| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Akaike, M Sasa, S Takaor. Muscarinic inhibition as a dominant role in cholinergic regulation of transmission in the caudate nucleus. The Journal of pharmacology and experimental therapeutics. vol 246. issue 3. 1988-10-21. PMID:2843628. |
a combination of acetylcholine (10(-6) to 10(-4) m) with physostigmine (10(-6) m) also inhibited the orthodromic response of cn neuron, but nicotine (10(-6) to 10(-3) m) had no effects on the neuronal activity. |
1988-10-21 |
2023-08-11 |
rat |
| I Wessler, C Apel, U Hille. Increase by tubocurarine of [3H]acetylcholine release from the rat phrenic nerve after desensitization of nicotine receptors. European journal of pharmacology. vol 151. issue 1. 1988-10-21. PMID:3416921. |
increase by tubocurarine of [3h]acetylcholine release from the rat phrenic nerve after desensitization of nicotine receptors. |
1988-10-21 |
2023-08-11 |
rat |
| I Wessler, C Apel, U Hille. Increase by tubocurarine of [3H]acetylcholine release from the rat phrenic nerve after desensitization of nicotine receptors. European journal of pharmacology. vol 151. issue 1. 1988-10-21. PMID:3416921. |
tubocurarine reduced the neurally evoked [3h]acetylcholine release in the absence of nicotine, indicating positive nicotinic feedback. |
1988-10-21 |
2023-08-11 |
rat |
| I Wessler, C Apel, U Hille. Increase by tubocurarine of [3H]acetylcholine release from the rat phrenic nerve after desensitization of nicotine receptors. European journal of pharmacology. vol 151. issue 1. 1988-10-21. PMID:3416921. |
tubocurarine, however, enhanced [3h]acetylcholine release after pretreatment with nicotine, a condition which causes desensitization of nicotine autoreceptors. |
1988-10-21 |
2023-08-11 |
rat |
| P G Gillberg, R d'Argy, S M Aquiloniu. Autoradiographic distribution of [3H]acetylcholine binding sites in the cervical spinal cord of man and some other species. Neuroscience letters. vol 90. issue 1-2. 1988-10-13. PMID:3137509. |
the distribution of [3h]acetylcholine ([3h]ach) and [3h]ach co-incubated with 1-mm nicotine (muscarinic receptor), and [3h]ach co-incubated with 1.5 microm atropine (nicotinic receptor) binding sites were studied in man and compared to monkey, cat and rat using quantitative in vitro autoradiography. |
1988-10-13 |
2023-08-11 |
rat |
| A S Pivovarov, G N Saganelidz. [Identification of the nicotinic and muscarinic cholinoreceptors of the soma of the RPa4 neuron in the edible snail]. Neirofiziologiia = Neurophysiology. vol 20. issue 2. 1988-09-06. PMID:3398972. |
selective desensitization of receptors by nicotine and muscarine as well as occupation of receptors by cytisine and arecoline reduced depolarization in response to acetylcholine. |
1988-09-06 |
2023-08-11 |
Not clear |
| R W Behling, T Yamane, G Navon, M J Sammon, L W Jelinsk. Measuring relative acetylcholine receptor agonist binding by selective proton nuclear magnetic resonance relaxation experiments. Biophysical journal. vol 53. issue 6. 1988-09-02. PMID:3395661. |
a method is presented that uses selective proton nuclear magnetic resonance (nmr) relaxation measurements of nicotine in the presence of the acetylcholine receptor to obtain relative binding constants for acetylcholine, carbamylcholine, and muscarine. |
1988-09-02 |
2023-08-11 |
Not clear |
| R W Behling, T Yamane, G Navon, M J Sammon, L W Jelinsk. Measuring relative acetylcholine receptor agonist binding by selective proton nuclear magnetic resonance relaxation experiments. Biophysical journal. vol 53. issue 6. 1988-09-02. PMID:3395661. |
for receptors from torpedo californica the results show that (a) the binding constants are in the order acetylcholine greater than nicotine greater than carbamylcholine greater than muscarine; (b) selective nmr measurements provide a rapid and direct method for monitoring both the specific and nonspecific binding of agonists to these receptors and to the lipid; (c) alpha-bungarotoxin can be used to distinguish between specific and nonspecific binding to the receptor; (d) the receptor--substrate interaction causes a large change in the selective relaxation time of the agonists even at concentrations 100x greater than that of the receptor. |
1988-09-02 |
2023-08-11 |
Not clear |
| P J Whitehouse, A M Martino, K A Marcus, R M Zweig, H S Singer, D L Price, K J Kella. Reductions in acetylcholine and nicotine binding in several degenerative diseases. Archives of neurology. vol 45. issue 7. 1988-08-05. PMID:3390025. |
reductions in acetylcholine and nicotine binding in several degenerative diseases. |
1988-08-05 |
2023-08-11 |
Not clear |
| P J Whitehouse, A M Martino, K A Marcus, R M Zweig, H S Singer, D L Price, K J Kella. Reductions in acetylcholine and nicotine binding in several degenerative diseases. Archives of neurology. vol 45. issue 7. 1988-08-05. PMID:3390025. |
in this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding. |
1988-08-05 |
2023-08-11 |
Not clear |
| G T Prusky, C Shaw, M S Cynade. The distribution and ontogenesis of [3H]nicotine binding sites in cat visual cortex. Brain research. vol 467. issue 2. 1988-07-15. PMID:3378167. |
the laminar pattern of binding of [3h]nicotine during early development of the visual cortex is complimentary to that for muscarinic acetylcholine receptors. |
1988-07-15 |
2023-08-11 |
cat |
| E Klinge, S Alaranta, N O Sjöstran. Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle. The Journal of pharmacology and experimental therapeutics. vol 245. issue 1. 1988-06-02. PMID:3361446. |
relaxations of the isolated bovine retractor penis muscle elicited by nicotine and the three other nicotinic agonists acetylcholine, carbachol, and dimethylphenylpiperazinium were studied. |
1988-06-02 |
2023-08-11 |
cattle |
| E Klinge, S Alaranta, N O Sjöstran. Pharmacological analysis of nicotinic relaxation of bovine retractor penis muscle. The Journal of pharmacology and experimental therapeutics. vol 245. issue 1. 1988-06-02. PMID:3361446. |
provided that sufficient concentrations of scopolamine and eserine were present, the relaxations caused by acetylcholine (30-140 microm) were exactly like those evoked by nicotine, and they were identically affected by hypoxia and the blocking drugs. |
1988-06-02 |
2023-08-11 |
cattle |
| M A Young, D R Knight, S F Vatne. Parasympathetic coronary vasoconstriction induced by nicotine in conscious calves. Circulation research. vol 62. issue 5. 1988-06-01. PMID:3359575. |
we studied the effects of intracoronary injection of nicotine and acetylcholine on coronary blood flow in nine conscious calves chronically instrumented to measure coronary blood flow, left ventricular (lv) and mean arterial pressure, lv dp/dt, and heart rate. |
1988-06-01 |
2023-08-11 |
Not clear |
| J E Jumblatt, G T Nort. Cholinergic inhibition of adrenergic neurosecretion in the rabbit iris-ciliary body. Investigative ophthalmology & visual science. vol 29. issue 4. 1988-05-13. PMID:2833461. |
stimulation-evoked release of 3h-norepinephrine was inhibited by the cholinergic agonists methacholine, oxotremorine, muscarine, carbamylcholine and acetylcholine (plus eserine), but was unmodified by pilocarpine or nicotine. |
1988-05-13 |
2023-08-11 |
rabbit |
| Y Kizawa, I Takayanag. Substance P-containing nerves mediate nicotine-induced contractions of rabbit bronchial smooth muscle. General pharmacology. vol 19. issue 2. 1988-05-12. PMID:2450807. |
nicotine caused a contraction which was attributed to the release of acetylcholine in the rabbit bronchus. |
1988-05-12 |
2023-08-11 |
rabbit |
| Y Kizawa, I Takayanagi, M Shinkai, Y Ohn. Pharmacological action of nicotine in the isolated urinary bladder from rabbit: special reference to the chronic nicotine treatment. General pharmacology. vol 19. issue 2. 1988-05-12. PMID:3350334. |
these findings suggest that the contractile response to nicotine was mediated through an action on the nicotinic receptors and partially due to the release of acetylcholine and tachykinins. |
1988-05-12 |
2023-08-11 |
rabbit |
| H Nishikawa, T Taniguchi, H Ninomiya, M Fujiwar. Nicotinic acetylcholine receptors in the rat stomach: I. (-)-[3H]nicotine binding. European journal of pharmacology. vol 146. issue 1. 1988-05-03. PMID:3350060. |
the nicotinic acetylcholine receptors in the rat stomach were characterized by means of a radioligand binding assay with (-)-[3h]nicotine as ligand. |
1988-05-03 |
2023-08-11 |
rat |
| H Nishikawa, T Taniguchi, H Ninomiya, M Fujiwar. Nicotinic acetylcholine receptors in the rat stomach: I. (-)-[3H]nicotine binding. European journal of pharmacology. vol 146. issue 1. 1988-05-03. PMID:3350060. |
the ic50 values of cholinergic drugs to inhibit (-)-[3h]nicotine binding in fundus membranes were as follows: (-)nicotine, 0.12 nm; cytosine, 9.3 nm; acetylcholine, 17.7 nm; carbachol, 700 nm; hexamethonium, 2270 nm. |
1988-05-03 |
2023-08-11 |
rat |
| I Takayanagi, Y Kizawa, T Toyoda, A Furukaw. Characterization of nicotine-induced contraction in the canine bronchus. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 89. issue 1. 1988-04-18. PMID:2894268. |
these findings suggest that the contractile response to nicotine was mediated through an action on the nicotinic receptors and due to the release of acetylcholine. |
1988-04-18 |
2023-08-11 |
dog |