| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bruno Buisson, Daniel Bertran. Nicotine addiction: the possible role of functional upregulation. Trends in pharmacological sciences. vol 23. issue 3. 2002-06-14. PMID:11879680. |
upregulation of binding to nicotinic acetylcholine receptors (nachrs) is observed in the brains of both smokers and animals chronically exposed to nicotine, although whether this in vivo change is accompanied by an increase in receptor function is unknown. |
2002-06-14 |
2023-08-12 |
Not clear |
| K J Kellar, M I Dávila-García, Y Xia. Pharmacology of neuronal nicotinic acetylcholine recceptors: effects of acute and chronic nicotine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 1 Suppl 2. 2002-05-22. PMID:11768167. |
pharmacology of neuronal nicotinic acetylcholine recceptors: effects of acute and chronic nicotine. |
2002-05-22 |
2023-08-12 |
Not clear |
| K J Kellar, M I Dávila-García, Y Xia. Pharmacology of neuronal nicotinic acetylcholine recceptors: effects of acute and chronic nicotine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 1 Suppl 2. 2002-05-22. PMID:11768167. |
neuronal nicotinic acetylcholine receptors mediate nicotine's diverse effects on the brain, spinal cord and autonomic nervous system. |
2002-05-22 |
2023-08-12 |
Not clear |
| M R Picciotto, M Zoli, J P Changeu. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 1 Suppl 2. 2002-05-22. PMID:11768168. |
nicotine binds and activates nicotinic acetylcholine receptors (nachrs) which are made up of combinations of individual nicotinic subunits. |
2002-05-22 |
2023-08-12 |
mouse |
| Roger L Papk. Enhanced inhibition of a mutant neuronal nicotinic acetylcholine receptor by agonists: protection of function by (E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine (TC-2403). The Journal of pharmacology and experimental therapeutics. vol 301. issue 2. 2002-05-13. PMID:11961083. |
the incorporation of a beta4(6'f10't) subunit, which contains sequence from the muscle beta subunit at the tm2 6' and 10' positions of the neuronal beta4 subunit, increases the loss of receptor responsiveness after the application of acetylcholine (ach), nicotine, or 3-(2,4-dimethoxybenzylidene)-anabaseine (dmxb), an alpha7-selective partial agonist. |
2002-05-13 |
2023-08-12 |
Not clear |
| Erin L Meyer, Lorise C Gahring, Scott W Roger. Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor. The Journal of biological chemistry. vol 277. issue 13. 2002-05-10. PMID:11751897. |
nicotine, through interaction with neuronal nicotinic acetylcholine receptors, possesses the ability to modulate neurotransmitter systems through numerous mechanisms that define this critical balance. |
2002-05-10 |
2023-08-12 |
Not clear |
| E Hagforsen, M Edvinsson, K Nordlind, G Michaëlsso. Expression of nicotinic receptors in the skin of patients with palmoplantar pustulosis. The British journal of dermatology. vol 146. issue 3. 2002-05-07. PMID:11952537. |
nicotine acts as an agonist on nicotinic acetylcholine receptors (nachrs) and can influence a variety of cellular functions. |
2002-05-07 |
2023-08-12 |
Not clear |
| N A ANIKIN. [Electrophysiological investigations on the mechanism of chemoreception. I. Modification of afferent impulse conduction in intestinal nerves following chemical irritation with nicotine and acetylcholine of receptors]. Biulleten' eksperimental'noi biologii i meditsiny. vol 42. issue 7. 2002-05-01. PMID:13373904. |
modification of afferent impulse conduction in intestinal nerves following chemical irritation with nicotine and acetylcholine of receptors]. |
2002-05-01 |
2023-08-12 |
Not clear |
| U TRENDELENBUR. The action of morphine on the superior cervical ganglion and on the nictitating membrane of the cat. British journal of pharmacology and chemotherapy. vol 12. issue 1. 2002-05-01. PMID:13413156. |
similar amounts of morphine did not abolish the stimulation of the ganglion by nicotine, tetramethylammonium and potassium chloride.the results provide further evidence for the view that histamine, pilocarpine, and 5-hydroxytryptamine have no "nicotine-like" properties but act on receptors of the ganglion cells different from the acetylcholine receptors. |
2002-05-01 |
2023-08-12 |
cat |
| Davide Franceschini, Richard Paylor, Ron Broide, Ramiro Salas, Laura Bassetto, Cecilia Gotti, Mariella De Bias. Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. Brain research. Molecular brain research. vol 98. issue 1-2. 2002-04-29. PMID:11834293. |
because alpha7-containing neuronal nicotinic acetylcholine receptors (nachrs) represent the major binding site for alpha-btx, mice lacking the alpha7 nachr subunit were predicted to be less sensitive to the convulsive effects of nicotine. |
2002-04-29 |
2023-08-12 |
mouse |
| Nicolas Le Novère, Thomas Grutter, Jean-Pierre Changeu. Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 5. 2002-04-26. PMID:11867716. |
the intrinsic affinities inferred from docking give a rank order epibatidine > nicotine > acetylcholine, in agreement with experimental values. |
2002-04-26 |
2023-08-12 |
Not clear |
| Erik Dybing, Tore Sanne. [Nicotine dependence--medico-biological aspects]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 122. issue 3. 2002-04-18. PMID:11894603. |
nicotine acts as an addictive substance by binding to acetylcholine receptors and causing the release of dopamine in the brain, though other signalling substances are also important for the action of nicotine in the central nervous system. |
2002-04-18 |
2023-08-12 |
Not clear |
| A V Terry, V B Risbrough, J J Buccafusco, F Menzagh. Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys. The Journal of pharmacology and experimental therapeutics. vol 301. issue 1. 2002-04-18. PMID:11907185. |
nicotine, a nonselective ligand for nicotinic acetylcholine receptors (nachrs), has been shown to improve attention and reduce distractibility in humans. |
2002-04-18 |
2023-08-12 |
human |
| Masashi Katsura, Yutaka Mohri, Keijiro Shuto, Yan Hai-Du, Taku Amano, Atsushi Tsujimura, Masashi Sasa, Seitaro Ohkum. Up-regulation of L-type voltage-dependent calcium channels after long term exposure to nicotine in cerebral cortical neurons. The Journal of biological chemistry. vol 277. issue 10. 2002-04-15. PMID:11756415. |
effects of long term (72-h) exposure to low concentration (0.1 mum) of nicotine on various types of voltage-dependent ca(2+) channels (vdccs) and neuronal nicotinic acetylcholine receptors (nnachrs) were examined using primary cultures of mouse cerebral cortical neurons. |
2002-04-15 |
2023-08-12 |
mouse |
| John G Partridge, Subbu Apparsundaram, Greg A Gerhardt, Jennifer Ronesi, David M Lovinge. Nicotinic acetylcholine receptors interact with dopamine in induction of striatal long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 7. 2002-04-08. PMID:11923419. |
dopamine release is modulated by activation of nicotinic receptors in the dorsal striatum, and activation of nicotinic receptors during high-frequency synaptic activation appears to be capable of interacting with dopaminergic actions that lead to striatal ltd. our results suggest that stimulation of mechanisms involved in striatal synaptic plasticity is an important role for striatal nicotinic acetylcholine receptors and that these mechanisms may contribute to the enhancement of learning and habit formation produced by nicotine intake. |
2002-04-08 |
2023-08-12 |
Not clear |
| Li-Mei Shan, Hai Wan. Pharmacological characteristics of the endothelial target for acetylcholine induced vascular relaxation. Life sciences. vol 70. issue 11. 2002-03-21. PMID:11883707. |
among cholinergic receptor agonists, arecoline and oxotremorine rather than nicotine could mimic the effects of acetylcholine. |
2002-03-21 |
2023-08-12 |
rat |
| Brian T Hawkins, Rachel C Brown, Thomas P Davi. Smoking and ischemic stroke: a role for nicotine? Trends in pharmacological sciences. vol 23. issue 2. 2002-03-19. PMID:11830264. |
however, recent studies indicate that nicotine might also interact with intracellular signaling pathways that are independent of acetylcholine receptors. |
2002-03-19 |
2023-08-12 |
Not clear |
| P J Kenny, A Marko. Neurobiology of the nicotine withdrawal syndrome. Pharmacology, biochemistry, and behavior. vol 70. issue 4. 2002-03-12. PMID:11796152. |
recent studies have shown that both central and peripheral populations of nicotinic acetylcholine receptors (nachrs) are involved in mediating somatic signs of nicotine withdrawal as measured by the rodent nicotine abstinence scale. |
2002-03-12 |
2023-08-12 |
human |
| P J Kenny, A Marko. Neurobiology of the nicotine withdrawal syndrome. Pharmacology, biochemistry, and behavior. vol 70. issue 4. 2002-03-12. PMID:11796152. |
nicotine interacts with several neurotransmitter systems, including acetylcholine, dopamine, opioid peptides, serotonin, and glutamate systems. |
2002-03-12 |
2023-08-12 |
human |
| Layla Azam, Ursula H Winzer-Serhan, Yiling Chen, Frances M Lesli. Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. The Journal of comparative neurology. vol 444. issue 3. 2002-03-05. PMID:11840479. |
nicotine regulates dopamine release not only by stimulation of nicotinic acetylcholine receptors (nachrs) on dopamine cell bodies within the substantia nigra and ventral tegmental area (sn/vta), but also on presynaptic nachrs located on striatal terminals. |
2002-03-05 |
2023-08-12 |
Not clear |