| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R B Langdon, R S Jacob. Irreversible autonomic actions by lophotoxin suggest utility as a probe for both C6 and C10 nicotinic receptors. Brain research. vol 359. issue 1-2. 1986-01-24. PMID:3000521. |
somewhat longer treatments (80 min) of in vitro ileal sections resulted in loss of sensitivity to nicotine, but not to acetylcholine, for at least 5 h. these data indicate that lophotoxin can serve as a more universal nicotinic receptor probe than the alpha-neurotoxins, which may bind to both c6 and c10 sub-types, but block only the c10. |
1986-01-24 |
2023-08-11 |
Not clear |
| R F Taylor, D T Frazie. Chemosensitivity of crayfish slowly adapting stretch receptors to nicotine. Journal of applied physiology (Bethesda, Md. : 1985). vol 59. issue 5. 1986-01-06. PMID:4066591. |
the crayfish muscle receptor organ was chosen, since crayfish muscle is reported to be insensitive to nicotine or acetylcholine and therefore permits the testing of any direct chemical effect of nicotine on the muscle stretch receptors. |
1986-01-06 |
2023-08-11 |
dog |
| W R Tracey, D I Alexander, P Eyre, A Sing. Cholinergic properties of the bronchial artery and contribution of the endothelium. Artery. vol 12. issue 4. 1986-01-03. PMID:4074135. |
longitudinal strips responded poorly to both acetylcholine and nicotine. |
1986-01-03 |
2023-08-11 |
cattle |
| D C Smith, D V Priola, C Anagnosteli. Comparison of in vivo and in vitro cholinergic responses of normal and denervated canine hearts. The Journal of pharmacology and experimental therapeutics. vol 235. issue 1. 1985-11-08. PMID:4045726. |
the negative inotropic responses of their hearts were compared with those of nine normal controls with respect to acetylcholine (ach; 0.1-1.0 micrograms) and nicotine (0.5-100 micrograms) administered intra-coronary. |
1985-11-08 |
2023-08-11 |
Not clear |
| T Kub. [Brain nicotinic acetylcholine receptors and their functions in special reference to central cardiovascular regulation]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 85. issue 6. 1985-10-08. PMID:2993138. |
however, recent studies have reported the pharmacological character and regional distribution of a high-affinity binding of [3h]acetylcholine or [3h]nicotine. |
1985-10-08 |
2023-08-11 |
Not clear |
| C Ksir, R Hakan, D P Hall, K J Kella. Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors. Neuropharmacology. vol 24. issue 6. 1985-09-24. PMID:4022267. |
exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3h]acetylcholine to nicotinic receptors. |
1985-09-24 |
2023-08-11 |
rat |
| C Ksir, R Hakan, D P Hall, K J Kella. Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors. Neuropharmacology. vol 24. issue 6. 1985-09-24. PMID:4022267. |
tissue from the cerebral cortex of these rats, exposed to nicotine for 5 days, was assayed for binding of [3h]acetylcholine to nicotinic receptors. |
1985-09-24 |
2023-08-11 |
rat |
| C Ksir, R Hakan, D P Hall, K J Kella. Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of [3H]acetylcholine to nicotinic receptors. Neuropharmacology. vol 24. issue 6. 1985-09-24. PMID:4022267. |
these data imply that increased binding of [3h]acetylcholine to nicotinic sites and the enhanced behavioral effect of nicotine are functionally linked. |
1985-09-24 |
2023-08-11 |
rat |
| H Sershen, M E Reith, A Hashim, A Lajth. Comparison of [3H]nicotine and [3H]acetylcholine binding in mouse brain: regional distribution. Research communications in chemical pathology and pharmacology. vol 48. issue 3. 1985-09-23. PMID:4023418. |
comparison of [3h]nicotine and [3h]acetylcholine binding in mouse brain: regional distribution. |
1985-09-23 |
2023-08-11 |
mouse |
| H Sershen, M E Reith, A Hashim, A Lajth. Comparison of [3H]nicotine and [3H]acetylcholine binding in mouse brain: regional distribution. Research communications in chemical pathology and pharmacology. vol 48. issue 3. 1985-09-23. PMID:4023418. |
in a continuing study of nicotine binding sites, we determined the relative amount of nicotine binding and acetylcholine binding in various brain regions of c57/bl and of dba mice. |
1985-09-23 |
2023-08-11 |
mouse |
| H Sershen, M E Reith, A Hashim, A Lajth. Comparison of [3H]nicotine and [3H]acetylcholine binding in mouse brain: regional distribution. Research communications in chemical pathology and pharmacology. vol 48. issue 3. 1985-09-23. PMID:4023418. |
although midbrain showed the highest and cerebellum the lowest binding for both [3h]nicotine and [3h]acetylcholine, the ratio of nicotine to acetylcholine binding showed a three-fold regional variation. |
1985-09-23 |
2023-08-11 |
mouse |
| H Sershen, M E Reith, A Hashim, A Lajth. Comparison of [3H]nicotine and [3H]acetylcholine binding in mouse brain: regional distribution. Research communications in chemical pathology and pharmacology. vol 48. issue 3. 1985-09-23. PMID:4023418. |
acetylcholine inhibition of [3h]nicotine binding indicated that a portion of nicotine binding was not inhibited by acetylcholine. |
1985-09-23 |
2023-08-11 |
mouse |
| H Sershen, M E Reith, A Hashim, A Lajth. Comparison of [3H]nicotine and [3H]acetylcholine binding in mouse brain: regional distribution. Research communications in chemical pathology and pharmacology. vol 48. issue 3. 1985-09-23. PMID:4023418. |
these results indicate important differences between the binding of (+/-)-[3h]nicotine and that of [3h]acetylcholine. |
1985-09-23 |
2023-08-11 |
mouse |
| S Shimohama, T Taniguchi, M Fujiwara, M Kameyam. Biochemical characterization of the nicotinic cholinergic receptors in human brain: binding of (-)-[3H]nicotine. Journal of neurochemistry. vol 45. issue 2. 1985-08-20. PMID:2861250. |
ic50 values for cholinergic drugs of (-)-[3h]nicotine binding were as follows: (-)-nicotine, 0.51 nm; acetylcholine, 12.6 nm; (+)-nicotine, 19.9 nm; cytisine, 27.3 nm; and carbachol, 527 nm. |
1985-08-20 |
2023-08-11 |
human |
| A L Morrow, R Loy, I Crees. Alteration of nicotinic cholinergic agonist binding sites in hippocampus after fimbria transection. Brain research. vol 334. issue 2. 1985-07-24. PMID:3995322. |
chronic administration of the agonist nicotine (4 mg/kg/day) by osmotic minipumps produced an increase in the binding of 10 nm [3h]acetylcholine after 14 days (49% increase over control) and after 28 days (141% increase over controls). |
1985-07-24 |
2023-08-11 |
rat |
| P B Clarke, R D Schwartz, S M Paul, C B Pert, A Per. Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 5. issue 5. 1985-06-28. PMID:3998824. |
nicotinic binding in rat brain: autoradiographic comparison of [3h]acetylcholine, [3h]nicotine, and [125i]-alpha-bungarotoxin. |
1985-06-28 |
2023-08-11 |
rat |
| P B Clarke, R D Schwartz, S M Paul, C B Pert, A Per. Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 5. issue 5. 1985-06-28. PMID:3998824. |
three radioligands have been commonly used to label putative nicotinic cholinoceptors in the mammalian central nervous system: the agonists [3h]nicotine and [3h]acetylcholine ([3h]ach--in the presence of atropine to block muscarinic receptors), and the snake venom extract, [125i]-alpha-bungarotoxin([125i]btx), which acts as a nicotinic antagonist at the neuromuscular junction. |
1985-06-28 |
2023-08-11 |
rat |
| J E Friedman, P I Lelkes, E Lavie, K Rosenheck, F Schneeweiss, A S Schneide. Membrane potential and catecholamine secretion by bovine adrenal chromaffin cells: use of tetraphenylphosphonium distribution and carbocyanine dye fluorescence. Journal of neurochemistry. vol 44. issue 5. 1985-05-28. PMID:3989537. |
acetylcholine and nicotine evoked a large secretory response without a sufficiently sustained depolarization to be detectable by the relatively slow potential sensitive chemical probes. |
1985-05-28 |
2023-08-11 |
cattle |
| V Petkov, V Georgiev, K Roussinov, I Grigorov, L Slokoska, M Angelova, M Lazarova, D Getova, S Todorov, R Radomiro. On the pharmacology of the ergot alkaloid elymoclavine. Biomedica biochimica acta. vol 43. issue 11. 1985-05-14. PMID:6442580. |
at 1 x 10(-6) m, without producing any per se effect, elyoclavine decreased the contractile effects of acetylcholine, nicotine, bacl2 and pge1 as well as the field electrical stimulation-induced contractions in an isolated segment from guinea-pig ileum. |
1985-05-14 |
2023-08-12 |
mouse |
| E G Mendes, J C de Freita. The responses of isolated preparations of Bunodosoma caissarum (Correa, 1964) (Cnidaria, Anthozoa) to drugs. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 79. issue 2. 1985-03-18. PMID:6151470. |
propionylcholine, butyrylcholine and nicotine never failed to evoke a response; acetylcholine eventually was inactive. |
1985-03-18 |
2023-08-12 |
Not clear |