| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Panagis, A Kastellakis, C Spyraki, G Nomiko. Effects of methyllycaconitine (MLA), an alpha 7 nicotinic receptor antagonist, on nicotine- and cocaine-induced potentiation of brain stimulation reward. Psychopharmacology. vol 149. issue 4. 2000-10-03. PMID:10867966. |
it has been shown that nicotine facilitates intracranial self-stimulation (icss) reward and that nicotinic acetylcholine receptors (nachrs) in the ventral tegmental area (vta) are of primary importance for its reinforcing and dependence-producing actions. |
2000-10-03 |
2023-08-12 |
Not clear |
| A E Drew, A E Derbez, L L Werlin. Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex. Synapse (New York, N.Y.). vol 38. issue 1. 2000-09-28. PMID:10941136. |
using a superfusion system, we found that nicotine and other agonists at nicotinic acetylcholine receptors enhanced the release of radiolabeled dopamine that was stimulated by 10 microm amphetamine from slices prepared from rat prefrontal cortex. |
2000-09-28 |
2023-08-12 |
rat |
| H D Mansvelder, D S McGehe. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron. vol 27. issue 2. 2000-09-26. PMID:10985354. |
nicotine reinforces smoking behavior by activating nicotinic acetylcholine receptors (nachrs) in the midbrain dopaminergic (da) reward centers, including the ventral tegmental area (vta). |
2000-09-26 |
2023-08-12 |
Not clear |
| M Ericson, J A Engel, B Söderpal. Peripheral involvement in nicotine-induced enhancement of ethanol intake. Alcohol (Fayetteville, N.Y.). vol 21. issue 1. 2000-09-20. PMID:10946156. |
the present study focuses on the possible involvement of central and/or peripheral nicotine acetylcholine receptors (nachr) in nicotine-induced sensitization to dopamine-related behavioral effects of ethanol. |
2000-09-20 |
2023-08-12 |
mouse |
| T Tojima, E It. Bimodal effects of acetylcholine on synchronized calcium oscillation in rat cultured cortical neurons. Neuroscience letters. vol 287. issue 3. 2000-09-01. PMID:10863024. |
application of acetylcholine and nicotine increased, decreased, or did not change the frequency of synchronized ca(2+) oscillation, depending on the colonies in the culture. |
2000-09-01 |
2023-08-12 |
rat |
| M Ericson, P Olausson, J A Engel, B Söderpal. Nicotine induces disinhibitory behavior in the rat after subchronic peripheral nicotinic acetylcholine receptor blockade. European journal of pharmacology. vol 397. issue 1. 2000-08-29. PMID:10844104. |
it was concluded that the induction of locomotor sensitization to nicotine involves stimulation of central nicotinic acetylcholine receptors, whereas the development of nicotine-induced behavioral disinhibition involves blockade of peripheral nicotinic acetylcholine receptors, and that the latter, but not the former, phenomenon from a pharmacological point of view appears to be related to the increased ethanol consummatory behavior observed after subchronic nicotine administration. |
2000-08-29 |
2023-08-12 |
rat |
| R Iturriaga, J Alcayaga, P Zapat. Lack of correlation between cholinergic-induced changes in chemosensory activity and dopamine release from the cat carotid body in vitro. Brain research. vol 868. issue 2. 2000-08-18. PMID:10854594. |
we studied the effects of nicotine, acetylcholine (ach) and dopamine (da) on the frequency of chemosensory discharges (f(x)) and catecholamine (ca) efflux in the cat carotid body superfused in vitro. |
2000-08-18 |
2023-08-12 |
cat |
| N Durany, R Zöchling, K W Boissl, W Paulus, G Ransmayr, T Tatschner, W Danielczyk, K Jellinger, J Deckert, P Riedere. Human post-mortem striatal alpha4beta2 nicotinic acetylcholine receptor density in schizophrenia and Parkinson's syndrome. Neuroscience letters. vol 287. issue 2. 2000-08-17. PMID:10854724. |
as an upregulation of alpha4beta2 receptors has been observed due to nicotine consumption, the beneficial effects of nicotine described in patients with schizophrenia may be partly due to a compensation for a decrease in alpha4beta2 nicotinic acetylcholine receptors. |
2000-08-17 |
2023-08-12 |
human |
| A Kuryatov, F A Olale, C Choi, J Lindstro. Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10770993. |
we have shown previously that chronic exposure to submicromolar concentrations of nicotine permanently inactivates alpha4beta2 and alpha7 neuronal nicotinic acetylcholine receptors while alpha3beta2 acetylcholine receptors are resistant to inactivation. |
2000-08-11 |
2023-08-12 |
human |
| A Kuryatov, F A Olale, C Choi, J Lindstro. Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10770993. |
thus, inactivation of acetylcholine receptors produced by chronic exposure to nicotine results primarily from effects of the agonist on the extracellular and transmembrane domains of the alpha subunit. |
2000-08-11 |
2023-08-12 |
human |
| B M Conti-Fine, D Navaneetham, S Lei, A D Mau. Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity? European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10771024. |
however, also non-excitable cells, and particularly the tegumental cells that line external and internal body surfaces, express acetylcholine receptors of neuronal type sensitive to nicotine. |
2000-08-11 |
2023-08-12 |
Not clear |
| M M Francis, R W Vazquez, R L Papke, R E Oswal. Subtype-selective inhibition of neuronal nicotinic acetylcholine receptors by cocaine is determined by the alpha4 and beta4 subunits. Molecular pharmacology. vol 58. issue 1. 2000-08-10. PMID:10860932. |
in summary, the present work describes sequence elements critical in both cocaine inhibition and acetylcholine activation of nachrs and indicates that nachrs may provide a site of interaction for the effects of nicotine and cocaine in the nervous system. |
2000-08-10 |
2023-08-12 |
Not clear |
| N Hallquist, A Hakki, L Wecker, H Friedman, S Pros. Differential effects of nicotine and aging on splenocyte proliferation and the production of Th1- versus Th2-type cytokines. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 224. issue 3. 2000-07-24. PMID:10865228. |
nicotine has a multitude of biological actions in the central and peripheral nervous systems where nicotinic acetylcholine receptors are found. |
2000-07-24 |
2023-08-12 |
mouse |
| N Hallquist, A Hakki, L Wecker, H Friedman, S Pros. Differential effects of nicotine and aging on splenocyte proliferation and the production of Th1- versus Th2-type cytokines. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 224. issue 3. 2000-07-24. PMID:10865228. |
nicotinic acetylcholine receptors have also been identified on immune cells, but the effects of nicotine on immune responses are not well characterized. |
2000-07-24 |
2023-08-12 |
mouse |
| J M López-Arrieta, J L Rodríguez, F San. Nicotine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2000-07-06. PMID:10796667. |
nicotine is a cholinergic agonist that acts, not only post-synaptically, but also releases pre-synaptic acetylcholine, and in animal models has been shown to reverse spatial memory decline in rats with lesion in the medial septal nucleus and to show recovery on memory in aged monkeys. |
2000-07-06 |
2023-08-12 |
rat |
| O Salminen, T Seppä, H Gäddnäs, L Ahte. Effect of acute nicotine on Fos protein expression in rat brain during chronic nicotine and its withdrawal. Pharmacology, biochemistry, and behavior. vol 66. issue 1. 2000-07-06. PMID:10837847. |
the observed attenuation of the response to acute nicotine during constant nicotine infusion in pvn and son may be attributable to the desensitization of nicotinic acetylcholine receptors (nachrs) mediating the effects of nicotine in these areas or in their input areas. |
2000-07-06 |
2023-08-12 |
rat |
| O Salminen, L Ahte. The effects of acute nicotine on the body temperature and striatal dopamine metabolism of mice during chronic nicotine infusion. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771156. |
on the 7th day of nicotine infusion dopac and hva concentrations were similar to control; and acute nicotine did not increase them suggesting that nicotinic acetylcholine receptors (nachrs) regulating striatal dopamine metabolism were desensitized. |
2000-07-03 |
2023-08-12 |
mouse |
| C L PATHA. Antagonistic effects of acetylcholine and nicotine on isolated frog hearts. The American journal of physiology. vol 195. issue 1. 2000-07-01. PMID:13583121. |
antagonistic effects of acetylcholine and nicotine on isolated frog hearts. |
2000-07-01 |
2023-08-12 |
Not clear |
| G BURNSTOC. The effect of drugs on spontaneous motility and on response to stimulation of the extrinsic nerves of the gut of a teleostean fish. British journal of pharmacology and chemotherapy. vol 13. issue 3. 2000-07-01. PMID:13584720. |
both nicotine and hexamethonium antagonized the action of acetylcholine, suggesting that its principal site of action is the neurone. |
2000-07-01 |
2023-08-12 |
Not clear |
| H W KOSTERLITZ, J A ROBINSO. The inhibitory action of morphine on the contraction of the longitudinal muscle coat of the isolated guinea-pig ileum. British journal of pharmacology and chemotherapy. vol 13. issue 3. 2000-07-01. PMID:13584732. |
markedly inhibited the contractions of the isolated guinea-pig ileum caused by nicotine, barium, and 5-hydroxytryptamine while the actions of acetylcholine, carbachol, and histamine were affected only a little. |
2000-07-01 |
2023-08-12 |
Not clear |