| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Yamada, Y Nakazato, S Ito, H Teraoka, A Ohg. Catecholamines and dopamine-beta-hydroxylase secretion from perfused goat adrenal glands. Quarterly journal of experimental physiology (Cambridge, England). vol 73. issue 1. 1988-04-18. PMID:3347691. |
acetylcholine (ach) and nicotine also caused a dose-dependent increase in ca secretion. |
1988-04-18 |
2023-08-11 |
Not clear |
| P B Clarke, D W Hommer, A Pert, L R Skirbol. Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence. Neuroscience. vol 23. issue 3. 1988-04-05. PMID:3437988. |
dopaminergic neurons of the substantia nigra pars compacta are excited by nicotine and acetylcholine, and possess both high-affinity nicotine binding sites and intense acetylcholinesterase activity, consistent with a cholinoceptive role. |
1988-04-05 |
2023-08-11 |
rat |
| J A Stitzel, S M Campbell, A C Collins, M J Mark. Sulfhydryl modification of two nicotinic binding sites in mouse brain. Journal of neurochemistry. vol 50. issue 3. 1988-03-23. PMID:3339366. |
two distinct binding sites with properties corresponding to those expected for nicotinic cholinergic receptors can be identified in brain by the specific binding of nicotine (or acetylcholine) and alpha-bungarotoxin. |
1988-03-23 |
2023-08-11 |
mouse |
| A Orts, C Orellana, T Cantó, V Ceña, C González-García, A G Garcí. Inhibition of adrenomedullary catecholamine release by propranolol isomers and clonidine involving mechanisms unrelated to adrenoceptors. British journal of pharmacology. vol 92. issue 4. 1988-03-22. PMID:2827826. |
3 either, racemic propranolol or the (+)- or (-)-isomers (1-10 microm) equally inhibited [3h]-noradrenaline release evoked by nicotine or acetylcholine from cultured bovine adrenal chromaffin cells; clonidine (10 microm) inhibited secretion by 50% and yohimbine or isoprenaline did not affect it. |
1988-03-22 |
2023-08-11 |
cat |
| K Nakatsuji, Y Matsuno, N Nakamura, B Fujitani, T Ito, T Kadokaw. General pharmacology of the novel antiepileptic compound zonisamide. 2nd communication: effects on cardiovascular, visceral, renal and blood functions. Arzneimittel-Forschung. vol 37. issue 10. 1988-03-04. PMID:3435584. |
in isolated guinea-pig ileum, contractions induced by acetylcholine, histamine and bradykinin were not affected by zonisamide up to a concentration of 10(-3) g/ml zonisamide, although those by serotonin and nicotine were depressed with high concentrations over 10(-5) g/ml. |
1988-03-04 |
2023-08-11 |
mouse |
| P J Whiting, R Liu, B J Morley, J M Lindstro. Structurally different neuronal nicotinic acetylcholine receptor subtypes purified and characterized using monoclonal antibodies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 12. 1988-01-28. PMID:3694260. |
acetylcholine receptors that bind nicotine with high affinity but do not bind alpha-bungarotoxin have recently been immunoaffinity purified from brains of chickens and rats (whiting and lindstrom, 1986a, b; whiting and lindstrom, 1987a). |
1988-01-28 |
2023-08-11 |
rat |
| S A Lipton, E Aizenman, R H Lorin. Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells. Pflugers Archiv : European journal of physiology. vol 410. issue 1-2. 1988-01-15. PMID:3684508. |
currents produced by acetylcholine (5-20 mumol/l) or nicotine (5-20 mumol/l) reversed in polarity near -5 mv and were unaffected by atropine (10 mumol/l). |
1988-01-15 |
2023-08-11 |
rat |
| G A Weiland, J A Durkin, J M Henley, S M Simask. Effects of substance P on the binding of ligands to nicotinic acetylcholine receptors. Molecular pharmacology. vol 32. issue 5. 1988-01-06. PMID:2446113. |
consistent with the results for [3h]acetylcholine binding to torpedo membranes, the peptide had no effect on the binding of the cholinergic agonist [3h](-)nicotine to these tissue preparations. |
1988-01-06 |
2023-08-11 |
rat |
| J Boulter, J Connolly, E Deneris, D Goldman, S Heinemann, J Patric. Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proceedings of the National Academy of Sciences of the United States of America. vol 84. issue 21. 1987-12-09. PMID:2444984. |
these receptors are activated by acetylcholine and nicotine and are blocked by bungarus toxin 3.1. |
1987-12-09 |
2023-08-11 |
rat |
| P Boksa, R Quirio. [3H]N-methyl-carbamylcholine, a new radioligand specific for nicotinic acetylcholine receptors in brain. European journal of pharmacology. vol 139. issue 3. 1987-11-27. PMID:3666008. |
with atropine used to block muscarinic acetylcholine sites and nicotine to define non-specific binding, [3h]methyl-carbachol bound specifically, saturably and with high affinity (kd = 11.0 nm, bmax = 118.4 fmol/mg protein and hill coefficient = 0.92) to a population of presumably nicotinic sites in cerebral cortex membranes. |
1987-11-27 |
2023-08-11 |
rat |
| P Boksa, R Quirio. [3H]N-methyl-carbamylcholine, a new radioligand specific for nicotinic acetylcholine receptors in brain. European journal of pharmacology. vol 139. issue 3. 1987-11-27. PMID:3666008. |
when nicotine was used to block nicotinic acetylcholine sites and atropine to define non-specific binding there was no specific binding of [3h]methyl-carbachol (concentrations up to 45 nm) to possible muscarinic sites in cerebral cortex membranes. |
1987-11-27 |
2023-08-11 |
rat |
| P Boksa, R Quirio. [3H]N-methyl-carbamylcholine, a new radioligand specific for nicotinic acetylcholine receptors in brain. European journal of pharmacology. vol 139. issue 3. 1987-11-27. PMID:3666008. |
its stability and high selectivity constitute distinct advantages over previously used nicotinic radioligands such as acetylcholine and nicotine. |
1987-11-27 |
2023-08-11 |
rat |
| F Okwuasaba, C Ejike, O Parr. Comparison of the skeletal muscle relaxant properties of Portulaca oleracea extracts with dantrolene sodium and methoxyverapamil. Journal of ethnopharmacology. vol 20. issue 2. 1987-11-20. PMID:3657249. |
the extracts and d-600 proved more effective in attenuating nicotinic agonist (acetylcholine, carbachol and nicotine)-induced contractures on the rectus abdominis muscle than dantrolene. |
1987-11-20 |
2023-08-11 |
rat |
| T D White, J E Bourke, B G Livet. Direct and continuous detection of ATP secretion from primary monolayer cultures of bovine adrenal chromaffin cells. Journal of neurochemistry. vol 49. issue 4. 1987-10-19. PMID:3114430. |
acetylcholine, nicotine, the ca2+ ionophore a23187, bacl2, and kcl induced release of atp. |
1987-10-19 |
2023-08-11 |
cattle |
| T D White, J E Bourke, B G Livet. Direct and continuous detection of ATP secretion from primary monolayer cultures of bovine adrenal chromaffin cells. Journal of neurochemistry. vol 49. issue 4. 1987-10-19. PMID:3114430. |
induction of release of atp by acetylcholine was dose dependent, with a threshold at 10(-7) m and a maximum at 10(-4) m. the dose-response curve for nicotine was bell shaped, with a threshold at 10(-7) m, a maximum at 10(-5) m, and diminished release at higher concentrations, an observation indicative of desensitization. |
1987-10-19 |
2023-08-11 |
cattle |
| T D White, J E Bourke, B G Livet. Direct and continuous detection of ATP secretion from primary monolayer cultures of bovine adrenal chromaffin cells. Journal of neurochemistry. vol 49. issue 4. 1987-10-19. PMID:3114430. |
induction of release of atp by acetylcholine or nicotine was biphasic, with a rapid, initial phase of release followed by a plateau at 0.5-1.5 min and a second phase of release beginning at 1.5-2 min, reaching a maximum by 2-3 min. |
1987-10-19 |
2023-08-11 |
cattle |
| A D Nozdrachev, A N Fedi. [Effect of cholinergic substances on the spontaneous activity of lower respiratory tract neurons]. Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. vol 73. issue 6. 1987-10-15. PMID:3040481. |
acetylcholine and low concentrations of nicotine were shown to increase firing rate, to induce grouping of spikes of spontaneously active cells and to activate "silent" neurons. |
1987-10-15 |
2023-08-11 |
Not clear |
| A S Pivovarov, G N Saganelidz. [Differences in the habituation of the nicotinic and muscarinic cholinoreceptors of Helix neuron PPa4]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 37. issue 3. 1987-10-14. PMID:3630387. |
pharmacological division of the snail cholinoreceptors population of the identified neurone rpa4 by cholinoblockators of muscarine (atropine, platyphylline) and nicotine (d-tubocurarine) receptors allowed to reveal differences in the dynamics of reversible reduction of sensitivity of these receptors during their habituation to repeated iontophoretic acetylcholine applications. |
1987-10-14 |
2023-08-11 |
Not clear |
| A S Pivovarov, G N Saganelidz. [Differences in the habituation of the nicotinic and muscarinic cholinoreceptors of Helix neuron PPa4]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 37. issue 3. 1987-10-14. PMID:3630387. |
maximum desensitization of nicotine receptors is weaker, develops slower and is eliminated faster after the end of rhythmic acetylcholine applications. |
1987-10-14 |
2023-08-11 |
Not clear |
| C C Chang, M J Jou, S J Hong, L C Chio. Pre- and postsynaptic effects of nicotine on the mouse phrenic nerve-diaphragm preparation. Proceedings of the National Science Council, Republic of China. Part B, Life sciences. vol 11. issue 2. 1987-09-18. PMID:3615668. |
at higher frequencies of transmission, nicotine (greater than or equal to 22 microm) also produced a remarkable run-down of epp just like other receptor antagonists suggesting that the nerve terminal acetylcholine receptors are not particularly sensitive to nicotine as those on the autonomic ganglia. |
1987-09-18 |
2023-08-11 |
mouse |