| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia C Harkness, Neil S Milla. Changes in conformation and subcellular distribution of alpha4beta2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 23. 2002-12-23. PMID:12451118. |
chronic exposure to nicotine, as occurs during tobacco smoking, is one of several factors that have been reported to cause an upregulation of neuronal nicotinic acetylcholine receptors (nachrs). |
2002-12-23 |
2023-08-12 |
Not clear |
| Maria A Sullivan, Lirio S Cove. Nicotine dependence: the role for antidepressants and anxiolytics. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 2. 2002-12-17. PMID:12020058. |
nicotine stimulates the release of several neurotransmitters including dopamine, norepinephrine, acetylcholine, 5-hydroxytryptamine, gamma-aminobutyric acid (gaba) and endorphins [3]. |
2002-12-17 |
2023-08-12 |
Not clear |
| Patrick O J Covernton, Robin A J Leste. Prolonged stimulation of presynaptic nicotinic acetylcholine receptors in the rat interpeduncular nucleus has differential effects on transmitter release. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175860. |
alterations in nicotinic acetylcholine (nachr) receptor number can be induced by chronic exposure to nicotine possibly by stabilization of the desensitized state(s) of the receptor. |
2002-12-17 |
2023-08-12 |
rat |
| Jean-François Rolland, Jean-Claude Henquin, Patrick Gilo. G protein-independent activation of an inward Na(+) current by muscarinic receptors in mouse pancreatic beta-cells. The Journal of biological chemistry. vol 277. issue 41. 2002-11-25. PMID:12161432. |
using voltage-clamped beta-cells, we identified a small inward current produced by acetylcholine, which was suppressed by atropine or external na(+) omission, but was not mimicked by nicotine, and was insensitive to nicotinic antagonists, tetrodotoxin, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (dids), thapsigargin pretreatment, and external ca(2+) and k(+) removal. |
2002-11-25 |
2023-08-12 |
mouse |
| Michele Zoli, Milena Moretti, Alessio Zanardi, J Michael McIntosh, Francesco Clementi, Cecilia Gott. Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 20. 2002-11-25. PMID:12388584. |
neuronal nicotinic acetylcholine receptors (nachrs) expressed on mesostriatal dopaminergic neurons are thought to mediate several behavioral effects of nicotine, including locomotion, habit learning, and reinforcement. |
2002-11-25 |
2023-08-12 |
rat |
| Aaron J Middlebrook, Cherie Martina, Yung Chang, Ronald J Lukas, Dominick DeLuc. Effects of nicotine exposure on T cell development in fetal thymus organ culture: arrest of T cell maturation. Journal of immunology (Baltimore, Md. : 1950). vol 169. issue 6. 2002-10-23. PMID:12218105. |
there is evidence for both physiological functions of the natural neurotransmitter, acetylcholine, and pharmacological actions of the plant alkaloid, nicotine, on the development and function of the immune system. |
2002-10-23 |
2023-08-12 |
Not clear |
| Xiaoping Zhou, Jim Ren, Erika Brown, David Schneider, Yessi Caraballo-Lopez, James J Galliga. Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183644. |
acetylcholine and nicotine caused inward currents that desensitized in approximately 4 s. the current-voltage (i-v) relationship rectified inwardly with a reversal potential near 0 mv. |
2002-09-18 |
2023-08-12 |
Not clear |
| Xiaoping Zhou, Jim Ren, Erika Brown, David Schneider, Yessi Caraballo-Lopez, James J Galliga. Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183644. |
the agonist rank order potency was 1,1-dimethyl-4-phenyl-piperazinium > acetylcholine = nicotine >> cytisine. |
2002-09-18 |
2023-08-12 |
Not clear |
| Christopher Heeschen, Michael Weis, Alexandra Aicher, Stefanie Dimmeler, John P Cook. A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. The Journal of clinical investigation. vol 110. issue 4. 2002-09-06. PMID:12189247. |
we have recently reported that nicotine has angiogenic effects, which appear to be mediated through non-neuronal nicotinic acetylcholine receptors (nachrs). |
2002-09-06 |
2023-08-12 |
Not clear |
| Darren L Beene, Gabriel S Brandt, Wenge Zhong, Niki M Zacharias, Henry A Lester, Dennis A Doughert. Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. Biochemistry. vol 41. issue 32. 2002-09-03. PMID:12162741. |
cation-pi interactions in ligand recognition by serotonergic (5-ht3a) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. |
2002-09-03 |
2023-08-12 |
mouse |
| Darren L Beene, Gabriel S Brandt, Wenge Zhong, Niki M Zacharias, Henry A Lester, Dennis A Doughert. Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. Biochemistry. vol 41. issue 32. 2002-09-03. PMID:12162741. |
the binding mode of nicotine to the nicotinic receptor of mouse muscle is examined by the same technique and found to differ significantly from that of the natural agonist, acetylcholine. |
2002-09-03 |
2023-08-12 |
mouse |
| Per Plenge, Erling T Mellerup, Gitta Wörtwei. Characterization of epibatidine binding to medial habenula: potential role in analgesia. The Journal of pharmacology and experimental therapeutics. vol 302. issue 2. 2002-08-29. PMID:12130741. |
the objective of the present study was to characterize a recently described binding site in the habenula, which has high affinity for [(3)h]epibatidine and low affinity for nicotine and acetylcholine. |
2002-08-29 |
2023-08-12 |
rat |
| Per Plenge, Erling T Mellerup, Gitta Wörtwei. Characterization of epibatidine binding to medial habenula: potential role in analgesia. The Journal of pharmacology and experimental therapeutics. vol 302. issue 2. 2002-08-29. PMID:12130741. |
the affinity (k(d)) of the medial habenula receptors for [(3)h]epibatidine was estimated to be 0.5 nm using an autoradiographic saturation assay, whereas the affinity of the binding site for nicotine and acetylcholine was estimated to be 5 and 8 microm, respectively. |
2002-08-29 |
2023-08-12 |
rat |
| Ewa Nurowska, Fabio Ruzzie. Modulation of acetylcholine receptor channel kinetics by hydrocortisone. Biochimica et biophysica acta. vol 1564. issue 1. 2002-08-27. PMID:12100991. |
the effects of hc on the open and blocked time constants did not depend on agonist concentration, but was dependent on the type of agonist used (acetylcholine or nicotine). |
2002-08-27 |
2023-08-12 |
cattle |
| Min-Liang Si, Tony J F Le. Alpha7-nicotinic acetylcholine receptors on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilation. Circulation research. vol 91. issue 1. 2002-07-30. PMID:12114323. |
it has been suggested in isolated porcine cerebral arteries that stimulation by nicotine of alpha7-nicotinic acetylcholine receptors (alpha7-nachrs) on sympathetic nerves, but not direct stimulation of parasympathetic nitrergic nerves, caused nitrergic neurogenic dilation. |
2002-07-30 |
2023-08-12 |
Not clear |
| Yumiko Kanemoto, Hitoshi Ishibashi, Atsushi Doi, Norio Akaike, Yushi It. An electrophysiological study of muscarinic and nicotinic receptors of rat paratracheal ganglion neurons and their inhibition by Z-338. British journal of pharmacology. vol 135. issue 6. 2002-07-10. PMID:11906953. |
acetylcholine (ach) or nicotine, and muscarine or oxotremorine-m (ox-m) induced membrane depolarization with rapid and slow time courses respectively, followed by repetitive generation of action potentials in the ganglion cell. |
2002-07-10 |
2023-08-12 |
rat |
| Y Villiger, I Szanto, S Jaconi, C Blanchet, B Buisson, K-H Krause, D Bertrand, J-A Roman. Expression of an alpha7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes. Journal of neuroimmunology. vol 126. issue 1-2. 2002-07-08. PMID:12020960. |
however, nicotine and acetylcholine (ach) failed to elicit current in leukocytes. |
2002-07-08 |
2023-08-12 |
human |
| M R Picciotto, B J Caldarone, D H Brunzell, V Zachariou, T R Stevens, S L Kin. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacology & therapeutics. vol 92. issue 2-3. 2002-06-19. PMID:11916531. |
nicotinic acetylcholine receptors (nachrs) in the muscle, autonomic ganglia, and brain are targets for pharmacologically administered nicotine. |
2002-06-19 |
2023-08-12 |
mouse |
| Ana María Cárdenas, David D Allen, Christian Arriagada, Alexis Olivares, Lori B Bennett, Raúl Caviedes, Alexies Dagnino-Subiabre, Isabel E Mendoza, Juan Segura-Aguilar, Stanley I Rapoport, Pablo Caviede. Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome. Journal of neuroscience research. vol 68. issue 1. 2002-06-18. PMID:11933048. |
finally, we examined cholinergic function in both cell lines and found no significant differences in the [3h]-choline uptake, but fractional acetylcholine release induced by either k+, glutamate or nicotine was significantly higher in mth cells. |
2002-06-18 |
2023-08-12 |
mouse |
| Ray Rush, Alexander Kuryatov, Mark E Nelson, Jon Lindstro. First and second transmembrane segments of alpha3, alpha4, beta2, and beta4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine. Molecular pharmacology. vol 61. issue 6. 2002-06-17. PMID:12021403. |
the first three transmembrane segments (m1-m3) of human nicotinic acetylcholine receptors (nachrs) have been implicated in determining the efficacy of nicotine by studies of alpha3/alpha4 subunit chimeras. |
2002-06-17 |
2023-08-12 |
human |