| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Brek Eaton, Jian-Hong Peng, Katherine M Schroeder, Andrew A George, John D Fryer, Chandra Krishnan, Lori Buhlman, Yen-Ping Kuo, Ortrud Steinlein, Ronald J Luka. Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Molecular pharmacology. vol 64. issue 6. 2004-01-16. PMID:14645658. |
heterologously expressed alpha4beta2-nachr functional studies using 86rb+ efflux assays indicate full efficacy of epibatidine, nicotine, and acetylcholine; partial efficacy for 1,1-dimethyl-4-phenyl-piperazinium, cytisine, and suberyldicholine; competitive antagonism by dihydro-beta-erythroidine, decamethonium, and methyllycaconitine; noncompetitive antagonism by mecamylamine and eserine; and mixed antagonism by pancuronium, hexamethonium, and d-tubocurarine. |
2004-01-16 |
2023-08-12 |
human |
| Rosario Garrido, Joe E Springer, Bernhard Hennig, Michal Tobore. Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced of neurotrophic factors. Journal of neurotrauma. vol 20. issue 11. 2004-01-16. PMID:14651807. |
in addition, the present study focused on the effects of nicotine and neuronal nicotinic acetylcholine receptors (nachrs) on these processes. |
2004-01-16 |
2023-08-12 |
Not clear |
| Raad Nashmi, Mary E Dickinson, Sheri McKinney, Mark Jareb, Cesar Labarca, Scott E Fraser, Henry A Leste. Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 37. 2004-01-16. PMID:14684858. |
fura-2 recording of ca2+ influx was used to show that incubation in 1 microm nicotine (2-6 d) upregulates several pharmacological components of acetylcholine (ach) responses in ventral midbrain cultures, including a mla-resistant, dhbetae-sensitive component that presumably corresponds to alpha4beta2 receptors. |
2004-01-16 |
2023-08-12 |
human |
| Sumiko Iho, Yukie Tanaka, Rumiko Takauji, Chino Kobayashi, Ikunobu Muramatsu, Hiromichi Iwasaki, Kishiko Nakamura, Yutaka Sasaki, Kazuwa Nakao, Takayuki Takahash. Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB. Journal of leukocyte biology. vol 74. issue 5. 2004-01-09. PMID:12960242. |
to test the hypothesis that tobacco nicotine stimulates neutrophils in the respiratory tract to produce il-8, which causes neutrophilia in vivo, we examined whether nicotine induces neutrophil-il-8 production in vitro; the causative role of nf-kappab in its production, in association with the possible production of reactive oxygen intermediates that activate nf-kappab; and the nicotinic acetylcholine receptors (nachrs) involved in il-8 production. |
2004-01-09 |
2023-08-12 |
human |
| James P Boorman, Marco Beato, Paul J Groot-Kormelink, Steven D Broadbent, Lucia G Sivilott. The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors. The Journal of biological chemistry. vol 278. issue 45. 2004-01-05. PMID:12912995. |
nevertheless, there was no change in the rank order of potency for agonists (epibatidine >> lobeline > cytisine, 1,1-dimethyl-4-phenylpiperazinium iodide, nicotine > acetylcholine > carbachol for both receptors; measured at low agonist concentrations). |
2004-01-05 |
2023-08-12 |
human |
| Rodrigo Iturriaga, Verónica Cerpa, Patricio Zapata, Julio Alcayag. Catecholamine release from isolated sensory neurons of cat petrosal ganglia in tissue culture. Brain research. vol 984. issue 1-2. 2003-12-10. PMID:12932844. |
application of acetylcholine (ach) or nicotine (nic) as well as adenosine 5'-triphosphate (atp) to the pg in vitro increases the frequency of csn discharges, an effect that is modified by the concomitant application of dopamine (da). |
2003-12-10 |
2023-08-12 |
cat |
| Matthieu Schapira, Ruben Abagyan, Maxim Totro. Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine. BMC structural biology. vol 2. 2003-12-09. PMID:11860617. |
structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine. |
2003-12-09 |
2023-08-12 |
Not clear |
| Xiu Liu, Andrei O Koren, Susan K Yee, Robert N Pechnick, Russell E Poland, Edythe D Londo. Self-administration of 5-iodo-A-85380, a beta2-selective nicotinic receptor ligand, by operantly trained rats. Neuroreport. vol 14. issue 11. 2003-11-20. PMID:12960773. |
nicotine interacts with several subtypes of nicotinic acetylcholine receptors (nachrs). |
2003-11-20 |
2023-08-12 |
rat |
| Marina R Picciott. Nicotine as a modulator of behavior: beyond the inverted U. Trends in pharmacological sciences. vol 24. issue 9. 2003-10-21. PMID:12967775. |
recent data from knockout mouse studies, neurotransmitter release studies and electrophysiological experiments support the hypothesis that conflicting behavioral effects elicited by nicotine can result from the activation of different subtypes of nicotinic acetylcholine receptors and the stimulation of antagonistic neuronal pathways. |
2003-10-21 |
2023-08-12 |
mouse |
| Amy M Avila, Martha I Dávila-García, Veronica S Ascarrunz, YingxIan Xiao, Kenneth J Kella. Differential regulation of nicotinic acetylcholine receptors in PC12 cells by nicotine and nerve growth factor. Molecular pharmacology. vol 64. issue 4. 2003-10-16. PMID:14500754. |
differential regulation of nicotinic acetylcholine receptors in pc12 cells by nicotine and nerve growth factor. |
2003-10-16 |
2023-08-12 |
human |
| Kaoru Kubo, Taizo Kita, Itaru Narushima, Takeshi Tanaka, Toshiaki Nakatani, Toshikatsu Nakashim. Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. Pharmacology & toxicology. vol 92. issue 3. 2003-10-06. PMID:12753427. |
moreover, the immunological inflammatory decreasing effects of a single subcutaneous injection of nicotine (0.4 mg/kg) were antagonized by intraperitoneal preinjection with mecamylamine (1.0 mg/kg; blocking the brain nicotinic acetylcholine receptors) as well as by subcutaneous preinjection with mifepristone (30 mg/kg; a glucocorticoid receptor antagonist) but not by intraperitoneal preinjection with hexamethonium (2.0 mg/kg; a peripheral nicotinic acetylcholine receptors antagonist). |
2003-10-06 |
2023-08-12 |
rat |
| Robert A Neff, Jijiang Wang, Sunit Baxi, Cory Evans, David Mendelowit. Respiratory sinus arrhythmia: endogenous activation of nicotinic receptors mediates respiratory modulation of brainstem cardioinhibitory parasympathetic neurons. Circulation research. vol 93. issue 6. 2003-09-30. PMID:12907666. |
this study establishes a neurochemical link between neurons essential for respiration and cpns, reveals a functional role for endogenous acetylcholine release and the activation of nicotinic receptors in the generation of rsa, and demonstrates that this cardiorespiratory interaction is exaggerated in rats prenatally exposed to nicotine. |
2003-09-30 |
2023-08-12 |
rat |
| Nicolas Champtiaux, Cecilia Gotti, Matilde Cordero-Erausquin, Denis J David, Cédric Przybylski, Clément Léna, Francesco Clementi, Milena Moretti, Francesco M Rossi, Nicolas Le Novère, J Michael McIntosh, Alain M Gardier, Jean-Pierre Changeu. Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 21. 2003-09-16. PMID:12944511. |
nicotinic acetylcholine receptors (nachrs) expressed by dopaminergic (da) neurons have long been considered as potential therapeutic targets for the treatment of several neuropsychiatric diseases, including nicotine and cocaine addiction or parkinson's disease. |
2003-09-16 |
2023-08-12 |
mouse |
| Bruno Bontempi, Kevin T Whelan, Victoria B Risbrough, G Kenneth Lloyd, Frédérique Menzagh. Cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 7. 2003-09-02. PMID:12700710. |
cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and sib-1553a, a subtype-selective ligand for nicotinic acetylcholine receptors. |
2003-09-02 |
2023-08-12 |
mouse |
| Małgorzata Dukat, Richard A Glenno. Epibatidine: impact on nicotinic receptor research. Cellular and molecular neurobiology. vol 23. issue 3. 2003-08-13. PMID:12825833. |
apart from acetylcholine and nicotine, probably no other agent has had as much recent impact on nach research as has epibatidine. |
2003-08-13 |
2023-08-12 |
Not clear |
| Ramiro Salas, Fredalina Pieri, Beryl Fung, John A Dani, Mariella De Bias. Altered anxiety-related responses in mutant mice lacking the beta4 subunit of the nicotinic receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 15. 2003-08-13. PMID:12867510. |
nicotine, acting at nicotinic acetylcholine receptors (nachrs), is the primary addictive component of tobacco. |
2003-08-13 |
2023-08-12 |
mouse |
| Douglas P Dohrman, Cindy K Reite. Ethanol modulates nicotine-induced upregulation of nAChRs. Brain research. vol 975. issue 1-2. 2003-07-28. PMID:12763596. |
chronic nicotine exposure results in a deactivation and subsequent upregulation of the expression of nicotinic acetylcholine receptors (nachrs). |
2003-07-28 |
2023-08-12 |
Not clear |
| Martha I Dávila-García, John L Musachio, Kenneth J Kella. Chronic nicotine administration does not increase nicotinic receptors labeled by [125I]epibatidine in adrenal gland, superior cervical ganglia, pineal or retina. Journal of neurochemistry. vol 85. issue 5. 2003-07-24. PMID:12753083. |
neuronal nicotinic acetylcholine receptors (nachrs) were measured in cns and peripheral tissues following continuous exposure to saline or nicotine hydrogen tartrate (3.3 or 10 mg/kg/day) for 14 days via osmotic pumps. |
2003-07-24 |
2023-08-12 |
rat |
| Maryam Eidi, Mohammad-Reza Zarrindast, Akram Eidi, Shahrbanoo Oryan, Kazem Pariva. Effects of histamine and cholinergic systems on memory retention of passive avoidance learning in rats. European journal of pharmacology. vol 465. issue 1-2. 2003-07-21. PMID:12650837. |
cholinoceptor agonist, acetylcholine (1-10 microg/rat) or nicotine (1-10 microg/rat), increased, while a cholinoceptor antagonist, scopolamine (5-20 microg/rat), decreased memory retention. |
2003-07-21 |
2023-08-12 |
rat |
| Lingke Zhao, Yen-Ping Kuo, Andrew A George, Jian-Hong Peng, Madhuri Singh Purandare, Katherine M Schroeder, Ronald J Lukas, Jie W. Functional properties of homomeric, human alpha 7-nicotinic acetylcholine receptors heterologously expressed in the SH-EP1 human epithelial cell line. The Journal of pharmacology and experimental therapeutics. vol 305. issue 3. 2003-07-07. PMID:12626641. |
concentration-response curves show that nicotine, acetylcholine, and choline are efficacious agonists at human alpha 7-nachrs. |
2003-07-07 |
2023-08-12 |
human |