| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D E Comings, K Blu. Reward deficiency syndrome: genetic aspects of behavioral disorders. Progress in brain research. vol 126. 2001-01-18. PMID:11105655. |
however, the same release of dopamine and production of sensations of pleasure can be produced by 'unnatural rewards' such as alcohol, cocaine, methamphetamine, heroin, nicotine, marijuana, and other drugs, and by compulsive activities such as gambling, eating, and sex, and by risk taking behaviors. |
2001-01-18 |
2023-08-12 |
human |
| R Isola, A M Duchemin, G A Tejwani, N H Neff, M Hadjiconstantino. Glutamate receptors participate in the nicotine-induced changes of met-enkephalin in striatum. Brain research. vol 878. issue 1-2. 2001-01-04. PMID:10996137. |
based on the ability of selective antagonists of dopamine (sch 23390, d1; sulpiride, d2), glutamate (cpp, competitive nmda; dizocilpine, non-competitive nmda; nbqx, ampa) and gaba (bicuculline, gaba(a); sch 50911, gaba(b)) receptors, to inhibit or enhance the response to nicotine, we conclude that nicotine alters striatal met-enk, in part, via glutamate nmda and ampa receptors. |
2001-01-04 |
2023-08-12 |
mouse |
| A El-Nabawi, M Quesenberry, K Saito, E Silbergeld, G Vasta, A Eldefraw. The N-methyl-D-aspartate neurotransmitter receptor is a mammalian brain target for the dinoflagellate Pfiesteria piscicida toxin. Toxicology and applied pharmacology. vol 169. issue 1. 2001-01-04. PMID:11076700. |
seven rat brain neurotransmitter receptors were selected to study because of their reported roles in cognitive function: receptors for nicotine, muscarine, ampa/kainate, n-methyl-d-aspartate (nmda), gamma-aminobutyric acid, and dopamine 1 and 2. |
2001-01-04 |
2023-08-12 |
rat |
| H Gäddnäs, K Pietilä, L Ahte. Effects of chronic oral nicotine treatment and its withdrawal on locomotor activity and brain monoamines in mice. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942033. |
locomotor activity as well as cerebral concentrations of dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), 5-hydroxytryptamine (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), noradrenaline (na) and 3-methoxy-4-hydroxyphenylethyleneglycol (mopeg) were measured post mortem on the 50th day of nicotine administration or at 12-14 or 23-25 h after withdrawal. |
2001-01-03 |
2023-08-12 |
mouse |
| D J Balfour, A E Wright, M E Benwell, C E Birrel. The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942034. |
the putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence. |
2001-01-03 |
2023-08-12 |
Not clear |
| D J Balfour, A E Wright, M E Benwell, C E Birrel. The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942034. |
nicotine, like other psychostimulant drugs of abuse, increases dopamine release in the principal terminal field of the mesolimbic system, the nucleus accumbens, and there is evidence that this mediates the 'rewarding' properties of the drug, which reinforce its self-administration. |
2001-01-03 |
2023-08-12 |
Not clear |
| D J Balfour, A E Wright, M E Benwell, C E Birrel. The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942034. |
this review focuses on the working hypothesis that addiction to nicotine, and other psychostimulant drugs, depends upon their ability to evoke a sustained increase in dopamine release directly into the extracellular space which lies between the cells in the nucleus accumbens where it stimulates extra-synaptic dopamine receptors. |
2001-01-03 |
2023-08-12 |
Not clear |
| D J Balfour, A E Wright, M E Benwell, C E Birrel. The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942034. |
the receptors, which mediate the effects of nicotine on mesoaccumbens dopamine neurones, are desensitised by sustained exposure to nicotine at concentrations commonly found in the plasma of habitual smokers. |
2001-01-03 |
2023-08-12 |
Not clear |
| D J Balfour, A E Wright, M E Benwell, C E Birrel. The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942034. |
as a result, studies with nicotine have the potential to contribute to our understanding of the neurobiology of addiction which cannot easily be explored using drugs, such as cocaine and amphetamine, which invariably increase dopamine overflow in the forebrain. |
2001-01-03 |
2023-08-12 |
Not clear |
| B Söderpalm, M Ericson, P Olausson, O Blomqvist, J A Enge. Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942035. |
moreover, subchronic nicotine treatment enhances the reinforcing and dopamine activating properties of ethanol. |
2001-01-03 |
2023-08-12 |
mouse |
| G G Nomikos, B Schilström, B E Hildebrand, G Panagis, J Grenhoff, T H Svensso. Role of alpha7 nicotinic receptors in nicotine dependence and implications for psychiatric illness. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942036. |
based on the data reviewed in the present study, it is suggested that nicotine by stimulating presynaptic alpha7 nicotinic receptors within the vta, that are probably localized on glutamatergic afferents from the medial prefrontal cortex, produces sequentially an increase in glutamate concentrations, stimulation of nmda receptors found on dopamine (da)-containing neurons in the vta, enhanced firing activity of vta-da neurons, augmented da release in the nerve terminal regions, and enhanced c-fos expression in the dopaminergic projection areas through activation of d1-da receptors. |
2001-01-03 |
2023-08-12 |
Not clear |
| N R Mirza, A Misra, J L Brigh. Different outcomes after acute and chronic treatment with nicotine in pre-pulse inhibition in Lister hooded rats. European journal of pharmacology. vol 407. issue 1-2. 2000-12-29. PMID:11050293. |
the deficit in pre-pulse inhibition after chronic treatment with nicotine may be the result of non-specific behavioural activation due to increased mesolimbic dopamine release or, possibly, nicotine may rapidly desensitize nicotinic receptors important for normal information processing. |
2000-12-29 |
2023-08-12 |
rat |
| b' K Kiianmaa, P Tuomainen, N Makova, T Sepp\\xc3\\xa4, J A Mikkola, T Petteri Piepponen, L Ahtee, P Hyyti\\xc3\\xa. The effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats. European journal of pharmacology. vol 407. issue 3. 2000-12-27. PMID:11068025.' |
the effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring aa and alcohol-avoiding ana rats. |
2000-12-27 |
2023-08-12 |
rat |
| b' K Kiianmaa, P Tuomainen, N Makova, T Sepp\\xc3\\xa4, J A Mikkola, T Petteri Piepponen, L Ahtee, P Hyyti\\xc3\\xa. The effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats. European journal of pharmacology. vol 407. issue 3. 2000-12-27. PMID:11068025.' |
this was done by comparing the effects of nicotine on locomotor activity and release of dopamine in the nucleus accumbens of the alcohol-preferring alko alcohol (aa) and alcohol-avoiding alko non-alcohol (ana) rats. |
2000-12-27 |
2023-08-12 |
rat |
| b' K Kiianmaa, P Tuomainen, N Makova, T Sepp\\xc3\\xa4, J A Mikkola, T Petteri Piepponen, L Ahtee, P Hyyti\\xc3\\xa. The effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats. European journal of pharmacology. vol 407. issue 3. 2000-12-27. PMID:11068025.' |
an acute dose of nicotine increased locomotor activity and the extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid (dopac), and homovanillic acid (hva) measured with in vivo microdialysis suggesting stimulation of dopamine release by nicotine. |
2000-12-27 |
2023-08-12 |
rat |
| b' K Kiianmaa, P Tuomainen, N Makova, T Sepp\\xc3\\xa4, J A Mikkola, T Petteri Piepponen, L Ahtee, P Hyyti\\xc3\\xa. The effects of nicotine on locomotor activity and dopamine overflow in the alcohol-preferring AA and alcohol-avoiding ANA rats. European journal of pharmacology. vol 407. issue 3. 2000-12-27. PMID:11068025.' |
no difference in the stimulation of locomotor activity or in the increase in the extracellular concentrations of dopamine or its metabolites by nicotine was found between the rat lines. |
2000-12-27 |
2023-08-12 |
rat |
| B Schilström, M V Fagerquist, X Zhang, P Hertel, G Panagis, G G Nomikos, T H Svensso. Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044884. |
we have previously provided evidence that the stimulatory action of systemic nicotine on dopamine release in the rat nucleus accumbens is initiated in the ventral tegmental area (vta), and that it appears to be mediated partly through an indirect, presynaptic mechanism. |
2000-12-14 |
2023-08-12 |
rat |
| B Schilström, M V Fagerquist, X Zhang, P Hertel, G Panagis, G G Nomikos, T H Svensso. Putative role of presynaptic alpha7* nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044884. |
thus, it was found that blockade of n-methyl-d-aspartate (nmda) receptors in the vta attenuates the enhancing effect of nicotine on extracellular levels of dopamine in the nucleus accumbens. |
2000-12-14 |
2023-08-12 |
rat |
| M R Gerasimov, M Franceschi, N D Volkow, O Rice, W K Schiffer, S L Dewe. Synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor. Synapse (New York, N.Y.). vol 38. issue 4. 2000-12-14. PMID:11044890. |
synergistic interactions between nicotine and cocaine or methylphenidate depend on the dose of dopamine transporter inhibitor. |
2000-12-14 |
2023-08-12 |
Not clear |
| M E Jarvik, N H Caskey, W C Wirshing, D C Madsen, P N Iwamoto-Schaap, J L Elins, N I Eisenberger, R E Olmstea. Bromocriptine reduces cigarette smoking. Addiction (Abingdon, England). vol 95. issue 8. 2000-12-14. PMID:11092065. |
animal studies have shown that nicotine releases dopamine, a neurotransmitter implicated in drug reinforcement. |
2000-12-14 |
2023-08-12 |
Not clear |