocki, A Baird, D Yurgelun-Tod. Biological aspects of the link between smoking and depression. Harvard review of psychiatry. vol 8. issue 3. 2000-10-12. PMID:10973935. |
nicotine binds to nicotinic receptors in the brain, augmenting the release of numerous neurotransmitters, including dopamine, serotonin, norepinephrine, acetylcholine, gamma-aminobutyric acid, and glutamate. |
2000-10-12 |
2023-08-12 |
Not clear |
| P Grillner, T H Svensso. Nicotine-induced excitation of midbrain dopamine neurons in vitro involves ionotropic glutamate receptor activation. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941135. |
however, to what extent the excitatory effect of nicotine on the dopamine (da) neurons in the ventral tegmental area (vta) is mediated via their glutamatergic input remains unclear. |
2000-09-28 |
2023-08-12 |
Not clear |
| P Grillner, T H Svensso. Nicotine-induced excitation of midbrain dopamine neurons in vitro involves ionotropic glutamate receptor activation. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941135. |
dhbe and mecamylamine but not mla completely blocked the effect of nicotine, indicating that nachrs other than alpha(7)-subtype are involved in the nicotine-induced excitation of the dopamine neurons in the brain slice preparation. |
2000-09-28 |
2023-08-12 |
Not clear |
| A E Drew, A E Derbez, L L Werlin. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941136. |
the objective of this study was to determine whether nicotine could selectively influence dopamine levels in the prefrontal cortex as compared with other dopaminergic areas of brain. |
2000-09-28 |
2023-08-12 |
rat |
| A E Drew, A E Derbez, L L Werlin. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941136. |
using a superfusion system, we found that nicotine and other agonists at nicotinic acetylcholine receptors enhanced the release of radiolabeled dopamine that was stimulated by 10 microm amphetamine from slices prepared from rat prefrontal cortex. |
2000-09-28 |
2023-08-12 |
rat |
| A E Drew, A E Derbez, L L Werlin. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941136. |
in contrast, nicotine had no effect on amphetamine-stimulated [(3)h]dopamine release from slices of nucleus accumbens nor striatum. |
2000-09-28 |
2023-08-12 |
rat |
| A E Drew, A E Derbez, L L Werlin. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941136. |
under the conditions used, which included no added calcium to exclude contribution by exocytotic release, nicotine had no effect on basal release of [(3)h]dopamine. |
2000-09-28 |
2023-08-12 |
rat |
| A E Drew, A E Derbez, L L Werlin. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941136. |
the potencies of nicotine, epibatidine, cytisine, and a85380 to enhance amphetamine-stimulated dopamine release, as well as the sensitivity of nicotine enhanced release to antagonists, are consistent with mediation via a high-affinity nicotinic acetylcholine receptor containing alpha 4 and beta 2 subunits, the major species of nicotinic receptor in forebrain. |
2000-09-28 |
2023-08-12 |
rat |
| F Lebarg. [Nicotine dependence]. Revue de pneumologie clinique. vol 56. issue 3. 2000-09-26. PMID:10880944. |
acute stimulation with nicotine provokes a rise in cerebral dopamine levels in the accumbens. |
2000-09-26 |
2023-08-12 |
Not clear |
| F Lebarg. [Nicotine dependence]. Revue de pneumologie clinique. vol 56. issue 3. 2000-09-26. PMID:10880944. |
dopamine release is greatly lowered in animals having undergone chronic exposure to nicotine, suggesting desensitization of the nicotinic receptors. |
2000-09-26 |
2023-08-12 |
Not clear |
| H Yu, H Matsubayashi, T Amano, J Cai, M Sas. Activation by nicotine of striatal neurons receiving excitatory input from the substantia nigra via dopamine release. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924698. |
activation by nicotine of striatal neurons receiving excitatory input from the substantia nigra via dopamine release. |
2000-09-20 |
2023-08-12 |
rat |
| H Yu, H Matsubayashi, T Amano, J Cai, M Sas. Activation by nicotine of striatal neurons receiving excitatory input from the substantia nigra via dopamine release. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924698. |
these findings suggested that nicotine enhances dopamine release from the sn-derived dopaminergic nerve terminals by activating the neurons via d2 receptors. |
2000-09-20 |
2023-08-12 |
rat |
| M R Gerasimov, W K Schiffer, J D Brodie, I C Lennon, S J Taylor, S L Dewe. gamma-aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine. European journal of pharmacology. vol 395. issue 2. 2000-09-06. PMID:10794818. |
we previously demonstrated that increased gamma-aminobutyric acid (gaba)-ergic activity produced by gamma-vinyl gaba [d,l-4-amino-hex-5-enoic acid (vigabatrin(r))], an irreversible inhibitor of gaba-transaminase, attenuated cocaine, nicotine, heroin, alcohol, and methamphetamine-induced increases in extracellular nucleus accumbens dopamine as well as behaviors associated with these biochemical changes. |
2000-09-06 |
2023-08-12 |
Not clear |
| I S Shim, J S Won, J K Lee, D K Song, S E Kim, S O Huh, Y H Kim, H W Su. Modulatory effect of ginseng total saponin on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the rat. Journal of ethnopharmacology. vol 70. issue 2. 2000-09-01. PMID:10771206. |
modulatory effect of ginseng total saponin on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the rat. |
2000-09-01 |
2023-08-12 |
rat |
| Y Fu, S G Matta, W Gao, V G Brower, B M Shar. Systemic nicotine stimulates dopamine release in nucleus accumbens: re-evaluation of the role of N-methyl-D-aspartate receptors in the ventral tegmental area. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900219. |
systemic nicotine stimulates dopamine release in nucleus accumbens: re-evaluation of the role of n-methyl-d-aspartate receptors in the ventral tegmental area. |
2000-08-24 |
2023-08-12 |
rat |