| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W K RIKE. Reflexes from the intestinal mesentery elicited by veratridine, acetylcholine and nicotine. The Journal of pharmacology and experimental therapeutics. vol 124. issue 2. 2000-07-01. PMID:13588522. |
reflexes from the intestinal mesentery elicited by veratridine, acetylcholine and nicotine. |
2000-07-01 |
2023-08-12 |
Not clear |
| E BULBRING, A CREM. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. British journal of pharmacology and chemotherapy. vol 13. issue 4. 2000-07-01. PMID:13618550. |
in isolated guinea-pig intestine 5-hydroxytryptamine increased the longitudinal muscle contractions in response to acetylcholine while the ganglionic action of nicotine was first facilitated and then blocked. |
2000-07-01 |
2023-08-12 |
Not clear |
| E BULBRING, A CREM. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. British journal of pharmacology and chemotherapy. vol 13. issue 4. 2000-07-01. PMID:13618550. |
phenyldiguanide, veratrine, veratridine and protoveratrine, like 5-hydroxytryptamine, depressed the response to nicotine, leaving that to acetylcholine unaffected.the sensory stimulants, like 5-hydroxytryptamine, facilitated the peristaltic reflex when applied to the mucosa, and abolished it when applied to the serosa. |
2000-07-01 |
2023-08-12 |
Not clear |
| J J Vilches, X Navarr. Evaluation of direct and axon reflex sweating in the mouse. Journal of the autonomic nervous system. vol 78. issue 2-3. 2000-06-30. PMID:10789693. |
the nicotinic axon reflex-mediated sudomotor response was studied in mice and rats by recording the impressions of sweat droplets made in silicone molds after local injection of nicotine, and compared with sweating induced by acetylcholine and pilocarpine. |
2000-06-30 |
2023-08-12 |
mouse |
| G A Buznikov, L Rakic. Cholinoreceptors of early (preneural) sea urchin embryos. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768372. |
in the presence of pma, acetylcholine and carbachol had actions which were much weaker than those of nicotine, while muscarine was completely inactive in these conditions. |
2000-06-02 |
2023-08-12 |
Not clear |
| R Yin, E D Frenc. A comparison of the effects of nicotine on dopamine and non-dopamine neurons in the rat ventral tegmental area: an in vitro electrophysiological study. Brain research bulletin. vol 51. issue 6. 2000-05-31. PMID:10758341. |
nicotinic acetylcholine receptors on dopamine containing neurons in the ventral tegmental area are thought to be a prime target for nicotine's stimulatory effects. |
2000-05-31 |
2023-08-12 |
rat |
| E Merlo Pich, C Chiamulera, L Carbon. Molecular mechanisms of the positive reinforcing effect of nicotine. Behavioural pharmacology. vol 10. issue 6-7. 2000-05-23. PMID:10780500. |
the role of the mesocorticolimbic da system as the main substrate of the reinforcing properties of nicotine is supported by converging experiments, including the evidence that nicotine self-administration is attenuated in mutant mice lacking the beta2 subunit of neural acetylcholine nicotinic receptor. |
2000-05-23 |
2023-08-12 |
mouse |
| S Fucile, E Palma, A M Mileo, R Miledi, F Euseb. Human neuronal threonine-for-leucine-248 alpha 7 mutant nicotinic acetylcholine receptors are highly Ca2+ permeable. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 7. 2000-04-24. PMID:10716716. |
when activated by acetylcholine (accho), the receptors expressed generated currents that had low desensitization, linear current-voltage relation, and high apparent affinity for both accho and nicotine. |
2000-04-24 |
2023-08-12 |
human |
| K C Schroff, S Aschhoff, J Schulze, U Nägele, J Remie. A new method for recording surface compound potentials in sympathetic ganglia from mouse, rat, and guinea pig--application to muscarinic and nicotinic depolarizations. Journal of pharmacological and toxicological methods. vol 41. issue 4. 2000-04-14. PMID:10691025. |
agonists used to trigger potential changes are the cholinergic agonists acetylcholine, muscarine, nicotine, and carbachol. |
2000-04-14 |
2023-08-12 |
mouse |
| Y S Ding, N D Volkow, J Logan, V Garza, N Pappas, P King, J S Fowle. Occupancy of brain nicotinic acetylcholine receptors by nicotine doses equivalent to those obtained when smoking a cigarette. Synapse (New York, N.Y.). vol 35. issue 3. 2000-04-11. PMID:10657031. |
occupancy of brain nicotinic acetylcholine receptors by nicotine doses equivalent to those obtained when smoking a cigarette. |
2000-04-11 |
2023-08-12 |
Not clear |
| J Auta, P Longone, A Guidotti, E Cost. The regulation of hippocampal nicotinic acetylcholine receptors (nAChRs) after a protracted treatment with selective or nonselective nAChR agonists. Journal of molecular neuroscience : MN. vol 13. issue 1-2. 2000-03-21. PMID:10691290. |
in rats, 1 mg/kg twice daily for 10 d of nicotine, a nonselective agonist of nicotinic acetylcholine receptors (nachrs), fails to change alpha4 and beta2 nachr subunit mrna but significantly decreased alpha7 nachr subunit mrna and protein expression, which is associated with a 35-40% decrease in the number of 125i-alpha-bgtx binding sites in hippocampus. |
2000-03-21 |
2023-08-12 |
rat |
| S S Watkins, L Stinus, G F Koob, A Marko. Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects. The Journal of pharmacology and experimental therapeutics. vol 292. issue 3. 2000-03-17. PMID:10688623. |
in the present studies in rats, brain stimulation reward thresholds, conditioned place aversions, and somatic signs of withdrawal were used to investigate the role of central and peripheral nicotinic acetylcholine and opioid receptors in nicotine withdrawal. |
2000-03-17 |
2023-08-12 |
human |
| W M Zago, R P Marku. Melatonin modulation of presynaptic nicotinic acetylcholine receptors located on short noradrenergic neurons of the rat vas deferens: a pharmacological characterization. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 32. issue 8. 2000-03-16. PMID:10454762. |
in contrast, methyllycaconitine inhibited the nicotine-induced response only at 21:00 h. since alpha7 nicotinic acetylcholine receptors (nachrs) have low affinity for nicotine in binding assays, we suggest that a mixed population composed of alpha3ss4 - plus alpha7-bearing nachr subtypes is present at night. |
2000-03-16 |
2023-08-12 |
rat |
| M Zaninetti, C Blanchet, E Tribollet, D Bertrand, M Raggenbas. Magnocellular neurons of the rat supraoptic nucleus are endowed with functional nicotinic acetylcholine receptors. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658610. |
these effects could be mimicked, in part, by nicotine or blocked by nicotinic antagonists, suggesting that they might be mediated by nicotinic acetylcholine receptors. |
2000-02-29 |
2023-08-12 |
rat |
| M Zaninetti, C Blanchet, E Tribollet, D Bertrand, M Raggenbas. Magnocellular neurons of the rat supraoptic nucleus are endowed with functional nicotinic acetylcholine receptors. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658610. |
autoradiography indicated that alpha-bungarotoxin binding sites are present in the supraoptic nucleus; however, neither acetylcholine nor nicotine binding sites could be detected. |
2000-02-29 |
2023-08-12 |
rat |
| V N Offiah, U A Chikwend. Antidiarrhoeal effects of Ocimum gratissimum leaf extract in experimental animals. Journal of ethnopharmacology. vol 68. issue 1-3. 2000-02-28. PMID:10624896. |
on the isolated ileum of guinea-pig, the extract showed no direct action; however, it reduced the responses of the guinea-pig ileum to acetylcholine, nicotine and histamine. |
2000-02-28 |
2023-08-12 |
rat |
| S L Jinks, E Carsten. Activation of spinal wide dynamic range neurons by intracutaneous microinjection of nicotine. Journal of neurophysiology. vol 82. issue 6. 2000-02-03. PMID:10601440. |
these data indicate that nicotine ic excites spinal wdr neurons, partly via neuronal nicotinic acetylcholine receptors that are presumably expressed in cutaneous nociceptor terminals. |
2000-02-03 |
2023-08-12 |
rat |
| C J Keiger, J C Walke. Individual variation in the expression profiles of nicotinic receptors in the olfactory bulb and trigeminal ganglion and identification of alpha2, alpha6, alpha9, and beta3 transcripts. Biochemical pharmacology. vol 59. issue 3. 2000-01-04. PMID:10609551. |
such variations are likely to be reflected in the composition of functional receptor subtypes in the rat ob and tg that have different activation and desensitization characteristics to acetylcholine and nicotine. |
2000-01-04 |
2023-08-12 |
rat |
| W Sihver, K J Fasth, M Ogren, H Lundqvist, M Bergström, Y Watanabe, B Långström, A Nordber. In vivo positron emission tomography studies on the novel nicotinic receptor agonist [11C]MPA compared with [11C]ABT-418 and (S)(-)[11C]nicotine in rhesus monkeys. Nuclear medicine and biology. vol 26. issue 6. 1999-12-30. PMID:10587101. |
the novel 11c-labeled nicotinic agonist (r,s)-1-[11c]methyl-2(3-pyridyl)azetidine ([11c]mpa) was evaluated as a positron emission tomography (pet) ligand for in vivo characterization of nicotinic acetylcholine receptors in the brain of rhesus monkeys in comparison with the nicotinic ligands (s)-3-methyl-5-(1-[11c]methyl-2-pyrrolidinyl)isoxazol ([11c]abt-418) and (s)(-)[11c]nicotine. |
1999-12-30 |
2023-08-12 |
monkey |
| B A O'Gara, A Abbasi, K Kaniecki, F Sarder, J Liu, L H Narin. Pharmacological characterization of the response of the leech pharynx to acetylcholine. The Journal of experimental zoology. vol 284. issue 7. 1999-12-22. PMID:10589505. |
the order of potency derived from the ec50 of each agonist was (+/-)epibatidine > acetylcholine (in the presence of physostigmine) >> mcn a-343 >> carbachol > nicotine. |
1999-12-22 |
2023-08-12 |
Not clear |