| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Kawai, D K Ber. Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure. Journal of neurochemistry. vol 78. issue 6. 2001-10-25. PMID:11579145. |
chronic exposure to (-)nicotine has been widely reported to up-regulate nicotinic acetylcholine receptors on neurons and induce long-term inactivation as a possible cause. |
2001-10-25 |
2023-08-12 |
rat |
| M B Newman, S J Nazian, P R Sanberg, D M Diamond, R D Shytl. Corticosterone-attenuating and anxiolytic properties of mecamylamine in the rat. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 3. 2001-10-11. PMID:11371000. |
recent findings also suggest that stress indirectly (via acetylcholine) and nicotine directly stimulates the hpa axis through activation of nachrs. |
2001-10-11 |
2023-08-12 |
rat |
| J A Dani, D Ji, F M Zho. Synaptic plasticity and nicotine addiction. Neuron. vol 31. issue 3. 2001-09-13. PMID:11516393. |
nicotine, the main addictive component of tobacco, activates and desensitizes nicotinic acetylcholine receptors (nachrs). |
2001-09-13 |
2023-08-12 |
Not clear |
| T Narahashi, B Söderpalm, M Ericson, P Olausson, J A Engel, X Zhang, A Nordberg, W Marszalec, G L Aistrup, L G Schmidt, U Kalouti, M Smolka And, L Hedlun. Mechanisms of alcohol-nicotine interactions: alcoholics versus smokers. Alcoholism, clinical and experimental research. vol 25. issue 5 Suppl ISBRA. 2001-09-06. PMID:11391065. |
a. engel; (2) chronic nicotine and ethanol: differential regulation in gene expression of nicotinic acetylcholine receptor subunits, by x. zhang and a. nordberg; (3) nicotine-ethanol interactions at neuronal nicotinic acetylcholine receptors, by toshio narahashi, william marszalec, and gary l. aistrup; (4) relapse prevention in alcoholics by cigarette smoking? |
2001-09-06 |
2023-08-12 |
rat |
| E L Meyer, Y Xiao, K J Kella. Agonist regulation of rat alpha 3 beta 4 nicotinic acetylcholine receptors stably expressed in human embryonic kidney 293 cells. Molecular pharmacology. vol 60. issue 3. 2001-09-06. PMID:11502889. |
the potencies of seven agonists varied over a 7000-fold range, with a rank order of epibatidine >> a85380 > cytisine approximately 1,1-dimethyl-4-phenyl-piperazinium iodide (dmpp) approximately nicotine > acetylcholine > carbachol. |
2001-09-06 |
2023-08-12 |
human |
| E L Meyer, Y Xiao, K J Kella. Agonist regulation of rat alpha 3 beta 4 nicotinic acetylcholine receptors stably expressed in human embryonic kidney 293 cells. Molecular pharmacology. vol 60. issue 3. 2001-09-06. PMID:11502889. |
the efficacies of all of the agonists studied here were similar except for dmpp, which seemed to be a partial agonist compared with nicotine and acetylcholine. |
2001-09-06 |
2023-08-12 |
human |
| N Barazangi, L W Rol. Nicotine-induced enhancement of glutamatergic and GABAergic synaptic transmission in the mouse amygdala. Journal of neurophysiology. vol 86. issue 1. 2001-08-30. PMID:11431525. |
presynaptic nicotinic acetylcholine receptors (nachrs) are thought to mediate some of the cognitive and behavioral effects of nicotine. |
2001-08-30 |
2023-08-12 |
mouse |
| C Du, L W Rol. Differential modulation of nicotinic acetylcholine receptor subtypes and synaptic transmission in chick sympathetic ganglia by PGE(2). Journal of neurophysiology. vol 85. issue 6. 2001-07-26. PMID:11387396. |
the diversity of neuronal nicotinic acetylcholine receptors (nachrs) is likely an important factor in the modulation of synaptic transmission by acetylcholine and nicotine. |
2001-07-26 |
2023-08-12 |
chicken |
| C Heeschen, J J Jang, M Weis, A Pathak, S Kaji, R S Hu, P S Tsao, F L Johnson, J P Cook. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nature medicine. vol 7. issue 7. 2001-07-26. PMID:11433349. |
these effects of nicotine were mediated through nicotinic acetylcholine receptors at nicotine concentrations that are pathophysiologically relevant. |
2001-07-26 |
2023-08-12 |
mouse |
| R Girod, L W Rol. Long-lasting enhancement of glutamatergic synaptic transmission by acetylcholine contrasts with response adaptation after exposure to low-level nicotine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 14. 2001-07-26. PMID:11438593. |
long-lasting enhancement of glutamatergic synaptic transmission by acetylcholine contrasts with response adaptation after exposure to low-level nicotine. |
2001-07-26 |
2023-08-12 |
Not clear |
| M L Si, T J Le. Presynaptic alpha7-nicotinic acetylcholine receptors mediate nicotine-induced nitric oxidergic neurogenic vasodilation in porcine basilar arteries. The Journal of pharmacology and experimental therapeutics. vol 298. issue 1. 2001-07-19. PMID:11408533. |
we further demonstrated in this artery that nicotine acted on nicotinic acetylcholine receptors (nachrs) on presynaptic sympathetic nerve terminals to release norepinephrine (ne), which then acted on beta2-adrenoceptors located on the neighboring noergic nerve terminals to release no, resulting in vasodilation. |
2001-07-19 |
2023-08-12 |
Not clear |
| b' P A Ferchmin, R J Lukas, R M Hann, J D Fryer, J B Eaton, O R Pag\\xc3\\xa1n, A D Rodr\\xc3\\xadguez, Y Nicolau, M Rosado, S Cort\\xc3\\xa9s, V A Eterovi\\xc4\\x8. Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function. Journal of neuroscience research. vol 64. issue 1. 2001-07-12. PMID:11276047.' |
the present study established that tobacco cembranoids inhibit behavioral sensitization to nicotine in rats and block several types of nicotine acetylcholine receptors (achrs). |
2001-07-12 |
2023-08-12 |
human |
| V Zachariou, B J Caldarone, A Weathers-Lowin, T P George, J D Elsworth, R H Roth, J P Changeux, M R Picciott. Nicotine receptor inactivation decreases sensitivity to cocaine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 5. 2001-07-12. PMID:11282258. |
this study investigates the role of high affinity nicotinic acetylcholine receptors (nachrs) in cocaine place preference and examines some neurochemical changes in the mesolimbic da system that might account for the interaction between nicotine and cocaine. |
2001-07-12 |
2023-08-12 |
mouse |
| J Kim, D S Poole, L E Waggoner, A Kempf, D S Ramirez, P A Treschow, W R Schafe. Genes affecting the activity of nicotinic receptors involved in Caenorhabditis elegans egg-laying behavior. Genetics. vol 157. issue 4. 2001-07-12. PMID:11290716. |
agonists of nicotinic acetylcholine receptors such as nicotine and levamisole stimulate egg laying; however, the genetic and molecular basis for cholinergic neurotransmission in the egg-laying circuitry is not well understood. |
2001-07-12 |
2023-08-12 |
caenorhabditis_elegans |
| I C Lai, C J Hong, S J Tsa. Association study of a nicotinic receptor variant with schizophrenic disorders. Neuropsychobiology. vol 43. issue 1. 2001-07-05. PMID:11150893. |
nicotine acetylcholine receptors (nachrs) are implicated in the pathogenesis of schizophrenia because the prevalence of smoking among schizophrenic patients is extraordinarily high, and nicotine has been demonstrated to improve some psychophysiological dysfunction in schizophrenics. |
2001-07-05 |
2023-08-12 |
human |
| R Courjaret, B Lapie. Complex intracellular messenger pathways regulate one type of neuronal alpha-bungarotoxin-resistant nicotinic acetylcholine receptors expressed in insect neurosecretory cells (dorsal unpaired median neurons). Molecular pharmacology. vol 60. issue 1. 2001-07-05. PMID:11408603. |
under 0.5 microm alpha-bungarotoxin treatment, pressure ejection application of nicotine or acetylcholine onto the cell body induced an inward current exhibiting a biphasic current-voltage relationship. |
2001-07-05 |
2023-08-12 |
Not clear |
| J A Court, C Martin-Ruiz, A Graham, E Perr. Nicotinic receptors in human brain: topography and pathology. Journal of chemical neuroanatomy. vol 20. issue 3-4. 2001-05-24. PMID:11207426. |
they participate in the physiological and behavioural effects of acetylcholine and mediate responses to nicotine. |
2001-05-24 |
2023-08-12 |
human |
| R A Bevins, J Beshee. Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors. Physiology & behavior. vol 72. issue 1-2. 2001-05-10. PMID:11240002. |
individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors. |
2001-05-10 |
2023-08-12 |
rat |
| R A Bevins, J Beshee. Individual differences in rat locomotor activity are diminished by nicotine through stimulation of central nicotinic acetylcholine receptors. Physiology & behavior. vol 72. issue 1-2. 2001-05-10. PMID:11240002. |
this data pattern suggests that the disruptive effects of acute and chronic nicotine on individual differences were mediated by neural nicotinic acetylcholine (nach) receptors. |
2001-05-10 |
2023-08-12 |
rat |
| D Morgan, M E Parsons, C J Whela. Investigation of nicotine binding to THP-1 cells: evidence for a non-cholinergic binding site. Biochemical pharmacology. vol 61. issue 6. 2001-04-19. PMID:11266659. |
nicotine is known to modulate immune function, but reports have produced conflicting evidence as to whether nicotinic acetylcholine (nach) receptors are responsible for these effects. |
2001-04-19 |
2023-08-12 |
human |