| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A O'Gara, A Abbasi, K Kaniecki, F Sarder, J Liu, L H Narin. Pharmacological characterization of the response of the leech pharynx to acetylcholine. The Journal of experimental zoology. vol 284. issue 7. 1999-12-22. PMID:10589505. |
however, when response amplitude was considered, the order of potency to the tested agonists was (+/-)epibatidine >> nicotine >> mcn a-343 >> carbachol > acetylcholine. |
1999-12-22 |
2023-08-12 |
Not clear |
| W Sihver, P G Gillberg, A L Svensson, A Nordber. Autoradiographic comparison of [3H](-)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease. Neuroscience. vol 94. issue 3. 1999-12-17. PMID:10579560. |
autoradiographic comparison of [3h](-)nicotine, [3h]cytisine and [3h]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in alzheimer's disease. |
1999-12-17 |
2023-08-12 |
Not clear |
| W Sihver, P G Gillberg, A L Svensson, A Nordber. Autoradiographic comparison of [3H](-)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease. Neuroscience. vol 94. issue 3. 1999-12-17. PMID:10579560. |
the laminar binding distribution of three nicotinic receptor agonists, [3h](-)nicotine, [3h]cytisine, and [3h]epibatidine, and their relation to the [3h]vesamicol binding, which is known to represent the vesicular acetylcholine transport sites, was performed employing in vitro autoradiography on the medial temporal cortex (brodmann area 21). |
1999-12-17 |
2023-08-12 |
Not clear |
| T Audesirk, L Cabel. Nanomolar concentrations of nicotine and cotinine alter the development of cultured hippocampal neurons via non-acetylcholine receptor-mediated mechanisms. Neurotoxicology. vol 20. issue 4. 1999-12-10. PMID:10499362. |
however, at all concentrations tested, nicotine significantly increased branching of both axons and dendrites, an effect which was not reversed by co-culturing with alpha-bungarotoxin, which blocks the nicotinic acetylcholine receptors that predominate in hippocampal cultures (alkondon and albuquerque, 1993; barrantes et al., 1995b). |
1999-12-10 |
2023-08-12 |
human |
| W G Mayhan, G M Sharpe, P Andin. Agonist-induced release of nitric oxide during acute exposure to nicotine. Life sciences. vol 65. issue 17. 1999-12-07. PMID:10576562. |
we measured the release of nitric oxide (sievers no analyzer) in response to repeated topical application of acetylcholine (1.0 microm) and 5'-adenosine diphosphate (adp; 1.0 microm) during infusion of vehicle and during infusion of nicotine (2.0 microg/kg/min i.v. |
1999-12-07 |
2023-08-12 |
Not clear |
| W G Mayhan, G M Sharpe, P Andin. Agonist-induced release of nitric oxide during acute exposure to nicotine. Life sciences. vol 65. issue 17. 1999-12-07. PMID:10576562. |
in contrast, in hamsters treated with nicotine, there was a marked inhibition of nitric oxide release in response to acetylcholine and adp. |
1999-12-07 |
2023-08-12 |
Not clear |
| W G Mayhan, G M Sharpe, P Andin. Agonist-induced release of nitric oxide during acute exposure to nicotine. Life sciences. vol 65. issue 17. 1999-12-07. PMID:10576562. |
we found that treatment of the hamster cheek pouch microcirculation with superoxide dismutase prior to infusion of nicotine prevented nicotine-induced impairment of nitric oxide release in response to acetylcholine and adp. |
1999-12-07 |
2023-08-12 |
Not clear |
| I I Stepanov, N A Lose. [The characteristics of the cholinoreceptors on the identified TAN neuron of the giant African snail Achatina fulica]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 85. issue 4. 1999-11-24. PMID:10513392. |
acetylcholine, nicotine, a selective agonist of n-cholinoreceptors suberildicholine dibromide, as well as a selective agonist of m-cholinoreceptors 5-methylfurmethide inhibited spike discharges in a dose-dependent manner up to a complete ceasing of the firing in cholinoreceptors situated on the identified neurone tan of african giant snail achatina fulica. |
1999-11-24 |
2023-08-12 |
Not clear |
| Z Némethy, G B Makara, Z Ac. Effect of cholinergic drugs on the concentration of intracellular free calcium of rat pituitary intermediate lobe cells. Brain research bulletin. vol 50. issue 1. 1999-11-10. PMID:10507472. |
acetylcholine, muscarine, carbachol, and nicotine resulted in a significant rise in this parameter. |
1999-11-10 |
2023-08-12 |
rat |
| O Riah, J C Dousset, P Courriere, J L Stigliani, G Baziard-Mouysset, Y Belahse. Evidence that nicotine acetylcholine receptors are not the main targets of cotinine toxicity. Toxicology letters. vol 109. issue 1-2. 1999-10-14. PMID:10514027. |
evidence that nicotine acetylcholine receptors are not the main targets of cotinine toxicity. |
1999-10-14 |
2023-08-12 |
mouse |
| M M El-Etri, M Ennis, E R Griff, M T Shiple. Evidence for cholinergic regulation of basal norepinephrine release in the rat olfactory bulb. Neuroscience. vol 93. issue 2. 1999-10-07. PMID:10465445. |
intrabulbar infusion of acetylcholine (40 mm) or nicotine (40 mm) increased norepinephrine levels (317% and 178% of control, respectively), while infusion of the muscarinic receptor agonist pilocarpine (40 mm) reduced norepinephrine levels (54% of control). |
1999-10-07 |
2023-08-12 |
rat |
| F Lembec. Epibatidine: high potency and broad spectrum activity on neuronal and neuromuscular nicotinic acetylcholine receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 5. 1999-09-28. PMID:10498287. |
the activity of epibatidine at neuronal and neuromuscular nicotinic acetylcholine receptors was investigated in several in situ and in vitro systems and compared with the activity of nicotine and suxamethonium. |
1999-09-28 |
2023-08-12 |
mouse |
| P A Akah, C N Aguwa, R U Ag. Studies on the antidiarrhoeal properties of pentaclethra macrophylla leaf extracts. Phytotherapy research : PTR. vol 13. issue 4. 1999-09-16. PMID:10404533. |
on isolated tissue preparations, the extracts significantly reduced in a non-specific manner contractions evoked by acetylcholine, nicotine and histamine. |
1999-09-16 |
2023-08-12 |
mouse |
| M Gebauer, B Versen, R Schip. Inhibitory cholinergic effects on the autonomously contractile bulbus cordis branchialis of the cephalopod Sepia officinalis L. General pharmacology. vol 33. issue 1. 1999-09-10. PMID:10428017. |
apart from acetylcholine, nicotine and carbachol (nicotinic agonists), the muscarinic agonists muscarine, arecoline, pilocarpine, and oxotremorine also exerted concentration-dependent negative inotropic effects on the preparations. |
1999-09-10 |
2023-08-12 |
Not clear |
| A Gondou, N Toyoda, M Nishikawa, T Yonemoto, N Sakaguchi, T Tokoro, M Inad. Effect of nicotine on type 2 deiodinase activity in cultured rat glial cells. Endocrine journal. vol 46. issue 1. 1999-09-02. PMID:10426574. |
to analyze further the factors that regulate d2 activity in the cns, we investigated the effects of nicotine and of mecamylamine, which inhibits the binding of nicotine with nicotinic acetylcholine receptors, on d2 activity in cultured mixed glial cells of the rat brain. |
1999-09-02 |
2023-08-12 |
rat |
| A Gondou, N Toyoda, M Nishikawa, T Yonemoto, N Sakaguchi, T Tokoro, M Inad. Effect of nicotine on type 2 deiodinase activity in cultured rat glial cells. Endocrine journal. vol 46. issue 1. 1999-09-02. PMID:10426574. |
in conclusion, nicotine increases d2 activity probably via nicotinic acetylcholine receptors, and may influence brain function, at least in part, by affecting thyroid hormone metabolism. |
1999-09-02 |
2023-08-12 |
rat |
| J Alcayaga, R Varas, J Arroyo, R Iturriaga, P Zapat. Dopamine modulates carotid nerve responses induced by acetylcholine on the cat petrosal ganglion in vitro. Brain research. vol 831. issue 1-2. 1999-08-18. PMID:10411987. |
we have recently reported that application of acetylcholine (ach) or nicotine to the petrosal ganglion-the sensory ganglion of the glossopharyngeal nerve-elicits a burst of discharges in the carotid nerve branch, innervating the carotid body and sinus, but not in the glossopharyngeal branch, innervating the tongue and pharynx. |
1999-08-18 |
2023-08-12 |
cat |
| D S McGehe. Molecular diversity of neuronal nicotinic acetylcholine receptors. Annals of the New York Academy of Sciences. vol 868. 1999-08-12. PMID:10414338. |
the potent behavioral and cognitive effects of nicotine highlight the physiological importance of nicotinic acetylcholine receptors (nachrs). |
1999-08-12 |
2023-08-12 |
Not clear |
| K A Radcliffe, J L Fisher, R Gray, J A Dan. Nicotinic modulation of glutamate and GABA synaptic transmission of hippocampal neurons. Annals of the New York Academy of Sciences. vol 868. 1999-08-12. PMID:10414340. |
modulation of synaptic activity by presynaptic calcium influx may represent a physiological role of acetylcholine in the brain, as well as a mechanism of action of nicotine. |
1999-08-12 |
2023-08-12 |
Not clear |
| S Vailati, W Hanke, A Bejan, B Barabino, R Longhi, B Balestra, M Moretti, F Clementi, C Gott. Functional alpha6-containing nicotinic receptors are present in chick retina. Molecular pharmacology. vol 56. issue 1. 1999-07-22. PMID:10385679. |
the alpha6-containing receptors bind [3h]epi (kd = 35 pm) and a number of other nicotinic agonists with very high affinity, the rank order being epi >> cytisine > nicotine > 1, 1-dimethyl-4-phenylpiperazinium > acetylcholine > carbamylcholine. |
1999-07-22 |
2023-08-12 |
chicken |