| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dörthe Brüggmann, Katrin S Lips, Uwe Pfeil, Rainer V Haberberger, Wolfgang Kumme. Rat arteries contain multiple nicotinic acetylcholine receptor alpha-subunits. Life sciences. vol 72. issue 18-19. 2003-04-04. PMID:12628463. |
except the alpha9-subunit, all other mammalian non-muscular alpha-subunits were expressed in the arterial wall--either in endothelial or in smooth muscle cells--suggesting it as a direct target of nicotine and endogenous acetylcholine. |
2003-04-04 |
2023-08-12 |
rat |
| P Song, H S Sekhon, B Proskocil, J K Blusztajn, G P Mark, E R Spinde. Synthesis of acetylcholine by lung cancer. Life sciences. vol 72. issue 18-19. 2003-04-04. PMID:12628474. |
nicotine is an agonist for acetylcholine receptors and stimulates lung cancer growth. |
2003-04-04 |
2023-08-12 |
Not clear |
| Pingfang Song, Harmanjatinder S Sekhon, Yibing Jia, Jennifer A Keller, Jan Krzysztof Blusztajn, Gregory P Mark, Eliot R Spinde. Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer research. vol 63. issue 1. 2003-03-27. PMID:12517800. |
it is well established that small cell lung carcinomas (sclcs) express receptors for acetylcholine (ach) and that stimulation of these receptors by nicotine or other cholinergic agonists stimulates cell growth via activation of nicotinic cholinergic receptors (nachrs) and/or muscarinic cholinergic receptors (machrs). |
2003-03-27 |
2023-08-12 |
Not clear |
| H Moore Arnold, Christopher L Nelson, Martin Sarter, John P Brun. Sensitization of cortical acetylcholine release by repeated administration of nicotine in rats. Psychopharmacology. vol 165. issue 4. 2003-03-20. PMID:12454730. |
sensitization of cortical acetylcholine release by repeated administration of nicotine in rats. |
2003-03-20 |
2023-08-12 |
rat |
| H Moore Arnold, Christopher L Nelson, Martin Sarter, John P Brun. Sensitization of cortical acetylcholine release by repeated administration of nicotine in rats. Psychopharmacology. vol 165. issue 4. 2003-03-20. PMID:12454730. |
this study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. |
2003-03-20 |
2023-08-12 |
rat |
| K O Haustein, S Haffner, B G Woodcoc. A review of the pharmacological and psychopharmacological aspects of smoking and smoking cessation in psychiatric patients. International journal of clinical pharmacology and therapeutics. vol 40. issue 9. 2003-03-12. PMID:12358157. |
the secretion of neurotransmitters such as noradrenaline, serotonin, dopamine, acetylcholine, gamma-amino-butyric acid and glutamate is increased by the binding of nicotine to central nicotine receptors. |
2003-03-12 |
2023-08-12 |
Not clear |
| Li Jia, Karen Flotildes, Maureen Li, Bruce N Cohe. Nicotine trapping causes the persistent desensitization of alpha4beta2 nicotinic receptors expressed in oocytes. Journal of neurochemistry. vol 84. issue 4. 2003-03-05. PMID:12562520. |
to determine whether prolonged nicotine exposure persistently inactivates rat alpha4beta2 nicotinic receptors expressed in xenopus oocytes, we measured the voltage-clamped alpha4beta2 response to acetylcholine (ach) before and 24 h after, 1-h or 12-h incubations in 10 microm nicotine. |
2003-03-05 |
2023-08-12 |
rat |
| Kip A West, John Brognard, Amy S Clark, Ilona R Linnoila, Xiaowei Yang, Sandra M Swain, Curtis Harris, Steven Belinsky, Phillip A Denni. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. The Journal of clinical investigation. vol 111. issue 1. 2003-03-03. PMID:12511591. |
activation of akt by nicotine or nnk occurred within minutes at concentrations achievable by smokers and depended upon alpha(3)-/alpha(4)-containing or alpha(7)-containing nicotinic acetylcholine receptors, respectively. |
2003-03-03 |
2023-08-12 |
mouse |
| C E Richardson, J M Morgan, B Jasani, J T Green, J Rhodes, G T Williams, J Lindstrom, S Wonnacott, S Peel, G A O Thoma. Effect of smoking and transdermal nicotine on colonic nicotinic acetylcholine receptors in ulcerative colitis. QJM : monthly journal of the Association of Physicians. vol 96. issue 1. 2003-02-25. PMID:12509650. |
effect of smoking and transdermal nicotine on colonic nicotinic acetylcholine receptors in ulcerative colitis. |
2003-02-25 |
2023-08-12 |
Not clear |
| Qin Fang, Hong Sun, William G Mayha. Impairment of nitric oxide synthase-dependent dilatation of cerebral arterioles during infusion of nicotine. American journal of physiology. Heart and circulatory physiology. vol 284. issue 2. 2003-02-14. PMID:12388280. |
we measured the diameter of pial arterioles to nos-dependent (adp and acetylcholine) and nos-independent (nitroglycerin) agonists before and after the infusion of nicotine (2 microg x kg(-1) x min(-1) iv for 30 min, followed by a maintenance dose of 0.35 microg x kg(-1) x min(-1)). |
2003-02-14 |
2023-08-12 |
Not clear |
| Christopher Bray, Jung-Ho Son, Stanley Meize. A nicotinic acetylcholine receptor is involved in the arosome reaction of human sperm initiated by recombinant human ZP3. Biology of reproduction. vol 67. issue 3. 2003-02-13. PMID:12193385. |
acetylcholine (ach) at concentrations of 10-250 micro m and nicotine at 10-250 nm significantly initiate the ar of capacitated human sperm. |
2003-02-13 |
2023-08-12 |
human |
| K A Ismail, S C Bergmeie. Structure-activity studies with ring E analogues of methyllycaconitine. Synthesis and evaluation of enantiopure isomers of selective antagonist at the alpha3 nicotinic receptor. European journal of medicinal chemistry. vol 37. issue 6. 2003-02-13. PMID:12204473. |
this indicates that the binding at nicotine acetylcholine receptors (nachrs) is probably non-stereospecific. |
2003-02-13 |
2023-08-12 |
Not clear |
| Héric Valette, Michel Bottlaender, Frédéric Dollé, Christine Coulon, Michèle Ottaviani, André Syrot. Long-lasting occupancy of central nicotinic acetylcholine receptors after smoking: a PET study in monkeys. Journal of neurochemistry. vol 84. issue 1. 2003-01-23. PMID:12485406. |
the aim of this study was to compare the degree of occupancy of central nicotinic acetylcholine receptors (nachr) in isoflurane anaesthetized baboon brain following inhalation of tobacco smoke (one cigarette containing 0.9 mg nicotine) or i.v. |
2003-01-23 |
2023-08-12 |
monkey |
| X-Q Gong, M A Bisso. Acetylcholine-activated Cl- channel in the Chara tonoplast. The Journal of membrane biology. vol 188. issue 2. 2003-01-22. PMID:12172636. |
the effect of acetylcholine is enhanced by nicotine, with the open probability increasing from 0.05 in the presence of 4 mm acetylcholine to 0.3 in the presence of 4 mm acetylcholine + 6 mm nicotine. |
2003-01-22 |
2023-08-12 |
Not clear |
| Manolo Mugnaini, Michela Tessari, Giorgio Tarter, Emilio Merlo Pich, Cristiano Chiamulera, Bernd Bunneman. Upregulation of [3H]methyllycaconitine binding sites following continuous infusion of nicotine, without changes of alpha7 or alpha6 subunit mRNA: an autoradiography and in situ hybridization study in rat brain. The European journal of neuroscience. vol 16. issue 9. 2003-01-13. PMID:12431215. |
it is well established that exposure of experimental animals to nicotine results in upregulation of the alpha4beta2-subtype of neuronal nicotinic acetylcholine receptors (nachrs). |
2003-01-13 |
2023-08-12 |
rat |
| Michael W Quick, Robin A J Leste. Desensitization of neuronal nicotinic receptors. Journal of neurobiology. vol 53. issue 4. 2003-01-13. PMID:12436413. |
this type of mechanism can be extended to explain how the continuous occupation of desensitized receptors during chronic nicotine exposure contributes to drug addiction, and highlights the potential significance of prolonged nachr desensitization that would also occur as a result of extended acetylcholine lifetime during treatment of alzheimer's disease with cholinesterase inhibitors. |
2003-01-13 |
2023-08-12 |
Not clear |
| Huibert D Mansvelder, Daniel S McGehe. Cellular and synaptic mechanisms of nicotine addiction. Journal of neurobiology. vol 53. issue 4. 2003-01-13. PMID:12436424. |
the chain of cause and effect of nicotine addiction starts with the interaction of this tobacco alkaloid with nicotinic acetylcholine receptors (nachrs). |
2003-01-13 |
2023-08-12 |
Not clear |
| Edmond I Eger, Diane Gong, Yilei Xing, Douglas E Raines, Pamela Floo. Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane. Anesthesia and analgesia. vol 95. issue 6. 2003-01-02. PMID:12456426. |
most high-affinity binding sites on nicotinic acetylcholine receptors for nicotine, cytisine, and epibatidine in the brain contain the beta2 subunit of the receptor. |
2003-01-02 |
2023-08-12 |
mouse |
| Lidia Serova, Esther L Sabba. Involvement of alpha 7 nicotinic acetylcholine receptors in gene expression of dopamine biosynthetic enzymes in rat brain. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438507. |
the effects of several concentrations of nicotine (0.08, 0.17, or 0.33 mg/kg body weight) and involvement of alpha7 nicotinic acetylcholine receptors (nachrs) in gene expression of key enzymes in dopamine biosynthesis were evaluated in the ventral tegmental area (vta) and substantia nigra (sn), cell bodies of the mesocorticolimbic and nigrostriatal pathways. |
2002-12-24 |
2023-08-12 |
rat |
| Patricia C Harkness, Neil S Milla. Changes in conformation and subcellular distribution of alpha4beta2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 23. 2002-12-23. PMID:12451118. |
changes in conformation and subcellular distribution of alpha4beta2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras. |
2002-12-23 |
2023-08-12 |
Not clear |