| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M López-Arrieta, J L Rodríguez, F San. Efficacy and safety of nicotine on Alzheimer's disease patients. The Cochrane database of systematic reviews. issue 2. 2002-02-28. PMID:11406005. |
nicotine is a cholinergic agonist that also has a presynaptic effect in releasing acetylcholine. |
2002-02-28 |
2023-08-12 |
rat |
| C L Devlin, W Schlosser, D T Belz, K Kodiak, R F Nash, N Zitome. Pharmacological identification of acetylcholine receptor subtypes in echinoderm smooth muscle (Sclerodactyla briareus). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 125. issue 1. 2002-02-07. PMID:11790330. |
sclerodactyla briareus) smooth muscle, the longitudinal muscle of the body wall (lmbw), were evoked by acetylcholine (ach) and agonists: epibatidine, muscarine and nicotine (in order of force generation: ach>muscarine=epibatidine>nicotine). |
2002-02-07 |
2023-08-12 |
Not clear |
| Harmanjatinder S Sekhon, Jennifer A Keller, Becky J Proskocil, Ellen L Martin, Eliot R Spinde. Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. American journal of respiratory cell and molecular biology. vol 26. issue 1. 2002-01-31. PMID:11751201. |
the recent identification of nicotinic acetylcholine receptors (nachr) in pulmonary fibroblasts suggests that in utero nicotine exposure may alter collagen expression by these cells in the developing lung. |
2002-01-31 |
2023-08-12 |
monkey |
| P A St John, H Gordo. Agonists cause endocytosis of nicotinic acetylcholine receptors on cultured myotubes. Journal of neurobiology. vol 49. issue 3. 2002-01-30. PMID:11745659. |
in addition, agonist-induced endocytosis of nicotinic acetylcholine receptors (nachrs) in particular might be involved in nicotine tolerance and addiction. |
2002-01-30 |
2023-08-12 |
Not clear |
| Ayuko Igarashi, Sumio Amagasa, Hideo Horikawa, Machiko Shirahat. Vecuronium directly inhibits hypoxic neurotransmission of the rat carotid body. Anesthesia and analgesia. vol 94. issue 1. 2002-01-25. PMID:11772812. |
acetylcholine and nicotine increased csna, and the values of deltacsna were significantly attenuated by vecuronium. |
2002-01-25 |
2023-08-12 |
rat |
| J W Pettegrew, K Panchalingam, R J McClure, J Levin. Brain metabolic effects of acute nicotine. Neurochemical research. vol 26. issue 2. 2002-01-14. PMID:11478746. |
(-)nicotine acetylcholine receptors are located on both nerve cell bodies and synaptic terminals, are permeable to calcium, and function perhaps predominantly by facilitating the release of neurotransmitters and neuropeptides. |
2002-01-14 |
2023-08-12 |
rat |
| J Arredondo, V T Nguyen, A I Chernyavsky, D L Jolkovsky, K E Pinkerton, S A Grand. A receptor-mediated mechanism of nicotine toxicity in oral keratinocytes. Laboratory investigation; a journal of technical methods and pathology. vol 81. issue 12. 2002-01-10. PMID:11742036. |
oral keratinocytes (okc) express nicotinic acetylcholine receptors (nachrs) that bind nicotine (nic). |
2002-01-10 |
2023-08-12 |
mouse |
| M E Nelson, F Wang, A Kuryatov, C H Choi, V Gerzanich, J Lindstro. Functional properties of human nicotinic AChRs expressed by IMR-32 neuroblastoma cells resemble those of alpha3beta4 AChRs expressed in permanently transfected HEK cells. The Journal of general physiology. vol 118. issue 5. 2002-01-08. PMID:11696612. |
agonist potencies (ec(50) values) followed the rank order of 1,1-dimethyl-4-phenylpiperazinium (dmpp; 16+/-1 microm) > nicotine (nic; 48 +/- 7 microm) > or = cytisine (cyt; 57 +/- 3 microm) = acetylcholine (ach; 59 +/- 6 microm). |
2002-01-08 |
2023-08-12 |
human |
| V V Bezuglov, G N Zinchenko, L A Nikitina, G A Buzniko. [Arachidonoylcholine and N,N-dimethylaminoethyl arachidonate are new cholinergic compounds]. Bioorganicheskaia khimiia. vol 27. issue 3. 2002-01-03. PMID:11443948. |
experiments on the embryos and larvae of sea urchins, sensitive to cholinergic compounds, showed that arachidonoylcholine exhibited cholinomimetic activity similar to that of nicotine whereas n,n-dimethylaminoethyl arachidonate acted as an acetylcholine antagonist. |
2002-01-03 |
2023-08-12 |
Not clear |
| K Matsunaga, T W Klein, H Friedman, Y Yamamot. Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 11. 2002-01-02. PMID:11714820. |
involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to legionella pneumophila infection by nicotine. |
2002-01-02 |
2023-08-12 |
Not clear |
| K Matsunaga, T W Klein, H Friedman, Y Yamamot. Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine. Journal of immunology (Baltimore, Md. : 1950). vol 167. issue 11. 2002-01-02. PMID:11714820. |
nicotinic acetylcholine receptors (nachrs) are the receptor for nicotine and may be involved in the modulation of macrophage function by nicotine. |
2002-01-02 |
2023-08-12 |
Not clear |
| Y Wang, E F Pereira, A D Maus, N S Ostlie, D Navaneetham, S Lei, E X Albuquerque, B M Conti-Fin. Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors. Molecular pharmacology. vol 60. issue 6. 2001-12-21. PMID:11723227. |
exposure of cultured bec to nicotine (1 microm) for 3 days up-regulated functional alpha7 and alpha3 nachrs, as indicated by the increased number of cells responding to acetylcholine and choline, with both fast-desensitizing currents, which were blocked irreversibly by alpha-bungarotoxin, and with slowly desensitizing currents, which are alpha-bungarotoxin-insensitive currents. |
2001-12-21 |
2023-08-12 |
human |
| F I Carroll, J R Lee, H A Navarro, L E Brieaddy, P Abraham, M I Damaj, B R Marti. Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted-3'-phenyl-5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Novel nicotinic antagonist. Journal of medicinal chemistry. vol 44. issue 24. 2001-12-12. PMID:11708907. |
a series of 2'-substituted-3'-phenyl epibatidine analogues were synthesized and evaluated for inhibition of binding at nicotine acetylcholine receptors and for antinociceptive properties in mice. |
2001-12-12 |
2023-08-12 |
mouse |
| I Wessler, E Roth, S Schwarze, W Weikel, F Bittinger, C J Kirkpatrick, H Kilbinge. Release of non-neuronal acetylcholine from the human placenta: difference to neuronal acetylcholine. Naunyn-Schmiedeberg's archives of pharmacology. vol 364. issue 3. 2001-12-04. PMID:11521162. |
a concentration of 10 microm nicotine was ineffective, but 100 microm nicotine enhanced acetylcholine release gradually over a 50-min period without desensitization of the response. |
2001-12-04 |
2023-08-12 |
human |
| I Wessler, E Roth, S Schwarze, W Weikel, F Bittinger, C J Kirkpatrick, H Kilbinge. Release of non-neuronal acetylcholine from the human placenta: difference to neuronal acetylcholine. Naunyn-Schmiedeberg's archives of pharmacology. vol 364. issue 3. 2001-12-04. PMID:11521162. |
thus, cholinesterase inhibitors increase assayed acetylcholine by two mechanisms, protection of hydrolysis and stimulation of facilitatory nicotine receptors. |
2001-12-04 |
2023-08-12 |
human |
| K L Brain, S J Trout, V M Jackson, N Dass, T C Cunnan. Nicotine induces calcium spikes in single nerve terminal varicosities: a role for intracellular calcium stores. Neuroscience. vol 106. issue 2. 2001-12-04. PMID:11566509. |
while nicotine is known to act at neuronal nicotinic acetylcholine receptors (nachrs) to facilitate neurotransmitter release, the mechanisms underlying this action are poorly understood. |
2001-12-04 |
2023-08-12 |
mouse |
| H S Sekhon, J A Keller, N L Benowitz, E R Spinde. Prenatal nicotine exposure alters pulmonary function in newborn rhesus monkeys. American journal of respiratory and critical care medicine. vol 164. issue 6. 2001-12-04. PMID:11587984. |
the recent identification of nicotinic acetylcholine receptors (nachr) in fetal lung suggests that the direct interaction between nicotine and nachr in fetal lung may underlie the postnatal pulmonary abnormalities seen in such infants. |
2001-12-04 |
2023-08-12 |
human |
| P Rada, K Jensen, B G Hoebe. Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens. Psychopharmacology. vol 157. issue 1. 2001-10-25. PMID:11512050. |
effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens. |
2001-10-25 |
2023-08-12 |
rat |
| P Rada, K Jensen, B G Hoebe. Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens. Psychopharmacology. vol 157. issue 1. 2001-10-25. PMID:11512050. |
prior research suggests that high levels of acetylcholine (ach) in the nucleus accumbens (nac) are associated with aversive states such as morphine withdrawal, but this has not been tested for nicotine withdrawal. |
2001-10-25 |
2023-08-12 |
rat |
| H Kawai, D K Ber. Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure. Journal of neurochemistry. vol 78. issue 6. 2001-10-25. PMID:11579145. |
nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure. |
2001-10-25 |
2023-08-12 |
rat |