| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Wu, Andrew A George, Katherine M Schroeder, Lin Xu, Syndia Marxer-Miller, Linda Lucero, Ronald J Luka. Electrophysiological, pharmacological, and molecular evidence for alpha7-nicotinic acetylcholine receptors in rat midbrain dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 311. issue 1. 2004-12-15. PMID:15178698. |
dopamine (da) neurons located in the mammalian midbrain have been generally implicated in reward and drug reinforcement and more specifically in nicotine dependence. |
2004-12-15 |
2023-08-12 |
human |
| A Clark, H J Littl. Interactions between low concentrations of ethanol and nicotine on firing rate of ventral tegmental dopamine neurones. Drug and alcohol dependence. vol 75. issue 2. 2004-12-07. PMID:15276226. |
interactions between low concentrations of ethanol and nicotine on firing rate of ventral tegmental dopamine neurones. |
2004-12-07 |
2023-08-12 |
Not clear |
| S Rahman, J Zhang, W A Corrigal. Local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine preexposure. Neurochemical research. vol 29. issue 9. 2004-12-07. PMID:15453263. |
local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine preexposure. |
2004-12-07 |
2023-08-12 |
rat |
| S Rahman, J Zhang, W A Corrigal. Local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine preexposure. Neurochemical research. vol 29. issue 9. 2004-12-07. PMID:15453263. |
we examined the effects of nicotine perfusion into the ventral tegmental area (vta) on extracellular dopamine (da) levels in rats using in vivo microdialysis. |
2004-12-07 |
2023-08-12 |
rat |
| Bankole A Johnso. Topiramate-induced neuromodulation of cortico-mesolimbic dopamine function: a new vista for the treatment of comorbid alcohol and nicotine dependence? Addictive behaviors. vol 29. issue 7. 2004-12-02. PMID:15345276. |
topiramate-induced neuromodulation of cortico-mesolimbic dopamine function: a new vista for the treatment of comorbid alcohol and nicotine dependence? |
2004-12-02 |
2023-08-12 |
Not clear |
| Bankole A Johnso. Topiramate-induced neuromodulation of cortico-mesolimbic dopamine function: a new vista for the treatment of comorbid alcohol and nicotine dependence? Addictive behaviors. vol 29. issue 7. 2004-12-02. PMID:15345276. |
the results of our proof-of-concept study showed that topiramate is a promising medication for the treatment of both alcohol and nicotine dependence, presumably by its ability to modulate cortico-mesolimbic dopamine function profoundly; however, other mechanisms might also contribute to this effect. |
2004-12-02 |
2023-08-12 |
Not clear |
| Brian M Kelley, James D Rowa. Long-term, low-level adolescent nicotine exposure produces dose-dependent changes in cocaine sensitivity and reward in adult mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 22. issue 5-6. 2004-12-02. PMID:15380833. |
a follow-up study was undertaken to evaluate dopamine d1, d2, and d3 receptor function in adult mice exposed to the highest dose of nicotine from the first study. |
2004-12-02 |
2023-08-12 |
mouse |
| Peter A Crooks, Joshua T Ayers, Rui Xu, Sangeetha P Sumithran, Vladimir P Grinevich, Lincoln H Wilkins, A Gabriela Deaciuc, David D Allen, Linda P Dwoski. Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. Bioorganic & medicinal chemistry letters. vol 14. issue 8. 2004-11-09. PMID:15050618. |
n-n-alkylation of nicotine converts it from an agonist into an antagonist at neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. |
2004-11-09 |
2023-08-12 |
Not clear |
| Ivan Bednar, Linda Friberg, Agneta Nordber. Modulation of dopamine release by the nicotinic agonist epibatidine in the frontal cortex and the nucleus accumbens of naive and chronic nicotine treated rats. Neurochemistry international. vol 45. issue 7. 2004-11-09. PMID:15337304. |
modulation of dopamine release by the nicotinic agonist epibatidine in the frontal cortex and the nucleus accumbens of naive and chronic nicotine treated rats. |
2004-11-09 |
2023-08-12 |
rat |
| Wei-Hua Huang, Wei Cheng, Zhen Zhang, Dai-Wen Pang, Zong-Li Wang, Jie-Ke Cheng, Da-Fu Cu. Transport, location, and quantal release monitoring of single cells on a microfluidic device. Analytical chemistry. vol 76. issue 2. 2004-10-19. PMID:14719902. |
after location of a single pc12 cell on the microfluidic chip, the cell was stimulated by nicotine that was also introduced through the micro-channels, and the quantum release of dopamine from the cell was amperometricly detected with our designed carbon fiber microelectrode. |
2004-10-19 |
2023-08-12 |
Not clear |
| Elaine C Johnstone, Patricia L Yudkin, Kate Hey, Sarah J Roberts, Sarah J Welch, Michael F Murphy, Siân E Griffiths, Robert T Walto. Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch. Pharmacogenetics. vol 14. issue 2. 2004-09-30. PMID:15077009. |
short-term effectiveness of the nicotine patch may be related to dopamine beta-hydroxylase and dopamine d2 receptor genotype. |
2004-09-30 |
2023-08-12 |
human |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
differential regulation of dopamine d1 and d2 signaling by nicotine in neostriatal neurons. |
2004-09-30 |
2023-08-12 |
mouse |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine, acting on nicotinic acetylcholine receptors (nachrs) expressed at pre-synaptic dopaminergic terminals, has been shown to stimulate the release of dopamine in the neostriatum. |
2004-09-30 |
2023-08-12 |
mouse |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
depending on the concentration of nicotine, either dopamine d2 or d1 receptor signaling was predominantly activated. |
2004-09-30 |
2023-08-12 |
mouse |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine at a low concentration (1 microm) activated dopamine d2 receptor signaling in striatopallidal/indirect pathway neurons, likely by activating alpha4beta2* nachrs at dopaminergic terminals. |
2004-09-30 |
2023-08-12 |
mouse |
| Miho Hamada, Hideho Higashi, Angus C Nairn, Paul Greengard, Akinori Nish. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. Journal of neurochemistry. vol 90. issue 5. 2004-09-30. PMID:15312165. |
nicotine at a high concentration (100 microm) activated dopamine d1 receptor signaling in striatonigral/direct pathway neurons, likely by activating (i) alpha4beta2* nachrs at dopaminergic terminals and (ii) alpha7 nachrs at glutamatergic terminals, which, by stimulating the release of glutamate, activated nmda/ampa receptors at dopaminergic terminals. |
2004-09-30 |
2023-08-12 |
mouse |
| Matt J Neville, Elaine C Johnstone, Robert T Walto. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Human mutation. vol 23. issue 6. 2004-09-24. PMID:15146457. |
the dopamine d2 receptor has been extensively studied in relation to alcoholism, substance abuse, and nicotine dependence. |
2004-09-24 |
2023-08-12 |
Not clear |
| Zhong-Hua Liu, Wen-Qiao Ji. Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194878. |
decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats. |
2004-09-16 |
2023-08-12 |
rat |
| Zhong-Hua Liu, Wen-Qiao Ji. Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194878. |
the present study was designed to examine the ventral tegmental area (vta) dopamine neuronal activity in nicotine withdrawal rats by means of in vivo single-unit extracellular recordings. |
2004-09-16 |
2023-08-12 |
rat |
| Zhong-Hua Liu, Wen-Qiao Ji. Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194878. |
one day after the last nicotine administration, the firing rates of the vta dopamine neurons were found to be significantly decreased. |
2004-09-16 |
2023-08-12 |
rat |