| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Whiting, F Esch, S Shimasaki, J Lindstro. Neuronal nicotinic acetylcholine receptor beta-subunit is coded for by the cDNA clone alpha 4. FEBS letters. vol 219. issue 2. 1987-09-03. PMID:3609304. |
acetylcholine receptors (achrs) with high affinity for nicotine but no affinity for alpha-bungarotoxin, which have been purified from rat and chicken brains by immuno-affinity chromatography, consist of two types of subunits, alpha and beta. |
1987-09-03 |
2023-08-11 |
mouse |
| L G Abood, X Lu, S Banerje. Receptor binding characteristics of a 3H-labeled azetidine analogue of nicotine. Biochemical pharmacology. vol 36. issue 14. 1987-08-19. PMID:3606644. |
insofar as [3h]methylcarbamylcholine, a nicotinic ligand resembling acetylcholine, exhibits a linear scatchard with a kd of 1 x 10(-9) m, the higher affinity site appears to be characteristic of nicotine analogues. |
1987-08-19 |
2023-08-11 |
rat |
| R J Bjercke, J J Langon. Monoclonal anti-idiotypic antibodies that recognize the binding site for nicotine on rat brain receptor. Biochemical and biophysical research communications. vol 145. issue 2. 1987-07-23. PMID:3593375. |
acetylcholine, several cholinergic agonists and antagonists, nicotine metabolites, and other structurally related compounds were poor inhibitors. |
1987-07-23 |
2023-08-11 |
rat |
| P J Whiting, R Schoepfer, L W Swanson, D M Simmons, J M Lindstro. Functional acetylcholine receptor in PC12 cells reacts with a monoclonal antibody to brain nicotinic receptors. Nature. vol 327. issue 6122. 1987-07-09. PMID:2438558. |
these receptors do not bind alpha-bungarotoxin but have a high affinity for nicotine and antibodies raised against them block the function of acetylcholine receptors in ciliary ganglia. |
1987-07-09 |
2023-08-11 |
rat |
| I Wessler, B Scheuer, H Kilbinge. [3H]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors. European journal of pharmacology. vol 135. issue 1. 1987-06-15. PMID:3569426. |
[3h]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors. |
1987-06-15 |
2023-08-11 |
Not clear |
| I Wessler, B Scheuer, H Kilbinge. [3H]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors. European journal of pharmacology. vol 135. issue 1. 1987-06-15. PMID:3569426. |
nicotinic agonists (nicotine, 1,1-dimethyl-4-phenylpiperazinium (dmpp) increased [3h]acetylcholine release when the pre-exposure time was short (20 s). |
1987-06-15 |
2023-08-11 |
Not clear |
| I Wessler, B Scheuer, H Kilbinge. [3H]acetylcholine release from the phrenic nerve is increased or decreased by activation or desensitization of nicotine receptors. European journal of pharmacology. vol 135. issue 1. 1987-06-15. PMID:3569426. |
after a longer pre-exposure time (3 min) 10 microm nicotine significantly decreased the evoked [3h]acetylcholine release, probably because desensitization of the nicotine autoreceptors had abolished the nicotinic autofacilitation of transmitter release. |
1987-06-15 |
2023-08-11 |
Not clear |
| G B Freeman, K A Sherman, G E Gibso. Locomotor activity as a predictor of times and dosages for studies of nicotine's neurochemical actions. Pharmacology, biochemistry, and behavior. vol 26. issue 2. 1987-06-02. PMID:2883664. |
dopamine (da) and its metabolites as well as acetylcholine (ach) synthesis were measured at the point of nicotine's maximal depressant action. |
1987-06-02 |
2023-08-11 |
mouse |
| G B Freeman, K A Sherman, G E Gibso. Locomotor activity as a predictor of times and dosages for studies of nicotine's neurochemical actions. Pharmacology, biochemistry, and behavior. vol 26. issue 2. 1987-06-02. PMID:2883664. |
nicotine's depressant action appears not to be due to altered da but may be related to changes in carbohydrate and acetylcholine metabolism. |
1987-06-02 |
2023-08-11 |
mouse |
| I Wessler, M Halank, J Rasbach, H Kilbinge. Presynaptic nicotine receptors mediating a positive feed-back on transmitter release from the rat phrenic nerve. Naunyn-Schmiedeberg's archives of pharmacology. vol 334. issue 4. 1987-04-20. PMID:2881216. |
the effects of 1,1-dimethyl-4-phenylpiperazinium (dmpp) and of nicotine receptor antagonists on [3h]acetylcholine release from the rat phrenic nerve preincubated with [3h]choline were investigated in the absence and presence of cholinesterase inhibitors (presynaptic effects). |
1987-04-20 |
2023-08-11 |
rat |
| T M Blomquist, D V Priola, A M Romer. Source of intrinsic innervation of canine ventricles: a functional study. The American journal of physiology. vol 252. issue 3 Pt 2. 1987-04-16. PMID:3826405. |
the effects of intracoronary acetylcholine (ach; 1-5 micrograms) and intracoronary nicotine (nic; 25-100 micrograms) on cardiac isovolumic pressures were evaluated after beta-blockade. |
1987-04-16 |
2023-08-11 |
Not clear |
| S Hashimoto, C Tanaka, K Taniyam. Presynaptic muscarinic and alpha-adrenoceptor-mediated regulation of GABA release from myenteric neurones of the guinea-pig small intestine. British journal of pharmacology. vol 89. issue 4. 1987-04-02. PMID:3028551. |
acetylcholine and oxotremorine, at concentrations ranging from 10(-9) to 10(-6) m inhibited the evoked release of [3h]-gaba in a concentration-dependent manner, while nicotine was without effect. |
1987-04-02 |
2023-08-11 |
Not clear |
| S C Sukhdeo, N C Sangster, D F Mettric. Effects of cholinergic drugs on longitudinal muscle contractions of Fasciola hepatica. The Journal of parasitology. vol 72. issue 6. 1987-04-01. PMID:3819962. |
in order of their effects on the inhibition of muscle contractions, the cholinergic agonists can be ranked as nicotine greater than carbachol greater than acetylcholine. |
1987-04-01 |
2023-08-11 |
Not clear |
| R de la Garza, P C Bickford-Wimer, B J Hoffer, R Freedma. Heterogeneity of nicotine actions in the rat cerebellum: an in vivo electrophysiologic study. The Journal of pharmacology and experimental therapeutics. vol 240. issue 2. 1987-03-26. PMID:3806420. |
much controversy surrounds the actions of nicotine on mammalian central neurons, especially with respect to the question of presence of multiple nicotine receptors and with respect to similarities of responses to those induced by acetylcholine (ach). |
1987-03-26 |
2023-08-11 |
rat |
| A M Martino-Barrows, K J Kella. [3H]acetylcholine and [3H](-)nicotine label the same recognition site in rat brain. Molecular pharmacology. vol 31. issue 2. 1987-03-26. PMID:3807893. |
[3h]acetylcholine and [3h](-)nicotine label the same recognition site in rat brain. |
1987-03-26 |
2023-08-11 |
human |
| A M Martino-Barrows, K J Kella. [3H]acetylcholine and [3H](-)nicotine label the same recognition site in rat brain. Molecular pharmacology. vol 31. issue 2. 1987-03-26. PMID:3807893. |
high affinity binding sites for [3h]acetylcholine and [3h](-)nicotine in rat brain were compared with respect to key characteristics, any one of which should distinguish them if they are different. |
1987-03-26 |
2023-08-11 |
human |
| A M Martino-Barrows, K J Kella. [3H]acetylcholine and [3H](-)nicotine label the same recognition site in rat brain. Molecular pharmacology. vol 31. issue 2. 1987-03-26. PMID:3807893. |
the affinity of [3h](-)nicotine was higher than that of [3h]acetylcholine, but nicotinic cholinergic drugs competed for the sites labeled by the two ligands with similar affinities; and in each case, the site labeled displayed marked stereoselectivity for the enantiomers of nicotine. |
1987-03-26 |
2023-08-11 |
human |
| A M Martino-Barrows, K J Kella. [3H]acetylcholine and [3H](-)nicotine label the same recognition site in rat brain. Molecular pharmacology. vol 31. issue 2. 1987-03-26. PMID:3807893. |
the binding of [3h]acetylcholine and [3h](-)nicotine was decreased to the same extent by preincubation of tissues with dithiothreitol, and the binding was restored by subsequent treatment with 5,5'-dithiobis-2-nitrobenzoic acid, indicating that a disulfide bond is required at or near the binding site for each ligand. |
1987-03-26 |
2023-08-11 |
human |
| A M Martino-Barrows, K J Kella. [3H]acetylcholine and [3H](-)nicotine label the same recognition site in rat brain. Molecular pharmacology. vol 31. issue 2. 1987-03-26. PMID:3807893. |
taken together, these results indicate that [3h]acetylcholine and [3h](-)nicotine bind to the same nicotinic cholinergic recognition site in rat brain. |
1987-03-26 |
2023-08-11 |
human |
| O Barochovsky, H F Bradfor. Modulation of dopamine release from neuron-enriched tissue cultures by cholinergic agents. Journal of neurochemistry. vol 48. issue 3. 1987-03-19. PMID:3806105. |
modulation of [3h]dopamine release by cholinergic agents (acetylcholine, atropine, d-tubocurarine, oxotremorine, and nicotine) was studied in primary cell cultures derived from whole brains of foetal rats (17 days of gestation). |
1987-03-19 |
2023-08-11 |
rat |