| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Marchi, M Lupinacci, E Bernero, F Bergaglia, M Raiter. Nicotinic receptors modulating ACh release in rat cortical synaptosomes: role of Ca2+ ions in their function and desensitization. Neurochemistry international. vol 34. issue 4. 1999-07-20. PMID:10372918. |
increasing concentrations of acetylcholine (plus atropine), nicotine and (+)-anatoxin-a produced elevations of the k+-evoked [3h]acetylcholine overflow resulting in bell-shaped concentration-response curves. |
1999-07-20 |
2023-08-12 |
rat |
| M Marchi, M Lupinacci, E Bernero, F Bergaglia, M Raiter. Nicotinic receptors modulating ACh release in rat cortical synaptosomes: role of Ca2+ ions in their function and desensitization. Neurochemistry international. vol 34. issue 4. 1999-07-20. PMID:10372918. |
synaptosomes pretreated with different concentrations (10 microm to 0.001 microm) of acetylcholine or nicotine responded to a subsequent nicotinic stimulus (10 microm acetylcholine plus 0.1 microm atropine, in 15 mm k+) in a manner reflecting varying degrees of desensitization. |
1999-07-20 |
2023-08-12 |
rat |
| S S Watkins, M P Epping-Jordan, G F Koob, A Marko. Blockade of nicotine self-administration with nicotinic antagonists in rats. Pharmacology, biochemistry, and behavior. vol 62. issue 4. 1999-07-09. PMID:10208381. |
these results indicate that nicotine is an effective reinforcer in wistar rats under the present parameters, and that these reinforcing effects are mediated by activation of nicotinic acetylcholine receptors. |
1999-07-09 |
2023-08-12 |
rat |
| N B Lawand, Y Lu, K N Westlun. Nicotinic cholinergic receptors: potential targets for inflammatory pain relief. Pain. vol 80. issue 1-2. 1999-06-30. PMID:10204742. |
epibatidine (ep), a potent agonist for neuronal nicotinic acetylcholine receptors sharing similar structural and functional characteristics with acetylcholine and nicotine, has been used in this study. |
1999-06-30 |
2023-08-12 |
rat |
| E Zornik, K Paisley, R Nichol. Neural transmitters and a peptide modulate Drosophila heart rate. Peptides. vol 20. issue 1. 1999-06-29. PMID:10098623. |
acetylcholine and nicotine decrease larval and pupal heart rate, while acetylcholine decreases and nicotine increases adult heart rate. |
1999-06-29 |
2023-08-12 |
drosophila_melanogaster |
| C P Fenster, T L Whitworth, E B Sheffield, M W Quick, R A Leste. Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366615. |
it is hypothesized that desensitization of neuronal nicotinic acetylcholine receptors (nachrs) induced by chronic exposure to nicotine initiates upregulation of nachr number. |
1999-06-28 |
2023-08-12 |
Not clear |
| W Marszalec, G L Aistrup, T Narahash. Ethanol-nicotine interactions at alpha-bungarotoxin-insensitive nicotinic acetylcholine receptors in rat cortical neurons. Alcoholism, clinical and experimental research. vol 23. issue 3. 1999-06-25. PMID:10195816. |
in the presence of alpha-bungarotoxin both acetylcholine (ach) and nicotine evoked currents with respective ec50 values of 4.3 and 3.4 microm. |
1999-06-25 |
2023-08-12 |
rat |
| L M Marubio, M del Mar Arroyo-Jimenez, M Cordero-Erausquin, C Léna, N Le Novère, A de Kerchove d'Exaerde, M Huchet, M I Damaj, J P Changeu. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature. vol 398. issue 6730. 1999-06-14. PMID:10235262. |
nicotine exerts antinociceptive effects by interacting with one or more of the subtypes of nicotinic acetylcholine receptors (nachrs) that are present throughout the neuronal pathways that respond to pain. |
1999-06-14 |
2023-08-12 |
mouse |
| R Reitstetter, R J Lukas, R Gruene. Dependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure. The Journal of pharmacology and experimental therapeutics. vol 289. issue 2. 1999-05-20. PMID:10215636. |
we investigated the recovery from desensitization of muscle-type nicotinic acetylcholine receptors in te671/rd cells induced by exposure to acetylcholine or nicotine. |
1999-05-20 |
2023-08-12 |
Not clear |
| R Reitstetter, R J Lukas, R Gruene. Dependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure. The Journal of pharmacology and experimental therapeutics. vol 289. issue 2. 1999-05-20. PMID:10215636. |
the recovery from nicotine-induced desensitization is consistently faster than the recovery from acetylcholine-induced desensitization regardless of whether nicotine or acetylcholine is used to assess levels of desensitization. |
1999-05-20 |
2023-08-12 |
Not clear |
| M I Dávila-García, R A Houghtling, S S Qasba, K J Kella. Nicotinic receptor binding sites in rat primary neuronal cells in culture: characterization and their regulation by chronic nicotine. Brain research. Molecular brain research. vol 66. issue 1-2. 1999-05-13. PMID:10095073. |
5 nm, and the binding is inhibited by the agonists nicotine, acetylcholine, and epibatidine with ic50 values of 1 to 20 nm, and by carbachol and the antagonist dihydro-beta-erythroidine with ic50 values of 0.5 to 1.5 microm. |
1999-05-13 |
2023-08-12 |
rat |
| W G Mayhan, G M Sharp. Chronic exposure to nicotine alters endothelium-dependent arteriolar dilatation: effect of superoxide dismutase. Journal of applied physiology (Bethesda, Md. : 1985). vol 86. issue 4. 1999-05-03. PMID:10194193. |
we measured the diameter of cheek pouch resistance arterioles (approximately 50 microm in diameter) in response to endothelium-dependent (acetylcholine and adp) and -independent (nitroglycerin) agonists in control hamsters and hamsters treated with nicotine (2 microg. |
1999-05-03 |
2023-08-12 |
Not clear |
| W G Mayhan, G M Sharp. Chronic exposure to nicotine alters endothelium-dependent arteriolar dilatation: effect of superoxide dismutase. Journal of applied physiology (Bethesda, Md. : 1985). vol 86. issue 4. 1999-05-03. PMID:10194193. |
in contrast, acetylcholine (0.1 and 1.0 microm) dilated arterioles by only 5 +/- 2 and 12 +/- 3%, respectively, and adp (1.0 and 10 microm) dilated arterioles by only 7 +/- 2 and 13 +/- 3%, respectively, in animals treated with nicotine (p < 0.05 vs. response in control hamsters). |
1999-05-03 |
2023-08-12 |
Not clear |
| E Gálvez-Ruano, I Iriepa-Canalda, A Morreale, K B Lipkowit. A computational model of the nicotinic acetylcholine binding site. Journal of computer-aided molecular design. vol 13. issue 1. 1999-04-28. PMID:10087500. |
this was accomplished by using three known agonists (acetylcholine, nicotine and epibatidine) as templates around which polypeptide side chains, found to be part of the receptor cavity from published molecular biology studies, are allowed to flow freely in molecular dynamics simulations and mold themselves around these templates. |
1999-04-28 |
2023-08-12 |
Not clear |
| G A Buznikov, L Raki. [Cholinergic receptors in early (pre-nervous) sea urchin embryos]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 84. issue 10. 1999-04-26. PMID:10097271. |
agonists of nicotinic acetylcholine receptors (nachr) nicotine and 1-acetyl-4-methylpiperazine do not act on the early sea urchin embryogenesis but evoke calcium shock in both oocytes and early embryos under certain conditions. |
1999-04-26 |
2023-08-12 |
Not clear |
| H Kobayashi, T Suzuki, R Kamata, S Saito, I Sato, S Tsuda, N Matsusak. Recent progress in the neurotoxicology of natural drugs associated with dependence or addiction, their endogenous agonists and receptors. The Journal of toxicological sciences. vol 24. issue 1. 1999-04-22. PMID:10073332. |
such active substances and receptors include acetylcholine (ach) and the nicotinic ach receptor (nachr) for nicotine, anandamide and cb1 for delta 9-thc, and endomorphins (1 and 2) and the mu (op3) opioid receptor for morphine, respectively. |
1999-04-22 |
2023-08-12 |
Not clear |
| J Q Zheng, X P He, A Z Yang, C G Li. Kinetic properties of nicotinic receptors in cultured rat sympathetic neurons from superior cervical ganglia. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 18. issue 4. 1999-04-15. PMID:10072915. |
to analyze the kinetic properties of the effect of nicotine on nicotinic acetylcholine receptors (nachr) in the cultured sympathetic neurons from neonatal rat superior cervical ganglia (scg). |
1999-04-15 |
2023-08-12 |
rat |
| P Plenge, E Melleru. Non-acetylcholine displaceable 3[H]epibatidine binding in the rat brain. Neuroscience letters. vol 248. issue 1. 1999-03-30. PMID:9665665. |
using acetylcholine and nicotine in concentrations able to displace 3[h]epibatidine from the alpha4beta2 and alpha3beta4 subunits, in a few brain structures a non-acetylcholine and non-nicotine displaceable 3[h]epibatidine binding was found. |
1999-03-30 |
2023-08-12 |
rat |
| H M Schuller, M Orlof. Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells. Biochemical pharmacology. vol 55. issue 9. 1999-03-30. PMID:10076528. |
because of the structural similarity of nnn and nnk with nicotine, we hypothesized that these carcinogens are ligands for nicotinic acetylcholine receptors (nachrs). |
1999-03-30 |
2023-08-12 |
human |
| B V Rama Sastry, M E Hemontolor, M Olenic. Prostaglandin E2 in human placenta: its vascular effects and activation of prostaglandin E2 formation by nicotine and cotinine. Pharmacology. vol 58. issue 2. 1999-03-03. PMID:9873232. |
nicotine activates nicotinic receptors and releases placental acetylcholine, a vasodilator of placental arteries. |
1999-03-03 |
2023-08-12 |
human |